冠心病患者心率变异性分析

目的 分析冠心病人的心率变异性的变化.方法 利用动态心电图监测40例冠心病人(28例ST段下移者为Ⅰ组,12例无ST段下移者为Ⅱ组)和30例正常人(对照组)的心率变异指数和心率,进行心率变异性变化的分析.结果 和正常人比较,冠心病人(Ⅰ组和Ⅱ组)HRVI降低非常明显(P<0.01,P<0.01).最大心率数变慢(P<0.01,P<0.05),最小心率教、平均心率数变快(P<0.05,P<0.05).冠心病Ⅰ组HKVI明显低于对照组(P<0.05).结论 冠心病HRV明显低于正常人.     

冠心病与长程心率变异性

本文用24h动态心电图观察冠心病患者和对照组的心率变异性,并对冠心病患者室性心律失常的心率变异性进行分析。结果显示冠心病组SDNN、SDANN低于对照组,高危室早组SDNN、SDANN亦明显你于低危室早组（Lown分级≤Ⅱ组）。提示冠心病患者交感神经功能亢进和迷走神经功能减弱,促使高危室早发生。     

冠心病患者心率变异性指数的临床意义

目的：研究冠心病患者心率变异性的临床意义。方法：以正常人为对照，应用24小时动态心电图测定84例冠心病患者心率变异指数（HRVI）。结果：冠心病患者HRVI显著低于对照组（P＜0．01）。结论：结果提示冠心病患者HRVI降低的程度与疾病的严重程度有关。     

冠心病患者心率变异性分析

心率变异（HRV）是一种无创伤心血管检查方法，可以准确评估心血管病者的植物神经功能，它是独立于其他传统指标之外的用于预测心肌梗死和心脏性猝死预后的有力指标。本文选择冠心病（CHD）和正常人进行心率变异检查，测定时域分析和频域分析的差异，探讨两种方法与冠心病人的相关性。     

慢性阻塞性肺疾病患者的心率变异性研究

心率变异性常用于反映心脏自主神经功能 ,其分析方法简便、无创伤、重复性好。慢性阻塞性肺疾病 ( COPD)的心率变异性国内外报道较少。本文通过 42例 COPD患者的心率变异性指标测定来研究 COPD与心率变异性的关系。1　资料与方法1.1　资料　 42例男性 COPD患者 ,诊断符合 1997年中华呼吸学会制订的标准 [1 ] ,并排除肺心病及其他心脏疾患 ,年龄6 2～ 78( 6 6± 8.7)岁 ,按第 1秒用力肺活量占预计值百分比( FEV1 % )的多少又分为两组 : 组 18例 ,FEV1 %≥ 70 % ; 组 2 4例 ,FEV1 % <70 %。 40例健康男性作为对照组 ,年龄 6 1～ 75 …     

甲状腺亢进患者50例心率变异性分析

目的：观察甲状腺功能亢进患者与对照组心率变异性的差异。方法：应用24小时动态心电图系统心率变异性中SDNN、SDANN、RMSSD、PNN50四项时域指标，对50例甲状腺功能亢进患者和21例正常人进行心率变异性分析。结果：（1）甲状腺功能亢进患者与对照组各项指标显著降低，差异有统计学意义（P〈0．05）。（2）甲状腺功能亢进患者女性与男性间各项指标差异无统计学意义（P〉0．05）。结论：甲状腺功能亢进患者心率变异性改变主要原因与交感神经和迷走神经的调控功能失衡有关。     

甲状腺亢进患者50例心率变异性分析

目的：观察甲状腺功能亢进患者与对照组心率变异性的差异。方法：应用24小时动态心电图系统心率变异性中SDNNsDANN、RM竺：晶N50四项时域指标，对50例甲状腺功能亢进患者和21例正常人进行心率变异性分析。结果：（1）甲状腺功能亢进患者与对照组各项指标孚著吁低，差异有统计学意义（P〈0．05）。（2）甲状腺功能亢进患者女性与男性间各项指标差异无统计学意义（P〉0.05）。结论：甲状腺功能亢进患者心率变异性改变主要原因与交感神经和迷走神经的调控功能失衡有关。     

康复运动对冠心病患者心脏自主神经功能的影响

摘要 目的：探讨有氧运动对冠心病患者心脏自主神经功能的影响。 方法：18例女性冠心病患者（实验组）,14例女性非冠心病患者（对照组）为本研究的受试者,在康复程序前、后,对她们进行了运动前（安静时）和运动后的心率变异性（HRV）指标的测定,其中包括极低频功率（VLF）、低频功率（LF）、高频功率（HF）、总功率（TP）和低高频比值（LF/HF）。 结果：①与对照组相比,实验组康复程序前安静时VLF、LF、HF和TP均显著降低,而LF/HF显著增高（P＜0.01）,运动后也有相似的趋势。②与康复程序前相比,12周心脏康复程序后,实验组安静时VLF、LF、HF和TP均有显著增高,LF/HF有所降低（P＜0.01和P＜0.05）;运动后HF显著增高,LF/HF显著降低（P＜0.05）。③与安静时相比,康复程序前实验组递增负荷运动后心率变异性指标均无显著性改变;康复程序后实验组递增负荷运动后VLF、LF、TP和LF/HF均有显著降低（P＜0.01和P＜0.05）;对照组递增负荷运动后VLF、LF、HF和TP均有显著降低（P＜0.01和P＜0.05）,LF/HF有显著增高（P＜0.01）。 结论：12周运动心脏康复程序不仅可以提高冠心病患者安静时自主神经的调节功能,而且对改善一次急性运动后自主神经的均衡性也有积极作用。     

美托洛尔对冠心病心绞痛患者心率变异性的影响

目的 分析美托洛尔对冠心病心绞痛患者心率变异性的影响.方法 回顾性选取2020年1月至2021年1月本院收治的98例冠心病心绞痛患者作为研究对象,依据治疗方法将其分为常规治疗组和美托洛尔组,各49例.常规治疗组依据患者的实际病情给予个体化心内科西药治疗,美托洛尔组在常规治疗组基础上给予美托洛尔治疗.比较两组的心绞痛发作...     

12周运动康复对冠心病患者心脏变时性功能和心率恢复值的影响

目的:探讨12周运动康复对冠心病患者心脏变时性功能和心率恢复值(HRR1)的影响。方法:对30例男性冠心病患者进行递增负荷运动试验,根据实验结果将其分为两组,变时性功能正常组(G1,n=19,HRR%≥0.8);变时性功能不全组(G2,n=11,HRR%0.8),并测定受试者运动前、运动中和运动后心率(HR)、摄氧量(VO2)、ST段下降数值和血压。12周运动康复后再次进行递增负荷运动实验,对患者的运动能力和上述指标进行测定分析。结果:与康复程序前相比,12周康复程序后,G1和G2组的VO2peak、HRR1均有显著增加(G1,8%,P0.01;G2,4%,P0.05)、(G1,18.6±3.3—23.8±4.5,P0.01;G2,12.8±4.2—13.7±3.5,P0.05),而G1比G2提高的更加明显。ST段降低显著改善(G1,-0.7±0.5—-0.2±0.5,P0.05;G2,-0.9±0.5—-0.3±0.6,P0.05)。HRR%有显著增加(G1,84.2±2.5—88.9±6.1,P0.05;G2,60.2±8.3—75.8±3.8,P0.05)。结论:12周运动康复可以改善冠心病患者(包括变时性功能正常者和变时性功能不全者)的运动能力,提高冠心病患者运动时自主神经的调节功能,上述积极作用对变时性功能正常者的体现则更为明显。     

Autonomic dysfunction in HIV patients on antiretroviral therapy: studies of heart rate variability

BACKGROUND: The presence of autonomic dysfunction in HIV patients is largely unknown. Early studies found autonomic dysfunction in patients with AIDS. Introduction of highly active antiretroviral combination therapy (ART) has dramatically changed the course of the disease and improved prognosis and decreased morbidity. At present it is not known whether introduction of ART also has decreased autonomic dysfunction. AIM: To evaluate whether autonomic dysfunction is present in an ART-treated HIV population. METHODS: HIV patients receiving ART for at least 3 years (n = 16) and an age-matched control group of healthy volunteers (n = 12) were included. All were non-smokers, non-diabetic and had never received medication for dyslipidaemia or hypertension. Following a 10 min resting period a 5 min ECG recording was performed. Heart rate variability (HRV) analysis was performed in accordance with current guidelines and data reported as median (interquartile range). RESULTS: The resting heart rate was higher in HIV patients compared with controls [69 (62-74) versus 57 (52-60); P<0.001]. Total HRV measured as standard deviation of normal-to-normal (SONN) was lower in the HIV group compared with the controls [36 (25-55) versus 74 (57-84) ms; P<0.01] as was parasympathetic activity measured as square root of the mean squared difference of successive normal-to-normal intervals (RMSSD) [22 (9-30) versus 35 (24-62) ms; P<0.05]. Low frequency power was lower in the HIV group compared with the control group [294 (161-602) versus 946 (711-1668) ms(2); P<0.01]. High frequency power as well as systolic and diastolic blood pressure did not differ between the groups. CONCLUSIONS: The HIV patients in ART have increased resting heart rate and decreased short-term heart rate variability indicating parasympathetic dysfunction.     

Correlation of heart rate recovery and heart rate variability with atrial fibrillation progression

ObjectiveTo examine the combination of heart rate recovery (HRR) and heart rate variability (HRV) in predicting atrial fibrillation (AF) progression.MethodsData from patients with a first detected episode of AF who underwent treadmill exercise testing and 24-h Holter electrocardiography were retrospectively analysed. Autonomic dysfunction was verified using HRR values. Sympathetic and parasympathetic modulation was analysed by HRV. AF progression was defined as transition from the first detected paroxysmal episode to persistent/permanent AF.ResultsOf 306 patients, mean LF/HF ratio and HRR did not differ significantly by AF progression regardless of age (< or ≥65 years). However, when the LF/HF ratio was divided into tertiles, in patients aged <65 years, the mid LF/HF (1.60–2.40) ratio was significantly associated with lower AF progression rates and longer maintenance of normal sinus rhythm. For patients aged <65 years, less metabolic equivalents were related to higher AF progression rates. For patients aged ≥65 years, a low HRR was associated with high AF progression rates.ConclusionIn relatively younger age, high physical capacity and balanced autonomic nervous system regulation are important predictors of AF progression. Evaluation of autonomic function assessed by age could predict AF progression.     

家庭干预对冠心病患者心率变异性的影响

目的探讨家庭干预对冠心病患者心率变异性的影响。方法将92例冠心病患者分为2组,对照组46例,进行常规冠心病健康宣教;干预组46例,在常规冠心病健康宣教的同时进行家庭干预,时间1年。对两组患者进行心率功率谱时域和频域分析。结果两组患者心率变异性（HRV）时域及频域指标均有改善;与对照组相比,干预组HRV值改善更为明显,其中R-R间期的标准差、每5分钟R—R间期均值标准差、SDNN的均值、正常相邻R—R间期差值的均方根、正常相邻R—R间期差值〉50ms的百分比均有改善,超低频（VLF）、低频（LF）和高频（HF）改善均有统计学意义（P〈0．05）。结论家庭干预可明显改善冠心病患者的心率变异性。     

病毒性心肌炎患儿心率及心率变异性的特点分析

目的 分析病毒性心肌炎(VMC)患儿心率及心率变异性(HRV)的特点.方法 将150例VMC患儿作为观察组,同期100例健康儿童作为对照组.2组儿童均进行24 h动态心电图检查,记录24 h最快心率、最慢心率、平均心率,以及醒时和睡时最快心率、最慢心率,并分析HRV.结果 与对照组比较,观察组不同年龄段的患儿24 h最慢心率及平均心率均显著加快;8～16岁患儿24 h最快心率显著减慢.与对照组比较,观察组不同年龄段的患儿醒时及睡时最慢心率均显著加快;仅8～16岁患儿睡时及醒时最快心率显著减慢.除2组4～7岁患儿R-R间期平均值的标准差(SDANN)之间无显著差异以外,观察组各年龄段HRV指标均显著低于对照组.结论 VMC患儿不同年龄段的最慢心率及平均心率均增快,年龄偏大的患儿最快心率减慢;各年龄段HRV指标普遍降低.将心率及HRV结合起来可更全面、更客观地指导VMC诊断并判断预后.     

Effect of diabetes mellitus on heart rate variability in patients with congestive heart failure

This study sought to determine if the severity of autonomic perturbations in patients with heart failure are affected by the presence of diabetes. Decreased HRV is frequent in diabetic patients free of clinically apparent heart disease and has been invoked as a risk factor for sudden cardiac death. However, reduced HRV is also commonly present in patients with left ventricular dysfunction. The effect of diabetes on autonomic dysfunction in this setting is not known. Holter ECGs from 69 diabetic patients and 85 nondiabetic control subjects with heart failure were analyzed. The severity of autonomic dysfunction was assessed using 24-hour time- and frequency-domain HRV analysis. Prognostically important time- and frequency-domain HRV measures (SDNN, SDANN5, total power, and ultra-low frequency power) were not different between the two groups. Time- and frequency-domain parameters modulated by parasympathetic tone (pNN50, RMSSD, and HF power) were depressed to a similar degree in the diabetic and the nondiabetic groups. The low frequency power was significantly lower in diabetic patients (5.8 +/- 0.7 vs 5.3 +/- 1.0, P = 0.02). The ratio of low to high frequency power was substantially lower in the diabetic group (2.2 +/- 0.2 vs 1.4 +/- 0.2, P < 0.0001). These differences were more apparent in insulin-treated diabetics. In the presence of heart failure, HRV parameters that are most predictive of adverse outcome are similar in diabetic and nondiabetic patients. Furthermore, during increased sympathetic stimulation in the setting of heart failure, diabetes does not worsen parasympathetic withdrawal but may mitigate sympathetic activation.     

慢性压力对冠心病患者心率变异性的影响

冠心病是一种公认的心身疾病,严重威胁人类健康,慢性压力在冠心病发生和发展的整个过程中起到了重要作用,心脏神经功能紊乱可能是慢性压力导致冠心痛的机制之一.心率变异性分析（HRV）是一种快捷无创的检查,可用于评价心脏自主神经系统的功能,并且HRV也被认为是急性冠脉综合征（ACS）患者重要的危险分层因子.本文就近年来关于慢性压力对冠心病患者HRV影响的研究成果进行简述.     

Peripheral arterial disease alters heart rate variability in cardiovascular patients

Background: Autonomic regulation analysis is useful in risk stratification of ventricular tachycardia and sudden cardiac death in chronic heart failure (CHF). Heart rate variability (HRV) reflects the condition of autonomic regulation. For analyzing the autonomic control the whole cardiovascular system has to be considered. Therefore, the aim of our study was to assess the influence of peripheral arterial disease (PAD) on the autonomic regulation.
Methods: In 53 men (age: 67 ± 11 years) from the cardiovascular unit we compared standard HRV parameters in 27 with (ankle brachial index, ABI < 0.9) and 26 patients without (ABI >0.9) PAD as well as with 12 healthy subjects as reference. High-resolution electrocardiograms were recorded over 30 minutes under resting conditions. Pulse wave velocity as well as ABI was estimated using the vascular screening system VASERA.
Results: In cardiac patients with PAD, we found both significant differences in linear and nonlinear HRV parameters. Higher increase of low-than high-frequency components indicated higher elevated sympathetic than vagal activation. Altered autonomic control can be interpreted as a compensatory mechanism for diminished vascular arteriolar vasodilator capacity in PAD. To maintain the arterial blood pressure, an elevated setpoint of sympathovagal balance is required.
Conclusions: Our data indicate PAD alters the HRV in cardiaovascular patients. PAD should be considered in the assessment of cardiac autonomic regulation especially in risk stratification.