共查询到18条相似文献,搜索用时 78 毫秒
1.
应用地衣芽胞杆菌调治肠道菌群失调的研究 总被引:2,自引:0,他引:2
报道1株从正常待产妇阴道分离培养的地衣芽胞杆菌的生物学特性,并经系统鉴定和生物毒性检测。观察了该菌与葡萄球菌、白色念珠菌、大肠菌等定量混合培养的体外抑菌作用及用该菌制成的生态制剂对雏鸡白痢的实验治疗和临床抢救重症肠菌群微生态失调的效果和机理。 相似文献
2.
目的探讨地衣芽孢杆菌联合肠宁舒颗粒治疗肠易激综合征的临床疗效。方法选择2015年1月至2016年1月收治的腹泻型肠易激综合征患者160例,采用数字表法随机分为联合治疗组(A组)与地衣芽孢杆菌治疗组(B组)。B组口服地衣芽孢杆菌治疗,0.5 g/次,3次/d;A组在地衣芽孢杆菌治疗同时,联合肠宁舒颗粒治疗,5 g/次,3次/d。两组患者疗程均为4周,评价其临床疗效。结果 A组与B组总有效率分别为77.5%、47.5%,A组临床疗效显著优于B组,差异有统计学意义(P<0.05);A组患者腹痛时间、腹痛频率、排便性状异常、腹胀症状缓解的疗效均明显优于B组,差异有统计学意义(P<0.05)。结论地衣芽孢杆菌联合肠宁舒颗粒治疗肠易激综合征的临床疗效显著,值得临床上应用与推广。 相似文献
3.
目的:研究分析对腹泻型肠易激综合征患者采用益生菌治疗的效果。方法将200例腹泻型肠易激综合征患者的入选时间为2013年6月~2014年3月,将患者随机分为两组,对照组100例,采用蒙脱石散治疗,观察组100例,加用益生菌治疗,比较两组患者的治疗效果和不良反应情况。结果观察组患者的治疗有效率为92.0%,对照组72.0%,观察组明显高于对照组,P<0.05;观察组患者的不良反应发生情况低于对照组,P<0.05。结论对腹泻型肠易激综合征患者采用益生菌治疗效果显著,安全性高,值得临床重视和推广。 相似文献
4.
5.
目的 观察应用四苓加芩芍汤治疗腹泻型肠易激综合征临床疗效。方法 采用随机对照试验 ,将 70例患者随机分成治疗组和对照组 ,治疗组 4 0例 ,服用四苓加芩芍汤 ,对照组 30例 ,服用易蒙停。结果 治疗组与对照组总有效率分别为 92 .5 %和 6 6 .7% ,其差异比较有显著统计学意义 (P <0 .0 1)。结论 本方主要针对肝气过旺 ,脾湿下注病机 ,具有柔肝燥湿运脾作用 ,治疗腹泻型肠易激综合征临床效果良好 相似文献
6.
目的 分析肠易激综合征(IBS)及其亚型与胆囊结石的相关性。方法 选取2019年1月-2023年3月于解放军总医院第六医学中心消化内科就诊的患者556例,其中IBS组161例,非IBS组395例。对研究对象进行问卷调查、体格检查及血液检查,比较两组性别、年龄、身高、体重、血压、血生化指标等资料。采用logistic回归分析IBS与胆囊结石的关系。结果 556例患者中胆囊结石90例(16.2%),其中IBS组胆囊结石37例(23.0%),非IBS组胆囊结石53例(13.4%),IBS组胆囊结石患病率高于非IBS组(P<0.05)。IBS组胆囊泥沙样结石6例(3.7%),非IBS组胆囊泥沙样结石3例(0.8%),IBS组患者胆囊泥沙样结石患病率高于非IBS组(P<0.05)。Logistic回归分析发现,年龄、BMI、总胆汁酸(TBA)、总胆固醇(TC)及合并IBS是胆囊结石的独立影响因素(P<0.05)。161例IBS患者中,腹泻型IBS 114例,其中胆囊结石26例(22.8%);便秘型IBS47例,其中胆囊结石11例(23.4%);395例非IBS患者中胆囊结石53... 相似文献
7.
8.
9.
肠易激综合征(irritable bowel syndrome,IBS)是一种最常见的功能性肠道疾病,以腹痛或腹部不适伴排便习惯改变为特征的功能性肠病,经检查可排除这些症状的器质性疾患,其中以腹泻为主的肠易激综合征(D—IBS)最常见。目前缺乏有效治疗IBS的单一药物,我院消化内科联合培菲康和小剂量阿米替林治疗IBS取得较好疗效。 相似文献
10.
11.
目的 探讨盐酸帕罗西汀对难治性肠易激综合征(irritable bowel syndrome,IBS)疗效的影响.方法 124例IBS患者,随机分为常规组和盐酸帕罗西汀组,各62例.常规组口服马来酸曲美布汀0.1 g,3次/d,双歧杆菌活菌胶囊(商品名:培菲康)420 mg,3次/d.盐酸帕罗西汀组在常规组治疗的基础上给予盐酸帕罗西汀20 mg,1次/d,口服.两组疗程均为4周.在治疗前和治疗结束后分别予以焦虑自评量表(SAS)和抑郁自评量表(SDS)测评.观察两组治疗后症状改善情况及有效率.结果 盐酸帕罗西汀组总有效率为96.77%,常规组总有效率为77.42%,两组比较有统计学差异(P<0.01).IBS患者的SAS和SDS治疗前评分与正常人组之间存在显著性差异(P<0.01).盐酸帕罗西汀组患者的SAS和SDS治疗后较治疗前评分有统计学差异(P<0.01),常规组治疗前后SAS和SDS评分无统计学差异(P>0.05).结论 盐酸帕罗西汀对IBS疗效影响较大且能改善患者的情绪状态. 相似文献
12.
目的 调查我海军某部官兵肠易激综合征(IBS)患病情况并分析其可能的影响因素.方法 采用多级分层随机整群抽样方法,对海军某部8600名官兵进行功能性胃肠病(FGIDs)罗马Ⅲ问卷调查,了解IBS的患病情况,同时比较罗马Ⅲ与罗马Ⅱ标准对IBS诊断的差异,并分析其相关影响因素.结果 符合罗马Ⅲ标准的IBS患病率为15.91%(1205/7574),女性患者高于男性(20.37%vs 15.73%,P=0.009),41~45岁为发病高峰年龄,占34.6%;IBS患者以排便困难,腹胀、腹部疼痛或不适为主要症状;饮酒、经常服用药物、有痢疾史、家族史、感到疲劳等为IBS的可能影响因素.罗马Ⅱ标准的IBS患病检出率(1.75%)明显低于罗马Ⅲ标准(P=0.000).结论 我海军某部官兵IBS患病率高,应予以重视.基于罗马Ⅲ标准的患病率明显高于罗马Ⅱ标准. 相似文献
13.
目的 调查肠易激综合征(IBS)患者的生活质量、胃肠道症状及精神心理状况,分析影响其生活质量的主要因素.方法 应用IBS特异生活质量调查表、HAD焦虑抑郁量表和胃肠道症状调查表对IBS患者(n=55)及健康人(对照组,n=40)进行问卷调查,了解其生活质量、胃肠道症状及精神心理状况,并对结果进行统计分析.结果 IBS患者生活质量各方面积分均低于对照组(P<0.05).相关分析显示,生活质量积分与症状严重程度无关,而与焦虑、抑郁积分呈负相关(P<0.05).结论 IBS患者生活质量明显降低,不良精神心理状况是其主要影响因素. 相似文献
14.
目的探讨中枢神经递质系统在肠易激综合征(IBS)发病机制中的可能作用。方法应用冰水灌胃法建立便秘型肠易激综合征(GIBS)大鼠模型,取大鼠的脊髓后角及下丘脑标本,分别应用抗乙酰胆碱酯酶(AchE)、酪氨酸羟化酶(TH)抗体进行免疫组织化学染色,应用彩色病理图像分析系统对阳性表达的面积、不透光率密度值进行半定量分析。结果大鼠IBS模型脊髓后角及下丘脑AchE表达的阳性面积、不透光率密度值均明显增高(P〈0.05),而TH表达的阳性面积、不透光率密度值与正常对照组比较无显著差异(P〉0.05)。结论中枢胆碱能神经系统可能参与了C-IBS的病理生理机制。 相似文献
15.
John G. Hardy Elizabeth Wood Alan G. Clark Jonathan R. Reynolds 《European journal of nuclear medicine and molecular imaging》1986,11(10):393-396
The transit of radiolabelled preparations through the stomach, small intestine and colon was monitored in ten patients with the irritable bowel syndrome. Five patients complained of diarrhoea, and five complained of constipation. The preparations comprised a non-disintegrating capsule and a multiparticulate system. Both preparations emptied from the stomach together and at the same rates in both groups of patients. In the patients complaining of constipation, the transit times through the small intestine were the same for both preparations. In the patients complaining of diarrhoea, the capsule passed through the small intestine slightly faster than the particles, but there were no significant differences in the small-intestinal transit rates of the two patient groups. Within the colon, the transit of the capsule was faster than that of the small particles. Although movement through the colon was, on average, faster in the group of patients complaining of diarrhoea, there was considerable intersubject variability, and the differences in transit rates between the two patient groups were not statistically significant. 相似文献
16.
目的 探讨针刺治疗对腹泻型肠易激综合征(IBS-D)病人静息态功能MRI (rs-fMRI)的脑功能连接(FC)的影响。方法 前瞻性纳入性别、年龄及受教育程度相匹配的IBS-D病人24例及正常对照(NC)组23例。IBS-D病人接受“调神健脾”针刺法治疗6周(3次/周),分别于治疗前、后采用严重程度评分(SSS)、生活质量量表(QOL)及汉密尔顿焦虑量表(HAMA)评价病情及针刺疗效。NC组仅于纳入当日行rs-fMRI检查,IBS-D病人分别于纳入当日和针刺治疗6周结束后48 h内行rs-fMRI检查。在自动解剖标记(AAL)脑区模板上选取双侧岛叶,扣带回(前、中、后部),杏仁核及丘脑为种子点,构建其与全脑各脑区的FC。治疗前后量表评分比较采用配对t检验。NC组及治疗前后IBS-D病人的FC值比较采用单因素方差分析,组间两两比较采用事后检验。采用Pearson相关对IBS-D病人治疗前后的差异脑区FC值与临床量表评分进行分析。结果 IBS-D病人经针刺治疗后较治疗前的SSS、HAMA 评分下降(均P<0.05),QOL评分升高(P<0.05)。与NC组相比,治疗前IBS-D病人的左侧岛叶-右侧颞中回、左侧中扣带回-右侧颞极颞中回脑区的FC增强(均P<0.05);治疗后,上述FC均减弱(均P<0.05)。与NC组相比,治疗后右侧前扣带回-小脑蚓部3区的FC增强(P<0.05),左侧杏仁核-左侧中央后回的FC减弱(P<0.05);而治疗前上述FC差异无统计学意义(P>0.05)。治疗后IBS-D病人的右侧前扣带回-小脑蚓部3区间FC值(0.1±0.2)与HAMA评分(8.2±3.9)呈负相关(r=-0.451, P=0.027),左侧杏仁核-左侧中央后回间FC值(-0.1±0.2)与HAMA评分(8.2±3.9)呈负相关(r=-0.456, P=0.025)。结论 针刺治疗可改变IBS-D病人与内脏疼痛、情绪调节相关脑区的FC,且与临床症状改善相关。 相似文献
17.
Richard G Kavanagh John O’Grady Brian W Carey Owen J O’Connor Michael M Maher 《World journal of radiology》2018,10(11):143-149
The role of radiologic imaging in the investigation of irritable bowel syndrome (IBS) remains a subject of debate and there is some evidence, from recent studies of utilization of imaging in IBS, which focused on associated costs and radiation exposure, that imaging is being used relatively widely in these patients. This review aims to assess current best evidence to accurately define the role of radiologic imaging in IBS patients. Primary and secondary literature searches were performed. Evidence suggests that the lack of “red flag” or alarm features in IBS patients should reassure the clinician that the diagnosis of IBS is correct and United States and United Kingdom guidelines recommend no radiologic imaging for IBS patients if alarm features are not present. In patients presenting with IBS symptoms and alarm features, radiologic testing may be used to exclude an alternative diagnosis and the imaging modality should be chosen based on the most likely alternative diagnosis. 相似文献
18.
Antonio M. Caballero-Plasencia Manuel Valenzuela-Barranco Juan M. Herrerías-Gutiérrez José M. Esteban-Carretero 《European journal of nuclear medicine and molecular imaging》1999,26(4):404-409
Irritable bowel syndrome is the most frequent functional disorder of the digestive system. Patients with irritable bowel syndrome
have motor disorders not only in the colon, but also in other parts of the digestive tract such as the oesophagus and small
intestine; however, it is not known whether the stomach is also involved. We used a radiolabelled mixed solid-liquid meal
(technetium-99m for the solid component, indium-111 for the liquid component) to study gastric emptying of solids (GES), liquids
(GEL) and indigestible solids (GER) in 50 patients diagnosed as having irritable bowel syndrome (30 with predominant constipation
and 20 with predominant diarrhoea). GER was measured by counting the number of indigestible solids remaining in the stomach
4 h after they were swallowed. In patients with irritable bowel syndrome, GES and GEL were slower than in control subjects
(P<0.05). GER was normal in all patients except for two women. Thirty-two patients (64%) showed delayed GES, 29 (58%) delayed
GEL, and 2 (4%) delayed GER. Among patients with irritable bowel syndrome, GES was slower in those with predominant constipation
than in those with predominant diarrhoea (P<0.05); GEL and GER were similar in both groups. Gastroparesis was found in a large proportion of patients with irritable
bowel syndrome, suggesting the presence of a more generalised motor disorder of the gut.
Received 29 July and in revised form 29 December 1998 相似文献