共查询到19条相似文献,搜索用时 62 毫秒
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传统的肿瘤治疗策略是寻找和消灭肿瘤。当肿瘤治疗进入精准治疗时代,肿瘤的治疗策略也转变为靶向、控制、调变和重构,即通过精确的靶向治疗,控制肿瘤的复制、血管生成以及侵袭和转移,调变肿瘤细胞进入凋亡或休眠状态,同时重构新的结构、微环境和代谢体系。治疗策略的新转变无疑将提高肿瘤患者的临床获益。 相似文献
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个体化治疗可以提高肿瘤病人的生存质量和生存时间,而肿瘤患者基因状态指导个体化用药,商业化的液滴数字PCR(droplet digital PCR,ddPCR)已经上市,并且可以在一个样本中对核酸精确定量。它是通过将模板稀释到20000个水包油微滴实现的,每个液滴可被微滴阅读器判定为阳性或阴性,因此某个等位基因的浓度可以被精确计算,它能够用于检测稀有突变体以及定量。与传统的实时PCR(qPCR)相比,ddPCR具有许多优点,尤其是灵敏且能够获得精确定量,例如,可以检测石蜡包埋样品中基因组扩增;可以以非侵入性的方式通过体液,如血液和痰来检测肿瘤基因突变;也可通过ddPCR检测拷贝数变异,从而研究其与癌症的相关性。 相似文献
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吴润叶 《中华放射肿瘤学杂志》2014,(6):539-539
2014年4月11日全国老年肿瘤学会放射肿瘤学分委会正式成立,并在北京九华山庄举行了成立仪式和首次学术会议。在我国逐渐进入老年化社会和肿瘤发病率不断升高情况下,医科院肿瘤医院储大同教授发起成立了全国老年肿瘤学会,旨在不断提高针对老年肿瘤患者的研究和治疗水平。作为肿瘤学的一个重要分支,放射肿瘤学在肿瘤治疗中起着重要作用,尤其对老年肿瘤患者而言更是一项损伤较小、有效的局部治疗手段。为此,在储大同教授指导下,在中华医学会放射肿瘤治疗学分会的关心和放疗界同仁的鼎力支持下正式成立了全国老年肿瘤学会放射肿瘤学分委会。 相似文献
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营养不良是肿瘤患者常见并发症,解决营养问题仍是临床实践中的挑战性任务之一。围放疗期头颈部肿瘤患者营养不良发生率高,与疾病介导的代谢紊乱、并发症及心理等因素有关,而放射治疗相关的不良反应是导致营养不良的重要原因。营养不良会降低放射治疗耐受性、准确性、治疗效果等,进而降低生活质量,甚至对疾病预后产生不良影响。医学营养治疗可以改善机体营养状况,保证放射治疗顺利进行,提高肿瘤综合治疗效果。在围放疗期对头颈部肿瘤患者进行规范的营养治疗与管理是必要且迫切的,需要定期进行营养风险筛查、营养评估及急性放射损伤评估等,制订个体化营养治疗方案并动态调整。本文在回顾、归纳、总结国内外现有头颈部放疗营养治疗相关文献的基础上,对头颈部肿瘤患者围放疗期的规范化营养治疗进行综述。 相似文献
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现代医学模式已经由单纯的生物医学模式转变为"生物-心理-社会"医学模式,由经验医学转变为以证据为基础的循证医学(EBM),这一指导临床医学实践的新模式,在肿瘤的综合治疗中起到了重要的指导作用;同时"个体化治疗"也是肿瘤综合治疗中不可忽视的原则之一,在肿瘤的治疗中占有越来越重要的地位.在实际的临床工作中,"循证医学"和"个体化治疗"这两个概念并非相互对立,而是相辅相成、密不可分的,现代肿瘤专科医师,必须掌握这些概念并在实际工作中努力贯彻、综合运用,才能制定合理的肿瘤综合治疗方案,最大限度维护患者的利益、得到最佳的治疗效果. 相似文献
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金属离子在生物医学和化学催化等领域发挥着重要的作用,多酚是广泛存在于植物中具有潜在保健作用的化合物,金属离子和多酚结构可以相互交联自组装形成金属-多酚网络(metalpolyphenolic network,MPN),发挥金属与多酚的协同效应。近年来,基于MPN的表面涂层具有独特的优势被广泛用于装载各种抗肿瘤药物和构建多功能治疗诊断纳米服务平台,具有显著的诊疗效果。该文首先介绍了MPN的构建类型,详细论述了MPN的功能特性及其在肿瘤诊疗应用中的最新进展,包括肿瘤生物医学成像和抗肿瘤疗法。最后,总结了MPN在肿瘤治疗中的研究进展,并对其在纳米医学中的发展趋势进行了展望。 相似文献
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0引言尽管辅助治疗很大程度上改善了乳腺癌患者的预后,然而,来自循证医学的群体证据证明它不能使所有患者受益,因此治疗的个体化、精确化是目前乳腺癌治疗的重要方向。肿瘤发生发展是一个多因素、多个过程参与的复杂过程,具有精确而又复杂的调控机制。肿瘤微环境对肿瘤生长转移的重要调控作用已被众多学者关注并公认。 相似文献
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Targeting telomerase for cancer therapeutics 总被引:1,自引:0,他引:1
One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells. 相似文献
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Developments in genomic techniques have provided insight into the remarkable genetic complexity of malignant tumours. There is increasing evidence that solid tumours may comprise of subpopulations of cells with distinct genomic alterations within the same tumour, a phenomenon termed intra-tumour heterogeneity. Intra-tumour heterogeneity is likely to have implications for cancer therapeutics and biomarker discovery, particularly in the era of targeted treatment, and evidence for a relationship between intra-tumoural heterogeneity and clinical outcome is emerging. Our understanding of the processes that exacerbate intra-tumoural heterogeneity, both iatrogenic and tumour specific, is likely to increase with the development and more widespread implementation of advanced sequencing technologies, and adaptation of clinical trial design to include comprehensive tissue collection protocols. The current evidence for intra-tumour heterogeneity and its relevance to cancer therapeutics will be presented in this mini-review. 相似文献
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Zhe Fan Pengcheng Zhou Binghui Jin Guangyao Li Lu Feng Chengjun Zhuang Shuang Wang 《American journal of cancer research》2023,13(1):261
Hepatocellular carcinoma (HCC) is a malignant tumor of hepatocytes. It is a common malignant tumor of the digestive system that often has initially hidden presentation followed by rapid progression. There are no obvious symptoms in the early stage of HCC. When diagnosed, most patients have locally advanced tumor or distant metastasis; therefore, HCC is difficult to treat and only supportive and symptomatic treatment is adopted. The prognosis is poor and survival time is short. How to effectively treat HCC is important clinically. In recent years, advances in medical technology have resulted in comprehensive treatment methods based on surgery. 相似文献
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Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by cancer cells from many tumor types, and is a component of the pH regulatory system invoked by these cells to combat the deleterious effects of a high rate of glycolytic metabolism. CAIX functions to help produce and maintain an intracellular pH (pHi) favorable for tumor cell growth and survival, while at the same time participating in the generation of an increasingly acidic extracellular space, facilitating tumor cell invasiveness. Pharmacologic interference of CAIX catalytic activity using monoclonal antibodies or CAIX-specific small molecule inhibitors, consequently disrupting pH regulation by cancer cells, has been shown recently to impair primary tumor growth and metastasis. Many of these agents are in preclinical or clinical development and constitute a novel, targeted strategy of cancer therapy. 相似文献