硬斑病样基底细胞癌

报告1例硬斑病样基底细胞癌。患者女,38岁。左眉间淡黄色丘疹3年,增大伴糜烂、结痂2年。皮肤科检查：眉间偏左有一基底约3cm×3.5cm大、略隆起的局限性浸润性蜡样硬斑块,表面有一约1.2cm×1.5cm、高低不平的浅溃疡。组织病理诊断：硬斑病样基底细胞癌。     

硬斑病样基底细胞癌1例

患者女,36岁。前额起淡黄色斑块6年,5分币大,质硬,略高出皮面,表面光滑平坦,可见毛细血管扩张,中央有一绿豆大浅溃疡。组织病理表现为基底细胞瘤团呈小团索壮或腺体样镶嵌在增生的结缔组织间,可见特征性裂隙。     

硬斑病样基底细胞癌

报告硬斑病样基底细胞癌1例。患者女,47岁。左鼻背外侧斑疹10余年,溃疡及出血3个月。皮肤科检查可见左鼻背外侧象牙白色至淡黄色斑片,中央可见红斑及淡黄色痂。皮损组织病理：真皮内有嗜碱性肿瘤细胞团块,周边细胞栅栏状排列,并可见收缩间隙。诊断：硬斑病样基底细胞癌。     

硬斑病样型基底细胞癌

报告1例硬斑病样型基底细胞癌.患者女,46 岁.上唇左上方淡黄色质硬斑块缓慢增大40 余年,无自觉症状,表面发生浅溃疡半年.皮损组织病理检查示真皮内由基底样细胞组成的肿瘤团块,周围细胞呈栅栏状排列,并见收缩间隙,团块周围间质胶原纤维增生.诊断为硬斑病样型基底细胞癌.     

硬斑病样型基底细胞癌

<正> 患者男,52岁。主诉:面部斑块2年。现病史:患者2年前无明显诱因于鼻左侧出现一肤色丘疹,曾于外院行冷冻治疗,嗣后皮损复发并缓慢增大,无破溃,偶有轻度瘙痒,于2008年2月来我科就诊。     

皮肤转移癌误诊为硬斑病样基底细胞癌1例

皮肤转移癌在临床上不少见,但极易误诊,现将1例皮肤转移癌误诊为硬斑病样基底细胞癌病例报告如下.1 病历摘要患者男,66岁.右肩胛部结节4个月余.患者于2009年4月右肩胛部发现一结节,约蚕豆大,局部红肿,其后中央出现破溃伴疼痛感,于当地医院行手术切除,病理诊断为右背硬斑病样基底细胞癌,术后未做进一步检查及治疗.2009年7月,患者发现原手术瘢痕上及其周围又出现包块,渐增大,伴痒痛,于2009年8月13日到我院就诊.患者自觉近半年体力及体重明显下降,二便正常.     

硬斑病样型基底细胞癌2例及其皮肤镜表现

例1女,38岁,因面部皮疹30余年就诊。例2女,70岁,因鼻背皮疹5年,右面部皮疹1年伴糜烂3个月就诊。例1和例2鼻背上皮损均表现为浸润性斑块,皮肤镜检查符合基底细胞癌,皮肤组织病理检查证实为硬斑病样型。例2右面部皮疹经病理证实为结节型基底细胞癌。均采用Mohs显微外科手术治疗。     

Mohs显微描记手术治疗硬斑病样型基底细胞癌

报告1例发生于额部左侧的硬斑病样型基底细胞癌。患者女,35岁,额部左侧白斑5年,瘢痕样损害2年。皮肤科检查:额部左侧一直径约5 cm大色素减退斑。皮损组织病理检查:真皮内可见由基底样细胞组成的肿瘤团块或条索,周围细胞呈栅栏状排列,可见收缩间隙,肿瘤团块周围结缔组织明显增生及硬化。诊断:硬斑病样型基底细胞癌。予行Mohs显微描记手术,经过4次扩大切除,肿瘤切除干净,术后创面予以全厚皮片植皮,伤口愈合良好。     

痣样基底细胞癌综合征一例

痣样基底细胞癌综合征是一种罕见的常染色体显性遗传病,以泛发性皮肤基底细胞癌和多器官发育异常为主要临床特征。本文报告1例痣样基底细胞癌综合征患者,并结合相关文献对该病的发病率、发病机制、诊断标准、治疗方法等进行讨论。     

息肉样基底细胞癌

报告1例息肉样基底细胞癌.患者女,77岁.右腋下赘生物25年,变红伴疼痛1年.皮肤科检查:右侧腋下可见蚕豆大暗红色息肉样半球形赘生物.皮损组织病理检查:表皮增生肥厚,部分区域向下增生,形成条索状及块状肿瘤细胞团块,肿瘤细胞团块由基底样细胞组成,细胞核大深染,可见核分裂象,部分边缘呈栅栏状排列,可见收缩间隙;真皮内可见间...     

色素性基底细胞癌

报告1例色素性基底细胞癌。患者女,68岁。右侧腋下黑色条状斑块10余年。皮肤科检查:右侧腋下约3.0 cm×0.2 cm大黑色斑块,边界尚清,其上散在分布数个米粒大黑色丘疹,斑块中部可见糜烂、渗液,渗液周边可见炎症性红斑,无触痛。皮损组织病理检查:表皮层局灶瘤细胞巢,表皮至真皮层可见一肿块,由嗜碱性基底样细胞组成,可见细胞异形性及有丝分裂象,在肿块周边细胞呈栅栏状排列,可见收缩间隙。诊断:色素性基底细胞癌。     

痣样基底细胞癌综合征

报告1例痣样基底细胞癌综合征.患者女,45岁.左足背无痛性红斑4个月余.皮肤科检查:左足背一3 cm×4 cm红色斑块,表面糜烂、结痴.左耳后一黄豆大暗红色丘疹,质地软.左胴窝一直径0.5 cm的淡红色斑片.双掌、跖部可见密集针尖大点状凹陷.皮损组织病理检查示基底细胞癌.诊断:痣样基底细胞癌综合征.     

毛漏斗囊性基底细胞癌

报告1例毛漏斗囊性基底细胞癌.患者男,54岁.面部无痛性丘疹3年.3年前右下颌出现单个绿豆大肤色丘疹,质韧,表面光滑.皮损组织病理检查示真皮内境界清楚的肿瘤,呈上皮样细胞条索状增殖,相互交织成网状,中间有多个毛囊漏斗部上皮样细胞结构的囊肿,内含角蛋白或毳毛,但无毛球、毛乳头样结构.有少量间质成分和成纤维细胞,黏蛋白丰富.诊断:毛漏斗囊性基底细胞癌.     

Granular cell basal cell carcinoma: A case report

Granular cell basal cell carcinoma (BCC) is a rare histopathological variant of BCC. Our review of the literature revealed only 17 previously identified cases. We report the case of a 47‐year‐old man who presented with an ulceration on his right upper lip which was subsequently removed. Histopathologic examination revealed that the tumor was composed solely of granular cells with numerous cytoplasmic eosinophilic round inclusion bodies. Mitotic figures ranged from 8 to 15 per 10 high‐power fields, with a Ki‐67 proliferative index of ~5%. Immunohistochemically, the granular cells showed strong and diffuse positivity for Ber‐EP4, pan‐cytokeratin, AE1/AE3, CK5/6 and p63 and focal positivity for lysozyme, CD68 (clone KP1) and Bcl‐2.     

色素性基底细胞癌一例

患者女,67岁.主因左耳后皮疹20年,溃烂2年余就诊.患者自述20年前左耳后长出一绿豆大小皮肤色丘疹,无自觉症状,数年后丘疹略增大,表面变粗糙,当地医院诊断刺瘊,自行数次用头发捆勒祛除之,未见效,皮疹增长缓慢无不适感.近5年常令其子用烟头烫,2年来丘疹反复糜烂、渗液、结痂,基底渐增大,色变黑,皮疹增大至鸽卵大小,中心溃烂不愈,无痛、痒感.     

Multiple lesions of granular cell basal cell carcinoma: a case report

Granular cell change in basal cell carcinoma (BCC) occurs rarely. Only 11 such cases have been reported; all of them were solitary nodular BCC. We report herein a case of multiple granular cell BCC with infundibulocystic features. The tumors presented as papules on the anterior neck of a 44‐year‐old female with a prior history of a well‐differentiated squamous cell carcinoma (SCC) of the tongue and radiation involving the area in which BCC developed. Microscopically, the tumors were circumscribed small dermal nodules composed of epithelial cords with granular eosinophilic cytoplasm and entrapped infundibular keratocysts. Given the eosinophilic appearance of the tumor, history of SCC and the lesions multiplicity, the initial biopsy was first interpreted as metastatic SCC. The correct diagnosis of granular cell BCC was established upon rereview of the slides at a cancer center. Given the diagnostic controversy, immunohistochemical stains were performed. The tumor cells expressed Ber‐EP4, CD63 (NKI/C3) and CD68. The tumors were compared to the prior SCC finding different morphologies. Extensive clinical evaluation showed no evidence of recurrent SCC. This report expands the clinicopathologic spectrum of granular cell variant of BCC and documents for the first time eruption of multiple such tumors in a localized area.