Case 3

Female, born 1947

Family history: uneventful

Personal history: at the age of 2, angina followed by proteinuria

At 5 years: trauma to the back followed by hematuria

Until 26 years, recurrent macrohematuria following upper respiratory tract infections and mild proteinuria

Laboratory findings:

At the age of 26 years, laboratory blood findings all normal

Inulin-105, PAH clearance 621 ml/min • 1.73 m² BP 105/75 mmHg

Urine: proteinuria 1 g/day; microhematuria, no casts

Clinical diagnosis: Glomerulonephritis     

BookReview

IMMUNOLOGY FOR SURGEONS, J.E. Castro, ed.

HOST DEFENSE AGAINST CANCER AND ITS POTENTIATION, Edited by D. Mizuno

RECEPTOR-SPECIFIC PROTEINS (Plant and Animal Lectins), E.R. Gold

THE MACROPHAGE IN NEOPLASIA, M.A. Fink, Editor

COMPARATIVE IMMUNOLOGY, J.J. Marchalonis, Editor

THE NEUTROPHIL, P. Murphy

METHODS IN IMMUNOLOGY AND IMMUNOCHEMISTRY V, C.A. Williams

TEXTBOOK OF IMMUNOPATHOLOGY, P.A. Miescher

CONTROL OF NEOPLASIA BY MODULATION OF THE IMMUNE SYSTEM, M.A. Chirigos     

Book Review

MECHANISMS OF DISEASE: A Textbook of Comparative General Pathology, D. O. Slauson, B. J. Cooper

PHAGOCYTIC CELLS, J. I. Gallin, A. S. Fauci, eds.

MICROBIAL PERTURBATION OF HOST DEFENCES, Francis 0'Grady, Harry Smith, Eds.

IMMUNOMODULATION BY BACTERIA AND THEIR PRODUCTS, H. Friedman, T.W. Klein, A. Szentivanyi, eds.

DIAGNOSIS AND MANAGEMENT OF UVEITIS AT ATLAS APPROACH, Editors: A.H. Friedman M. Luntz, W.L. Henley

BLOOD: GIFT OR MERCHANDISE, P.J. Hagen

IMMUNOGENETICS, M.B. Zaleski, S. Dubiski, E.G. Niles, R.K. Cunningham

COPING WITH THE BIOMEDICAL LITERATURE, K.S. Warren, Ed.

IMMUNOBIOLOGY OF THE EOSINOPHIL, T. Yoshida M. Torisu, Eds.

STRUCTURE AND FUNCTION OF Fc RECEPTORS, A. Froese, F. Paraskevas, Eds.

THE RETICULOENDOTHELIAL SYSTEM, N. Cohen

THE RETICULOENDOTHELIAL SYSTEM, N.R. Rose, B.V. Siegel, Eds.     

Book Reviews

Immunological Tolerance, (British Medical Bulletin, Volume 32, No. 2, May, 1976), D. W. Dresser, ed.

Immune Reactivity of Lymphocytes (Development, Expression and Control), M. Feldman, A. Globerson, ed.

Immunogenetics and Immunodeficiency, B. Benacerraf, ed.

Manual of Clinical Immunology, N.R. Rose, H. Friedman, eds.

Immunobiology of the Tumor-Host Relationship, R.T. Smith, M. Landy, eds.

The White Cell, M. L. Cline

Transfer Factor, Basic Properties and Clinical Applications, S. Asbher, A. Gotlieb, Ch. H. Kirkpatrick eds.

The Immune System of Secretions, T.B. Tomasi, Jr.

Surgical Immunology, A.M. Minister, ed.

Comparative Immunology, E.L. Cooper

The Immune System A Course on the Molecular and Cellular Basis of Immunity, M.J. Hobart, I. McConnell, eds.

Immunological Response of the Female Reproductive Tract, B. Cinader, A. de Week

Patch Testing, S. Fregert, H. J. Bandmann, eds.

The Role of Immunological Factors in Infectious, Allergic, and Autoimmune Processes, R. F. Beers, Jr., E. G. Bassett, Eds.     

Book Review

GENERAL IMMUNOLOGY by E. L. Cooper

ANTIBODY AS A TOOL The Applications of Immunochemistry, J. J. Marchalonis, G. W. Warr, Eds., A. Johnstone

Both of the above-mentioned works provide a vast array of immunochemical techniques, for the non-immunologist or the beginning immunologist (on a graduate level).

CLINICAL IMMUNOLOGY OF THE KIDNEY, J.B. Zabriskie H., Fillit H., Villareal Jr. E.L. Becker, Eds.

IMMUNE MECHANISMS IN RENAL DISEASES, N.B. Cummings, A.F., Michael

SERUM PROTEIN ABNORMALITIES (Diagnostic and Clinical Aspects), S.E. Ritzmann, J.C. Daniels, Eds.

IMMUNITY AND CONCOMMITANT IMMUNITY IN INFECTIOUS DISEASES P. Kallos, ed.

SEMINAR ON AUTIGEN-AMTIBODY REACTIONS REVISITED, C.A. Bell, Ed.     

Book Review

CELLULAR AND MOLECULAR MECHANISMS OF IMMUNOLOGIC TOLERANCE, T. Hraba, M. Hasek, Eds.

SEMINARS IN INFECTIOUS DISEASE VOLUME IV: BACTERIAL VACCINES, L. Weinstein, B.N. Fields, Editors

CELLULAR IMMUNOLOGY (Selected Readings and Critical Commentar, V.L. Sato, M.L. Gefter, Eds.

DNA, CHROMATIN AND CHROMOSONES, E.M. Bradbury, N. Maclean, H.R. Matthews

CALCIUM AND cAMP AS SYNARCHIC MESSENGERS, H. Rasmussen

LEUKOCYTE FUNCTION, Editor: M. J. Cline     

Book Review

Comparative Immunobiology, M. J. Manning, R. J. Turner

Immunity In Evolution, J. J. Marchalonis, Carel J. van Oss

Microbiology, D, Schlessinger, Editor

THE LYMPHOCYTE Structure and Function—Parts I & II, J.J. Marchalonis, Ed., Marcel Dekker.

Basic And Clinical Immunology, H.H. Fudeuberg, D.P. Sites, J.L. Caldwell, J.V. Wells, Eds.

TUMOR VIRUS INFECTIONS AND IMMUNITY, R.L. Crowell, H. Friedman, J.E. Prier:hardbound

HISTOCOMPATIBILITY, George D. Snell, Jean Dausset     

Book Review

LYMPHOKINES 2, Edgar Pick, Ed.

LYMPHOCYTE CIRCULATION: EXPERIMENTAL AND CLINICAL ASPECTS, By Maria de Sousa

COMPREHENSIVE IMMUNOLOGY, VOL. 7: IMMUNODERMATOLOGY, Edited By: Bijan Safai

THE DISTRIBUTION OF THE HUMAN IMMUNOGLOBULIN ALLOTYPES, A.G. Steinberg & C.E. Cook

INFECTIONS IN THE WMUNOCOMPROMISED HOST-PATHOGENESIS, PREVENTION, AND THERAPY, J. Verhoef, P.K. Peterson, F.G. Quil, Eds.

TUMOR CELL SURFACES AND MALIGNANCY, R.O. Hynes, C. F. Fox, Eds.

PROGRESS IN IMMUNOLOGY IV (“IMMUNOLOGY - 80”), M. Fougereau     

Book Review

Current Trends in Histocompatibility by R. A. Reisfeld, S. Ferrone

Bacterial Adherence by E.H. Beachey

Comprehensive Immunology

The Interferon System. Second Edition. by William E. Stewart II     

Book Reviews

IMMUNOLOGIC DISORDERS IN INFANTS AND CHILDREN, E.R. Stiehm, V.A. Fulginiti, Eds.

T AND B LYMPHOCYTES: ORIGINS, PROPERTIES AND ROLES IN IMMUNE RESPONSES, M.F. Greaves, J. J. T. Owen.

PROGRESS IN IMMUNOLOGY II, L. Brent, J. Holborow, eds.

IMMUNOLOGICAL TOLERANCE (Mechanisms and Potential Therapeutic Applications), D.H. Katz, B. Benacerraf, eds.

ESSENTIAL IMMUNOLOGY, by I.M. Roitt.     

Case 5

A 53-year-old man with a heavy exposure to asbestos 25 years earlier was admitted to the East Orange Veterans Administration Medical Center with a rapidly enlarging chest wall mass of 4-5 weeks duration.

The mass, overlying the ninth and tenth ribs in the infraaxillary area, was firm. On X-ray the ribs appeared eroded and the mass was seen to extend into the pleural space. A chest wall resection was performed, and the tumor was sharply dissected from the diaphragm to which it was firmly adherent. Grossly, it measured 7.5 X 5.0 X 3.0 cm and was yellow-tan with homogeneous and nodular areas The inferior aspect of the ninth rib was obviously involved and the tumor extended between the pleura and intercostal muscle.

The patient did not receive further therapy and was asymptomatic 7 months after surgery.     

Book Review

HEPATITIS B VACCINE, Harshad R. Thacore, Ph. D.

IMMUNOLOGY Part I Cell Interactions Part II Regulation, Edward S. Golub, Ed.

INFECTIONS OF THE GASTROINTESTINAL TRACT Microbiology, Pathophysiology, and Clinical Features, H. L. DuPont, L. K. Pickering

ANAEROBIC BACTERIA, D. W. Lambe, Jr., R. J. Genco, K. J. Mayberry-Carson

MICROBIAL ADHESION TO SURFACES, Editors: R. Berkeley, J. Lynch J. Melling, P. Rutter, B. Vincent     

Regulation of Murine T-Lymphocyte Function by Spleen Cell-Derived and Exogenous Serotonin

The modulatory effects of serotonin on T-cell activity were investigated. T-cell blastogenesis of normal spleen cells was slightly stimulated by the addition of low doses (1 and 10 ng/ml) of the inducer of serotonin release, fenfluramine. In contrast to the stimulatory effects of low doses of fenfluramine, high doses of fenfluramine (1 and 10 ug/ml) or of exogenously added serotonin (≥0.1 ug/ml) inhibited T-cell activation. Both the stimulation by low dose fenfluramine and the inhibition by high dose fenfluramine were accentuated by pretreating mice with tryptophan to heighten intracellular stores of serotonin and then inducing serotonin release. Pretreatment of mice with the serotonin inhibitor p-cholorphenylalanine (PCPA) abolished the fenfluramine inhibition of T-cell activation indicating that the fenfluramine inhibitory effect was mediated via endogenous spleen cell-derived serotonin. However, the PCPA treatment diminished T-cell activation. These results suggest that endogenous serotonin causes a biphasic dose-response effect on T-cell activity with serotonin being required for optimal T-cell function, low doses being immune stimulatory and higher doses being suppressive.

Con-A, concanavain A

5-HT, 5-hydroxytryptamine

LAK, lymphokine-activated killer

NK, natural killer

PCPA, p-cholorphenylalanine

PHA, phytohemagglutinin     

Book Reviews

mmunochemistry by M.F. Steward

In Defense of the Body (An Introduction to the New Immunology) by R. Lewin

Cellular Selection and Regulation in the Immune Response Vol. 29, Gerald M. Edelman, ed.

The Immune System (Genes, Receptors, Signals), E.E. Sercarz, A.R. Williamson and C.F. Fox, eds.     

Book Review

Molecular Immunology A Textbook M.Z. Atassi, C.J. van Oss and D.R. Absolom, Eds. Marcel Dekker, Inc., New York, 1984; hardbound, x + 725 pages, $47.50.

ESSENTIALS OF IMMUNOLOGY W.H. Hildemann Elsevier, New York/Amsterdam, 1984; hardbound, 164 pages, $19.50

THE RETICULOENDOTHELIAL SYSTEM Volume 6: Immunology J.A. Bellanti and H.B. Herscowitz, Eds. Plennum Press, New York, 1984; hardbound, 347 pages, $55.00

THE RETICULOENDOTHELIAL SYSTEM Vol. 7A: Physiology S.M. Reichard and J.P. Filkins, Eds. Plenum, New York, 1984; hardbound, 411 pages, $59.50

WHITE CELL MECHANICS Basic Science and Clinical Aspects H.J. Meiselman, K.A. Lichtman & P.L. LaCelle, Eds. Alan R. Liss, New York, 1984; hardbound, 318 pages

IMMUNOLOGY OF PARASITIC INFECTIONS Second Edition S. Cohen and K.S. Warren, Eds. Blackwell Scientific Publications, Oxford, 1982 hardbound, 848 pages, $96.00

IMMUNOBIOLOGY OF PARASITES AND PARASITIC INFECTIONS J.J. Marchalonis, editor Plenum Press, New York, 1984; hardbound, 497 pages

GIARDIA AND GIARDIASIS L. Erlandsen and E.A. Meyer, Eds. Plenum Press, New York, 1984; hardbound, 407 pages, $65.00     

Book Review

FRONTLERS IN LMMUNOGENETICS W.H. Hildeman, Editor Elsevier/North-Holland, New York, Amsterdam, Oxford, 1981 Hardbound, 268 pages, $45.00

JENNER'S SMALLPOX VACCINE The Riddle of Vaccinia Virus and its Origin D. Baxby Heinemann, London; Exeter, NH, 1981, Hardbound, 214 pages, $25.00

IMMIJNOLOGICAL ASPECTS OF INFECTIOUS DISEASES G. Dick, Editor University Park Press, Baltimore, 1979; hardbound, 524 pages, $29.95

IMMUNOLOGICAL METHODS Volume II I. Lefkovits and B. Pernis Academic Press, New York, 1981; hardbound 316 pages, $35.00

IMMUNOCHEMICAL TECHNIQVES PARTS B & C, H. Van Vunakis & J.J. Langone, Eds. Academic Press, New York, 1981; hardbound, 739 and 729 pages; $59.00 and $58.00.

SELECTED METHODS IN CELLULAR IMMUNOLOGY B.B. Mishell and S.M. Shiigi W.H. Freeman and Co., San Francisco, 1980 Hardcover, 486 pages, $31.95     

Book Review

Immune-aspects of the Spleen J.R. Battisto and J.W. Streilein (eds.) North-Holland Publishing Co., Amsterdam-New York-Oxford, 1976; hardbound, 471 pages, $38.95

Molecular and Biological Aspects of the Acute Allergy Reaction Edited by S.G.O. Johansson, Kjell Strandberg and Borje Unvas Nobel Foundation Symposium 33 Plenum Press, New York 1976 463 pages; hardbound; $39.50

Radioimmunoassay of Biologically Active Compounds. Charles W. Parker Prentice-Hall, Inc.:Englewood Cliffs, N.J., 1976 Hardbound, xiv + 239 pages, $18.95

Endocrine Influences on Lymphatic Organs, Immune Responses, Inflammation and Autoimmunity by Johan Ahlqvist Almqvist & Wiksell, Stockholm, 1976; softbound, Sw. Kr. 76.50

Biological Amplification Systems in Immunology N.K. Day and R.A. Good, Eds. Plenum Medical Book Co., New York, 1977; hardbound, 325 pages, $29.50

Recent Advances in Clinical Virology I A.P. Waterson, Ed. Churchill Livingstone, London & New York, 1977; 200 pages, hardbound, $22.00

Slow Virus Infections of the Central Nervous System Volker ter Meulen and Michael Katz Springer-Verlag, New York, Heidelberg, Berlin, 1977 258 pages hardbound, $27.50     

Book Review

Microbiology-1980 Editor American Society for Microbiology, Washington, D.C., 1980; hardbound ix + 400 pages, $22.00

Infections in The Abnormal Host M.H. Grieco, Editor Yorke medical Books; New York, N.Y.; 1980; hardbound xxii + 1035 pages, $65.00

Intefferon, Vol. 1. Editor-in-Chief, Ion Gresser. Academic Press, 1979, 163 pages, $23.

Lmmuyochemistry of Proteins Volume 3 M.Z. Atassi, Ed. Plenum Press, New York, London, 1979; hardbound, 321 pages, $35.00

The, Antigens Volume V M. M. Sela, Ed. Academic Press, New York, 1979; hardbound, xiii + 410 pages, $35.00     

Book Reviews

Laboratory Diagnosis of Immunologic Disorders G.N. Vyas, D.P. Stites and G. Brecher, eds.; Grune 61 Stratton, New York, 1975; hard-bound, xii + 298 pages, $19.00

Immunologic Fundamentals N.J. Bigley; 225 pages, softbound Year Book Medical Publishers, Chicago, 1975; $9.95

Lymphocyte Stimulation N.R. Sing and J.E. Kay American Elsvier, New York, 1975 398 pages, hardbound, $45.95

The Immunoglobulin A System J. Mestecky and A.R. Lawton, eds.; Plenum, New York, 1974; hardbound, 555 pages; $28.00

Invertebrate Immlmity K. Maramorosch and R.E. Shope, eds. Hardbound, 365 pages; Academic Press London, 1975; $16.50     

Immunological Consequences of Zidovudine Treatment in Control and Morphine or Methadone Treated Mice

The effects of acute and chronic zidovudine (AZT) administration on immunologic test responses of mice were studied. The effects of AZT administration combined with morphine or methadone treatment, were also studied separately comparing the effects of each drug.

We noted that AZT-treatment did not modify the T-lymphocyte subsets (L₃T₄/LyT₂ rate), whereas morphine-treatment and AZT plus morphine treatment decreased the percentage of T helper cells.

Acute and chronic AZT-treatment increased Natural Killer cell (NK) activity and also recovered the decreased NK cell activity produced by morphine-treatment.

AZT-treatment, morphine-treatment, AZT plus morphine treatment and AZT plus methadone treatment strongly depressed the phagocytic physiological activity of Polymorphonuclear leukocytes (PMNs).

Another evidence of immunologic responsiveness against AZT was the reduction of the mitogenic and antigenic response of lymphocytes.

These results suggest a negative role of AZT-treatment especially on phagocytic activity and confirms a depressive effect of morphine-treatment on several immune functions studied. Furthermore, there is no indication of additive or synergistic toxic effects of AZT, morphine and methadone on the immune functions above that seen with each of these drugs when tested alone.