共查询到20条相似文献，搜索用时 31 毫秒
1.
Francisco Maduell Raquel Ojeda Lara Belmar Paula Munguía Cristina Sango Ana Isabel Martinez-Díaz Marta Arias-Guillén Manel Vera Néstor Fontseré Miquel Gómez Lida Rodas Nayra Rico 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2018,38(1):34-40
Introduction
Online haemodiafiltration (OL-HDF) has been associated with increased survival. To date, the influence of the inner diameter of the hollow fibres of the dialyser on convective volume has not been well established. The objective of the study was to evaluate the effect of increasing the inner diameter of the dialyser on the convective volume and removal capacity.Material and methods
We included 16 patients in posdilutional OL-HDF with autosubstitution. Each patient was analysed in 4 sessions in which the inner diameter varied; 185 μm (FX60 Cordiax and FX80 Cordiax) versus 210 μm (FX600 Cordiax and FX800 Cordiax). Different solutes were measured at the beginning and end of each dialysis session.Results
No differences in the convective volume were found with an increased inner diameter: 32.3 ± 3.1 vs. 31.8 ± 3.6 l/session (FX60 vs. FX600) and 33.7 ± 4.3 vs. 33.5 ± 3.8 l/session (FX80 vs. FX800). The reduction percentages also did not differ: urea 83.7 ± 4.5 vs. 84.1 ± 3.4 for FX60 and FX600, and 82.7 ± 4.1 vs. 83.6 ± 3.8 for FX80 vs. FX800; creatinine similar 78.2 ± 5.6 vs. 77.8 ± 4.6 y 77.1 ± 5.4 vs. 78.1 ± 4.9; β2-microglobulin 82.2 ± 4.3 vs. 82.9 ± 4.2, and 82.9 ± 4.7 vs. 84.0 ± 3.8; myoglobin 71.0 ± 10 vs. 70.2 ± 9 and 72.8 ± 11 vs. 75.0 ± 10; prolactin 70.4 ± 9 vs. 68.1 ± 9, and 72.2 ± 10 vs. 73.4 ± 8.2; and α1-microglobulin 22.9 ± 10 vs. 21.6 ± 10, and 26.5 ± 12 vs. 28.8 ± 11, respectively.Conclusion
The increase in the inner diameter of the hollow fibres did not result in improved convective volume and removal capacity. 相似文献2.
Carlos Antonio Amado Diago Luis Puente Maestu Beatriz Abascal Bolado Juan Agüero Calvo Mercedes Hernando Hernando Irene Puente Bats Ramón Agüero Balbín 《Archivos de bronconeumología》2018,54(2):74-78
Introduction
Dyspnea is a multidimensional symptom, but this multidimensionality is not considered in most dyspnea questionnaires. The Dyspnea-12 takes a multidimensional approach to the assessment of dyspnea, specifically the sensory and the affective response. The objective of this study was to translate into Spanish and validate the Dyspnea-12 questionnaire.Methods
The original English version of the Dyspnea-12 questionnaire was translated into Spanish and backtranslated to analyze its equivalence. Comprehension of the text was verified by analyzing the responses of 10 patients. Reliability and validation of the questionnaire were studied in an independent group of COPD patients attending the pulmonology clinics of Hospital Universitario Marqués de Valdecilla, diagnosed and categorized according to GOLD guidelines.Results
The mean age of the group (n = 51) was 65 years and mean FEV1 was 50%. All patients understood all questions of the translated version of Dyspnea-12. Internal consistency of the questionnaire was α=0.937 and intraclass correlation coefficient was = .969; P < .001. Statistically significant correlations were found with HADS (anxiety r = .608 and depression r = .615), mMRC dyspnea (r = .592), 6 MWT (r = –0.445), FEV1 (r = –0.312), all dimensions of CRQ-SAS (dyspnea r = –0.626; fatigue r = –0.718; emotional function r = –0.663; mastery r = –0.740), CAT (r = 0.669), and baseline dyspnea index (r = –0.615). Dyspnea-12 scores were 10.32 points higher in symptomatic GOLD groups (B and D) (P < .001).Conclusion
The Spanish version of Dyspnea-12 is a valid and reliable instrument to study the multidimensional nature of dyspnea. 相似文献3.
4.
F.M. Oña-Ortiz J. Sánchez-del Monte M.E. Ramírez-Solís J.G. de la Mora-Levy J.O. Alonso-Larraga L.S. Lino-Silva M.A. Herrera-Servín M. Jiménez-Morales M.C. Manzano-Robleda M. Yañez-Cruz A.I. Hernández-Guerrero 《Revista de gastroenterologia de Mexico》2019,84(4):434-441
Introduction and aimMantle cell lymphoma is an aggressive subtype of B-cell non-Hodgkin lymphoma and its incidence is 0.5/100,000 inhabitants. Gastrointestinal involvement at diagnosis is 15-30%. The aim of our study was to analyze the clinical and endoscopic characteristics of mantle cell lymphoma affecting the digestive tract.Material and methodsA retrospective study was conducted, based on a case series of patients with mantle cell lymphoma affecting the gastrointestinal tract that were diagnosed over a 10-year period.ResultsTen patients (11.7%) had gastrointestinal tract involvement. The upper endoscopic findings were polypoid lesions (66%), thickened folds (44%), and nonspecific changes in the mucosa (33%). At colonoscopy, polypoid lesions were viewed in 100% of the patients and ulcerated lesions in 40%.ConclusionPolypoid lesions are the most common endoscopic characteristics in patients with mantle cell lymphoma of the gastrointestinal tract. Upper endoscopy and colonoscopy should be carried out on patients with mantle cell lymphoma, even those with nonspecific symptoms, to check their gastrointestinal status. Gastrointestinal involvement has an impact on disease staging. 相似文献
5.
6.
7.
8.
9.
10.
11.
12.
The pathogenesis of arteriosclerosis in HIV-infected patients is complex. Both patient-related cardiovascular risk factors (CVRF) established for the general population and those related to highly-active antiretroviral therapy (HAART) and HIV infection per se are involved. Some traditional CVRF are more frequent in HIVinfected patients than in the general population. In developed countries, HIV infection is more frequent among men and, due to HAART, their life expectancy has significantly increased. The prevalence of smoking (37-72%) is higher than in the general population, as is that of diabetes mellitus (17%), insulin resistance (17-51%), dyslipidemia (22-49%) and hypertriglyceridemia (34%). The higher prevalence in these patients is probably due to lifestyle and length of exposure to HAART, especially to certain antiretroviral drugs. Although overall cardiovascular risk in patients with HIV remains low, CVRF established for the general population become more important with increasing age. Longitudinal cohort studies indicate the magnitude of the association of these risk factors with cardiovascular disease in patients with HIV infection. In view of all the factors that intervene in HIV infection, specific mathematical models should be designed for this population that would allow individual cardiovascular risk to be calculated in each patient and measures for cardiovascular prevention to be established. 相似文献
13.
14.
L.E. Cisneros-Garza M.S. González-Huezo J.A. López-Cossio A.L. Kuljacha-Gastelum 《Revista de gastroenterologia de Mexico》2018,83(3):223-227
Introduction and aims
In Mexico, complications of cirrhosis are the third leading cause of death in adult males. In recent decades, the incidence of hepatocellular carcinoma has increased worldwide. The aim of this study was to determine the characteristics of patients with hepatocellular carcinoma at two Mexican tertiary care hospitals.Material and methods
An observational, cross-sectional, retrospective study was conducted between January 2008 and April 2014. We described the clinical features, epidemiologic characteristics, diagnosis, and treatment of patients with hepatocellular carcinoma.Results
One hundred and forty-eight patients were included. There was a predominance in males and disease manifestation in the sixth decade of life. Liver disease was associated in 87% of subjects and was mainly attributed to alcohol abuse, hepatitis C infection, and nonalcoholic steatohepatitis. Sixty percent (60%) of cases were classified as Child-Pugh stage A cirrhosis, 75.5% harbored a single tumor at diagnosis, 27.7% had normal alpha-fetoprotein values, and only 39.2% of patients with known liver disease were under a surveillance program. Tumors were larger than 5 cm at diagnosis in 64.3% of patients, and well-differentiated lesions were most frequently detected. Over 70% of patients were diagnosed at a non-curative stage. By the 2014 study cutoff point, 77.7% of patients had died. Treatment was determined by the means available at each center and followed the therapeutic recommendations in international guidelines in 45.3% of cases, clearly impacting survival.Conclusions
Better surveillance methods are required to diagnose the disease at its early stages, but treatment still requires individual adaptation to each center's available resources. 相似文献15.
《Gastroenterologia y hepatologia》2020,43(8):464-471
The SARS-CoV-2 pandemic is leading to high mortality and a global health crisis. The primary involvement is respiratory; however, the virus can also affect other organs, such as the gastrointestinal tract and liver. The most common symptoms are anorexia and diarrhea. In about half of the cases, viral RNA could be detected in the stool, which is another line of transmission and diagnosis. covid19 has a worse prognosis in patients with comorbidities, although there is not enough evidence in case of previous digestive diseases.Digestive endoscopies may give rise to aerosols, which make them techniques with a high risk of infection. Experts and scientific organizations worldwide have developed guidelines for preventive measures.The available evidence on gastrointestinal and hepatic involvement, the impact on patients with previous digestive diseases and operating guidelines for Endoscopy Units during the pandemic are reviewed. 相似文献
16.
Raimundo M García del Moral Martín Juan Antonio Retamero Díaz Mercedes Cava Molina Belen M. Cobacho Tornel Juan Bravo Soto Antonio Osuna Ortega Francisco O’Valle Ravassa 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2018,38(3):297-303
Introduction
KDRI / KDPI are tools use in kidney donor evaluation. It has been proposed as a substitute of, or complementary to preimplantation renal biopsy. These scores has not been validated in Spain.Objective
1) To investigate the concordance between KDPI and histological scores (preimplantation renal biopsy) and 2) To assess the relationship between KDRI, KDPI and histological score on graft survival in the expanded criteria donors group.Methodology
Retrospective cohort study from 1 January 1998 until 31 December 2010.Results
During the study 120 donors were recruited, that resulted in 220 preimplantation renal biopsies. 144 (65%) grafts were considered suitable for kidney transplantation. 76 (34.5%) were discarded. Median follow up has been 6.4 years (sd 3.9). Median age 63.1 years (sd 8.2), males (145; 65.9%), non-diabetic (191; 86.8%) and without another cardiovascular risk factors (173; 78.6%). 153 (69.5%) donors died of cerebrovascular disease. There were significant differences in KDRI/KDPI score in both groups 1.56/89 (sd 0.22) vs 1.66/93 (sd 0.15), p<0.01). The KDPI showed moderate concordance and correlation with the histological score (AUC 0.64 / correlation coefficient 0.24, p <0.01). KDPI (HR 24.3, p<0.01) and KDRI (HR 23.3, p<0.01) scores were associated with graft survival in multivariate analysis.Conclusion
1) KPDI and histological scores show moderate concordance. The utility of both scores as combined tools it has to be determined. 2) KDPI score, and especially KDRI score, are valid for estimating graft survival and combined with the biopsy can help to individualized decision making in the expanded criteria donors pool. 相似文献17.
18.
Carla Burballa Marta Crespo Dolores Redondo-Pachón María José Pérez-Sáez Marisa Mir Carlos Arias-Cabrales Albert Francés Lluis Fumadó Lluis Cecchini Julio Pascual 《Nefrología : publicación oficial de la Sociedad Espa?ola Nefrologia》2018,38(2):207-212
Introduction
The evaluation of the measured Glomerular Filtration Rate (mGFR) or estimated Glomerular Filtration Rate (eGFR) is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function.Material and methods
We analysed the relationship between baseline GFR values measured by Tc-99m-DTPA (diethylene-triamine-pentaacetate) and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations in a series of living donors at our institution.Results
We included 64 donors (70.6% females; mean age 48.3 ± 11 years). Baseline creatinine was 0.8 ± 0.1 mg/dl and it was 1.1 ± 0.2 mg/dl one year after donation. The equations underestimated GFR when measured by Tc99m-DTPA (MDRD4–9.4 ± 25 ml/min, P<.05, and CKD-EPI–4.4 ± 21 ml/min). The correlation between estimation equations and the measured method was superior for CKD-EPI (r=.41; P<.004) than for MDRD4 (r=.27; P<.05). eGFR decreased to 59.6 ± 11 (MDRD4) and 66.2 ± 14 ml/min (CKD-EPI) one year after donation. This means a mean eGFR reduction of 28.2 ± 16.7 ml/min (MDRD4) and 27.31 ± 14.4 ml/min (CKD-EPI) at one year.Conclusions
In our experience, CKD-EPI is the equation that better correlates with mGFR-Tc99m-DTPA when assessing renal function for donor screening purposes. 相似文献19.
20.
A significant number of studies on pulmonary circulation diseases have been published in 2009 that are likely to have a notable clinical impact. Anticoagulant treatment is on the verge of a significant change with the arrival of new oral drugs that have an inhibitory effect over factor X (rivaroxaban, apixaban) or thrombin (dabigatran). New studies have shown an efficacy comparable to enoxaparin in the prevention of thromboembolic disease and in some cases a lower risk of haemorrhage. Also interesting is a study on the incidence of pulmonary thromboembolism in patients with chronic obstructive pulmonary disease, a little known aspect. A study that demonstrates some efficacy of rosuvastatin in the prevention of thromboembolic disease, something that could change our current practices.Pulmonary hypertension (PH) continues to produce numerous publications. One French study has shown a relatively low risk of developing PH in patients with systemic sclerosis over a period of 3 years. As regards treatment, ambrisentan seems to confirm it lower risk of hepatoxicity compared to other endothelin antagonists. A new phosphodiesterase-5 inhibitor, tadalafil, has made a strong impact on the PH scene during this year. Its results are similar to other oral drugs with a convenient posology. The surgical treatment of PH due to chronic thromboembolism in one of the hospitals of our country has been present with results that, particularly in the past few years, are perfectly comparable to other centres of excellence.To summarise, 2009 has continued to provide important news in the area of pulmonary circulation. 相似文献