急性下壁心肌梗死胸前导联心电图变化与冠状动脉造影结果的对比研究

目的 探讨胸前导联心电图变化在急性下壁心肌梗死患者诊治过程中的临床价值.方法 选择急性下壁心肌梗死患者80例,依据胸前导联ST段压低幅度和持续时间分为4组,所有患者均在发病7～10d内完成冠状动脉造影,统计各组患者不同血管病变例数并进行统计学分析.结果 胸前导联ST段压低持续时间不足72h与持续时间超过72h患者造影结果对比和胸前导联ST段压低<2mm与≥2mm患者造影结果对比,右冠状动脉病变及左回旋支病变例数差异无统计学意义(P>0.05),右冠状动脉或左回旋支合并左前降支病变例数差异有统计学意义(P相似文献   

胸前导联心电图变化与急性下壁心肌梗死相关动脉关系的临床研究

目的 探讨胸前导联心电图变化与急性下壁心肌梗死相关动脉之间的关系.方法 选择行冠状动脉造影的急性下壁心肌梗死患者103例,并依据胸前导联ST段压低幅度和持续时间分为四组,统计各组患者不同血管病变例数并进行统计学分析对比.结果 胸前导联ST段压低持续时间不足48小时与持续时间超过48小时患者造影结果对比、胸前导联ST段压低小于2mm与大于等于2mm患者造影结果对比:仅右冠脉病变及仅左回旋支病变例数差异无显著性,右冠脉或左回旋支合并左前降支病变例数差异有显著性.结论 下壁心梗患者若胸前导联ST段压低幅度较大,且持续时间较长,则右冠脉或左回旋支合并左前降支病变可能性大.     

急性下壁心肌梗死时胸前导联ST段压低的意义

目的 分析下壁急性心肌梗死(AMI)患者胸前导联ST段压的意义.方法 回顾性分析下壁AMI患者,选择发病当日典型AMI心电图测量ST段水平和住院1～2 d内进行的冠状动脉造影,评价梗死相关的右冠状动脉病变位置及左前降支动脉与ST段变化的关系.结果 38例患者分两组,A组不伴胸前导联ST段压低,B组伴有胸前导联ST段压低.B组多支冠状动脉病变明显多于A组(分别为87.5%和23.6%和19.0%,P<0.01).主要与并发左前降支病变有关.梗死相关的右冠状动脉近端病变B组明显多于A组(分别为54.5%和23.6%,P<0.01).结论 下壁AMT时胸前导联ST段压低提示多支冠状动脉病变和右冠状动脉近端病变.     

急性心梗前壁导联ST段压低与梗死动脉病变定位的关系

目的 对急性下壁心肌梗死前壁导联ST段压低与梗死动脉病变定位的关系进行研究分析.方法 抽取在2009～2011年在诊的急性下壁心肌梗死并伴有前壁导联ST段压低的患者88例,并且按照胸前导联ST段压低范围分为4组:无胸前导联ST段压低者为A组;胸前导联V1-3ST段压低者为B组;胸前导联V4-6ST段压低者为C组;前导联V1-6ST段压低者为D组.并对冠心病危险因素、心肌酶谱、心电图、冠状动脉造影、心脏彩超以及心肌梗死的并发症等内容进行分析.结果 C组与D组比无胸前导联ST段压低组冠状动脉多支病变的发生率有所增加.四组的前降支病变发生率分别为27.9%、17.8%、73.7%、83.2%,与A组相比,C组与D组的左前降支病变发生率高;四组的回旋支病变发生率分别为36.1%、55.2%、73.8%、61.9%.与A组相比,C组的左回旋支病变发生率高.结论 胸前导联V4-6ST和V1-6ST段压低患者出现冠状动脉多支病变和回旋支病变的可能性相对较高.     

急性心肌梗死梗死区与非梗死区导联的ST段改变

目的　探讨急性心肌梗死梗死区与非梗死区导联ST段变化及临床意义。　方法　 36例急性前壁心肌梗死 (AAMI)和 2 8例急性下壁心肌梗死 (AIMI)患者 ,对梗死区与非梗死区导联ST段变化及其与冠状动脉造影结果作相关分析。　结果　AAMI有下壁导联ST段压低中Ⅰ、avL导联ST段抬高占70 .5 9% (P <0 .0 1) ,左前降支近段病变占 76 .4 7% ,而冠脉多支病变与ST段压低差异无显著性。AIMI组Ⅰ、avL导联ST段压低占 71.4 2 % ,冠脉多支病变中Ⅴ4～Ⅴ6导联ST段压低占 5 2 .17% (P <0 .0 1)。　结论　AAMI或AIMI时Ⅰ、avL与Ⅱ、Ⅲ、avF导联ST段抬高与压低呈对应“镜像”改变 ;AAMI时下壁导联ST段压低 ,病变多位于左前降支近段 ,梗死面积大 ;AIMI时Ⅴ4～Ⅴ6的ST段压低则反映冠脉多支病变。AMI的ECG早期鉴别诊断有助于识别高危患者。     

急性下壁心肌梗死胸前导联ST段变化的临床分析

目的:通过冠状动脉造影探讨急性下壁心肌梗死患者合并胸前导联ST改变的临床意义。方法:47例急性下壁心肌梗死患者入院第1天标准12导联心电图记录,患者行冠状动脉造影,冠状动脉狭窄≥50%为异常。结果:冠脉多支病变者(2支以上有病变)易发生胸前导联ST段压低,P<0.05。结论:急性下壁心肌梗死合并胸前导联ST段变化的患者,提示冠脉有多支病变,是心肌供血不足的标志。     

急性下壁肌梗死伴胸导联ST段压低的临床价值

目的:探讨急性下壁心肌梗死常规心电图伴胸导联ST段压低的临床价值。方法:观察60例急性下壁心肌梗死心电图伴胸导联ST段改变,结合冠状动脉造影(CAG),超声心动描记术等检查结果三者之间的相关性。结果:(1)单纯下壁心肌梗死不伴有胸导联ST段改变显著多于伴有胸导联ST段改变者(P<0.01)。(2)下壁心肌梗死伴胸导联ST段压低者,冠状动脉造影其病变多位于左前降支的端或呈多支病变。(3)下壁心肌梗死伴胸导联ST段压低者左心室射血分数减低更显著,左室收缩与舒张末期容积增大。结论:急性下壁心肌梗死伴随胸导联ST段压低表明心肌梗死的净面积较大,心脏泵血功能障碍严重,预后较差。     

60例急性下壁心肌梗死胸前导联ST段下移的临床意义

目的:急性下壁心肌梗死早期常伴有胸前导联ST段压低,以往认为是一种对应性镜像反映[1],近年来则提出较多异议。它能否作为判断合并前支病变的依据,对临床诊治及判断有十分重要的意义。方法:本文分析了60例急性下壁心肌梗死(AIMI)患者胸前导联ST段压低变化和其冠状动脉造影结果,以探讨胸前导联ST段变化与前降支病变的关系。结果:急性下壁心肌梗死60例中,胸前导联ST段下移者41例,胸前导联ST段正常者19例。前者CK最高峰值达2356±1036,后者CK峰值最高达1630±421,P<0.01,冠状动脉显示右冠状段异常的41例中,4例死亡。KILLIPⅡ级以上心力衰竭15例,发生36.6%;心率失常30例,发生率73.2%,胸前导联ST段正常的19例中Ⅱ级以上心力衰竭2例,发生率10.5%,心率失常7例,发生率36.8%,P值均为P<0.05。结论:急性下壁心肌梗死胸前导联V1-V3ST段压低是急性下壁心肌梗死镜像改变,而伴胸前导联V4-V6ST压低则可能存在左前降支和/或回旋支的严重狭窄病变,存在较大面积,临床出现血流动力学紊乱,应引起重视。     

从体表心电图判断急性下壁心肌梗死的临床预后

目的：探讨急性下壁心肌梗死后心电图胸前导联ST段下移的临床意义。方法：回顾性分析42例急性下壁心肌梗死患者入院心电图及冠状动脉造影资料，分为无胸前导联ST段下移组（A）、胸前导联V4-6ST段下移组（B）、胸前导联V1-6ST段下移组（C）。结果：C组较A组冠状动脉多支病变发生率增加，临床心脏事件增加。结论：急性下壁心肌梗死后胸前导联V4-6ST段下移合并左冠状动脉病变的发生率低，胸前导联V1-6ST段下移多存在左前降支或回旋支病变，预后差，左室功能差，并发症多。     

入院心电图对急性前壁心肌梗死时左前降支近段急性闭塞的预测

目的 :评价入院心电图在急性前壁心肌梗死时预测左前降支 (L AD)近段急性闭塞的价值。方法 :回顾性分析 37例急性前壁心肌梗死并行急诊 PTCA或入院 2周内行冠脉造影患者的入院心电图和冠脉造影结果。结果 :LAD近段急性闭塞组下壁导联 ST段压低幅度和 a VL导联 ST段抬高幅度均较 LAD中远段急性闭塞组明显 (P<0 .0 1)。 导联 ST段压低和 a VL导联 ST段抬高经单因素线性回归分析呈负相关 (r=- 0 .80 ,P=0 .0 0 1)。下壁导联 ST段压低和 a VL导联 ST段抬高对 LAD近段急性闭塞的特异性高于敏感性。结论 :急性前壁心肌梗死时入院心电图的下壁 ST段压低和 a VL导联 ST段抬高提示左前降支在第一对角支分叉近侧段的急性闭塞。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.