首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 31 毫秒
1.

Objectives

Comparing the diagnostic accuracy of different MRI techniques in characterization of breast lesions.

Methods

The study was performed using 1.5T MRI and included 35 females with detected 47 breast lesions. Lesions were analyzed regarding their morphology, kinetic curve pattern, DWI and tCho peak measurement. The results of each MRI parameter were correlated to histo-pathology.

Results

The study included 35 females with 47 breast lesions. Sensitivity and specificity were 87.5% and 93.3% using morphology alone. By using curve pattern, they were 96.9% and 73.3%. DWI was 96.9% sensitive, 66.7% specific, and MRS was 74.2% sensitive and 71.4% specific. The cut-off ADC value was 1.063?×?10?3?mm2/s. Choline cut-off value was (0.36?mmol/l). Sensitivity and specificity were increased to 100% and 93.3% after combining either kinetic curve or DWI with morphology. Sensitivity was increased to 90.3%, after combining MRS with morphology, however this slightly reduced the specificity to 92.9%.

Conclusion

MRI is very sensitive for detection of breast lesions, however it lacks specificity. Post-processing tools and functional MRI have improved the specificity. MRS has increased the sensitivity, however specificity has been slightly decreased.

Advances in knowledge

Functional MRI is very helpful for characterization of different breast lesions, thus avoiding unnecessary intervention.  相似文献   

2.

Purpose

The purpose of this study is to evaluate the role of MR diffusion imaging (DWI) and apparent diffusion coefficient (ADC) measurement of solid and cystic mediastinal masses to differentiate benign from malignant lesions.

Patients and methods

The study included 52 patients with mediastinal masses underwent conventional MRI and DWI (b value 0, 500 and 1000?s/mm2) examinations with 1.5-T MRI. The signal intensity of the lesions and the ADC values of the solid and cystic lesions were obtained. Statistical analyses were performed with the Mann-Whitney U test (z), Pearson’s chi-square test and receiver operating characteristic (ROC) analysis.

Results

29 lesions were malignant and 23 lesions were benign. The diffusion signal of the malignant masses was significantly higher than benign masses (p?=?0.0001), the mean ADC value of benign lesions was higher than that of malignant lesions (p?=?0.0001). By ROC analysis, ADC cutoff value of 1.25?×?10?3?mm2/s was considered the threshold value, and the sensitivity and specificity were 94.4% and 86.2%, respectively. There was no statistical difference between the ADC values of the cystic part in either benign or malignant lesions.

Conclusion

Diffusion weighted MRI and measurement of ADC value can differentiate between solid benign and malignant mediastinal lesions.  相似文献   

3.

Aim of the work

To evaluate the role of diffusion weighted imaging (DWI) in the planning for CT guided biopsy of lung and mediastinal lesions.

Subjects and methods

This cross sectional study included 23 patients with mean age was 42.7?years came with clinical and imaging suspicion of chest malignancy, referred for CT guided transthoracic biopsy. DWI and apparent diffusion coefficient (ADC) were evaluated for all patients to choose the area of maximum restriction.

Results

The study showed that with DWI guidance; all the biopsy specimens were diagnostic and provide adequate material for analysis.

Conclusion

DWI and measurement of ADC value has a very helpful role in the pre-procedural planning of transthoracic biopsies.  相似文献   

4.

Aim

To evaluate accuracy of DWI in evaluating HCC response to DEB TACE and compare the results with DCE MRI.

Material and methods

42 patients with 59 lesions underwent precontrast abdominal MRI, DWI, ADC map with ADC value measurement and DCE MRI. The qualitative DWI and ADC values were correlated to the DCE MR findings.

Results

Comparing the qualitative DWI findings to DCE MRI, showed sensitivity of 83.9%, specificity of 64.3%, positive predictive value of 72.2%, and negative predictive value of 78.3% and overall accuracy of 74.5%. The measured ADC values showed significant difference (P value <0.05) between the ADC values measured in the active tumoral areas and necrotic areas with no significant difference between areas of active tumoral enhancement in the different groups. ROC analysis for ADC values showed area under curve 0.7 and maximum combined sensitivity and specificity of 79% and 69.6% respectively at cutoff ADC value of 1.395?mm2/sec.

Conclusion

DWI is useful highly sensitive technique in evaluation of HCC response to DEB TACE, yet it has low specificity related to high number of false positive results preventing using it solely. Also, DWIs is a reliable method in differentiation between active tumor residue/recurrence and benign perilesional enhancement.  相似文献   

5.

Background

Early diagnosis is crucial in management of pancreatic malignancy. DWMRI could be used in differentiating pancreatic lesions and judge about tumor aggressiveness.

Patients & methods

Fifty patients were included in this prospective study with mean age ±43?years. Histopathology & follow up clinical results revealed 34 malignant and 16 benign lesions. All patients underwent non-contrast MRI examination and DWI at different b-values with ADC value measurements.

Results

Conventional MRI poorly diagnosed pancreatic focal lesions with 79% Sensitivity, 68% specificity & 76% accuracy. In DWI with high b-value of 1000, 31/34 malignant lesions showed restricted diffusion with low ADC value (≤1.5?×?10?3?mm2/s) while 14/16 benign lesions showed mixed diffusion with higher ADC values (≥1.7?×?10?3?mm2/s). DWI at high b-value of 1000 with chosen ADC value of 1.5 as a cut-off value revealed high sensitivity (91.18%), 87.5% specificity, 93.84% PPV, 82.35% NPV and 90% accuracy in differentiating benign from malignant pancreatic lesions.

Conclusion

DWMRI found to be a simple and non-invasive tool that aid in the diagnosis of pancreatic pathology with recommended high b-value and a cut-off ADC value of 1.5 that approved the highest sensitivity & specificity in differentiating benign from malignant pancreatic focal lesions.  相似文献   

6.

Purpose

To evaluate the role of diffusion weighted MRI (DW MRI) in the differentiating between benign and malignant pancreatic masses.

Patients and Methods

Sixty patients (36 men, mean age, 62?years; range, 48–72?years], 24 women (mean age, 64?years; range, 54–69?years] suspected to have solid pancreatic masses were examined by conventional and DWI. None of our patients had a history of pancreatic disease. DWI of the pancreas was performed in addition to the routine liver MR. Final diagnosis was obtained by diagnostic biopsy, lab. data and follow up.

Results

38 patients had a benign lesion and 22 patients had a malignant lesion. Using DWI, 36 cases were diagnosed to have benign lesions and 24 cases were diagnosed to have malignant lesions. There were two false positive cases due to low ADC value. The mean ADC values of malignant lesions were lower compared with benign lesion. The mean ADC value for malignant lesions was 1.1?+/??0.201?×?10?3?mm2/sec, and for benign lesions it was 1.6?+?l???0.121?×?10?3?mm2/sec.

Conclusion

DWI and ADC values can help differentiate between benign and malignant pancreatic masses. Also DWI can be used for investigating patients for whom contrast-enhanced CT or MRI studies are contraindicated.  相似文献   

7.

Objectives

To evaluate the reliability of diffusion-weighted imaging (DWI) in evaluating kidney changes after extracorporeal shock wave lithotripsy (ESWL) treatment for kidney stones.

Patients and methods

This prospective study included 28 patients who subjected to ESWL treatment for renal stones. Color Doppler ultrasonography (CDUS) and DWI were achieved before and within one day after ESWL. Follow up DWI also performed 2?weeks after ESWL. DWI was performed with b factors of 0, 500 and 1000?s/mm2 at 1.5?T MRI. For each patient, the Resistive index (RI) and ADC values were calculated for both the affected and contralateral kidneys.

Results

The ADC values of the treated kidneys were lower in all three poles of the kidney compared with ADC values done before ESWL and in comparison with the contra lateral un-treated kidney. The RI showed no significant difference in the three poles of treated and untreated kidneys before and after with ESWL (p?>?0.05).

Conclusion

DWI is a reliable method in detecting renal changes after ESWL treatment that can give prediction about kidney changes produced by shock waves.  相似文献   

8.

Objective

The prognosis of different histologic subtypes of RCC varies and affects management. Patients with chromophobe or papillary RCC have better prognosis than those with clear cell RCC. The aim of our work was to study the utility of DCE and DWI in the preoperative prediction of renal cell carcinoma subtypes, using histopathology as a gold standard method of diagnosis.

Patients and methods

Thirty five patients with 38 renal masses were included in the study. All had DCE MRI studies with DWI sequences, CER and ADC values calculation for normal and diseased renal tissues.

Results

The Mean ADC value of normal renal parenchyma was significantly higher than RCC. The CER and ADC values for Clear cell RCC were higher than Papillary and Chromophobe RCC. No statistically significant difference was found between the CER & ADC values for Papillary and Chromophobe RCC. CER & ADC values of clear RCC were higher than non clear RCC.

Conclusions

DCE MRI in addition to DWI & ADC appears as a very helpful imaging tool in the differentiation between clear cell and non-clear cell RCCs.  相似文献   

9.

Objective

To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) with calculation of the apparent diffusion coefficient (ADC) value in characterizing benign and malignant breast lesions.

Patients and methods

The imaging data of thirty-nine female patients (mean age 48 years) who underwent breast MRI using conventional pulse sequences. DW-MRI and dynamic contrast enhanced (DCE) study were all analyzed and correlated with the results of histopathological evaluation.

Results

Forty-six breast lesions were detected in the thirty-nine patients of the study. According to the histopathological analysis, there were 27 malignant lesions (58.69%) and 19 benign lesions (41.31%). The malignant lesions showed a mean ADC value of 0.93?±?0.42?×?10?3?mm2/s. and the benign lesions showed a mean ADC value of 1.54?±?0.43?×?10?3?mm2/s. The receiver operating characteristic (ROC) curve could identify an ADC 1.26?×?10?3?mm2/s as a cut-off value to differentiate between benign and malignant lesions with sensitivity and specificity of 89% and 94.7% respectively.

Conclusion

DW-MRI is useful for differentiating malignant and benign breast lesions, increasing the specificity of breast MRI. DW-MRI doesn't cause significant increase in the total examination time and is recommended to be incorporated in the standard breast MRI protocol.  相似文献   

10.

Aim

To assess how beneficial is adding Magnetic Resonance Diffusion-Weighted Imaging (DWI) to conventional MRI in the identification, characterization, and prognostic assessment of pancreatic duct adenocarcinoma (PDAC).

Materials and Methods

We included 34 consecutive patients with pancreatic malignancies who had conventional MRI and DWI performed and were followed up after treatment.

Results

The apparent diffusion coefficient (ADC) values of malignant pancreatic mass lesions ranged from 0.9 to 1.5?×?10?3s/mm2 at b-1000, with a mean of 1.2?±?0.18093. For the surrounding parenchyma, the ADC values were from 1.8 to 2.9?×?10?3s/mm2 at b-1000, with a mean of 2.3?±?0.35506. These values showed a statistically significant difference (P?<?0.001). The ADC cut-off value for the differentiation of malignant pancreatic masses from surrounding normal tissue, in this group of patients was, 1.7?×?10?3 s/mm2 with a sensitivity of 97% and a specificity 93%.In PDAC, a statistically significant difference in survival was found according to ADC (p?=?0.026), as patients with high ADC had better survival.

Conclusion

DWI added to conventional imaging is a superior modality that aids in differentiating PDAC from the unaffected parenchyma, but not from other malignancies, with a recommended b-value 1000?s/mm2. Higher ADC may also be associated with better survival for PDAC patients.  相似文献   

11.

Background

Uterine tumors are considered one of the major, causes of death. Detection, characterization and staging of these tumors, remain the cornerstone for proper management.

Objective

Describe the, various uterine tumors at DWI and assess its ability in, detection, characterization and staging of these tumors.

Patients & methods

This study included 25 patients with suspected endometrial and, cervical masses between June 2015 to December 2016.These were referred from, the ultrasound unit to the MRI unit of Radiology Department for further, characterization and staging of the tumors. All patients were evaluated, with transvaginal ultrasound and only those with suspicious masses were, included in our study. Conventional MRI with DWIs was done. All images were, analyzed as regards the degree of signal intensity and interpreted into a, quantitative measurement using the ADC mapping. This was followed by, staging of tumors using FIGO staging. The sensitivity, specificity and, diagnostic accuracy of DWI with the ADC cut off value in each malignancy, were calculated.

Results

DWIs with ADC maps showed a sensitivity and, specificity of 80% in endometrial cancers, sensitivity of 87.5% and, specificity of 100% in cervical cancers. The mean ADC value for, endometrial cancers was 0.8?×?10?3?mm2/s and 0.6?×?10?3?mm2/s for cervical, cancers.

Conclusion

Conventional MRI findings in conjunction with DWI and, quantitative measurement of the ADC are effective methods in the, diagnosis and staging of uterine cancer.  相似文献   

12.

Objective

To assess the diagnostic accuracy of diffusion weighted imaging (DWI-MRI) being a non-contrast based MR sequence versus dynamic contrast enhanced MRI (DCE-MRI) in the preoperative loco-regional staging of the cervical carcinoma.

Methodology

Fifty cases of proved cancer cervix prior staging subjected to dynamic post contrast technique: one pre-and six post contrast phases (40?s each). DWI was scanned using different b values and ADC values were measured.

Results

DWI was the most accurate in staging operable cases (93.3%).Parametrial infiltration was overestimated in 3 cases versus 4 cases in DCE-MR. DWI showed 100% sensitivity, positive predictive value and accuracy in the assessment of locally advanced carcinomas. In metastatic lymph nodes, DCE-MR showed the least accuracy of 86%.

Conclusion

DWI is helpful in discriminating local from locally advanced cervical carcinomas. DCE-MR can delineate cervical carcinomas confined to the uterus and exclude bladder/rectal invasion.  相似文献   

13.

Aim of the work

To study the diagnostic performance of combined single voxel 1H-MRS and DW-MRI with ADC values as a non-contrast diagnostic tool, compared to the DCE-MRI, in suspicious breast lesions.

Materials and methods

113 female patients (mean age 45.8?years) with suspicious breast lesions, categorized as BI-RADS 3 or 4 by sono-mammographic examinations, were subjected to bilateral breast imaging with non-contrast MRI including conventional MRI, DW-MRI with quantitative ADC values, and single voxel 1H-MRS, in addition to DCE-MRI. They had 132 pathologically proved lesions (74 benign and 58 malignant).

Results

DW-MRI with ADC values was 96.97% accurate with 94.92% sensitivity and 98.63% specificity, while DCE-MRI was 97.73% accurate with 98.29% sensitivity but with 97.29% specificity, and 1H-MRS was 98.48% accurate with the highest sensitivity (100%) and 97.33% specificity. Furthermore, the combined use of DW-MRI with ADC values and 1H-MRS improved the diagnostic capability than utilization of each sequence alone with the highest accuracy of 99.24%, 100% sensitivity and 98.65% specificity.

Conclusion

The combined use of DW-MRI with quantitative ADC data and single-voxel 1H-MRS is a reliable non-contrast tool that provides higher accuracy in characterizing suspicious breast, and can efficiently be used in the absence of DCE-MRI.  相似文献   

14.

Background

MS plaques display different pattern of enhancement with variable clinical course. The purpose is to assess the role of ADC value as a predictive for MS histologic changes with different enhancing pattern and its correlation with disease activity.

Patients and methods

This prospective study included 28 chronic MS patients with 75 lesions, subjected for magnetic resonance imaging and ADC value measurement of the plaques and normally appearing white matter (NAWM) to be correlated with that of normal white matter (NWM) in 20 healthy controls.

Results

T1-Hypointense and confluent lesions had statistical significant higher mean ADC value relative to the isointense and discrete lesions. Statistical significance difference was detected between mean ADC value of homogeneously enhancing lesions (HELs) and ring enhancing lesions (RELs) and between HELs and non-enhancing lesions (NELs), but no difference between NELs and RELs. Statistical significance difference was detected between ADC of NAWM relative to NWM of healthy controls.

Conclusion

ADC value predicts histological changes in MS lesions. Pattern of enhancement doesn't correlate with neurologic deficits but ADC value is more valuable in assessing the disease activity.  相似文献   

15.

Purpose

To assess the role of dynamic contrast- enhanced and diffusion-weighted (DWI) MRI in the evaluation of the response of hepatocellular carcinoma (HCC) after chemoembolization.

Patient & method

30 patients having 40 HCC lesions underwent transcatheter arterial chemoembolization (TACE). Ages ranged between 41 and 76?years. All examinations were performed using Philips 1.5 Tesla MRI (Achieva). Precontrast T1, T2, Dynamic contrast enhanced and respiratory triggered DWI MR images with (b?=?50, 400, 800?mm/s). DWI MRI images and Contrast-enhanced MRI images after TACE are assessed to evaluate post treatment response. DWI was used to create ADC maps and ADC values were calculated looking for a cut off value using the ROC curve.

Results

Dynamic MRI had a sensitivity of 94.1%, a specificity of 95.6%, PPV value of 94.1%, NPV of 95.6% and an overall agreement of 95% compared to 82%, 73.9%, 70%, 85% and 77.5% respectively of DWI MRI. The difference between the malignant residual and well ablated groups' ADC variables was statistically significant P value 0.009.

Conclusion

Dynamic and diffusion MRI complete each other in assessment of HCC response to therapy, especially in those who cannot properly hold their breath that cause degradation of the dynamic MR quality.  相似文献   

16.

Background

Neoadjuvant chemotherapy (NAC) has clinically important outcome. Early evaluation of the treatment response is important to avoid unnecessary therapy in non-responders. MRI is the most sensitive imaging for monitoring NAC response.

Aim of this study

Is to test the ability of DWI to detect early response to NAC.

Results

The study was performed on 20 patients, proved pathologically to have invasive breast cancer. All patients underwent breast MRI before initiation of NAC, after one cycle and after completion of the NAC protocol. Regarding the mass size, results showed no significant change in maximum mass diameters occur after the 1st NAC cycle. Absolute value of the ADC show increase all along the treatment course which has no significant correlation with the pathological response. The relative increase ADC more than 20% calculated from subtraction of the pre-treatment ADCmean value from that after the first NAC, subdividing the result on the pre-treatment ADCmean value and multiply it by 100 reflected significantly on the pathological response (p value of 0.011).

Conclusion

ADC value can predict responder from non-responder as early as after the first cycle of chemotherapy.  相似文献   

17.

Purpose

To assess the value of (MRI), (DWI) and (MRS) in the diagnosis of different orbital masses and differentiation between benign and malignant masses.

Patients and methods

Sixty patients were enrolled in this study (31 females, 29 males, their ages ranged from 3?month to 75?years with mean age of 35.3?years). Clinical examination, (T1WI&T2WI) MRI and postcontrast T1WI, DWI, and MR Spectroscopy were done in all cases. Histopathological examination was done for 55 patients, and follow-up was done for 5 cases after medical treatment: two cases of pseudotumor and three cases of cellulites.

Results

The study comprised 60 patients complaining of proptosis, swelling and diminution of vision. Thirty-three (55%) of patients had benign orbital masses and 27 (45%) patients had malignant orbital masses. The mean ADC value of malignant lesions was 0.89?±?0.20. There was a statistically significant difference (p?=?≤.001) between benign and malignant ADC values. The Mean Cho/Cr ratio for benign lesions was 1.19?±?0.25 which showed statistically high significance (p?=?≤.0017) compared to Cho/Cr ratio of malignant lesions which was 2.44?±?0.30.Diffusion-weighted MRI could differentiate between benign and malignant masses in 75% of cases. However, MRS could overcome this overlap and could differentiate benign from malignant tumors in 96% of scanned patients.

Conclusion

Both DWI and MRS imaging are helpful tools in differentiating malignant orbital lesions from benign masses.  相似文献   

18.

Aim of the study

The aim of this study was to explore the role of the DWI in assessment of peri-anal fistula and whether it can replace post contrast study.

Patients and methods

MRI examinations was done for 35 patients. Images were reviewed for the presence and number of visible fistulas, internal openings, secondary extension, horse shoe and abscess. Apparent diffusion coefficient (ADC) measurement of suspected fistula tracks and abscess cavities was done to assess activity. Comparison between TIRM, DWI and post-contrast T1-weighted fat saturated sequences was done. Surgical findings were the reference standard.

Results

Contrast enhanced images were superior to DWI in detection of primary fistula and internal opening while they were equivalent in detection of secondary extensions and abscess. There was no significant difference in overall accuracy of detection of perianal fistula and its complications between combined (DWI and TIRM images) and post contrast images. There was significant difference between ADC values of active and inactive fistulae and between abscess and inflammatory reaction.

Conclusion

Combined DWI and TIRM is equivalent to post contrast images in detection of primary and complicated fistula. DWI is useful in differentiation between abscess and inflammatory reaction, and assessment of disease activity.  相似文献   

19.

Objective

To evaluate the additive value of Contrast Enhanced Spectral Mammography (CESM) in the preoperative assessment of malignant lesions in dense breast parenchyma regarding multiplicity.

Material and methods

The study included 160 women having heterogeneous dense breast parenchyma (ACR c and d) with suspicious lesions identified on sono mammography examination. All patients performed contrast enhanced spectral mammography to confirm or exclude lesion multiplicity. The number of lesions was calculated in the contrast high energy subtraction images with the reference standard being histopathological analysis.

Results

Adding CESM to sono-mammography the accuracy in identifying multiple malignant lesion increased from 81.8% accuracy of sono-mammography up to 100% accuracy after adding CESM.

Conclusion

Contrast enhanced spectral mammogram showed an added value in the preoperative assessment of breast masses increasing the accuracy of detection of lesions and multiplicity (multifocality and multi-centricity).  相似文献   

20.

Objectives

Comparison between digital mammography alone and with adding digital breast tomosynthesis in breast cancer screening.

Patients & methods

143 females underwent digital mammography, digital breast tomosynthesis and breast ultrasound.

Results

DBT+DM decreased recall rate by 38% in BI-RADS 0. From BI-RADS I till BI-RADS V DBT+DM showed more accuracy than DM. In BI-RADS IV DBT+DM decreased false positive results by 33%.

Conclusion

Adding digital breast tomosynthesis to digital mammography improves the diagnostic accuracy in breast cancer screening.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号