Drug compliance influence factors and countermeasure of hypertension patients

INTRODUCTIONThefirstassemblyinternationalconferenceaboutpatient＇sdiscom－pliancesuggestedthatpatientsnotcomplyingwiththerapycouldberegardedasdiscompliance．Patients＇non－complianceisanewtopicofmodernmedicine．Inclinical，HypertensionpatientsalwaystookdecompressiondrugorallyandmaintainsmalldosageafterBPinnormalrange．Doctorswilldeliverdifferenttherapyaccordingtopatients＇differentconditionsandregulatetherapyaccordingtocu－rativeeffectsintimeinordertogainthebesteffects．Patientsshouldcom…     

Clinical significance of rehabilitative education for diabetes patients

Background：Diabetesisakindofchronicallypermanentdisease．Managementduringhospitalizationwasinsufficient．Now，healtheducationistheimportantprojectindiabetesstudy．Patients＇lifestyle，attitudetoconditionandprevioustreat－mentshowedobviousimpactondiabetescontrol．Someinvestigatorsindicatedpatientshadlessknowledgeaboutdiabetes－relatedmat－ters，andtheirself－healthideawasunobvious．Theyrarelyabidedbyphysicians＇demands．So，rehabilitativeeducationisimportantfordiabetespatients．Objective：To…     

硬膜外恒速输注低浓度罗哌卡因、芬太尼复合液用于全髋关节等术后镇痛及对运动神经阻滞的影响

Thereweremanymedicinesandmethodswereusedinpain－controlledinepiduralcavityafteroperation，butthereweren＇tsameviewtorehabilitationafteroperation．Ropivacaineislowertoxicity，hasacharacterofsense－movementdivision．Lowerdensityropivacaineandfentanylwereusedinepiduralcavityafteropera－tion，theeffectsonpatients＇rehabilitationwereobserved．Nowre－portasfollow．１SubjectsandMethods１．１SubjectsTheselected４４patientsASAⅠ～Ⅱoperatedinlowerabdomenweresatisfiedanesthetized．Thepatientsweredi－…     

帕罗西汀对卒中后抑郁病人的功能恢复作用

Depressionisthecommoncomplicationofstroke，whichoccursinatleast３０％ofthestrokepatients．Depressionaffectsthepatients＇rehabilitationsignificantly．Itiscommonlyadmittedthat５－HTreup－takeinhibitorshavegoodeffectontreatingpoststrokedepression（PSD）．Thispaperstudiestheclinicaltherapeuticeffectofparoxetineoneofthe５－HTreuptakeinhibitorsintreatingPSDanditseffectonthepatients＇nervefunctions．Comparedwiththetricircularantide－pressionreagents，suchasdoxepin，themechanismofthetherapeuticeff…     

The therapy with the large dosage of methylprednisolone for the Bell palsy

Background：ThemainpathologicalimpairmentsincludeedemaoffacialnerveanddifferentleveldegenerationofmyelinsheathoraxiscylinderinBell＇spalsy．Theprognosisofthedis－easeresultsfromseveredegreeofthediseaseandwhethertreat－mentsaretimelyornot．ThetherapywithlargedosagesofMethylprednisolone（MPS）inveinforBell＇spalsy，canrelievelocaledema，improvenerveconduction，avoidprogressiveimpair－mentsofmyelinesheathandaxiscylinderandpromoterepairsofmyelinesheath．Objective：Todiscusstheeffectsoflargedosa…     

重组人红细胞生成素在肿瘤相关贫血中的应用

Itiswellknowthatrecombinanthumanerythropoietin（rhEPO）caneffectivelymanagechronicrenalfailure－relatedanemia．rhEPOcorrectedsymptoms，improvedqualityoflifeofanemiapatientsandreducedrisksassociatedwithheterotransfusion．Intheendof１９８０＇sandbeginningof１９９０＇s，someresearchersstudiedtherapeuticeffectofrhEPOinthetreatmentofanemiaduetootherdiseasesespeciallycancer－relatedanemiasuchaschemotherapyorradiotherapyinducedanemiaandneoplasticanemia．Manyfactorssuchasbleeding，infec－tion，hemo…     

The effect of QOG magnetopolarization quantum blood treatment machine on improving neural function defectio n of patients with stroke

BACKGROUND：MagnetopolarizationquantumbloodQOGtreatmentmeansusingauto－venousbloodorotherpeople＇sbloodofsametype１５０to２００mlandtransferringbacktobodyafterexternalanticoagulation．OBJECTIVE：ToobservetheeffectofQOGMagnetopolariza－tionquantumbloodtreatmentmachineonimprovingneuralfunctiondefectionofpatientswithstroke．UNIT：DepartmentofWesternMedicineandTraditionalChi－neseMedicine，FifthPeople＇sHospitalofJi＇nanCitySUBJECTS：１２０patientsenteredthisstudyaccordingtothed…     

Effect of music therapy and behavioral therapy on schizophrenia patients

BACKGROUND：Musicplaysstronginfluenceonhumanpsycheandphysiology．Itcanamelioratepeople＇semotionandcog－nitionlevelandchangepeople＇svolitionalbehavior．Behavioralcorrectionchangescognitiveprocessandideasandcorrectsbadmotionandbehaviorthroughpositivereinforcement，negativerein－forcement，positivepunishmentandnegativepunishment．OBJECTIVE：Toinvestigatetheeffectofmusictherapyandbehavioraltherapyonschizophreniapatients．UNIT：SchizophreniaPreventionandTreatmentHospitalofJiningCitySU…     

Impact of intervened hypertension,hyperlipemia,hyperviscosity syndrome in incidence of cardiovascular and cerebrovascular diseases

Background：AccordingtoAmericanHeartAssociation＇sre－port，deathcompositionofcerebrovascularandcerebrovasculardis－easewasincreasedto２９％in１９９６，andnow３３％from２５％in１９９２．Now，atherosclerosisseriouslyendangerhuman＇shealth．Hypertension，hyperlipemiaandhyperviscositysyndromearemainriskfactorsofcardiovascularandcerebrovasculardis－eases．Thereconditionsoftenexistedsimultaneouslyinel－ders．Interventiontothesediseasescanpreventcardiovascularandcerebrovascularevents，whichisfeasi…     

应用抑制性消减杂交技术克隆EB病毒致人B淋巴细胞永生化的差异性表达基因

INTRODUCTIONEpstein－BarrVirus（EBvirus）wasfirstisolatedfromculturedBruitt＇lymphomabyEpstein，BarrandAchongin１９６４．EBvirusbelongstohumanherpesvirus．MostpeopleexperiencedEBvirusinfectionwithoutobvioussymptoms．EBvirusisinvolvedinalotofconditionssuchasinfectiousmononucleosissyndrom（IM），Burkitt＇lymphoma（BL），nasopharyngealcarcinoma（NPC），chronicactiveEBvirusin－fection（CAEBV），Hodgkin＇sdisease（HD），peripheralTcelllym－phoma，gastriccancerandimmunodefficientlym…     

Constructive and biomechanical properties of material of decalcified bone matrix impregnated with bone cement

AIM:To analyze constructive and biomechanical properties of different quality ratio material impregnated decalcified bone matrix(DBM) with bone cement(BC).METHODS:The DBM particles and the materials impregnated 0mg/g,300mg/g and 400mg/g mass ratio DBM particles with BC were made according to the methods of Urist et al.The compound material constructions were observed by scanning electron microscope and the biomechanical properties were measured by Instron mechanics test-ing-machine.RESULTS:The DBM particles with irregular gaps existing within interspace were connected with BC by the multipoint mode in the compound material.The ultimate compressive strength were 0mg/g DBM in (59.3&;#177;2.2)MPa,300mg/g in(27.1&;#177;1.8)MPa,400mg/g in (19.3&;#177;1.6)MPa.The ultimate bending strength were 0mg/g in (54.3&;#177;3.7)MPa,300mg/g in (18.5&;#177;1.1)MPa,400mg/g in (13.3&;#177;1.4)MPa.CONCLUSION:The materials of DBM impregnated with BC had perfect plastic property with much more irregular gaps existing within interspace.The materials could provide abundant biomechanical support.     

牛煅烧骨颗粒复合骨水泥的生物力学性能评定

目的分析不同质量比的牛煅烧骨颗粒复合骨水泥结构特征及生物力学性能.方法把提取过bBMP的牛骨颗粒制成煅烧骨,以不同的质量比与骨水泥混合制成复合材料,测定其生物力学性能与电镜下结构.结果复合材料呈均匀混合分布并多点状结合,其中存在较多的裂隙;含牛煅烧骨颗粒质量比为500mg/g的复合材料的生物力学性能最为适宜.结论牛煅烧骨颗粒复合骨水泥后具有新骨长入的通道,含煅烧骨质量比为500mg/g的复合材料生物力学性能良好,能作为支架材料修复骨缺损.     

骨缺损修复材料可降解速固化骨水泥结构特征及力学性能

目的分析异体脱钙骨基质(DBM)骨粒复合磷酸钙骨水泥(CPC)及氰基丙烯酸正丁酯粘合剂(NBCA)后材料的扫描电镜结构特征及生物力学性能。方法将DBM骨粒与CPC以1:1体积比搅拌均匀,加入适量NBCA,制成DCN骨水泥;扫描电镜观察复合材料结构特征,力学试验机测定材料生物力学性能。结果扫描电镜发现,CPC与DBM均匀复合,CPC被覆DBM表面呈规则有序海绵状,其中存在较多大小不规则、相互连通的自然裂隙;材料的抗压及拉伸极限强度较CPC明显提高。结论DCN骨水泥具有相互联通的自然裂隙及潜在的骨粒通道,并可提供较好的机械支持和固定作用的骨修复材料。     

复合材料修复骨缺损血管化及结构特征变化

ThelecturesaboutcarriermaterialsofBMP（bonemorphogeneticprotein）areveryusual．ThecompoundmaterialscombinedwithBMPshouldhavefinemoldingability，biomechanicsandboneinductivecapability．Bonecementhasbeenusedwidespreadinartificialjointsurgery．WeusethecompoundmaterialofDBM（decalcifiedbonematrix）particleswhichwascombinedwithrhBMP－２（recombinedhumanbonemorphogeneticprotein）impregnatedwithbonecementtorepairtherabbitbonedefectandstudythechangesofcirculationandconstructionofthecompoundmateri…     

异体脱钙骨基质颗粒复合骨水泥修复兔下颌骨缺损的放射影像学和组织学研究

目的探讨异体脱钙骨基质颗粒和骨水泥复合修复下颌骨骨缺损的效果。方法用异体脱钙骨基质颗粒复合骨水泥修复兔右下颌骨的骨缺损,左侧单纯植入骨水泥做对照。分别于术后不同时间行X-射线照相、99mTc-MDP骨扫描、组织学观察。结果4周开始形成骨痂,12周骨痂最丰富,24周复合材料与宿主骨边缘模糊,边缘部分的异体脱钙骨基质颗粒被新生骨替代,并与宿主骨融合。结论异体脱钙骨基质颗粒和骨水泥复合易塑形,还具有生物学活性,是修复下颌骨缺损的理想材料。     

异体脱钙骨基质骨粒骨水泥骨形态发生蛋白复合材料成骨诱导活性

INTRODUCTIONTherecombinanthumanbonemorphogeneticprotein-2(rhBMP-2)hadbeenexpressedbytheeukaryoticcellsineightycentury犤1犦.TherhBMP-2combinedwiththedecalcifiedbonematrix(DBM)par-ticleswasimpregnatedwithbonecementtoproducethecompoundbonedefectrepairmaterialandtheboneinductivecapacityofitwasinvestigatedinourstudy.MATERIALSANDMETHODSDBMparticlesandthecompoundmaterialpreparationThe100-400μmgrainyDBMparticlesweremadeaccordingtotheUrist'smethods犤2犦.30mgDBMparticlescombinedwith…     

异体脱钙骨基质颗粒复合骨水泥修复兔股骨粉碎性骨折

目的探讨异体脱钙骨基质颗粒复合骨水泥修复严重粉碎性骨折的效果。方法制造兔右股骨粉碎性骨折的动物模型,a组用异体脱钙骨基质颗粒复合骨水泥并表面贴附自体骨渣进行修复;b组用异体脱钙骨基质颗粒复合骨水泥进行修复;c组单纯植入骨水泥进行修复作为对照组。分别于术后不同时间行X射线照相、99mTc-MDP骨扫描和组织学观察。结果a组和b组4周开始形成骨痂,12周骨痂最丰富,24周复合材料与宿主骨边缘模糊,边缘部分的异体脱钙骨基质颗粒被新生骨替代,并与宿主骨融合。a组较b组骨痂形成快。99mTc-MDP骨扫描计数a组大于b组,b组大于c组(P<0.01)。结论异体脱钙骨基质颗粒复合骨水泥易塑形,并具有生物学活性,能修复粉碎性骨折,表面贴附自体骨渣进行修复效果更为理想。     

骨形成蛋白复合材料修复狗椎板缺损的实验研究

目的探讨骨形成蛋白与脱钙骨基质颗粒、骨水泥复合后修复狗腰部椎板缺损的效果。方法制备异体狗脱钙骨基质颗粒,提取牛骨形成蛋白并行成骨诱导活性测定。将脱钙骨基质颗粒、骨水泥与骨形成蛋白复合后行扫描电镜观察和生物力学测定。无菌操作造成狗腰部椎板缺损,用复合材料覆盖修复,术后不同时间进行X射线照相、     

组织工程化骨替代材料的评价及其在修复骨肿瘤性骨缺损中的应用

目的制备和综合评价组织工程化骨替代材料并用于修复骨肿瘤所导致的骨缺损。方法制备狗和人的异体脱钙骨基质颗粒(DBM),提取牛骨形成蛋白(bBMP)并经成骨诱导活性测定,将bBMP与DBM用直接掺和的方法复合后,再与骨水泥(BC)混合制成组织工程化复合材料,进行综合评价后备用。56例下肢骨肿瘤患者在微波诱导高温原位灭活后,应用组织工程化复合材料对遗留的骨缺损进行修复重建。结果bBMP、DBM和BC组织工程化复合骨修复替代材料具有良好的生物相容性、很强的生物力学强度和成骨诱导活性,并且具有良好的粘合性和可塑形性。临床应用56例,经平均9个月的随访,效果良好且无任何不良反应。患肢膝关节功能评价,优52例(93%),良4例(7%),优良率100%。结论bBMP、DBM和BC组织工程化复合骨修复替代材料是目前修复骨缺损理想的产品,有广阔的临床应用前景。     

Demineralized bone matrix and human cancellous bone enhance fixation of porous‐coated titanium implants in sheep

Allogenic bone graft has been considered the gold standard in connection with bone graft material in revision joint arthroplasty. However, the lack of osteogenic potential and the risk of disease transmission are clinical challenges. The use of osteoinductive materials, such as demineralized bone matrix (DBM), alone or in combination with allograft or commercially available human cancellous bone (CB), may replace allografts, as they have the capability of inducing new bone and improving implant fixation through enhancing bone ongrowth. The purpose of this study was to investigate the effect of DBM alone, DBM with CB, or allograft on the fixation of porous‐coated titanium implants. DBM100 and CB produced from human tissue were included. Both materials are commercially available. DBM granules are placed in pure DBM and do not contain any other carrier. Titanium alloy implants, 10 mm long × 10 mm diameter, were inserted bilaterally into the femoral condyles of eight skeletally mature sheep. Thus, four implants with a concentric gap of 2 mm were implanted in each sheep. The gap was filled with: (a) DBM; (b) DBM:CB at a ratio of 1:3; (c) DBM:allograft at a ratio of 1:3; or (d) allograft (gold standard), respectively. A standardized surgical procedure was used. At sacrifice 6 weeks after implantation, both distal femurs were harvested. The implant fixation was evaluated by mechanical push‐out testing to test shear mechanical properties between implant and the host bone and by histomorphometry. Non‐parametric tests were applied; p < 0.05 was considered significant. Mechanical fixation showed that the strengths among the DBM/CB, DBM/allograft and allograft groups were not statistically different. The strength of the DBM group was 0.01 MPa, which was statistical significantly lower than the other three groups (p < 0.05). Histomorphometry results showed that the bone ongrowth in the DBM group was statistically significantly lower than the other three groups, while the volume fraction of new bone showed no significant difference among all the groups. Our data revealed that adding DBM to CB or to allograft resulted in comparable mechanical properties relative to the gold standard, allograft. We found inferior early effects of DBM alone on the fixation of porous‐coated titanium implant in this animal model, while the long‐term effects have to be investigated. The combination of DBM with CB, which can be used off the shelf, may represent an alternative to allograft. A cost–benefit analysis is necessary before application in clinical trial. Copyright © 2013 John Wiley & Sons, Ltd.