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1.
Chemopreventive agents are used to diminish the morbidity and mortality of cancer by delaying the course of carcinogenesis. Formation of ACF and amplified activity of colon biotransforming enzymes were considered to be hallmarks of colon carcinogenesis. Morin, a bioflavonoid present in fruits and show various pharmacological and biological activities. Our present study, shows the modulatory effect of morin administration on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) in rat colon, and fecal and mucosal biotransforming enzyme activities. A total of 64 rats were randomized into four groups. Group 1 served as control, groups 2 and 4 received 50 mg/kg b.w. of morin intragastrically for the entire period of the study (30 weeks). Groups 3 and 4 received subcutaneous injection of DMH (20 mg/kg b.w.) for 15 weeks. Rats were sacrificed at the end of 30 weeks. The incidence of tumors/polyps in the colon cancer of rats and treated with morin showed reduced incidence (40%) of tumors, as compared to DMH (100%) treated rats. Morin administration significantly reduced ACF formation and lowered the activities of fecal and mucosal biotransforming enzymes. Our findings suggest that morin (50 mg/kg b.w.) may be a possible chemopreventive agent against colon cancer. 相似文献
2.
Summary Colon cancer has become one of the major causes of cancer mortality. We determined the effect of caraway (Carum carvi L.) on the development of aberrant crypt foci (ACF) and modulation of fecal bacterial enzyme activities in 1,2-dimethylhydrazine
(DMH)-induced experimental rat colon carcinogenesis. Male Wistar albino rats were divided into six groups and all the animals
were fed 15.8% peanut oil making a total of 20% fat in the diet. Group 1 served as control and group 2 animals received 90
mg/kg body weight caraway p.o. daily for 15 weeks. To induce ACF, DMH (20 mg/kg body weight) was injected subcutaneously once
a week for the first four weeks (groups 3–6). In addition caraway was administered at the dose of 30, 60 and 90 mg/kg body
weight everyday orally for the entire period of 15 weeks (groups 4–6). First, we analyzed ACF number (incidence), multiplicity
and its distribution along the colon in all experimental groups at the end of 15 weeks. Subsequently, we also assayed the
fecal bacterial enzyme activities. ACF formation and the fecal bacterial enzyme activities were found to be significantly
high in DMH-alone treated group as compared to control group. Caraway supplementation at three different doses significantly
suppressed ACF development, bacterial enzyme activities and modulated oxidative stress significantly as compared to the unsupplemented
DMH-treated group. Results of our present study indicate that dietary caraway markedly inhibited DMH-induced colon carcinogenesis
and the optimal dose of 60 mg/kg body weight was more effective than the other two doses. 相似文献