中药热熨敷技术对乳腺癌化疗患者癌因性疲乏的干预效果

目的:探讨中药热熨敷技术对乳腺癌化疗患者癌因性疲乏的干预效果。方法:将64例存在癌因性疲乏症状的乳腺癌化疗患者作为研究对象,采用随机数字法分为两组,对照组32例接受医院常规护理,实验组32例在接受医院常规护理的基础上,接受5天中药热熨敷技术干预。使用修订的Piper疲乏量表(RPFS)评价干预效果。结果:干预结束后, 实验组RPFS得分明显低于对照组(P<0.05)。与干预前比较,实验组RPFS得分较5天前无显著变化(P>0.05),而对照组RPFS得分较5天前明显升高(P<0.01)。结论:中药热熨敷可延缓随化疗进行而导致的癌因性疲乏的加重。     

营养干预对结直肠癌术后辅助化疗患者营养状况及生活质量的影响

目的 探讨营养干预对结直肠癌术后辅助化疗患者营养状况和生活质量的影响。方法 选取56例结直肠癌术后辅助化疗患者,据其营养干预情况分为对照组（36例）和营养干预组（20例）,比较两组患者手术4周后血液指标、PG-SGA评分和生活质量评价SF-36量表评分差异。结果 营养干预组和对照组患者入院时的PG-SGA评分比较差异无统计学意义（t=-0.347, P=0.730）,而4周后的PG-SGA评分差异有统计学意义（t=-2.708, P=0.009）。4周后,两组患者血清前白蛋白、白蛋白、血红蛋白比较差异无统计学意义（P>0.05）;生活质量评分除了情感职能这一指标差异无统计学意义（P=0.083）,其他指标差异均有统计学意义（P<0.05）,且营养干预组得分均高于对照组。结论 营养干预能有效改善结直肠癌术后辅助化疗患者的营养状况和生活质量。     

协同干预模式对直肠癌新辅助化疗患者营养状况、癌因性疲乏程度及生活质量的影响

目的探讨协同干预模式对直肠癌新辅助化疗患者营养状况、癌因性疲乏程度及生活质量的影响。方法依据干预方式将150例直肠癌新辅助化疗患者分为观察组和对照组,每组75例,对照组患者化疗过程中给予常规干预,观察组患者化疗过程中给予协同干预模式管理。干预前后,采用主观整体营养评估量表(PGSGA)和血清白蛋白水平评估两组患者的营养状况;采用癌因性疲乏量表评估两组患者的癌因性疲乏程度;采用生活质量量表(QOL)评估两组患者的生活质量。结果干预后,观察组患者PG-SGA评分明显低于本组干预前,两组患者癌因性疲乏量表评分均明显低于本组干预前,血清白蛋白水平和QOL量表各维度评分均明显高于本组干预前,且观察组患者PG-SGA评分、癌因性疲乏量表评分均明显低于对照组患者,血清白蛋白水平和QOL量表各维度评分均明显高于对照组患者,差异均有统计学意义(P﹤0.01)。结论协同干预模式可改善直肠癌新辅助化疗患者的营养状况及癌因性疲乏程度,提高患者化疗期间的生活质量。     

足量营养支持改善肿瘤化疗患者癌因性疲乏和营养状况

目的:观察足量营养支持对肿瘤化疗患者癌因性疲乏（CRF）以及营养状况改善的影响。方法:选取我院自2018年03月-2019年03月间收治的恶性肿瘤化疗患者90例作为实验对象,按照数字随机原则分成两组,对照组45例行常规营养支持,观察组45例给予足量营养支持,采用营养风险筛查工具、Piper疲乏评估量表（RPFS-CV）以及癌症患者生命质量核心量表（EORTCQLQ-C30）对两组患者营养状况、癌因性疲乏、生活质量进行评估。结果:观察组营养风险评分明显低于对照组(P＜0.05);治疗前两组患者体质量指数（BMI）、前白蛋白（PA）、血清白蛋白（ALB）差异无统计学意义（P＞0.05）,治疗后观察组3项指标均显著升高,与对照组对比差异有统计学意义（P＜0.05）;治疗后两组情感疲乏、躯体疲乏和认知疲乏评分均显著下降,观察组降幅优于对照组（P＜0.05）;治疗后观察组EORTCQLQ-C30评分中功能领域、整体健康评分显著高于对照组,症状评分显著低于对照组（P＜0.05）。结论:肿瘤患者化疗期间采用足量营养支持能改善其营养状况,缓解癌因性疲乏等症状表现,全面提升患者的生活质量。     

反馈式健康教育干预对喉癌患者术后负性情绪及创伤后成长的影响

目的 探究反馈式健康教育干预对喉癌患者术后负性情绪及创伤后成长的影响。方法 将60例喉癌手术患者根据健康教育方式的不同分为对照组（n=32,行常规健康教育）和观察组（n=28,行反馈式健康教育）,比较干预前后两组患者负性情绪[焦虑自评量表（SAS）、抑郁自评量表（SDS）]、创伤后成长[创伤后成长量表（PTGI）]水平、癌因性疲乏[修订Piper疲乏量表（RPFS）]及生活质量[欧洲癌症研究与治疗组织生命质量测定量表（EORTC QLQ-C30）]。结果 干预后,两组患者SAS、SDS及RPFS各维度评分均降低,PTGI及EORTC QLQ-C30各维度评分均升高,且观察组患者SAS、SDS及RPFS各维度评分均低于对照组,PTGI及EORTC QLQ-C30各维度评分均高于对照组,差异均有统计学意义（P﹤0.05）。结论 相较于常规健康教育,反馈式健康教育可明显改善喉癌手术患者负性情绪,促进创伤后成长,减轻癌因性疲乏程度,提升生活质量。     

运动干预对卵巢癌化疗患者负性情绪、癌因性疲乏和生活质量的影响

目的探讨运动干预对卵巢癌化疗患者负性情绪、癌因性疲乏和生活质量的影响。方法选取200例卵巢癌化疗患者,依据干预方式的不同分为对照组和观察组,每组100例。对照组患者接受常规干预措施,观察组患者在此基础上联合运动干预。干预前和干预3个月后,采用焦虑自评量表(SAS)、抑郁自评量表(SDS)比较两组患者的负性情绪,采用Piper疲乏修正量表(RPFS)评估两组患者的癌因性疲乏程度,采用世界卫生组织生活质量量表(WHOQOL-100)评估两组患者的生活质量。结果干预前,两组患者SAS、SDS、RPFS和WHOQOL-100各维度评分比较,差异均无统计学意义(P﹥0.05)。干预3个月后,两组患者SAS、SDS、RPFS各维度评分均低于本组干预前,WHOQOL-100各维度评分均高于本组干预前,且观察组SAS、SDS、RPFS各维度评分均低于对照组患者,WHOQOL-100各维度评分均高于对照组患者,差异均有统计学意义(P﹤0.05)。结论运动干预能够有效缓解卵巢癌化疗患者焦虑抑郁情绪,减轻癌因性疲乏程度,从而提高患者生活质量。     

影响胃癌化疗期间患者癌性疲乏发生的危险因素分析及自我管理模式的干预效果研究

目的:探讨影响胃癌化疗期间患者癌性疲乏发生的危险因素,并分析自我管理模式对癌性疲乏的干预效果。方法:本研究由两部分组成。第一部分为横断面调查,收集2013年2月至2016年4月我院收治的胃癌患者为研究对象。发放问卷121份,有效回收107份（88.4%）,统计分析可能影响患者癌性疲乏发生的危险因素。第二部分为前瞻性研究,选取2016年5月至2017年12月我院收治的71例胃癌患者为研究对象,将患者随机分为对照组与实验组。对照组患者接受常规化疗管理,实验组在常规化疗管理基础上接受自我管理模式。利用癌症疲乏量表（CFS）、癌症治疗功能评价量表（FACT-G）评价两种管理模式的差异。结果:单因素及多因素Logistic分析发现,文化程度、职业、家庭经济压力是影响胃癌患者化疗期间癌性疲乏发生的独立性危险因素（P<0.05）。患者CFS各维度内部之间、FACT-G各维度内部之间均呈正相关关系（r＞0,P<0.05）;CFS各维度与FACT-G各维度,两两之间均呈显著负相关关系（r＜0,P<0.05）。组间比较:干预后,实验组CFS各维度得分均明显小于对照组（P<0.05）。组内比较:与干预前相比,实验组患者干预后CFS各维度得分均显著降低（P<0.05）。组间比较:干预后,实验组FACT-G各维度得分均明显大于对照组（P<0.05）。组内比较:与干预前相比,实验组患者干预后FACT-G各维度得分均显著升高（P<0.05）,但对照组患者仅有社会维度得分明显改善,其余指标与干预前无明显差异（P>0.05）。结论:多种因素参与了胃癌化疗患者癌性疲乏的发生,并导致患者生活质量下降。与常规化疗管理相比,自我管理模式能有效地缓解患者癌性疲乏,提高生活质量,有一定的临床推广价值。     

心理护理对宫颈癌术后放疗患者癌因性疲乏的干预效果

目的探讨心理护理对宫颈癌术后放疗患者癌因性疲乏的干预效果。方法选取2014年3月至2015年3月间收治的88例宫颈癌术后放疗出现癌因性疲乏的患者,采用随机数表法分为观察组和对照组,每组44例。观察组患者采取常规护理结合心理护理干预,对照组患者采取常规护理。比较两组患者干预前后的癌因性疲乏状况以及生活质量情况。结果干预前,两组患者的癌因性疲乏状况、总体生活质量评分和症状子量表总分的差异均无统计学意义(P>0.05)。干预后,观察组患者的Piper疲乏修定量表(RPFS)平均分显著优于对照组,RPFS评分为重度的人数更低,总体生活质量评分显著高于对照组,且症状子量表总分更低,差异均有统计学意义(P<0.05)。结论针对宫颈癌术后放疗患者癌因性疲乏应用心理护理的干预,能减缓放疗过程中患者癌因性疲乏症状的加重,减少重度患者,减缓不良症状,相对提高生活质量。     

结直肠癌术后辅助化疗对血脂变化的影响

目的:探讨结直肠癌患者术后辅助化疗前后血脂水平的变化及不同化疗方案对血脂变化的影响。方法:对127例结直肠癌患者术后辅助化疗前后总胆固醇（TC）、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)水平进行测定并比较分析。结果:化疗后,TG、HDL、LDL水平较化疗前升高,差异有统计学意义（P＜0.05）。TC值较化疗前增高,但差异无统计学意义（P＞0.05）。含奥沙利铂的化疗方案与卡培他滨单药方案相比对TC、TG、LDL的影响更加显著,差异有统计学意义（P＜0.05）。结论:结直肠癌患者在术后辅助化疗期间存在血脂代谢紊乱,以血清TG、HDL、LDL升高为特点;不同化疗方案对血脂变化的影响存在差异。     

不同强度有氧运动对脑胶质瘤术后化疗患者癌因性疲乏及HPA轴功能的影响

目的 探讨不同强度有氧运动对脑胶质瘤术后化疗患者癌因性疲乏(CRF)及下丘脑-垂体-肾上腺皮质(HPA)轴功能的影响.方法 选取脑胶质瘤术后化疗并发CRF患者76例,随机分为2组,各38例.A组予以25％VO2max的强度进行有氧运动,B组予以50％VO2max的强度进行有氧运动,2组均连用8周.统计分析2组治疗前后H...     

Effect of a Pedometer-based Exercise Program on Cancer Related Fatigue and Quality of Life amongst Patients with Breast Cancer Receiving Chemotherapy

Background: Breast cancer is the most common cancer amongst Indian women. Cancer treatments leads to various side effects out of which Cancer-Related fatigue (CRF) is one of the most under-addressed side-effects. It is experienced the most in patients receiving chemotherapy. Exercise has been proven to be a beneficial intervention to manage CRF but the benefits of pedometer-based exercise programs is under-studied in patients with breast cancer. Hence, we set out to investigate the effects of a pedometer-based exercise program for patients with breast receiving chemotherapy. Methods: The current study was a non-randomized controlled trial with 22 patients each in exercise and control group. The exercise group received a pedometer-based walking program, whereas the control group received standard physical activity advice. Fatigue, quality of life, functional capacity and body composition were assessed at baseline, 3rd week and 7th week. Results: At the end of 7 weeks intervention, functional capacity, quality of life and skeletal mass were found to have improved with statistical significance, while the fatigue and changes in total fat did improve but were not statistically significant. Conclusion: A 7-week pedometer-based exercise program improved functional capacity, quality of life and percentage of skeletal mass and also shows to have prevented deterioration in fatigue levels in patients with breast cancer receiving chemotherapy.     

Effects of cognitive behavior therapy combined with Baduanjin in patients with colorectal cancer

BACKGROUNDCancer-related fatigue (CRF) is the most common concomitant symptom in the treatment of colorectal cancer (CRC). Such patients often present with subjective fatigue state accompanied by cognitive dysfunction, which seriously affects the quality of life of patients.AIMTo explore the effects of cognitive behavior therapy (CBT) combined with Baduanjin exercise on CRF, cognitive impairment, and quality of life in patients with CRC after chemotherapy, and to provide a theoretical basis and practical reference for rehabilitation of CRC after chemotherapy. METHODSFifty-five patients with CRC after radical resection and chemotherapy were randomly divided into either an experimental or a control group. The experimental group received the intervention of CBT combined with exercise intervention for 6 mo, and indicators were observed and measured at baseline, 3 mo, and 6 mo to evaluate the intervention effect.RESULTSCompared with the baseline values, in the experimental group 3 mo after intervention, cognitive function, quality of life score, and P300 amplitude and latency changes were significantly better (P < 0.01). Compared with the control group, at 3 mo, the experimental group had significant differences in CRF, P300 amplitude, and quality of life score (P < 0.05), as well as significant differences in P300 latency and cognitive function (P < 0.01). Compared with the control group, at 6 mo, CRF, P300 amplitude, P300 latency, cognitive function and quality of life score were further improved in the experimental group, with significant differences (P < 0.01). The total score of CRF and the scores of each dimension were negatively correlated with quality of life (P < 0.05), while the total score of cognitive impairment and the scores of each dimension were positively correlated with quality of life (P < 0.05). CONCLUSIONCBT combined with body-building Baduanjin exercise can improve CRF and cognitive impairment in CRC patients after chemotherapy, and improve their quality of life.     

Effects of resistance exercise on fatigue and quality of life in breast cancer patients undergoing adjuvant chemotherapy: A randomized controlled trial

Multiple exercise interventions have shown beneficial effects on fatigue and quality of life (QoL) in cancer patients, but various psychosocial interventions as well. It is unclear to what extent the observed effects of exercise interventions are based on physical adaptations or rather on psychosocial factors associated with supervised, group‐based programs. It needs to be determined which aspects of exercise programs are truly effective. Therefore, we aimed to investigate whether resistance exercise during chemotherapy provides benefits on fatigue and QoL beyond potential psychosocial effects of group‐based interventions. One‐hundred‐one breast cancer patients starting chemotherapy were randomly assigned to resistance exercise (EX) or a relaxation control (RC) group. Both interventions were supervised, group‐based, 2/week over 12 weeks. The primary endpoint fatigue was assessed with a 20‐item multidimensional questionnaire, QoL with the EORTC QLQ‐C30/BR23. Analyses of covariance for individual changes from baseline to Week 13 were calculated. In RC, total and physical fatigue worsened during chemotherapy, whereas EX showed no such impairments (between‐group p = 0.098 and 0.052 overall, and p = 0.038 and 0.034 among patients without severe baseline depression). Differences regarding affective or cognitive fatigue were not significant. Benefits of EX were also seen to affect role and social function. Effect sizes were between 0.43 and 0.48. Explorative analyses indicated significant effect modification by thyroxin use (p‐interaction = 0.044). In conclusion, resistance exercise appeared to mitigate physical fatigue and maintain QoL during chemotherapy beyond psychosocial effects inherent to supervised group‐based settings. Thus, resistance exercise could be an integral part of supportive care for breast cancer patients undergoing chemotherapy.     

胃肠道癌患者生命质量影响因素初探

背景与目的:生命质量测评已广泛应用在肿瘤研究中,而癌症患者生命质量研究对于推动癌症治疗的进步也起着越来越重要的作用.本研究旨在评估胃癌、大肠癌患者的生命质量,探讨与之相关的影响因素.方法:自2005年2月1日至2006年8月31日,采用癌症患者生命质量测定量表核心量表EORTC QLQ C30调查了52例胃癌患者和50例大肠癌患者.各影响生命质量凶素的差异程度经t检验及方差分析处理.最优尺度回归分析和判别方程了解生命质量各个子量表与临床分期的关系.多重线性回归分析整体生命质量与功能量表、症状量表及单项量表的关系.结果:临床分期较早期、高文化程度、经过综合治疗后的患者显示较高的功能量表得分和整体生命质量得分,以及较低的症状量表及单项量表得分,因而生命质量较好.年龄、性别等对生命质量影响不大.胃癌组整体生命质量量表得分低于大肠癌组,提示胃癌患者相对于大肠癌患者生命质量较差.结论:临床分期、文化程度和治疗方法是影响胃肠道癌患者生命质量的最重要因素.     

辨证论治提高老年晚期非小细胞肺癌同步放化疗耐受性的临床观察

目的：采用国际生存质量量表评价中医辨证论治提高老年晚期非小细胞肺癌（NSCLC）同步放化疗的耐受性。方法：将20例III—IV期老年NSCLC患者随机分为两组,研究组（10例）接受中医辨证论治及同步放化疗,对照组（10例）仅进行同步放化疗,共观察两个疗程。采用EORTCQLQ—C30、KPS、ECOG作为测定工具。结果：研究组生存质量各领域评分治疗后改善明显,对照组则下降,两组间比较差异有显著性（P〈0．05）;KPS、ECOG评分显示相似结果。结论：老年晚期非小细胞肺癌同步放化疗配合中医辨证论治能够改善患者生存质量,改善体能状态。     

The Effect of Exercise on Life Quality and Depression Levels of Breast Cancer Patients

Introduction: The aim of this study is to determine the effects of aerobic and stretching exercises on quality of life and depression levels of breast cancer patients. Methods: A total of 48 women (mean age 45.0±2.2 years) who were previously diagnosed with breast cancer and completed their treatment with no metastasis, were included in the study. Of these, 24 women who received the exercise program were assigned as the study group, while the remaining 24 women who did not receive the exercise program were assigned as the control group. The study group received a 12-week aerobic exercise program at the fitness club and home-based resistance exercise program designed by a sport scientist at the doctoral level. The control group was encouraged to maintain their normal level of physical activity and exercise habits throughout the study. The WHOQOL-BREF, EORTC-QLQ-C30 quality of life assessments and Beck depression inventory (BDI) were used to evaluate quality of life and the severity of depression before and after 12-week exercise programs. Results: EORTC QLQ-C30 scoring showed that in the study group aerobic exercise positively impacted quality of life on the functional scales (physical p=0.001, role p=0.039, emotional p=0.031, social functioning p=0.010) and symptoms (fatigue p=0.001, pain p=0.001, sleep disturbance p=0.038 and financial impact p=0.015). WHOQOL-BREF assessment areas, (general p=0.001, physical p=0.02, mental p=0.001 and social health p=0.017) relationships also improved as a result of exercise. BDI showed that severity of depression in the study group decreased significantly (p=0.001). Conclusion: This study showed that aerobic and resistance exercises improved quality of life and decreased depression levels of women who previously received breast cancer treatments.     

护理干预对卵巢癌化疗患者生活质量的影响

目的探讨全程系统化护理干预对卵巢癌化疗患者生活质量的影响。方法将84例卵巢癌术后化疗患者随机分为干预组（41例）和对照组（43例）,对照组行常规护理,干预组实施全程系统化护理干预,化疗前和化疗后3个月使用焦虑自评量表（SAS）、抑郁自评量表（SDS）及生活质量核心量表（EORTCQLQ—c30）评定患者的生活质量。结果干预组的整体生活质量、躯体功能、情绪功能、社会功能得分高于对照组,症状维度和单项问题中疲倦、恶心呕吐、失眠、食欲下降得分低于对照组,两组差异均有统计学意义（P〈0．05）。结论对卵巢癌化疗患者实施全程系统化护理,可改善患者的焦虑、抑郁情绪,提高生活质量。     

营养干预对宫颈癌患者同步放化疗耐受性及生活质量的影响

目的:探讨营养干预对宫颈癌患者同步放化疗耐受性及生活质量(QOL)的影响。方法:将86例宫颈癌患者随机分为营养干预组和对照组,观察两组患者的放疗中断率、化疗完成次数及放疗剂量达40Gy时生活质量评分情况。结果:营养干预组的放疗中断率为2.3%（1/43）,对照组为18.6%（8/43）,P=0.03;营养干预组完成化疗周期数为4.0±0.98,对照组为3.3±1.28,P=0.005;放射剂量达40Gy时两组患者QOL评分的差异有统计学意义（P＜0.01）。结论:营养干预能有效提高宫颈癌患者同步放化疗的耐受性,提高其生活质量。     

Cultural Adaptation and Validation of the Moroccan Version of the EORTC QLQ-CR29 in Patients with Colorectal Cancer

The increasing incidence of colorectal cancer in Morocco has generated a need for a disease-specific quality-of-life measuring instrument. The present study aims to translate and evaluate the reliability and validity of the Moroccan Arabic version of the EORTC QLQ-C29 measure in Moroccan subjects with colorectal cancer (CRC). Methods: Following translation to Moroccan Arabic, The QLQ-C30 and QLQ-C29 were administered to 135 patients treated for colorectal cancer (CRC) at the national oncology institute of Rabat, in the period from February 2016 to June 2018. Statistical analysis included reliability, convergent, and discriminant validity as well as known-groups comparisons. Results: (89 %) patients completed the questionnaires of the EORTC QLQ C-29 and EORTC QLQ C-30. The test –retest, administered to 25 patients and the ICCs for each item ranged from 0.61 to 0.93 indicating good to excellent reproducibility. The internal consistency coefficients for body image, urinary frequency, stool frequency scales were acceptable (Cronbach’s alpha ≥ 0.70), while the blood and mucus in the stool dimensions had lower reliability (0.65).  Multi-trait scaling analysis showed that multi-item scales met standards of convergent and discriminate validity. All Correlations between the EORTC QLQ C-29 and EORTC QLQ C-30 scores were low (r < 40). The known- group comparisons showed differences between group of patients based on tumor location and with/ without a stoma. Conclusion: The Moroccan Arabic Dialectal version of the QLQ-C 29 is a valid and reliable measure of health related quality of life (HRQOL) in patients with colorectal cancer.     

Effects of exercise on angiogenesis and apoptosis‐related molecules,quality of life,fatigue and depression in breast cancer patients

The aim of this study was to explore the effects of exercise on angiogenesis and apoptosis‐related molecules, quality of life, fatigue and depression in patients who completed breast cancer treatment. Sixty breast cancer patients were randomised into three groups, as supervised exercise group, home exercise group and education group. Angiogenesis and apoptosis‐related cytokine levels and quality of life (EORTC QOL‐C30: European Organisation for Research and Treatment of Cancer Quality of Life C30), fatigue (Brief Fatigue Inventory) and depression (BDI: Beck Depression Inventory) scores were compared before and after a 12‐week exercise programme. After the exercise programme, statistically significant decreases were found in interleukin‐8 and neutrophil activating protein‐78 levels in the home exercise group (P < 0.05). The education group showed a statistically significant increase in monocyte chemoattractant protein‐1 level (P < 0.05). Functional score and global health score of EORTC QOL‐C30 in the supervised exercise group and functional score of EORTC QOL‐C30 in the home exercise group increased significantly after exercise programme (P < 0.05). BDI score was significantly lower in the supervised exercise group after the exercise programme (P < 0.05). Changes in angiogenesis and apoptosis‐related molecules in the study groups suggest a possible effect of exercise on these parameters. Exercise programmes are safe and effective on quality of life and depression in breast cancer patients whose treatments are complete.