胰腺实性-假乳头状瘤1例病案报道及文献回顾

目的：报道1例胰腺实性-假乳头状瘤,结合文献探讨其临床病理学特征、诊断及鉴别诊断要点。方法：对1例胰腺实性-假乳头状瘤进行临床病理分析及免疫组化观察。结果：胰腺实性-假乳头状瘤患者无特异性临床表现及体征,多在体检或其他原因开腹探查时偶被发现。镜下可见肿瘤由实性区、假乳头状区及囊性区混合组成,细胞形态一致、无异型的瘤细胞排列呈片状和假乳头状,肿瘤细胞围绕血管蒂呈复层排列成假乳头状突起为其特征。免疫组化染色结果：肿瘤细胞表达Vim、Syn,NSE;不表达PR、CEA、S-100、CK、CA19—9、EMA。结论：胰腺实性-假乳头状瘤好发于年轻女性,具有独特的临床病理特点,其诊断和鉴别诊断主要依靠病理组织学和免疫组化,治疗以手术切除为主,预后较好。     

胰腺实性-假乳头状瘤1例报告及文献回顾

1病历报告患者,女,22岁,因体检发现胰腺肿物3周入院。既往健康。查体:无明显阳性体征。辅助检查,腹部彩超:胰头厚16mm,胰管无扩张,胰尾可见一个实质性低回声光团,大小32mm×32mm。腹部增强CT:胰腺体尾部增大,形态欠规则,其内见类圆形低密度,胰腺二期增强扫描,边界清晰,其内密度     

胰腺实性-假乳头状瘤5例临床病理分析

目的 了解胰腺实性-假乳头状瘤临床病理特征，分析其与预后的关系。方法 石蜡切片，HE染色，免疫组织化学采用SP法。结果 5例均为女性，年龄9-26（平均17）岁，手术后均无复发。肿瘤较大，平均直径9．9cm，有包膜，由实性与囊性坏死区混合组成。组织学上，瘤细胞大小形态较一致，核圆形或卵圆形，核异型不明显，核分裂相偶见，以肿瘤细胞围绕血管排列成假乳头为其特征，瘤细胞退变、出血、泡沫细胞和胆固醇裂隙常见。免疫组化：肿瘤细胞阳性表达α1—AT4例，α1—ACT3例，Vimentin 3例，NSE、CK8、S100、PR均1例；ER、insulin均阴性。结论 胰腺实性-假乳头状瘤多发生于年轻女性，具有良性临床病程和较高的手术治愈率。     

胰腺实性-假乳头状瘤1例报告

胰腺实性-假乳头状瘤(solid-pseuedopapillary tumor,SPT)是少见的胰腺肿瘤,多见于年轻女性,临床上罕见,在第三军医大学第二附属医院学习期间接诊了1例,现报告如下. 1病例报告 患者女性,60岁,因“体检发现胰体尾部包块7月余”于2015年5月入院.2014年7月体检超声提示胰体尾区杂乱回声团.无发热、黄疸、恶心、呕吐、腹胀、腹痛等不适.     

胰腺实性假乳头状瘤1例

患者,女性,50岁.因间断上腹部隐痛1年入院。查体:腹部未触及肿物。血清CA242、CA199、CEA在正常范围,肝肾功能检查正常。     

胰腺实性假乳头状癌1例

恶性胰腺实性假乳头状肿瘤(SPTP)即胰腺实性假乳头状癌非常罕见,现诊断1例报道如下。患者男性,74岁。2005年8月因反复右上腹痛1年,加剧伴腹部肿块1个月入院,B超、CT示胰腺占位。行腹膜后肿物并胰体尾加脾加结肠脾曲切除术,术后予抗炎、免疫治疗。术后9个月出现腹盆腔广泛种植转移,二次开腹冰冻活检诊断同前,因无手术适应证未作治疗,半年后死亡。     

伴多发转移的胰腺实性-假乳头状瘤一例

患者女,23岁。体检发现胰腺占位就诊我院。超声及CT示胰腺体尾部实质性占位,肝右前叶囊实性包块,考虑为胰腺囊腺癌伴肝内转移。行胰、肝占位及脾切除术。术后大体病理检查:(1)胰腺:胰腺组织10.0 cm×8.0 cm×6.0 cm,切面见一8.0 cm×8.0 cm×4.0 cm的包块,肿块切面呈灰褐     

胰腺实性假乳头状瘤1例

患者女,21岁.临床症状:进食后恶心3个月,触及上腹部包块3 d.大体:单个肿物,体积19 cm×17cm×14 cm,包膜完整,切面灰白、淡黄、淡红、质细,局灶出血坏死,肿物切面与周边界线清晰.     

胰腺实性假乳头状瘤1例

患者女,21岁。临床症状：进食后恶心3个月,触及上腹部包块3d。大体：单个肿物,体积19cm×17cm×14cm,包膜完整,切面灰白、淡黄、淡红、质细,局灶出血坏死,肿物切面与周边界线清晰。镜检：SPPT细胞丰富,出现被覆数层上皮的假乳头,核椭园形并有折叠,核仁不清楚,几乎无核分裂,有泡沫细胞聚集,粗大的纤维血管轴心呈明显的黏液变性,血管丰富。免疫组化：胰蛋白酶、糜蛋白酶、淀粉酶阳性。其他神经内分泌标记物（＋）,CD10在SPPT细胞内阳性。病理诊断：胰腺实性假乳头状肿瘤（SPPT）。     

Solid-pseudopapillary tumor of the pancreas: One case report and literatures review

Introduction
Solid-pseudopapillary tumor （SPT） is a very rare primary neoplasm of the pancreas. Franz first described it in 1959. It is usually seen in young females. In spite of possible histological findings of malignancy, SPPT typically shows a benign clinical course and a low malignant potential. The pathogenesis of these tumors is still controversial. It has been suggested that it might originate from ductal and acinar pancreatic cells, endocrine cells or pluripotential stem cells.     

胰腺实性假乳头状肿瘤一例报告及文献复习

为了分析胰腺实性假乳头状肿瘤的临床病理特征及免疫组织化学特点,对胰腺实性假乳头状肿瘤的临床资料、大体观察、镜下观察及免疫组化结果进行分析.胰腺实性假乳头状肿瘤好发于年轻女性,镜下由实性区及假乳头状区组成,免疫组化程度不一的表达上皮性、间叶性、内分泌性标记.初步研究结果提示,胰腺实性假乳头状肿瘤是较少见的、预后较好的交界性肿瘤,其诊断主要依赖于临床资料、组织学形态及免疫组化标记.     

Solid-pseudopapillary tumor of the pancreas (Frantz tumor) in children: report of four cases and review of the literature

BACKGROUND: Solid-pseudopapillary tumor of the pancreas (SPT) is an exceptionally rare neoplasm in children. Its origin remains enigmatic. It is of low malignant potential and occurs most frequently in young females. PATIENTS AND METHODS: A cumulative review of the tumor's clinicopathological characteristics from the world's literature is presented. The clinical course, pathohistologic data and outcome of surgery of four Austrian children treated at the general hospital of Vienna are analyzed. RESULTS: Between 1987 and 1999, four girls (age: 12--16 years) with SPT were diagnosed at our institution. All patients presented with an abdominal mass and uncharacteristic abdominal pain. Two tumors were located in the tail, one in the body and tail and one in the head of the pancreas (diameter: 7--15 cm). Surgical procedures included three distal pancreatectomies and one partial duodenopancreatectomy (Whipple procedure). One patient had two recurrences with metastases that could only be partially resected. Chemotherapy was initiated for this patient. In the follow-up period (range: 6 months to 12 years) all patients are alive with no evidence of recurrence. CONCLUSIONS: SPT is a rare differential diagnosis of a pancreatic mass in children. It is mandatory to establish this diagnosis since complete surgical removal of the tumor even in case of metastases or local invasion offers an excellent prognosis.     

Osteoclastic giant cell tumor of the pancreas: case report and literature review

An unusual case of a 40-year-old woman seeking treatment for a 10-cm cystic neoplasm of the pancreas is described. Imaging revealed a large proteinaceous, fluid-filled cyst with a mural nodule. Laparotomy was successful with en bloc resection. Pathologic examination revealed a neoplastic mucinous epithelial tumor with an abundance of multinucleated tumor giant cells. This presentation is consistent with literature reports of an osteoclastic-type giant-cell tumor of the pancreas. The natural history, pathologic evaluation, and clinical implications of this rare neoplasm are discussed with reference to published reports.     

Granular cell tumor of the pancreas: A case report and review of literature

Granular cell tumors, also called Abrikossof's tumors, were originally described by Abrikossof A in 1926. The first case of a pancreatic granular cell tumor was described in 1975 and only 6 cases have been reported. We describe a case of granular cell tumor in the pancreas showing pancreatic duct obstruction. Because imaging studies showed findings compatible with those of pancreatic carcinoma, the patient underwent distal pancreatectomy. Histological examination showed that the tumor consisted of a nested growth of large tumor cells with ample granular cytoplasm and small round nuclei. The tumor cells expressed S-100 protein and were stained with neuron-specific enolase and periodic acid-Schiff, but were negative for desmin, vimentin, and cytokeratin. The resected tumor was diagnosed as a granular cell tumor. To our knowledge, this is the seventh case of Granular cell tumor of the pancreas to be reported.     

胰腺恶性孤立性纤维性肿瘤1例并文献复习

目的:讨论孤立性纤维性肿瘤（solitary fibrous tumor,SFT）的临床特征、病理学表现、影像学表现、诊断方法、鉴别诊断、治疗及预后,以提高临床医生对此病的认识及诊治水平。方法:报道1例术后肿瘤2次复发的胰腺恶性SFT的临床病理资料并文献复习。结果:患者女性,59岁,以“体检发现胰尾部肿物10天”为主诉首次入院,入院后诊断为胰体部占位,行胰体尾切除、脾切除术,术后石蜡病理提示胰体尾交界性梭形细胞肿瘤,考虑孤立性纤维性肿瘤。术后5月余复查,肿瘤复发于左上腹网膜囊内,再次手术切除复发肿物,术后石蜡病理提示交界性或低度恶性孤立性纤维性肿瘤。距二次术后4月余复查,肿瘤再次复发于左上腹网膜囊内,再次予手术切除肿物,术后石蜡病理提示交界性或低度恶性孤立性纤维性肿瘤。结论:胰腺恶性SFT病例极其罕见,术后复发者更是少之又少,确诊主要依靠病理组织形态学及免疫组化标记,并与其他相关性疾病加以鉴别,治疗方法以手术完全切除肿物为主,注意定期复查及远期随访。     

Giant phyllodes tumor in both breasts:one case report and literature review

Breast phyllodes tumor (BPT),which is composed of epithelial cells and fibrous connective tissue,is a special type of tumor and yet not unified in biological behavior and histological classification,with high risk of recurrence and potential metastasis.BPT in one side has high incidence in clinic while BPT in both sides is rarely found.We treated one patient with giant BPT in both sides and reported as follows. 1 Case report The patient,female,aged 49,was admitted due to a rapidly increased lump in the right breast in June 2010,and she complained that the lump had increased from the size of "an egg" to the size of "a basketball" in August and had then been treated as suspected inflammation with anti-inflammatory treatment before admission but failed.Physical examination on admission showed an about 35 cm× 32 cm ×33 cm huge lump in the right breast,firm and poorly-movable,with reddish purple and mildly warm epidermis,swollen but not ulcerated (Fig.1).     

甲状腺透明变梁状肿瘤一例并文献复习

目的提高对甲状腺透明变梁状肿瘤(HTT)的认识,掌握其诊断和治疗。方法回顾性分析2019年5月兰州大学第一医院收治的1例HTT患者的临床资料,并进行文献复习。结果该患者主要临床表现为颈部肿物渐进性增大、胸闷、气短等,入院行左侧甲状腺切除术,其病理及免疫组织化学证实为HTT伴微小乳头状癌。结论HTT是一种具有潜在低度恶性的甲状腺肿瘤,最大特点是具有小梁状的玻璃样变性,外科手术是主要治疗手段。     

乳腺恶性腺肌上皮瘤一例报道并文献回顾

正乳腺腺肌上皮瘤(adenomyoepithelioma,AME)是一种罕见肿瘤,而乳腺恶性腺肌上皮瘤(malignant adenomyoepithelioma,MAME)更为罕见,发生率仅占乳腺原发肿瘤的1%~([1])。1970年Hamperl~([2])提出AME是一种由腺上皮和肌上皮2种成分共同形成的肿瘤。2003年,WHO将肌上皮病变和上皮性肿瘤列为乳腺肿瘤,并提出腺肌上皮瘤是不同类型的肌上皮增生,呈实性巢团状分布,少数的肌上皮或腺上皮可发生癌变~([3])。2012年,WHO对AME的定义作了一定调整,将恶性