CLINICAL TRIAL OF LOW DOSE GOSSYPOL REGIMEN

Hypokalemia and irreversible infertility induced by the gossypol treatment have prcvented its clinical use on a large scale as a male contraceptive. In order to avoid these serious side effects, doses of gossypol, both in the loading phase and in the maintenance phase were     

A COMPARATIVE STUDY OF TRANSVAGINAL ULTRASONOGRAPHY AND PELVIC ARTERIOGRAM IN ASSESSMENT OF PATIENTS WITH GESTATIONAL TROPHOBLASTIC TUMOUR

Objective. To compare the reliability of transvaginal ultrasonography with pelvic arteriography in the assmssment of patients with gastational trophoblastic disease. Methods. Transvaginal ultrasonography was performed in 24 patients with gestational trophoblastic turnout. Within one week after ultrasound investigation, pelvic arteriography was carried out in each patient. Of 24 cases, 16 patients hadn‘‘t been treated by chemical reagent, 5 had accepted ,2 to 5 courses of chemotherapy, and 3 had achieved complete remission before both investigations performed. Results. In 3 patients with comphte remission, 2 had no evidence of abnormal findings either on transvaginal uhrasonography or on pelvic arteriography, 1 showed intramyometrial lesions by both methods. In the remaining 21 patients, all demostrated a abnormal uterine image, and 5 of them accompanied with the finding of parametrinm metastatic signs by transvnginal ultrasonography; these abnormal results were confirmed by pelvlc arteriogaaphie imaging. However, in two cases without clinical and ultrasonic signs of parametrittm metastasis, pelvic arteriography indicated the early metastasis of parametrium vessels. Conclusions. Even though it is difficult to predict the early paraametrium metastasis in patients with gastatinnal trophoblastic disease by B-ultraonic investigation, our data would support the introduction of transvaginal ultrasonography in the diagnosis and evaluation of gastational trophoblastic tumour.     

COMPARATIVE STUDY ON THE MECHANISM OF FORMATION OF PULSE MANIFESTATIONS IN CORONARY HEART DISEASE AND HEMATOPATHIC PATIENTS

Most patients suffering from coronary heart disease have string-like pulse due mainly to disorder of cardiac function, lowered arterial compliance and increased total peripheral resistance. The common type of pulse in hematopathy patients is rapid, thready, string-like and slippery, due mainly to increased compensatory pumping action of heart, shortening of ejection time of left ventricle, relatively better vessel compliance and blood rheology as well as low total peripheral resistance.     

A COMPARATIVE CLINICAL STUDY ON PREVENTION AND TREATMENT WITH SELECTED CHRONOMEDICATION OF LEUKOPENIA INDUCED BY CHEMOTHERAPY

During the period of therapy,leukopenia induced by chemotherapy was less severe and wascured more rapidly in the selected chronomedieation group (CMG) than in the routinemedication group (RMG).The incidence of leukopenia was markedly lower in CMG(12.9%) than in RMG (48.4%),and the rate of uneventful completion of chemotherapy wasalso higher in CMG (96.8%) than in RMG.These results suggest that selectedchronomedication may he beneficial to the successful completion of chemotherapy in pa-tients with malignant tumor.     

MR IMAGING OF CORONARY ARTERY BYPASS GRAFT： A PRELIMINARY STUDY

Objective. To make a preliminary investigation of the patency and function of coronary artery bypass grafts (CABG) by magnetic resonance(MR) images and to establish a suitable method for follow-up study after CABG operation among Chinese. Methods. MR imaging was performed with a Toshiba 1.5-T unit in 27 patients with 74 grafts. All patients were examined with a breath-hold ECG-gated two-dimensional fast field echo (FFE) sequence to evaluate the patency of bypass grafts, among them 16 patients with 42 grafts were further examined with a phase shift magnetic resonance angiography flow (PSMRAflow) sequence to evaluate the grafts patency as well as the flow velocity and flow volume vs.time. Results. The results showed that 66 of the 74 grafts in the patients of the present series studied with FFE were patent with a patency rate of 89.2%. The results evaluated both with FFE and PSMRAflow remained the same except that two grafts were patent with FFE and the results with PSMRAflow were uncertain. Diastolic perfusion pattern curves were found in 25 of the 32 grafts in patients of the present series. Comparing the flow curves of the grafted left internal manmmry artery with those of the native right internal mammary artery in 7 patients, the systolic peak velocity value (SPV) of the grafted arteries was significantly lower than that of the ungrafted ones, whereas the diastolic peak velocity value(DPV) and the ratio of DPV to SPV were significantly greater than that of the ungrafed ones. Conclusion. The FFE and PSMRAflow sequences were efficient in evaluating patency and obtaining the curves of flow velocity and volume of the bypass grafts. Therefore, they may offer a non-invasive screening method for follow-up study in patients after CABG surgery, although its accuracy should be further evaluated in more patients and comparatively studied with other methods.     

PHARMACOKINETICS OF MAGNESIUM ISOGLYCYRRHIZINATE AFTER SINGLE INTRAVENOUS DOSE IN HEALTHY VOLUNTEERS

Magnesium isoglycyrrhizinate (MgIG) is a sapo-nin, being catalyzed by alkali, isomerizated, salifiedand refined from glycyrrhizic acid which is extractedfrom the roots of the Plant Glycyrrhiza glabra (lico-rice)[1]. As isomer of glycyrrhizic acid, it has …     

A COMPARATIVE STUDY ON THE ANTIFERTILITY EFFECT OF PHENOL ALDEHYDES COMPOUNDS

The spermicidal activity of 5 phenol aldehydes compounds in vitro was compared in various species including rats, mice, rabbits, hamsters, dogs and human. In rats, mice, hamsters     

A COMPARATIVE STUDY OF IMOVANE AND ESTAZOLAM TREATMENT ON SLEEP DISTURBANCES

ＡＣＯＭＰＡＲＡＴＩＶＥＳＴＵＤＹＯＦＩＭＯＶＡＮＥＡＮＤＥＳＴＡＺＯＬＡＭ　ＴＲＥＡＴＭＥＮＴＯＮＳＬＥＥＰＤＩＳＴＵＲＢＡＮＣＥＳＬｉＳｈｕｎｗｅｉ（李舜伟）ａｎｄＷａｎｇＣｈａｎｇｈｕａ（王长华）（ＤｅｐａｒｔｍｅｎｔｏｆＮｅｕｒｏｐｓｙｃｈｉ...     

链激酶加速静脉溶栓治疗急性心肌梗死的疗效

应用冠状动脉造影评价链激酶加速静脉溶栓（ｎ＝２５，链激酶１５０万Ｕ／３０ｍｉｎ）治疗急性心肌梗死的临床效果，并与常规方法（ｎ＝２５，链激酶１５０万／６０ｍｉｎ）作对照，血管再通率分别为８４％和５６％，两组比较有显著性差异，Ｐ＞０．０５；副作用和住院期间死亡率组间比较无差异，Ｐ＞０．０５。结果显示，链激酶加速静脉溶栓治疗急性心肌梗死有增加血管再通率而不增加副作用的优点，值得临床推广。     

通心络胶囊联合静脉溶栓对急性心肌梗死的临床研究

目的:观察通心络胶囊联合静脉溶栓治疗急性心肌梗死(AMI)的疗效观察及其对心肌微循环再灌注影响。方法:将我院2010-01～2012-12间31例急性心肌梗死患者随机分为通心络胶囊组(A组)16例与对照组(B组)15例。A组在药物溶栓治疗(尿激酶/链激酶+硝酸酯类药物+低分子量肝素钙+血管紧张素转换酶抑制剂+β受体阻滞剂+阿司匹林肠溶片)基础上加用通心络胶囊,首剂6粒,以后常规2粒/次,3次/天口服,疗程15d;B组按常规溶栓治疗方案治疗。观察A、B两组开始溶栓后心电图ST段回落情况、心肌酶谱指标、并发症及60d后EF值测定,并对上述数据进行统计学处理(计量资料以x-±s表示,组间比较采用t检验,记数资料以百分率表示,组间比较用x2检验,P<0.05为显著性差异)。结果:A组与B组相比,A组有效率、心电图ST段回落情况、EF值大于B组,A组并发症小于B组,A组酶峰前移并明显下降。结论:通心络胶囊联合静脉药物溶栓对急性心肌梗死(AMI)患者的治疗效果肯定,对溶栓后的心肌再灌注的改善有明确的临床效果。     

尿激酶静脉溶栓治疗急性心肌梗死38例临床分析

目的探讨尿激酶静脉溶栓治疗急性心肌梗死的临床疗效及安全性。方法分析2006年2月—2011年2月收住我科的38例急性心肌梗死患者的临床资料。结果本组冠脉再通29例,再通率76.3%;6例（15.8%）发生轻微出血并发症。结论尿激酶静脉溶栓治疗可靠、安全、使用方便、并发症发生率低且轻微。     

急诊静脉溶栓治疗急性脑梗死临床观察

目的：了解急诊溶栓治疗急性脑梗死患者的院内延迟时间及不同治疗时间的治疗效果。探讨缩短病人院内延迟时间的方法及溶栓治疗的有效时间窗，方法：将80例急性脑梗死患者随机分为两组，每组40例，急诊溶栓组经CT或MRI确诊后立即应用尿激酶静脉溶栓治疗，住院溶栓组则在住院后进行。结果：急诊溶栓组病人来诊至溶栓治疗开始的平均时间为58min，发病6h内接受溶栓治疗者19例（47．5％），住院溶栓组来诊至溶栓治疗开始的平均时间为120min，发病6h内接受溶栓治疗者12例（30％），两组治疗前后神经功能缺损积分比较有显著性差异，组间比较亦有显著性差异（P＜0．05），发病6－48h内溶栓仍有效，结论：急诊尿激酶静脉溶栓治疗急性脑梗死可缩短院内延迟时间，减轻神经功能缺损程度。     

入院时血糖水平与脑梗死静脉溶栓患者预后的相关性研究

目的 探讨入院时血糖水平与急性脑梗死患者静脉溶栓预后的关联.方法 本项研究为回顾性研究,共纳入脑梗死溶栓患者97例,根据入院时血糖水平分为二组:入院时高血糖组(血糖≥7.8mmol/L)及血糖正常组(血糖＜7.8mmol/L).收集二组患者的基线资料,并应用改良的Rankin量表(mRS)评价预后,通过Logistic回归分析研究入院时血糖与静脉溶栓预后的相关性.结果 入院时高血糖组患者的入院时NIHSS评分、高脂血症及糖尿病比率高于血糖正常组,差异有统计学意义(P＜0.05).入院时高血糖组90d良好预后的患者比例较血糖正常组低,分别为46.15％、53.44％,差异具有统计学意义(P＜0.05).Logistic回归分析显示入院时高血糖(OR=2.893,95％CI 1.121～6.921,P=0.022)及糖尿病(OR=2.615,95％CI 1.032～3.997,P=0.029)与预后不良相关.结论 急性缺血性卒中患者入院时血糖水平的升高与静脉溶栓治疗预后不良相关.     

链激酶静脉溶栓治疗急性心肌梗死的效果

1目的　探讨链激酶静脉溶栓治疗急性心肌梗死的效果。2方法　给予 2 3例急性心肌梗死病人 15 0万单位链激酶行静脉溶栓治疗 ,根据临床血管再通指标 ,比较溶栓开始不同时间 (<6 h和 6～ 12 h)和不同的给药速度 (30 m in和 6 0 min滴完 )对疗效的影响。通过择期冠状动脉造影 ,比较临床再通组与未通组冠脉再通率。通过超声心动图及左室造影 ,比较再通组与未通组心功能。3结果　 6 h内溶栓血管再通率 6 8.4% ,6～ 12 h溶栓血管再通率5 0 .0 % ,两者比较差异有显著意义 (χ2 =8.11,P<0 .0 1) ;两种给药速度血管再通率差异无显著意义 (χ2 =0 .0 3,P>0 .0 5 )。左室造影示再通组心功能明显好于未通组 (t=3.2 1,P<0 .0 1)。4结论　链激酶静脉溶栓治疗急性心肌梗死安全有效。     

静脉溶栓对提高急性心肌梗死相关梗死动脉开通率的疗效分析

目的:观察急性心肌梗死尽早(小于6h)实施静脉溶栓治疗,开通相关梗死动脉恢复心肌血液再灌注的疗效。方法:入选治疗组为2009-01～2010-12在我院急诊就诊的228例急性心肌梗死病人,其中156例来院时发病距就诊时间均小于6h,最短者时间为30min,尽快给予静脉溶栓治疗,间接判断溶栓2h内相关梗死动脉开通情况,以及住院后尽早行冠状动脉造影直接观察相关梗死动脉开通情况,适合PCI治疗者同时进行治疗。对照组为72例来院时发病距就诊时间均超过6h,最长时间为2wk,未经静脉溶栓治疗,给予冠状动脉造影及PCI治疗。结果:静脉溶栓治疗组相关梗死动脉开通率为76.92%,对照组为48.61%,出院时治疗组心功能不全为4.81%,对照组19.44%,均有极显著性差异(P<0.001)。结论:尽早实施静脉溶栓治疗,可提高急性心肌梗死相关梗死动脉的开通率,恢复心肌血液再灌注     

尿激酶静脉溶栓治疗老年急性心肌梗塞

选同期入院的老年急性心肌梗塞（ＡＭＩ）患者２４例，分为对照组１４例和尿激酶ＵＫ）静脉溶栓组１０例，进行临床对比观察。结果：在缩小ＡＭＩ范围及改善心功能方面溶栓组优于对照组，两组具显著差异性；５周病死率溶栓组１０％低于对照组２１％；溶栓组再通率６０％与国内报道链激酶静脉栓再通率６６．６％相近；溶栓后再闭塞率１０％上报道１２％略低；溶栓后发生轻度出血占２０％。结论：只要严格选择病例，防止出血等并发症的     

直接冠状动脉内支架安置术和r-SK静脉溶栓治疗急性心肌梗死的对比研究

①目的　比较急性心肌梗死 (AMI)病人直接冠状动脉内支架安置和重组链激酶 (r SK)静脉溶栓治疗的临床疗效。②方法　对初次发病 1 2h以内的 1 0 5例AMI病人 ,随机给予直接冠状动脉内支架安置 (支架组 ,6 0例 )和静脉r SK溶栓 (溶栓组 ,5 5例 )治疗。观察两组梗死相关血管再通成功率、心肌梗死溶栓试验 (TIMI)Ⅲ级血流发生率、平均住院天数、住院病死率 ,出院前二维超声心动图测定并推算左心室射血分数 (LVEF)和梗死区室壁运动指数 (RWMI) ,出院后 6个月病死率、LVEF和RWMI。③结果　支架组与溶栓组相比较 ,梗死相关血管再通率显著提高、TIMIⅢ级血流发生率显著增加、平均住院天数显著缩短、住院病死率显著降低 (χ2 =5 .4 2 4～2 8.931 ,t=7.90 1 ,P <0 .0 5、0 .0 1 ) ;出院前LVEF和RWMI ,两组间存在显著差异 (t =3.2 91、2 .1 2 7,P <0 .0 5、0 .0 1 ) ;出院后 6个月病死率、LVEF和RWMI ,两组比较无显著差异。出院后 6个月LVEF、RWMI与出院前比较 ,支架组与溶栓组均有显著改善 (t=2 .1 92～ 4 .6 1 1 ,P <0 .0 5、0 .0 1 )。④结论　与静脉r SK溶栓治疗相比 ,直接冠状动脉内支架安置术治疗AMI,可更有效地再通梗死相关血管、降低住院病死率、更有效地保护病人心脏功能     

国产重组链激酶与尿激酶在急性下肢深静脉血栓溶栓中的疗效观察

目的观察国产重组链激酶(recombinant streptokinase,r-SK)与尿激酶(urokinase,UK)在急性下肢深静脉血栓(acute deep venious thrombosis,ADVT)溶栓治疗中的临床疗效和不良反应.方法采用平行随机单盲对照试验,自2004年1月～2004年10月对50例急性下肢深静脉血栓形成患者分为2组,每组各25例,A组给予r SK50万U溶栓,B组给予UK50万U溶栓治疗,疗程5 d,总量250万U.同时加用抗凝,抗血小板药物治疗.观察疗效的临床指标、过敏反应及出血并发症等.结果国产重组链激酶组(A组)溶栓有效率为88%,尿激酶组(B组)溶栓有效率为68%,两组间有显著性差异(P＜0.05).两组的不良反应及出血均无显著性差异(P＞0.05).结论重组链激酶和尿激酶都是治疗ADVT疗效肯定、安全的溶栓药物,重组链激酶的疗效明显优于尿激酶.