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1.
Masashi Ogasawara Akihiko Ishiyama Akira Sugiura Kazuhiko Segawa Ikuya Nonaka Eri Takeshita Yuko Shimizu-Motohashi Hirofumi Komaki Masayuki Sasaki 《Brain & development》2018,40(4):339-342
Introduction
Chilaiditi syndrome is a rare pathophysiology in which the colon or other organs are interposed between the diaphragm and liver, and respiratory or digestive symptoms sometimes manifest. Although there have been some cases of Chilaiditi syndrome complicating neuromuscular disorders, none have described resulting respiratory or digestive symptoms.Case presentation
Our patient was a 20-year-old man with DMD who had been receiving noninvasive positive-pressure ventilation during the night. He experienced respiratory distress when changing from a supine to sitting position. Ventilator adjustment did not relieve the respiratory distress. Abdominal computed tomography revealed marked constipation and interposition of the transverse colon between the diaphragm and liver, indicating Chilaiditi syndrome. The right side of the diaphragm was elevated by the interposed transverse colon when the respiratory distress was present on chest radiograph, but not when symptoms were absent. The patient was diagnosed with platypnea-orthodeoxia attributed to Chilaiditi syndrome. The respiratory distress was improved by the relief of constipation, in addition to the usage of the ventilator throughout the day.Conclusion
The rare symptoms and pathophysiology of DMD complicated by Chilaiditi syndrome are reported and discussed herein. 相似文献2.
Tetsushi Yamamoto Mariko Taniguchi-Ikeda Hiroyuki Awano Masaaki Matsumoto Tomoko Lee Risa Harada Takamitsu Imanishi Nobuhide Hayashi Yoshitada Sakai Ichiro Morioka Yasuhiro Takeshima Kazumoto Iijima Jun Saegusa Tatsushi Toda 《Brain & development》2017,39(10):861-868
Background
One of the main complications in patients with muscular dystrophies is cardiac dysfunction. The literature on cardiac involvement in patients with Fukuyama congenital muscular dystrophy (FCMD) is limited.Aim
To compare cardiac involvement between patients with FCMD and Duchenne muscular dystrophy (DMD).Methods
We compared cardiac involvement between 30 patients with FCMD and 181 patients with DMD using echocardiography and serum biomarkers. All patients were receiving regular checkups at Kobe University Hospital. We used single regression analysis to compare echocardiographic parameters, age, and serum biomarkers.Results
Almost all clinical and echocardiographic parameters were lower in patients with FCMD than DMD. The brain natriuretic peptide concentration in patients with FCMD showed no correlation with age or left ventricular ejection fraction (r = 0.231, p = 0.22 and r = 0.058, p = 0.76, respectively). A log-rank test revealed that the risk of left ventricular systolic dysfunction was lower in patients with FCMD than DMD (p = 0.046, hazard ratio = 0.348).Conclusion
The clinical progression of cardiac dysfunction is significantly milder in patients with FCMD than DMD, while skeletal muscle involvement is significantly worse in patients with FCMD. These data suggest that the pathophysiological findings of FCMD can be explained by less severe cardiac dysfunction in FCMD than DMD. 相似文献3.
Eri Takeshita Hirofumi Komaki Hisateru Tachimori Kazuhisa Miyoshi Ikuo Yamamiya Yuko Shimizu-Motohashi Akihiko Ishiyama Takashi Saito Eiji Nakagawa Kenji Sugai Masayuki Sasaki 《Brain & development》2018,40(10):918-925
Background
Patients with Duchenne muscular dystrophy (DMD) exhibit increased prostaglandin D2 (PGD2) expression in necrotic muscle and increased PGD2 metabolites in their urine. In mouse models, inhibiting PGD2 production suppresses muscle necrosis, suggesting a possible intervention through PGD2-mediated activities.Objective
We investigated the involvement of PGD2 and its potential use as a marker of pathological progression in DMD.Methods
Sixty-one male children with DMD and thirty-five age-matched controls were enrolled in the study. DMD patients were divided into “ambulant” and “non-ambulant” groups, which were further subdivided into “steroid” and “non-steroid” therapy groups. Levels of the PGD2 metabolite tetranor-PGDM (t-PGDM) and creatinine were measured in both spot and 24-hour urine samples, with comparisons between groups made according to geometric mean values.Results
DMD patients had significantly higher levels of creatinine-corrected t-PGDM in spot urine samples as compared with the control group. Additionally, both ambulant and non-ambulant DMD groups had significantly higher levels of t-PGDM as compared with controls, with no significant difference in t-PGDM levels observed between steroid and non-steroid groups. Moreover, total creatinine excretion in 24-hour urine samples was significantly lower in DMD patients as compared with controls, and although DMD patients had lower muscle mass than controls, their overall levels of t-PGDM did not differ significantly from those in the non-ambulant and control groups.Conclusion
PGD2 might help explain the progression and symptomatic presentations (e.g., ambulatory difficulty) associated with DMD, suggesting it as a useful pathological marker and use of a selective PGD2 inhibitor as a potential treatment modality. 相似文献4.
Hiroyuki Awano Chieko Itoh Yasuhiro Takeshima Tomoko Lee Masaaki Matsumoto Akihiro Kida Toshihiko Kaise Takeo Suzuki Masafumi Matsuo 《Brain & development》2018,40(6):465-472
Introduction
Few long-term cohort studies have addressed changes in the ambulatory capacity of patients with Duchenne muscular dystrophy (DMD), and no reports have evaluated the factors associated with ambulatory capacity in Japanese.Methods
The longitudinal changes in 10-meter run/walk ability and associated factors were retrospectively investigated using general practice data. The factors associated with loss of this ability before the age of 10?years were explored by logistic regression analysis using parameters of genetic mutations, corticosteroid use, the manual muscle test (MMT), and the joint range of motion (ROM). Explanatory variables of MMT grade included hip flexors, knee flexors, and knee extensors; ROM included hip extension, knee extension, and ankle dorsiflexion.Results
Among 418 patients diagnosed with DMD, 145 patients underwent the 10-meter run/walk test between March 1999 and July 2015. The median age at loss of 10-meter walking ability was 10.4 (interquartile range: 9.2–11.3) years. The 10-meter run/walk speed began to decline 3?years before the loss of 10-meter walking ability, and the median was <1?m/s 1?year before the loss of 10-meter walking ability. MMT grade for knee flexors and ROM for hip and knee extension were identified as independent predictors. Based on the change over time of these three items, limitation of the hip extension ROM preceded knee flexor weakness and limitation of the knee extension ROM.Conclusions
This knowledge can be used in optimizing rehabilitation programs and evaluating effect of treatment for DMD patients. 相似文献5.
Madoka Mori-Yoshimura Yukio Mizuno Sumiko Yoshida Narihiro Minami Naohiro Yonemoto Fumi Takeuchi Ichizo Nishino Miho Murata Shin&#x;ichi Takeda Yuji Takahashi En Kimura 《Brain & development》2018,40(4):268-277
Background
Little is known about the relationship between Becker Muscular Dystrophy (BMD) and developmental problems, school life, employment, and mental problems. We aimed to clarify whether BMD is a risk factor for developmental disorders, problematic behavior, psychiatric diseases, and other social difficulties in school life and employment.Methods
Adults with genetically or immunohistochemically confirmed BMD from the Registry of Muscular Dystrophy in Japan (REMUDY) were asked to complete a questionnaire regarding patient history, school life, employment, and mental problems.Results
In total, 125 (68.3%) of 183 participants with BMD (median age, 37.2?years) completed the questionnaire. Of these, ten had developmental disorders (mental retardation, autism, and speech disturbance). Fifty-eight (44%) experienced bullying in school, and 39 felt the reason for bullying was physical handicap. Sixteen participants experienced problematic behavior such as cutting class, domestic violence, violent incidents, suicide attempts, or self-mutilation. Employment histories were noted by 92 (73%), of whom 15 could not continue to work due to physical handicaps. Fifteen participants had psychiatric disorders, with 5, 3 and 1 having neurosis, depression, and bipolar disorder, respectively. The other 6 participants with psychiatric disorders did not specify their diagnoses. Patients carrying a Dp140 expression change had significantly more incidences of developmental disorders, but not bullying, problematic behavior, workplace difficulties, or psychiatric disorders.Conclusions
Patients with BMD risk bullying and workplace difficulties, as well as developing psychiatric disorders. Parents, teachers, and supporters should be mindful of the daily environment of BMD patients and provide support to help them cope with stress. 相似文献6.
Yuko Nakamura Yoshiaki Saito Norika Kubota Wataru Matsumura Chika Hosoda Akiko Tamasaki-Kondo Yoko Nishimura Yoshihide Sunada Masuyuki Fukada Takako Ohno Yoshihiro Maegaki Masafumi Matsuo Yasuko Tokita 《Brain & development》2018,40(7):537-543
Aim
To report on sleep hypercapnia in Becker muscular dystrophy (BMD) at earlier stages than ever recognized.Subjects and methods
This retrospective study examined nocturnal hypercapnia in six young Becker muscular dystrophy (BMD) patients with deletions of one or more exons of DMD gene. Clinical information, consecutive data on forced vital capacity (FVC%), forced expiratory volume in one second (FEV1%), peak expiratory flow (PEF%), peak cough flow (PCF), average PCO2 in all-night monitoring, and left ventricular ejection fraction (LVEF) were reviewed.Results
In five BMD patients, including three who were still ambulant, nocturnal average PCO2 was elevated to >45?mmHg at 12–31?years of age. Noninvasive positive pressure ventilation was initiated in four patients. Gradual declines in FVC% and PEF% were evident in one BMD patient with exon 3–7 deletion, whereas these functions did not change in the remaining BMD patients. PCF, FEV1%, and LVEF were less informative for the assessment of respiratory function in this patient series.Conclusion
Sleep hypercapnia was present in certain BMD patients, which was unexpected from the routine pulmonary function tests. Individualized assessment of nocturnal PCO2, partly based on the deletion types, should be further explored in the clinical practice of BMD patients. 相似文献7.
Bonifati DM Witchel SF Ermani M Hoffman EP Angelini C Pegoraro E 《Journal of neurology, neurosurgery, and psychiatry》2006,77(10):1177-1179
Background
Steroid administration is beneficial in Duchenne muscular dystrophy (DMD), but the response, incidence, and the severity of side effects are variable.Aims
To investigate whether glucocorticoid receptor (GRL) gene polymorphisms may be responsible for glucocorticoid sensitivity in DMD.Methods
Forty eight DMD patients treated either with prednisone or deflazacort were subjected to genetic analyses of the GRL gene.Results
Mutation studies revealed an heterozygous A to G mutation at GRL cDNA position 1220 in three DMD patients resulting in an asparagine to serine amino acid change at amino acid position 363 (N363S). The N363S carrier DMD patients showed a trend towards a later age at loss of ambulation in comparison with non‐carrier patients.Conclusions
These data suggest that the N363S GRL polymorphism may be implicated in the long term response to glucocorticoids. 相似文献8.
Mandava V. Rao Gaurang M. Sindhav Jitendra J. Mehta 《Annals of Indian Academy of Neurology》2014,17(3):303-307
Objective:
In India, various groups have studied different regions to find out deletion pattern of dystrophin gene. We have investigated its deletion pattern among Duchenne/Becker muscular dystrophy (D/BMD) patients across Gujarat. Moreover, in this study we also correlate the same with reading frame rule. However, we too consider various clinicopathological features to establish as adjunct indices when deletion detection fails.Materials and Methods:
In this pilot study, a total of 88 D/BMD patients consulting at our centers in Gujarat, India were included. All patients were reviewed on basis of their clinical characteristics, tested by three primer sets of 10-plex, 9-plex, and 7-plex polymerase chain reaction (PCR) for genetic analysis; whereas, biochemical indices were measured using automated biochemical analyzers.Results:
The diagnosis of D/BMD was confirmed by multiplex-PCR (M-PCR) in D/BMD patients. A number of 65 (73.86%) out of 88 patients showed deletion in dystrophin gene. The exon 50 (58.46%) was the most frequent deletion found in our study. The mean age of onset of DMD and BMD was 4.09 ± 0.15 and 7.14 ± 0.55 years, respectively. In patients, mean creatine phosphokinase (CPK), lactate dehydrogenase (LDH), and myoglobin levels were elevated significantly (P < 0.05) in comparison to controls. Addition to CPK, LDH and myoglobin are good adjunct when deletion detection failed. These data are further in accordance with world literature when correlated with frame rule.Conclusion:
The analysis has been carried out for the first time for a total of 88 D/BMD patients particularly from Gujarat, India. More research is essential to elucidate specific mutation pattern in association with management and therapies of proband. 相似文献9.
Claudio Babiloni Giuseppe Noce Alfredo Pennica Paolo Onorati Paolo Capotosto Claudio Del Percio Paolo Roma Valentina Correr Elisa Piccinni Ginevra Toma Andrea Soricelli Francesco Di Campli Laura Gianserra Lorenzo Ciullini Antonio Aceti Elisabetta Teti Loredana Sarmati Gloria Crocetti Stefano Ferracuti 《Clinical neurophysiology》2018,129(2):431-441
Objective
Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS).Methods
EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8?years?±?1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39.0?years?±?2.0 SE) subjects, selected from a local university archive, was used for control purposes. LORETA freeware was used for EEG source estimation in fronto-central, temporal, and parieto-occipital regions of interest.Results
Widespread sources of delta (<4?Hz) and alpha (8–12?Hz) rhythms were abnormal in the treatment-naïve HIV group. Fronto-central delta source activity showed a slight but significant (p?<?0.05, corrected) negative correlation with verbal and semantic test scores. So did parieto-occipital delta/alpha source ratio with memory and composite cognitive scores. These sources allowed a moderate classification accuracy between HIV and control individuals (area under the ROC curves of 70–75%).Conclusions
Regional EEG abnormalities in quiet wakefulness characterized treatment-naïve HIV subjects at the individual level.Significance
This EEG approach may contribute to the management of treatment-naïve HIV subjects at risk of cognitive deficits. 相似文献10.
Tomoyuki Fumuro Masao Matsuhashi Riki Matsumoto Kiyohide Usami Akihiro Shimotake Takeharu Kunieda Takayuki Kikuchi Kazumichi Yoshida Ryosuke Takahashi Susumu Miyamoto Akio Ikeda 《Clinical neurophysiology》2018,129(9):1884-1890
Objective
Neuro-feedback (NFB) training by the self-regulation of slow potentials (SPs) <0.5?Hz recorded from the vertex scalp has been applied for seizure suppression in patients with epilepsy. However, SP is highly susceptible to artifact contamination, such as the galvanic skin response (GSR). This study aimed to evaluate the correlation between SPs recorded from the scalp and intracranial electroencephalography (EEG) by event-related coherence analysis.Methods
The scalp and subdural SPs were simultaneously recorded during NFB training by the DC-EEG machine while undergoing invasive recordings before epilepsy surgery in 10 patients with refractory partial epilepsy. The SPs at the vertex electrode were used as a reference for coherence analysis.Results
The coherence of SPs negatively correlated with the distance between the subdural and scalp electrodes. A significant negative correlation was noted between the linear subdural–scalp electrode distance and the coherence value (r?=????0.916, p?<?0.001).Conclusion
Scalp-recorded SPs from the vertex area primarily reflect the cortical activity of high lateral convexity.Significance
Our results strongly suggest that SPs in NFB recorded from the vertex scalp electrode is derived from the cortices of high lateral convexity but not from the artifacts, such as GSR. 相似文献11.
Gabriella Musacchia Silvia Ortiz-Mantilla Cynthia P. Roesler Sree Rajendran Julie Morgan-Byrne April A. Benasich 《Clinical neurophysiology》2018,129(12):2623-2634
Objective
Background noise makes hearing speech difficult for people of all ages. This difficulty can be exacerbated by co-occurring developmental deficits that often emerge in childhood. Sentence-type speech-in-noise (SIN) tests are available clinically but cannot be administered to very young individuals. Our objective was to examine the use of an electrophysiological test of SIN, suitable for infants, to track developmental trajectories.Methods
Speech-evoked brainstem potentials were recorded from 30 typically-developing infants in quiet and +10?dB SNR background noise. Infants were divided into two age groups (7–12 and 18–24?months) and examined across development. Spectral power of the frequency following response (FFR) was computed using a fast Fourier Transform. Cross-correlations between quiet and noise responses were computed to measure encoding resistance to noise.Results
Older infants had more robust FFR encoding in noise and had higher quiet-noise correlations than their younger counterparts. No group differences were observed in the quiet condition.Conclusions
By two years of age, infants show less vulnerability to the disruptive effects of background noise, compared to infants under 12?months.Significance
Speech-in-noise electrophysiology can be easily recorded across infancy and provides unique insights into developmental differences that tests conducted in quiet may miss. 相似文献12.
Hunmin Kim Soo Yeon Kim Byung Chan Lim Hee Hwang Jong-Hee Chae Jieun Choi Ki Joong Kim Dennis J. Dlugos 《Brain & development》2018,40(8):693-698
Purpose
This study was performed 1) to determine the timing of spike normalization in patients with benign epilepsy with centrotemporal spikes (BECTS); 2) to identify relationships between age of seizure onset, age of spike normalization, years of spike persistence and treatment; and 3) to assess final outcomes between groups of patients with or without spikes at the time of medication tapering.Methods
Retrospective analysis of BECTS patients confirmed by clinical data, including age of onset, seizure semiology and serial electroencephalography (EEG) from diagnosis to remission. Age at spike normalization, years of spike persistence, and time of treatment onset to spike normalization were assessed. Final seizure and EEG outcome were compared between the groups with or without spikes at the time of AED tapering.Results
One hundred and thirty-four patients were included. Mean age at seizure onset was 7.52?±?2.11?years. Mean age at spike normalization was 11.89?±?2.11 (range: 6.3–16.8) years. Mean time of treatment onset to spike normalization was 4.11?±?2.13 (range: 0.24–10.08) years. Younger age of seizure onset was correlated with longer duration of spike persistence (r?=??0.41, p?<?0.001). In treated patients, spikes persisted for 4.1?±?1.95?years, compared with 2.9?±?1.97?years in untreated patients. No patients had recurrent seizures after AED was discontinued, regardless of the presence/absence of spikes at time of AED tapering.Conclusion
Years of spike persistence was longer in early onset BECTS patients. Treatment with AEDs did not shorten years of spike persistence. Persistence of spikes at time of treatment withdrawal was not associated with seizure recurrence. 相似文献13.
Keiko Ishigaki Ikuko Kato Terumi Murakami Takatoshi Sato Minobu Shichiji Kumiko Ishiguro Kiyonobu Ishizuka Makoto Funatsuka Kayoko Saito Makiko Osawa Satoru Nagata 《Brain & development》2019,41(1):43-49
Background
The leading cause of death in patients with Fukuyama congenital muscular dystrophy (FCMD) is congestive heart failure or respiratory dysfunction, which is same as that in Duchenne muscular dystrophy (DMD). Recent studies reported that renal dysfunction is a common complication and an increasing cause of death in advanced DMD. It can be attributable to circulatory instability or inappropriate use of drugs for treating cardiac dysfunction.Methods
We retrospectively evaluated renal function in 38 genetically diagnosed patients with FCMD (range, 1.3–32.9?years; mean age, 13.7?±?6.9?years) using cystatin C. We examined possible relationships of cystatin C with blood natriuretic peptide and creatinine levels along with cardiac echocardiography findings.Results
Twenty-five patients were treated for cardiac dysfunction. Elevated cystatin C level was detected only in two, who also showed proteinuria, glycosuria, hematuria, and extremely high β2-microglobulin levels on urine tests, and were thus diagnosed with renal tubular cell damage. Because both patients were treated for intractable epilepsy with various antiepileptic drugs, including valproic acid (VPA), and had low serum carnitine levels, renal tubular cell damage was considered as an adverse effect of VPA. Unlike patients with DMD, no patient with FCMD had renal dysfunction. Such a rare occurrence of renal dysfunction can be attributable to mild cardiac dysfunction, short disease duration, and careful and early fluid management.Conclusion
Renal dysfunction is rare in patients with FCMD; however, renal tubular cell damage should be ascertained, particularly in those undergoing VPA treatment for epilepsy. 相似文献14.
Tetsuya Takahashi Teruya Yamanishi Sou Nobukawa Shinya Kasakawa Yuko Yoshimura Hirotoshi Hiraishi Chiaki Hasegawa Takashi Ikeda Tetsu Hirosawa Toshio Munesue Haruhiro Higashida Yoshio Minabe Mitsuru Kikuchi 《Clinical neurophysiology》2017,128(8):1457-1465
Objective
Altered brain connectivity has been theorized as a key neural underpinning of autism spectrum disorder (ASD), but recent investigations have revealed conflicting patterns of connectivity, particularly hyper-connectivity and hypo-connectivity across age groups. The application of graph theory to neuroimaging data has become an effective approach for characterizing topographical patterns of large-scale functional networks. We used a graph approach to investigate alteration of functional networks in childhood ASD.Method
Magnetoencephalographic signals were quantified using graph-theoretic metrics with a phase lag index (PLI) for specific bands in 24 children with autism spectrum disorder and 24 typically developing controls.Results
No significant group difference of PLI was found. Regarding topological organization, enhanced and reduced small-worldness, representing the efficiency of information processing, were observed respectively in ASD children, particularly in the gamma band and delta band.Conclusions
Analyses revealed frequency-dependent atypical neural network topologies in ASD children.Significance
Our findings underscore the recently proposed atypical neural network theory of ASD during childhood. Graph theory with PLI applied to magnetoencephalographic signals might be a useful approach for characterizing the frequency-specific neurophysiological bases of ASD. 相似文献15.
Anouk van Westrhenen Elisabeth A. Cats Bart van den Munckhof Sandra M.A. van der Salm Nico W. Teunissen Cyrille H. Ferrier Frans S.S. Leijten Karin P.W. Geleijns 《Clinical neurophysiology》2018,129(10):2127-2131
Objective
To examine whether rhythmic high-amplitude delta with superimposed (poly)spikes (RHADS) in EEG allow a reliable early diagnosis of Alpers-Huttenlocher syndrome (AHS) and contribute to recognition of this disease.Methods
EEGs of nine patients with DNA-proven AHS and fifty age-matched patients with status epilepticus were retrospectively examined by experts for the presence of RHADS and for accompanying clinical signs and high-frequency ripples. Reproducibility of RHADS identification was tested in a blinded panel.Results
Expert defined RHADS were found in at least one EEG of all AHS patients and none of the control group. RHADS were present at first status epilepticus in six AHS patients (67%). Sometimes they appeared 5–10?weeks later and disappeared over time. RHADS were symptomatic in three AHS patients and five AHS patients showed distinct ripples on the (poly)spikes of RHADS. Independent RHADS identification by the blinded panel resulted in a sensitivity of 87.5% (95% CI 47–100) and a specificity of 87.5% (95% CI 77–94) as compared to the experts’ reporting.Conclusion
RHADS are a highly specific EEG phenomenon for diagnosis of AHS and can be reliably recognized. Clinical expression and EEG ripples suggest that they signify an epileptic phenomenon.Significance
RHADS provide a specific tool for AHS diagnosis. 相似文献16.
Reza Rostami Reza Kazemi Michael A. Nitsche Fatemeh Gholipour 《Clinical neurophysiology》2017,128(10):1961-1970
Objective
Previous studies investigated predictors of repetitive transcranial magnetic stimulation (rTMS) response in depressive disorders but there is still limited knowledge about clinical predictors. Moreover, predictors of rTMS response in bipolar depression (BDD) are less studied than unipolar depression (UDD).Methods
We performed a binary logistic regression analysis in 248 patients with depressive disorders (unipolar N = 102, bipolar N = 146) who received 20 sessions of DLPFC rTMS (High-frequency rTMS, low-frequency rTMS, bilateral rTMS) to investigate significant clinical and demographic predictors of rTMS response. We also investigated effects of depression type, response (yes, no) and time on reducing somatic and cognitive-affective symptoms of patients.Results
Depression type (unipolar vs. bipolar) did not have a significant effect on rTMS response. 45% of all patients, 51.5% of UDD patients and 41% of BDD patients, responded to rTMS treatment. Age was the only significant demographic predictor of treatment response in all patients. Cognitive-affective symptoms, compared to somatic symptoms were significant predictors for treatment response to rTMS. Common and unique clinical predictor for UDD and BDD were identified.Conclusions
Younger patients and those with cognitive-affective rather than somatic symptoms benefit more from DLPFC rTMS treatment. rTMS is effective in UDD and BDD patients. Patients should be selected based on clinical and demographic profile.Significance
Findings are based on the largest thus far reported sample of patients with depressive disorders that received DLPFC rTMS. 相似文献17.
Claudio Babiloni Claudio Del Percio Roberta Lizio Giuseppe Noce Susanna Lopez Andrea Soricelli Raffaele Ferri Maria Teresa Pascarelli Valentina Catania Flavio Nobili Dario Arnaldi Francesco Famà Francesco Orzi Carla Buttinelli Franco Giubilei Laura Bonanni Raffaella Franciotti Marco Onofrj Fabrizio Stocchi 《Clinical neurophysiology》2018,129(4):766-782
Objective
This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer’s (ADMCI) and Parkinson’s (PDMCI) diseases compared to healthy elderly subjects (Nold).Methods
rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N?=?75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals.Results
Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70–0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups.Conclusions
These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels.Significance
The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment. 相似文献18.
Eva Bültmann Loukia M. Spineli Hans Hartmann Annette Sander Heinrich Lanfermann 《Brain & development》2018,40(5):376-382
Objectives
To evaluate microstructural cerebral changes in children with neurofibromatosis type 1 (NF1) based on T2 relaxation time measurements at 3Tesla.Methods
From our dataset of pediatric MRI examinations at 3T 19 pediatric NF1 patients (1.9–14.3?years of age, 9 girls, 10 boys) were retrospectively selected and compared with the previously published group of 44 healthy children (0–16?years of age). MRI examination included a triple echo TSE sequence as basis for T2 maps. T2 relaxation times were measured in 37 brain regions.Results
Compared with healthy controls, T2 relaxation times had the tendency to be increased by 1.01% (GM) to 11.85% (dentate nucleus) for NF1 patients. Only in posterior limb of the internal capsule and parietooccipital white matter values were reduced. No differences were observed between both hemispheres. Overall, no strong evidence supporting a difference between NF1 patients with and without optic glioma or with normal and impaired neuropsychological development was observed.Conclusions
Using T2 relaxation times it was possible to describe measurable microstructural differences in multiple brain regions between NF1 patients and healthy children regardless of whether signal abnormalities were visible on conventional images. 相似文献19.
Daisuke Koshiyama Kenji Kirihara Mariko Tada Tatsuya Nagai Mao Fujioka Eriko Ichikawa Kazusa Ohta Motoko Tani Maiko Tsuchiya Akiko Kanehara Kentaro Morita Kingo Sawada Jun Matsuoka Yoshihiro Satomura Shinsuke Koike Motomu Suga Tsuyoshi Araki Kiyoto Kasai 《Clinical neurophysiology》2018,129(11):2268-2275
Objectives
The gamma-band auditory steady-state response (ASSR) is thought to reflect the function of parvalbumin-positive γ-aminobutyric acid (GABA)-ergic interneurons and may be a candidate biomarker in early psychosis. Although previous cross-sectional studies have shown that gamma-band ASSR is reduced in early psychosis, whether reduced gamma-band ASSR could be a predictor of the long-term prognosis remains unknown.Methods
In this longitudinal study, we investigated the association between gamma-band ASSR reduction and future global symptomatic or functional outcome in early psychosis. We measured 40-Hz ASSR in 34 patients with recent-onset schizophrenia (ROSZ), 28 ultra-high risk (UHR) individuals, and 30 healthy controls (HCs) at baseline. After 1–2?years, we evaluated the global assessment of functioning (GAF) in the ROSZ (N?=?20) and UHR (N?=?20) groups.Results
The 40-Hz ASSR was significantly reduced in the ROSZ and UHR groups. The attenuated 40-Hz ASSR was correlated with the future global symptomatic outcome in the ROSZ, but not in the UHR groups.Conclusions
A reduction in the gamma-band ASSR after the onset of psychosis may predict symptomatic outcomes in early psychosis.Significance
Gamma-band ASSR may be a potentially useful biomarker of the long-term prognosis in patients with recent-onset schizophrenia. 相似文献20.
Yoshiki Oitani Akihiko Ishiyama Motomichi Kosuga Kentaro Iwasawa Ayako Ogata Fumiko Tanaka Eri Takeshita Yuko Shimizu-Motohashi Hirofumi Komaki Ichizo Nishino Torayuki Okuyama Masayuki Sasaki 《Brain & development》2018,40(9):837-840