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Breast conserving surgery for invasive breast cancer: Risk factors for ipsilateral breast tumor recurrences 总被引:6,自引:0,他引:6
K. Dalberg A. Mattsson L.E. Rutqvist U. Johansson L. Riddez K. Sandelin 《Breast cancer research and treatment》1997,43(1):73-86
To identify risk factors associated with an increasedrisk for ipsilateral breast tumor recurrence following breast-conservingsurgery, a cohort of 759 women with T1–T2tumors were studied. The majority of the patients(88%) had received postoperative radiation therapy to thebreast. Median follow-up time was 10 (range: 6–17)years. There was a 1–1.5% yearly increase inipsilateral breast tumor recurrences. For women < 50ys the cumulative recurrence rate at 10 yearswas 18% and for women 50 ys,9%. Node positive women had a cumulative breastrecurrence rate of 25% versus 10% for nodenegative women. Ten years postoperatively, irradiated patients hada cumulative recurrence rate of 11% versus 26%when no irradiation was given. The beneficial effectof radiotherapy was substantial during the first fourpostoperative years. The relative risk for an ipsilateralbreast tumor recurrence during this period was 4.5times higher than for non irradiated patients. However,the protective effect of radiotherapy decreased with time.After ten years the relative risk of ipsilateralbreast tumor recurrence was the same among irradiatedand non-irradiated patients although the number of eventsduring this period was low.Univariate analysis showed that seven factors were significantlyassociated with an increased risk of ipsilateral breasttumor recurrence, namely age < 50 ys, increasingtumor size, uncertain microscopic margins, axillary lymph nodemetastases, no postoperative tamoxifen treatment, premenopausal status, andno postoperative radiotherapy. Three factors remained independently significantafter multivariate analysis: age < 50 ys,no postoperative radiation therapy, and positive lymph nodes.In conclusion, radiotherapy reduced the breast recurrence rate,but the effect decreased with time. Node-negative women 50 were a low risk-group for ipsilateralbreast tumor recurrence, with a cumulative risk at10 years of 9% without radiation therapy and5% with breast irradiation. 相似文献
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《Expert review of anticancer therapy》2013,13(8):1229-1238
In the modern era of breast-conserving therapy for early-stage breast cancer, ipsilateral breast tumor recurrence (IBTR) represents an increasingly common clinical dilemma. Two kinds of IBTRs have been described: true recurrences, which represent regrowth of uneradicated initial disease, and new primaries, which may be distinct from the index lesion in histology and location. Whether these two entities have different biologies and survival prognoses remains unclear. This article will examine contemporary clinical and pathologic methods to distinguish true recurrence from new primary tumors, focusing on available published data from prospective and retrospective studies. Current challenges and future avenues are discussed for developing a standardized, reproducible classification system for different types of IBTR that may be used in the clinical setting to prognosticate and individualize treatment for patients following in-breast recurrences. 相似文献
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Kristina Dalberg Anders Mattsson Kerstin Sandelin Lars E. Rutqvist 《Breast cancer research and treatment》1998,49(1):69-78
Introduction: The aims of the study were to assess the outcome among patients with early breast cancer operated on with wide local excision who developed a subsequent ipsilateral breast tumor recurrence, and to identify risk factors for uncontrolled local disease. Uncontrolled local disease (ULD) was defined as the appearance of clinically manifest invasive adenocarcinoma in the remaining breast or on the ipsilateral chest wall which could not be eradicated with salvage treatment during the period of follow-up (2–18 years). Patients and methods: Eighty-five patients in a cohort of 759 patients, treated for invasive Stage I–II breast cancer with breast-conserving surgery 1976–1985 in Stockholm, with a subsequent ipsilateral breast tumor recurrence (IBTR) were reviewed retrospectively. The majority of the patients were premenopausal (58%), node negative (72%), and had received postoperative radiotherapy (79%). Median follow-up time following breast-conserving surgery was 13 (9–19) years. Multivariate Cox's hazard regression was used in the statistical analysis to identify prognostic factors for ULD. Results: The majority (n = 61) of the IBTR's were located in the original tumor quadrant and showed the same histopathological features as the primary tumor. Salvage mastectomy (n = 65) or reexcision (n = 14) were performed in 79 (93%) of the patients. Twenty-one patients developed ULD. Five years following the diagnosis of IBTR the disease-free survival was 59%, the cumulative incidence for ULD was 24%, and for death in breast cancer 34%. In the cohort of 759 patients, patients who received radiotherapy following the primary breast-conserving surgery had 1% cumulative incidence of ULD following the diagnosis of IBTR compared to 4% among patients that received no postoperative radiotherapy. The cumulative incidence at 5 years of ULD following salvage mastectomy was 12% compared to 33% after salvage reexcision. Patients operated on with breast-conserving surgery with an original tumor size < 15 mm, who were treated with salvage mastectomy for IBTR, had in multivariate analysis the lowest relative risk for ULD. Adjuvant chemotherapy following IBTR treatment did not seem to improve local tumor control. Following the diagnosis of IBTR, 78% (n = 21) of the patients with ULD and/or regional recurrence (n = 27), died of a disseminated breast cancer in contrast to 10% (n = 6) among the remaining 58 patients. Conclusion: Uncontrolled local disease is an important outcome measure following breast-conserving surgery. In this cohort, salvage mastectomy provided a superior local control rate compared to salvage reexcision. A higher although not statistically significant rate of ULD was also seen in patients who had not received postoperative radiotherapy as part of their primary treatment.This revised version was published online in October 2005 with corrections to the Cover Date. 相似文献
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Panet-Raymond V Truong PT Alexander C Lesperance M McDonald RE Watson PH 《Cancer》2011,117(10):2035-2043
BACKGROUND:
The role of clinicopathologic characteristics of the recurrent tumor in determining survival in a cohort of patients with ipsilateral breast tumor recurrence (IBTR) was investigated.METHODS:
Among 6020 women with pT1‐T2, pN0‐1, M0 treated with breast‐conserving surgery from 1989 to 1999, 269 developed isolated IBTR. Ten‐year Kaplan‐Meier breast cancer‐specific survival (BCSS) and overall survival (OS), calculated from date of IBTR, were analyzed according to clinicopathologic characteristics.RESULTS:
Factors that were associated with diminished OS and BCSS on univariate analysis were: time to IBTR ≤48 months, lymphovascular invasion positive status, estrogen receptor (ER) negative status, high grade, clinical IBTR detection, biopsy alone, and close/positive margins (all P < .05). On multivariate analysis, time to IBTR ≤48 months (hazard ratio [HR], 1.87, P = .012), lymphovascular invasion positive status (HR, 2.46; P < .001), ER negative status (HR, 2.08; P = .013), high‐grade recurrent disease (HR, 1.88; P = .013), and close/positive margins after surgery for IBTR (HR, 1.94; P = .013) retained significance for prediction of diminished OS. When stratified according to number of adverse prognostic features, 10‐year OS was 70.4% in patients with 1 factor, 35.8% with 2 factors, and 19.9% with 3 or more factors (P < .001).CONCLUSIONS:
Time to recurrence ≤48 months, lymphovascular invasion positive status, ER negative status, high‐grade histology, and close/positive margins in association with the recurrent tumor are independent prognostic factors for survival after IBTR. The presence of 2 or more of these features at recurrence is significantly associated with poor OS. These criteria can be used to prognosticate and guide clinical decisions after recurrence. Cancer 2011. © 2010 American Cancer Society. 相似文献6.
目的分析两种放疗方案治疗早期乳腺癌保乳手术后患者的近期应用效果及安全性。方法将110例行保乳手术的早期乳腺癌患者依据保乳术后采用的放疗方法不同分为观察组(采用大分割放疗,n=55)与对照组(采用常规分割放疗,n=55),治疗后随访2年,比较两组生存情况、危及器官所受剂量、急慢性不良反应发生率、美容效果、治疗次数与治疗费用。结果两组患者近期生存率均达100%。观察组患者危及器官肺、心脏、脊髓、肝脏所受放疗剂量均明显低于对照组(P<0.01)。两组患者急慢性不良反应以Ⅰ级及Ⅱ级为主,且两组急慢性不良反应发生率比较,差异均无统计学意义(P>0.05)。两组患者美容效果比较,差异无统计学意义(P>0.05)。观察组患者治疗次数、治疗费用均少于对照组(P<0.01)。结论与常规分割放疗方案相比,大分割放疗有助于提高早期乳腺癌保乳术后患者疗效,有更好的社会经济学效益,且能减少危及器官受量,安全性可靠,美容效果相当。 相似文献
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Bhattacharyya M Ryan D Carpenter R Vinnicombe S Gallagher CJ 《British journal of cancer》2008,98(2):289-293
Contrast-enhanced magnetic resonance imaging (MRI) was used to monitor the response of patients undergoing neoadjuvant chemotherapy for breast cancer with the aim of undergoing breast-conserving surgery (BCS). Patients were prospectively recruited to undergo MRI as well as conventional methods of clinical examination, mammography (MM) and ultrasonography (USS) and response was assessed by each of these methods. Thirty-two patients with primary breast cancer were recruited. Magnetic resonance imaging correlation with histopathological size (r=0.71) was superior to USS (r=0.65) and to MM where tumour size was not measurable following chemotherapy in 71% of patients. Magnetic resonance imaging had 87.5% sensitivity (95% CI=68-97%) and 50% specificity (95% CI=16-84%) for a PPV (positive predictive value) of 99.8% and NPV (negative predictive value) of 80% for the detection of residual invasive cancer. Magnetic resonance imaging displayed 80% sensitivity (95% CI=28.4-99.5%) and 89% specificity (95% CI=71-98%) to detect pathological pCR in the breast. Eighty-four per cent of recruited patients were identified as potentially suitable candidates for BCS following chemotherapy and of those choosing to accept BCS, breast conservation was achieved in 90.5%, or 65.6% of all patients. Of those who proceeded to BCS, 9.5% required a re-do mastectomy because of positive margins; however, no residual tumour was found on histological examination of mastectomy specimens. Magnetic resonance imaging appears to be superior to conventional methods for assessing pathological response and the low rate of re-operation for positive margins indicates a valuable role in aiding the decision to undergo BCS or mastectomy. 相似文献
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Ishitobi M Ohsumi S Inaji H Ohno S Shigematsu H Akiyama F Iwase T Akashi-Tanaka S Sato N Takahashi K Oura S 《Cancer》2012,118(18):4385-4393
BACKGROUND:
There is limited information about the risk factors for ipsilateral breast tumor recurrence (IBTR) after patients undergo breast‐conserving surgery plus radiotherapy (breast‐conserving treatment [BCT]) subsequent to neoadjuvant chemotherapy (NAC). The objective of the current study was to analyze these risk factors.METHODS:
The authors collected data from 375 patients who underwent BCT and received NAC and analyzed the risk of IBTR associated with undergoing BCT after NAC. The usefulness of the MD Anderson Prognostic Index (MDAPI) for IBTR also was validated using the current data set.RESULTS:
The median follow‐up was 47.8 months, and the 4‐year IBTR‐free survival rate was 95.6%. Multivariate analysis demonstrated that estrogen receptor (ER) status and multifocality of the residual tumor were associated significantly with IBTR‐free survival. In addition, patients who had ER‐positive and human epidermal growth factor 2 (HER2)‐negative tumors did not develop IBTR during the observation period. Although prognostic stratification according to MDAPI was relatively good for the prediction of IBTR in the study patients, the IBTR rate in the high‐risk group was not very high and was lower than that in the intermediate‐risk group. Multivariate analyses demonstrated that IBTR was an independent predictive factor for overall survival.CONCLUSIONS:
ER status and multifocality of the residual tumor after NAC were independent predictors of IBTR after BCT. The MDAPI was barely adaptable to the study patients in terms of predicting IBTR. Patients with ER‐positive and HER2‐negative tumors had a favorable prognosis, whereas patients who developed IBTR after NAC had significantly worse overall survival. The authors propose a new IBTR prognostic index using the 2 factors that were identified as predictive of IBTR: ER status and multifocality of the residual tumor. Cancer 2012. © 2012 American Cancer Society. 相似文献9.
目的:探讨整形保乳术在早期乳腺癌治疗中的安全性及有效性。方法:回顾性分析2011年1 月至2013年12月广西医科大学附属肿瘤医院行整形保乳术组(67例)与常规保乳术组(117 例)的乳腺癌患者临床病理资料,比较两组的术后并发症、美容效果满意度、切除组织重量、手术切缘及二次扩切手术率。结果:整形保乳术组发生血清肿10例、血肿3 例、切口愈合不良2 例,常规保乳术组发生血清肿57例、血肿17例、切口愈合不良14例,两组比较差异具有统计学意义(均P < 0.05)。 整形保乳术组美容效果满意度优于常规保乳术组,差异具有统计学意义(均P < 0.05)。 整形保乳术组的切除组织重量、最小手术切缘及最大手术切缘均优于常规保乳术组,差异具有统计学意义(均P < 0.05)。 两组患者二次扩切手术率差异无统计学意义(P > 0.05)。 结论:整形保乳术不仅能有效保证保乳手术切缘,降低手术并发症发生率,而且能获得更好的美容效果满意度,是一种安全有效的保乳手术方式。 相似文献
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目的:探讨肿瘤整形技术应用于早期乳腺癌保乳术的近期疗效和美容效果。方法回顾性分析25例应用周围腺体组织瓣转位修复法或背阔肌肌皮瓣转位修复法行保乳术(观察组)和25例行传统保乳手术(对照组)患者的临床资料,比较两组患者的手术切除范围、切缘情况、RTOG美容等级评价、术后并发症及复发转移情况。结果观察组中21例行周围腺体组织瓣转位修复,4例行背阔肌皮瓣转位修复,切除乳腺体积为26~1105 cm3,中位体积343 cm3;对照组切除乳腺体积为15~504 cm3,中位体积262 cm3。术中冰冻病理示切缘阳性者观察组有3例,对照组5例,差异无统计学意义(χ2=0.504,P=0.478)。观察组和对照组美容等级评定为优或良的分别为22例(88%)和20例(80%),两组差异无统计学意义(χ2=0.611,P=0.737)。随访持续时间为2~12个月,中位随访时间为5个月,观察组中1例患者术后2个月出现多发骨转移,所有患者均未出现局部复发,无死亡病例。结论应用整形外科技术行保乳手术治疗早期乳腺癌在达到切缘无瘤累及的基础上,可获得更好的美容效果,且短期临床效果满意,值得进一步临床推广。 相似文献
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Nishimura S Takahashi K Akiyama F Oguchi M Tada K Makita M Iwase T Yoshimoto M Yamashita T Sakamoto G Kasumi F 《Breast cancer (Tokyo, Japan)》2005,12(2):112-117
PURPOSE: To classify and assess ipsilateral breast tumor recurrences (IBTR) after breast-conserving therapy. METHODS: Between 1986 and 2001, 2,137 patients who had breast cancer underwent breast-conserving surgery with or without radiotherapy at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research. Of these patients, 83 (3.9%) had an IBTR. We classified the IBTR as a new primary cancer (NP) if the primary tumor had completely negative margins at first operation by detailed pathological examination and if the IBTR had an intraductal component. All other IBTRs were judged true local recurrence (TR). RESULTS: Of the 83 patients, 42 patients were classified as TR (29 had no radiotherapy) and 41 as NP (40 had no radiotherapy). Mean time to disease recurrence was 37 months for TR (52% were within 2 years) versus 55 months for NP (19% were within 2 years) (p=0.031). Six patients (14%) with TR did not receive re-operation, and 67% received salvage mastectomy and 19% re-lumpectomy. All cases of NP were operable, 78% underwent salvage mastectomy and 22% underwent re-lumpectomy. Distant metastases were observed in 33% of patients with TR and 5% of patients with NP, and cause-specific death occurred in 6 cases with TR and in one with NP. The patients with NP had improved 5-year rates of overall survival (NP 91% vs. TR 76%, P=0.0627) and distant disease-free survival (NP 93% vs. TR 61%, P=0.0028). Patients with NP more often developed contralateral breast cancer (NP 37% vs. TR 12%, P=0.018) CONCLUSIONS: Patients with NP had better survival rates than those with TR. Distinguishing new primary breast carcinomas from local disease recurrences may have importance in therapeutic decisions and chemoprevention strategies. 相似文献
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《European journal of surgical oncology》2019,45(8):1317-1327
The standard of care for patients with an ipsilateral breast tumour recurrence (IBTR) after breast-conserving therapy (BCT) is a salvage mastectomy. However, there is growing interest in the feasibility of repeat BCT for these patients. This systematic review contains the latest insights on BCT options for patients with an IBTR after initial BCT.A PubMed literature search was performed for articles on BCT options for IBTR after primary lumpectomy followed by radiotherapy. Weighted estimates were calculated for 5- and 10-year local control, distant metastasis-free and overall survival rates. Secondary outcomes were toxicity, cosmesis and quality of life.In total, 34 studies were eligible for analysis, of which 5 reported on repeat breast-conserving surgery (BCS) alone, 10 with mixed populations (BCS ± RT and/or mastectomy), 18 on repeat BCS followed by re-irradiation (whole-breast or partial) and one on quality of life. The weighted estimates for 5-year overall survival for repeat BCS and repeat BCS followed by reirradiation were 77% and 87%, respectively. Five-year local control was 76% for repeat BCS alone and 89% for repeat BCS followed by re-irradiation. Grade III-IV toxicity rates after re-irradiation varied from 0 to 21%, whereas the cosmesis was excellent-good in 29–100% of patients and unacceptable in 0–18%.Repeat BCS followed by re-irradiation, with either whole breast or partial breast re-irradiation, seems a feasible alternative to mastectomy in case of IBTR, in selected patients. Toxicity rates are low and the cosmetic outcome is good, but the size and follow-up of the published patient series is limited. 相似文献
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Purpose
While results of intraoperative radiotherapy (IORT) during breast-conserving surgery (BCS) have been reported when used either as a boost at the time of surgery or as the sole radiation treatment, the clinical safety and cosmetic outcome of IORT in the Chinese Han population has not. This report reviews oncologic and cosmetic outcomes for Chinese Han breast cancer patients who received IORT either as a boost or as their sole radiation treatment at our hospital.Method
From July 2008 to December 2012, 50 early-stage Chinese Han breast cancer patients received BCS and IORT, either as boost or as their sole radiation treatment. Patients received adjuvant chemotherapy or hormonal therapy, according to our institution''s guidelines. Patients were followed to determine oncologic events, short-term toxicity and overall cosmesis.Results
With a median follow-up of 51.8 months (range 22.6 months to 75.7 months), 2 patients (4.0%) developed local relapses and were salvaged by mastectomy. There were no metastases and no deaths. The average wound healing time was 17 days. Three patients (6.0%) developed postoperative infection, 5 patients (10.0%) had delayed wound healing, and 2 patients (4.0%) experienced wound edema. There were no lyponecrosis or hematomas observed. The evaluation of cosmetic outcome showed 44 patients (88.0%) graded as excellent or good while 6 patients (12.0%) were graded as fair or poor. No patients experienced radiotherapy related acute hematological toxicity, but 3 patients (6.0%), all IORT boost patients, developed skin pigmentation.Conclusion
For early-stage breast cancer patients, intraoperative radiotherapy after breast-conserving surgery in the Chinese Han population is both safe and reliable and has resulted in very acceptable cosmetic outcomes. 相似文献15.
Predictive factors for local recurrence in 2006 patients with surgically resected small breast cancer. 总被引:4,自引:0,他引:4
R Arriagada M G Lê G Contesso J M Guinebretière F Rochard M Spielmann 《Annals of oncology》2002,13(9):1404-1413
BACKGROUND: Analyses of predictive factors for local recurrences are important, as an increasing number of patients with early breast cancer opt for a breast-conserving procedure. This study investigates whether factors predictive of local recurrence differ between patients treated with conservative or radical surgery. PATIENTS AND METHODS: Two thousands and six patients with invasive breast carcinoma (< or =25 mm) were included. Of these patients, 717 were treated conservatively (lumpectomy and breast irradiation) and 1289 were treated with total mastectomy. All patients had axillary dissection and received lymph node irradiation if axillary nodes were positive. Most patients did not receive adjuvant chemotherapy or additive hormonal treatments. The mean duration of follow-up was 20 years. The main end point was the total local recurrence rate. The risk factors of local recurrence were estimated by multivariate analyses and interaction tests were used for intergroup comparisons. RESULTS: Statistically significant predictive factors for mastectomized patients were histological grade, extensive axillary node involvement (10 nodes or more), and inner quadrant tumors, which were of borderline significance. Young age, however, was not a prognostic indicator for local recurrence. The main statistically significant factor for patients treated with a conservative approach was young age (< or =40 years). These younger patients had a five-fold increased risk of developing a breast recurrence compared with patients older than 60 years. CONCLUSIONS: Younger patients with early breast cancer treated with breast-conserving surgery should in particular be followed up at regular intervals so that any sign of local failure can be diagnosed early. 相似文献
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《Expert review of anticancer therapy》2013,13(4):737-745
From 20-year follow-up results of two pioneering randomized controlled trials demonstrating equal survival after mastectomy and breast-conservation therapy, recent high-quality, evidence-based clinical practice recommendations have been made. Breast-conservation therapy undoubtedly represents substantial progress for a better quality of life for women with early-stage breast cancer. However, lumpectomy is associated with a substantial proportion, approximately 10–20%, of local recurrence in long-term follow-up studies even after accounting for postoperative radiotherapy. Risk factors for local failure include margin status, young age and an extensive intraductal component. Young age and family history strongly suggest the need for genetic testing before initiation of treatment. Women with BRCA1 or BRCA2 mutations should be informed about the increased risk of contralateral breast cancer and ipsilateral failure after breast-conservation therapy. Bilateral mastectomy should also be offered as a treatment option. There is controversy over whether current effective adjuvant treatment, including chemotherapy and endocrine therapy, beyond appropriate local treatment as surgery and radiotherapy, can improve local control. Instead of debate over whether an ipsilateral tumor after breast-conservation therapy is local recurrence or a new primary cancer by analyzing conflicting data lacking strong evidence, efforts should be focused on reducing this risk irrespective of origin. Selecting women for breast-conservation therapy and achieving margin control can reduce ipsilateral failures. 相似文献
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目的:评价近乳晕区早期乳腺癌患者行整形保乳术的临床效果。方法:将2011年2 月至2013年11月唐山市人民医院乳腺外科(二)接受保乳手术治疗的60例近乳晕区早期乳腺癌患者随机分成两组,试验组30例行整形保乳术,对照组30例行标准保乳术,比较两组术中切除的乳腺局部标本质量,肿瘤距外科切缘最近的距离,术后患乳美容效果。结果:试验组与对照组患者术中切除的乳腺标本量为(71.03± 12.92)g vs .(41.53± 7.13)g,肿瘤距外科切缘最近的距离为(13.30± 2.97)mmvs .(10.63± 1.65)mm,比较两组差异具有统计学意义(P<0.05);试验组与对照组术后患者满意率为93.33% vs . 83.33% ,差异无统计学意义(P>0.05)。 结论:试验组切除的乳腺组织量更大、范围更广,而术后患乳美容效果与对照组无差别。早期乳腺癌患者实施整形保乳术可行、有效。 相似文献
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目的 探讨常规放疗与大分割放疗对行保乳手术早期乳腺癌患者的疗效及安全性.方法 保乳手术早期乳腺癌患者共120例,以随机区组法分为常规放疗组(60例)和大分割放疗组(60例),术后分别行常规放疗(总放射剂量50 Gy/25 f,瘤床加量10 Gy/5 f)与大分割放疗(总放射剂量42.4 Gy/16 f,瘤床加量10 Gy/4 f)治疗.比较两组患者生存率、复发转移率、美容效果优良率及不良反应发生率等.结果 两组患者1、2、3年生存率比较差异均无统计学意义(98.3% vs 100.0%,93.3%vs96.7%,88.3%vs90.0%,均P>0.05),3年局部复发率和远处转移率比较差异均无统计学意义(5.0% vs 1.7%,10.0% vs 6.7%,均P>0.05),美容效果优良率比较差异无统计学意义(88.3% vs 90.0%,P>0.05),不良反应发生率比较差异无统计学意义(P>0.05).结论 常规放疗与大分割放疗用于行保乳手术早期乳腺癌患者具有相似临床疗效及安全性,而大分割放疗方案具有放疗次数少、疗程短及经济性好等优势. 相似文献
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目的:探讨整形保乳术在早期乳腺癌治疗中的有效性及美容效果。方法:回顾性分析2015年5月至2016年5月我院行整形保乳术组(22例)与常规保乳术组(30例)的乳腺癌患者临床病理资料,比较两组的肿瘤特点、组织切除量、术后并发症、切缘情况及术后RTOG美容效果评价。结果:两组患者肿瘤分布位置的差异有统计学意义(P<0.05),应用整形保乳术的原发肿瘤更多见于中央区、内上象限和内下象限。整形保乳术组和常规保乳术组切除组织重量分别为(106.23±17.47) g和(62.47±8.36) g,最近手术切缘分别为(10.32±1.89) mm和(7.70±1.93) mm,最远手术切缘分别为(22.09±4.41) mm和(15.17±2.67) mm,整形保乳术组明显优于常规保乳术组,差异有统计学意义(均P<0.05)。整形保乳术组美容效果评价为优和良的为20例(90.9%),常规保乳术组美容效果评价为优和良的为24例(80.0%),两组差异无统计学意义(P=0.269)。结论:整形保乳术可切除更多的组织量以有效保证手术切缘,而术后美容效果较常规保乳术无明显差别,是一种安全有效的保乳手术方式。 相似文献