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1.

Objectives

We aimed to compare the recall rate (RR) and the cancer detection rate (CDR) of combined full field digital mammography and digital breast tomosynthesis (FFDM?+?DBT) to those of full field digital mammography (FFDM) alone in breast cancer survivors.

Methods

We enrolled 146 female breast cancer survivors schedule. All patients underwent FFDM and DBT in the same setting. Results of FFDM alone were compared to those of FFDM?+?DBT regarding patients' RR and CDR.Sensitivity, specificity, accuracy, positive and negative predictive values were also calculated for FFDM alone and for FFDM?+?DBT in detecting breast cancer lesions.

Results

Our results showed that FFDM?+?DBT decreased patients' RR by 3.4% and increased the CDR by 4.1%. Reduction in RR was evident in higher breast densities. FFDM mammography had 18 false negative lesions and 29 false positives. Sensitivity, specificity, accuracy, NPV and PPV in detecting breast lesions were: 84.2%, 53.1%, 64.0%, 86.7% and 48.9% for FFDM compared to 100%, 92.1%, 95.3%, 100% and 89.7% for FFDM?+?DBT.

Conclusion

Combined FFDM?+?DBT in the post breast cancer surveillance regimen has shown to reduce the patients' RR and to increase the CDR. FFDM?+?DBT had higher diagnostic accuracy than FFDM alone. FFDM?+?DBT ought to be a standard combination in the breast cancer surveillance in treated patients.  相似文献   

2.
3.

Purpose

To evaluate the value of dual energy contrast enhanced (DECE) soft tissue digital mammography and ultrasound elastography (UE) in the detection of breast lesions and discrimination between benign and malignant ones.

Patients and methods

32 female patients with breast lesions were prospectively evaluated at the female imaging unit of Diagnostic and Interventional Radiology Department of the National Cancer Institute, Cairo University. Routine sono-mammography was done for each patient then these patients were submitted to DECE soft tissue digital mammography as well as UE.The DECE digital mammography scans were held via GE Senographe 2000D “GE Healthcare; Chalfont St-Giles, UK” FFDM system with some specific software and hardware adaptations.The UE exams were held on ultrasound scanner with elastography unit and 7.5?Mhz linear array electronic probe (Hitachi digital, EUB- 7500; Hitachi medical, Tokyo, Japan).

Results

This study showed that sensitivity and specificity of DECE soft tissue digital mammography and UE were 86.3%, 60% and 80.9%, 40% respectively.

Conclusion

DECE soft tissue digital mammography demonstrated significant increase in the sensitivity without a loss in specificity. DECE soft tissue digital mammography is fast-reproducible imaging tool without operator dependency. DECE soft tissue digital mammography and UE are valuable tools to evaluate equivocal lesions.  相似文献   

4.

Objective

To assess the efficiency of dual energy contrast enhanced mammography in the assessment of the indeterminate breast lesions (BIRADS 3 and BIRADS 4).

Materials and methods

34 female having 39 indeterminate breast lesions (BIRADS 3 and BIRADS 4) by digital mammography were further examined by dual energy contrast enhanced mammography. Two images were acquired at low and high energy in MLO view after 2 min and in CC view at 4 min post iodinated contrast injection (1.5 ml/kg with flow of 4 ml/s). Images were processed to obtain subtracted images to enhance the areas of the contrast uptake.

Results

Results from pathology were detected for all cases. Contrast enhanced digital mammography showed specificity, sensitivity, PPV, NPV, FDR, FPR and accuracy of 93.75%, 91.3%, 88.2%, 95.4%, 11.7%, 8.6% and 92.3% respectively compared to full field digital mammography which were 68.75%, 69.5%, 61.1%, 76.1%, 38.8%, 30% and 69.2% respectively.

Conclusion

Contrast-enhanced digital mammography is a useful tool to be used for breast cancer detection especially in indeterminate lesions (BIRADS 3 and 4).  相似文献   

5.

Aim

Assess accuracy of contrast enhanced spectral mammography (CESM) versus conventional mammography and ultrasound in evaluation of BI-RADS 3 and 4 breast lesions with pathological correlation.

Patients and methods

Thirty female patients with 35 breast lesions diagnosed by conventional imaging as BI-RADS 3 and 4, presented to Women’s Imaging Unit of Radiology Department between January and December 2015, age ranged from 23 to 70 years. All patients underwent conventional mammography and ultrasound then CESM.

Results

Patients divided into two groups, benign and malignant lesions group according to histological analysis. Mammography results that malignant lesions detected in 18/35 (51.4%) while benign lesions 17/35 (48.6%). Ultrasound revealed 27/35 (77.1%) lesions were malignant and 8/35 (22.9%) lesions benign. But CESM, revealed 25/35 (71.4%) lesions were malignant & 10/35 (28.6%) lesions benign. Among 7 patients with multifocal/ multi-centric histologically proven malignant lesions, all detected by CESM 7/7 cases (100%) versus 2/7 cases (28.6%) and 6/7 cases (85.7%) detected by mammography and ultrasound respectively. Based on, CESM had 95.2% sensitivity and 82.9% diagnostic accuracy.

Conclusion

CESM has better diagnostic accuracy than mammography alone and mammography plus ultrasound. CESM has 82.9% diagnostic accuracy in comparison to 51.4% for mammography and 77.1% for ultrasound.  相似文献   

6.

Objective

To evaluate the additive value of Contrast Enhanced Spectral Mammography (CESM) in the preoperative assessment of malignant lesions in dense breast parenchyma regarding multiplicity.

Material and methods

The study included 160 women having heterogeneous dense breast parenchyma (ACR c and d) with suspicious lesions identified on sono mammography examination. All patients performed contrast enhanced spectral mammography to confirm or exclude lesion multiplicity. The number of lesions was calculated in the contrast high energy subtraction images with the reference standard being histopathological analysis.

Results

Adding CESM to sono-mammography the accuracy in identifying multiple malignant lesion increased from 81.8% accuracy of sono-mammography up to 100% accuracy after adding CESM.

Conclusion

Contrast enhanced spectral mammogram showed an added value in the preoperative assessment of breast masses increasing the accuracy of detection of lesions and multiplicity (multifocality and multi-centricity).  相似文献   

7.
The aim of this prospective study was to evaluate the diagnostic performance of the use of strain index ratio by sonoelastography to differentiate between benign and malignant breast lesions.

Patients & Methods

This prospective study including 40 females, complaining of breast masses which were suspicious to be malignant on clinical examination. All patients were submitted to B-mode Ultrasound and sonoelastography. Biopsy as a gold standard and pathological study were done for all breast lesions.

Results

US examination of every mass was done and categorized according to BI-RADS categories according to ACR2013, according to US lexicon. Sonoelastography examination with Lesions classification was performed on the basis of a 5-point scoring method proposed by Tsukuba elasticity score. Then measurements of strain ratio were done. Statistical analysis of combination of the three methods was sensitivity of 96.7%, specificity of 100% when we use cut off value of 3–4 in elastography score and ≤3 cut off value of strain ratio.

Conclusion

The combined use of strain ratio with Tsukuba score and BI-RADS categorization increased the diagnostic performance in differentiation between benign and malignant breast lesions.  相似文献   

8.

Objective

Assess the efficacy of using different imaging modalities aiming at proper characterization of benign and malignant inflammatory breast disorders.

Methods

A prospective study included 34 patients presenting with clinical signs of mastitis. The patients underwent imaging according to clinical status (mammography, ultrasound and Magnetic resonance imaging) and the signs encountered in each modality were tested for their efficiency to discriminate benign from malignant inflammatory breast disorders.

Results

Benign mastitis was finally diagnosed in 23 cases (67.4%) while 11 patients as malignant including inflammatory breast carcinoma.Mammogram was done in 22/34 cases (64.7%). The final diagnostic indices of mammography showed sensitivity 33.3%, specificity 61.54%, PPV 37.5%, NPV 57.14% and efficacy 50%.Ultrasound was done for all cases (34/34, 100%) with sensitivity 58.33%, specificity 72.73%, PPV 53.85%, NPV 76.19% and efficacy 67.6%.MRI was done for all cases (34/34, 100%) with sensitivity 91.67%, specificity 100%, PPV 100%, NPV of 95.65% and efficacy 97.1%.

Conclusion

Diagnostic approach to inflammatory disorders includes multi-imaging modalities. Each modality plays a specific role in diagnosis with the highest specificity encountered on MRI evaluation followed by ultrasound and limited specificity on mammographic evaluation. It is essential to discriminate benign from malignant etiologies as there are major differences in their prognosis, and treatment options.  相似文献   

9.

Objectives

To compare the diagnostic performance of digital breast tomosynthesis (DBT) and magnetic resonance imaging (MRI) added to mammography in women with known breast cancers.

Methods

Three radiologists independently reviewed image sets of 172 patients with 184 cancers; mammography alone, DBT plus mammography and MRI plus mammography, and scored for cancer probability using the Breast Imaging Reporting and Data System (BI-RADS). Jack-knife alternative free-response receiver-operating characteristic (JAFROC), which allows diagnostic performance estimation using single lesion as a statistical unit in a cancer-only population, was used. Sensitivity and positive predictive value (PPV) were compared using the McNemar and Fisher-exact tests.

Results

The JAFROC figures of merit (FOMs) was lower in DBT plus mammography (0.937) than MRI plus mammography (0.978, P?=?0.0006) but higher than mammography alone (0.900, P?=?0 .0013). The sensitivity was lower in DBT plus mammography (88.2 %) than MRI plus mammography (97.8 %) but higher than mammography alone (78.3 %, both P?<?0 .0001). The PPV was significantly higher in DBT plus mammography (93.3 %) than MRI plus mammography (89.6 %, P?=?0 .0282).

Conclusions

DBT provided lower diagnostic performance than MRI as an adjunctive imaging to mammography. However, DBT had higher diagnostic performance than mammography and higher PPV than MRI.

Key Points

? Digital breast tomosynthesis (DBT) plus mammography was compared with MRI plus mammography. ? DBT had lower sensitivity and higher PPV than MRI. ? DBT had higher diagnostic performance than mammography.
  相似文献   

10.

Purpose

To assess the additional diagnostic value of share wave elastography in combination with B-mode ultrasound versus B-mode ultrasound alone in characterization of solid breast lesions.

Patients and methods

prospective study included women with a single undiagnosed solid breast lesion, between May 2016 and May 2017. All patients underwent B-mode ultrasound and (SWE), and histopathology was performed on all lesions.

Results

150 women included in this study. 87 breast lesions were malignant & 63 were benign. B-mode ultrasound was performed and the lesions were categorized according to the (BI-RADS). With a sensitivity of 89.7%, specificity of 76.2%, overall accuracy of 84%. Using SWE alone based on elasticity, speed and color pattern, the cut-off values were ≥46?kPa and ≥3.25?m/s. These values demonstrated a sensitivity of 96.6%, specificity of 90.47%, and overall accuracy of 94%. The color pattern had a better sensitivity of 96.8%, specificity of 92%, and overall accuracy of 94.5%.The combination of SWE and B-mode ultrasound results using logistic regression modeling improved diagnostic performance, with an overall accuracy of 96%.

Conclusion

Combined B-mode ultrasound with shear-wave elastography will improve the overall diagnostic performance for the differentiation of benign and malignant breast lesions.  相似文献   

11.

Objectives

To compare interobserver variability (IOV), reader confidence, and sensitivity/specificity in detecting architectural distortion (AD) on digital mammography (DM) versus digital breast tomosynthesis (DBT).

Methods

This IRB-approved, HIPAA-compliant reader study used a counterbalanced experimental design. We searched radiology reports for AD on screening mammograms from 5 March 2012–27 November 2013. Cases were consensus-reviewed. Controls were selected from demographically matched non-AD examinations. Two radiologists and two fellows blinded to outcomes independently reviewed images from two patient groups in two sessions. Readers recorded presence/absence of AD and confidence level. Agreement and differences in confidence and sensitivity/specificity between DBT versus DM and attendings versus fellows were examined using weighted Kappa and generalised mixed modeling, respectively.

Results

There were 59 AD patients and 59 controls for 1,888 observations (59?×?2 (cases and controls)?×?2 breasts?×?2 imaging techniques?×?4 readers). For all readers, agreement improved with DBT versus DM (0.61 vs. 0.37). Confidence was higher with DBT, p?=?.001. DBT achieved higher sensitivity (.59 vs. .32), p?<?.001; specificity remained high (>.90). DBT achieved higher positive likelihood ratio values, smaller negative likelihood ratio values, and larger ROC values.

Conclusions

DBT decreases IOV, increases confidence, and improves sensitivity while maintaining high specificity in detecting AD.

Key points

? Digital breast tomosynthesis decreases interobserver variability in the detection of architectural distortion.? Digital breast tomosynthesis increases reader confidence in the detection of architectural distortion.? Digital breast tomosynthesis improves sensitivity in the detection of architectural distortion.
  相似文献   

12.

Objectives

Unenhanced MR imaging of the breast have recently been introduced. These include STIR, T2-weighted TSE and DWIBS sequences. These sequences could characterize breast lesions, although not yet able to avoid histological characterization.

Materials and methods

The study included 46 patients referred to our radiology department at Ain shams university Hospital from March 2015 till May 2016. Sonomammography was routinely done to all patients. Only 29 patients out of the 46 were included in our MRI study after exclusion of BIRADS I & II patients on sono mammography. Interpretation was performed using an adapted BI-RADS system for both sono mammography results and MRI results. Statistical analysis was performed to show the efficacy of the added DWIBS technique in comparison to DCE-MRI. The final histopathological examination served as gold standard.

Results

By DCE-MRI out of the 29 examined breast lesions, 15 (51.7%) were classified as malignant and 14 (48.3%) were benign. By non contrast study with the addition of DWIBS, patients were classified into16 (55.2%) malignant and 13 (44.8%) benign. Our histopathology results showed 14 (48.3%) malignant and 15 (51.7%) benign lesions. Thus the DWIBS had a sensitivity of 87.5% and a specificity of 86.7% while DCE-MRI had a higher sensitivity: 93.3% and specificity 93.3%.

Conclusion

DWIBS is a promising MRI technique, with a specificity near to DCE-MRI, and a large potential for improving the clinical efficiency of classical MRM.  相似文献   

13.

Objectives

To compare radiation dose delivered by digital mammography (FFDM) and breast tomosynthesis (DBT) for a single view.

Methods

4,780 FFDM and 4,798 DBT images from 1,208 women enrolled in a screening trial were used to ground dose comparison. Raw images were processed by an automatic software to determine volumetric breast density (VBD) and were used together with exposure data to compute the mean glandular dose (MGD) according to Dance’s model. DBT and FFDM were compared in terms of operation of the automatic exposure control (AEC) and MGD level.

Results

Statistically significant differences were found between FFDM and DBT MGDs for all views (CC: MGDFFDM=1.366 mGy, MGDDBT=1.858 mGy; p<0.0001; MLO: MGDFFDM=1.374 mGy, MGDDBT=1.877 mGy; p<0.0001). Considering the 4,768 paired views, Bland-Altman analysis showed that the average increase of DBT dose compared to FFDM is 38 %, and a range between 0 % and 75 %.

Conclusions

Our findings show a modest increase of radiation dose to the breast by tomosynthesis compared to FFDM. Given the emerging role of DBT, its use in conjunction with synthetic 2D images should not be deterred by concerns regarding radiation burden, and should draw on evidence of potential clinical benefit.

Key Points

? Most studies compared tomosynthesis in combination with mammography vs. mammography alone. ? There is some concern about the dose increase with tomosynthesis. ? Clinical data show a small increase in radiation dose with tomosynthesis. ? Synthetic 2D images from tomosynthesis at zero dose reduce potential harm. ? The small dose increase should not be a barrier to use of tomosynthesis.
  相似文献   

14.

Objective

To evaluate the outcome and the cost value of surgical clips use as guidance for breast cancer localization in patients prepared for neoadjuvant chemotherapy (NAC).

Methods

A prospective study of 43 patients confirmed histopathologically to have breast cancer and prepared to receive pre-operative NAC. Surgical clips were inserted via US guidance. The patients were followed up by mammography and US before surgery to evaluate the treatment response meanwhile, assessment of clips location, migration and complications. The overall cost of clips was also calculated.

Results

Only 32 patients completed the study; the mean time interval was 32?weeks?±?2?weeks between the clip insertion date and the surgery. The number of the inserted clips was 34 surgical clips. Only two cases showed positive migration yet with no evidence of other complications occurred in our study patients. The average cost of the surgical clips was 145?±?20 Egyptian pounds (average 8–9 US$).

Conclusion

Surgical clips can be used safely to replace the usual commercial markers in the localization of breast cancer before NAC. They showed effective results with no complications, don't interfere with the patients' imaging and of the significant low cost compared to the commercial ones.  相似文献   

15.

Introduction

Diffusion-weighted imaging (DWI) is a modality that depicts the diffusivity of water molecules. This technique has the potential to play an adjunct role to conventional and dynamic MRI in the assessment of breast tissue.

Aim of work

To evaluate the role of DWI with absolute and normalized ADC value measurements in characterization of breast lesions.

Patients and methods

Seventy patients with mass or non mass lesions on mammography or breast ultrasound were included in this study. DWI were added to routine MR study with calculation of ADC absolute value and normalized ratio for lesions before biopsy of their breast lesions and results were correlated with histopathology.

Results

Thirty out of 70 detected lesions were malignant. Malignant lesions showed lower ADC values and lower ratio of normalized ADC than benign lesions. The ROC study revealed that a cutoff ADC value of 1.1?×?10?3?mm2/s and normalized ADC ratio of 0.9 had high sensitivity of 89.75%, and 92.2% with specificity of 94.4% and 94.4% respectively in the differentiation between benign and malignant breast lesions.

Conclusion

DWI is a short unenhanced scan that can be potential adjunct to conventional breast MRI and can be used to accurately characterize breast lesions with high sensitivity and specificity Suggested.  相似文献   

16.

Introduction

Elastography is considered a non-invasive imaging modality which determines the tumors according to their stiffness. Strain images representing the stiffness of the lesions compared to that of the surrounding normal tissue.

Purpose

To prospectively evaluate the sensitivity and specificity of the real-time sonoelastography together with B-mode US for distinguishing benign from malignant breast lesions.

Methods

The study was conducted on 80 patients, each patient was subjected to complete history taking, thorough clinical examination. All patients had conventional US and elastography using Hitachi 7.5?MHz linear probe (Hitachi hi vision avirus ultrasound), while only in 68 patients mammography was done.

Results

Among the 80 patients, sensitivity and specificity of the elastography test of breast lesions according to the elastography score were 80% and 80.95% respectively, while sensitivity and specificity of conventional B mode US were 80% and 76% respectively and the combined B mode US and US elastography showed higher sensitivity and specificity of 86.6% and 90.4% respectively.

Conclusion

Elastography is a non-invasive imaging technique which is done in the same session of ultrasound in an attempt to increase and improve the accuracy of diagnostic efficiency of ultrasound.  相似文献   

17.

Objectives

To compare breast density measured on digital breast tomosynthesis (DBT) (BI-RADS-based breast composition and fully-automatic estimation) and magnetic resonance imaging (MRI) (BI-RADS amount of fibroglandular tissue), and to evaluate the diagnostic performance in terms of sensitivity and specificity of DBT and MRI in a predominantly dense breast population.

Methods

Between 2015 and 2016, 152 women with 103 breast malignancies, who underwent 3-T breast MRI and DBT within 2 months’ time, were enrolled in this study. Breast composition/fibroglandular tissue and findings on DBT (two readers) and MRI were reported using BI-RADS 5th edition. Digital mammography images were analysed for breast percent density (PD) using the Libra software tool.

Results

A majority of women had dense breasts as categorised by breast composition c (heterogeneously dense) (68%) and d (extremely dense) (15%). The mean PD was 44% (range, 18-89%) and the correlation between breast composition and PD was r = 0.6. The diagnostic performance of MRI was significantly higher compared to DBT for one reader as described by the area under the receiver operating characteristic (ROC) curve (p = 0.004) and of borderline significance for the other reader (p = 0.052).

Conclusions

MRI had higher diagnostic performance than DBT in a dense breast population in the tertiary setting.

Key Points

? MRI had higher diagnostic performance than DBT in a dense breast population ? Diagnostic performance of DBT was comparable to MRI in women with fatty breasts ? MRI was superior to DBT in preoperative breast cancer size assessment
  相似文献   

18.

Background

Neoadjuvant chemotherapy (NAC) has clinically important outcome. Early evaluation of the treatment response is important to avoid unnecessary therapy in non-responders. MRI is the most sensitive imaging for monitoring NAC response.

Aim of this study

Is to test the ability of DWI to detect early response to NAC.

Results

The study was performed on 20 patients, proved pathologically to have invasive breast cancer. All patients underwent breast MRI before initiation of NAC, after one cycle and after completion of the NAC protocol. Regarding the mass size, results showed no significant change in maximum mass diameters occur after the 1st NAC cycle. Absolute value of the ADC show increase all along the treatment course which has no significant correlation with the pathological response. The relative increase ADC more than 20% calculated from subtraction of the pre-treatment ADCmean value from that after the first NAC, subdividing the result on the pre-treatment ADCmean value and multiply it by 100 reflected significantly on the pathological response (p value of 0.011).

Conclusion

ADC value can predict responder from non-responder as early as after the first cycle of chemotherapy.  相似文献   

19.

Aim of the work

To study the diagnostic performance of combined single voxel 1H-MRS and DW-MRI with ADC values as a non-contrast diagnostic tool, compared to the DCE-MRI, in suspicious breast lesions.

Materials and methods

113 female patients (mean age 45.8?years) with suspicious breast lesions, categorized as BI-RADS 3 or 4 by sono-mammographic examinations, were subjected to bilateral breast imaging with non-contrast MRI including conventional MRI, DW-MRI with quantitative ADC values, and single voxel 1H-MRS, in addition to DCE-MRI. They had 132 pathologically proved lesions (74 benign and 58 malignant).

Results

DW-MRI with ADC values was 96.97% accurate with 94.92% sensitivity and 98.63% specificity, while DCE-MRI was 97.73% accurate with 98.29% sensitivity but with 97.29% specificity, and 1H-MRS was 98.48% accurate with the highest sensitivity (100%) and 97.33% specificity. Furthermore, the combined use of DW-MRI with ADC values and 1H-MRS improved the diagnostic capability than utilization of each sequence alone with the highest accuracy of 99.24%, 100% sensitivity and 98.65% specificity.

Conclusion

The combined use of DW-MRI with quantitative ADC data and single-voxel 1H-MRS is a reliable non-contrast tool that provides higher accuracy in characterizing suspicious breast, and can efficiently be used in the absence of DCE-MRI.  相似文献   

20.

Objectives

Comparing the diagnostic accuracy of different MRI techniques in characterization of breast lesions.

Methods

The study was performed using 1.5T MRI and included 35 females with detected 47 breast lesions. Lesions were analyzed regarding their morphology, kinetic curve pattern, DWI and tCho peak measurement. The results of each MRI parameter were correlated to histo-pathology.

Results

The study included 35 females with 47 breast lesions. Sensitivity and specificity were 87.5% and 93.3% using morphology alone. By using curve pattern, they were 96.9% and 73.3%. DWI was 96.9% sensitive, 66.7% specific, and MRS was 74.2% sensitive and 71.4% specific. The cut-off ADC value was 1.063?×?10?3?mm2/s. Choline cut-off value was (0.36?mmol/l). Sensitivity and specificity were increased to 100% and 93.3% after combining either kinetic curve or DWI with morphology. Sensitivity was increased to 90.3%, after combining MRS with morphology, however this slightly reduced the specificity to 92.9%.

Conclusion

MRI is very sensitive for detection of breast lesions, however it lacks specificity. Post-processing tools and functional MRI have improved the specificity. MRS has increased the sensitivity, however specificity has been slightly decreased.

Advances in knowledge

Functional MRI is very helpful for characterization of different breast lesions, thus avoiding unnecessary intervention.  相似文献   

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