共查询到19条相似文献,搜索用时 62 毫秒
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丙泊酚载药脂肪乳的处方及工艺研究 总被引:1,自引:0,他引:1
目的:考查处方和制备工艺对丙泊酚载药脂肪乳稳定性的影响。方法:以注射用大豆油为油相,大豆磷脂和泊洛沙姆为乳化剂,在单因素考查的基础上采用正交设计优化了大豆油、乳化剂和稳定剂的用量,并优化了制备工艺。结果:乳剂的最优处方为10%油相,1.2%乳化剂,1.0%稳定剂,最优工艺为水相和油相在55℃混合,10000 r/min均质5min,4.14×105Pa压力下通过微射流仪6次。结论:制得的丙泊酚乳剂物理稳定性良好,为进一步研究丙泊酚注射乳剂奠定了一定的基础。 相似文献
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微球作为新型给药载体,在提高药物稳定性、生物利用度尤其在药物缓控释,靶向方面优势明显,而这些优势在很大程度上取决于所选载体材料。就根据制备微球的常用载体的特点及具体制备方法进行了综述。 相似文献
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目的:制备水飞蓟宾脂肪乳并对其体外释放进行考察。方法:在单因素试验的基础上,采用正交试验设计优化水飞蓟宾脂肪乳处方。采用高压均质法制备水飞蓟宾脂肪乳。结果:脂肪乳平均粒径为(74.42±14) nm,粒径分布系数( PDI)为0.106,Zeta电位为(-30.2±2.13)mV,pH为6.48±0.04,包封率(91.45±0.0052)%,体外12 h内,累积释放原药的90%左右。结论:本试验获得了较理想的水飞蓟宾脂肪乳,其体外释放具有显著的缓释作用。 相似文献
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口服载药纳米粒的研究进展 总被引:1,自引:0,他引:1
综述近年来口服载药纳米粒的有关研究进展,着重从制备方法、表面修饰、药物释放及应用几个方面进行介绍。作为一种新型给药系统,纳米粒在口服给药方面具有广阔的开发及应用前景。 相似文献
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通过查阅国内外相关文献,对近几年静脉注射脂肪乳制剂学方面的研究进行分析综合,为静脉注射脂肪乳的工艺研究提供参考.结果表明静脉注射脂肪乳是一些水溶性差的药物的良好载体,用不同处方和方法制备而成的乳剂在制剂质量上有较大差别.影响其制剂质量的因素主要有处方组成和制备方法. 相似文献
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脂肪乳剂是肠外营养液中非蛋白能源之一,不仅能提供热能和必需脂肪酸,还能维持细胞结构和功能,影响机体免疫功能,有助于疾病康复。不同脂肪乳剂不同的代谢特点决定了其在临床的不同应用。本文对脂肪乳剂的临床应用进展作一综述。 相似文献
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Matilde Zaballos Ignacio Fernández Arturo Melone Lucía Rodríguez Olalla Varela Sergio García Oscar Quintela Elena Vazquez María José Anadón Jesús Almendral 《Basic & clinical pharmacology & toxicology》2023,132(2):211-222
Ropivacaine has been described as a safer local anaesthetic (LA); however, serious cardiotoxic accidents have been reported. Intravenous-lipid-emulsion (ILE) therapy during LA intoxication seems to act as an antidote. Sodium bicarbonate is the standard treatment for sodium channel blocker drug toxicity. We compared both antidotes on the reversion of electrophysiologic toxicity induced by ropivacaine. Ropivacaine 5 mg kg−1 was administered in 24 pigs, and 3 min later, the animals received ILE: 1.5 ml kg−1 + 0.25 ml kg−1 min−1 (ILE group); sodium bicarbonate: 2 mEq kg−1 + 1 mEq kg−1 h−1 (NaHCO3 group); saline solution (CTL group). Electrophysiological parameters were evaluated for 30 min. The area under the curve (AUC) for the first 5 or 30 min was compared between groups. Ropivacaine induced a lengthening of the PR interval by 17% (P = 0.0001), His-ventricle-interval by 58% (P = 0.001), sinus QRS complex by 56% (P = 0.0001), paced QRS at 150 bpm by 257% (P = 0.0001), and at 120 bpm by 143% (P = 0.0001) in all groups. At 5 min after treatment, sinus QRS in the NaHCO3 group was shorter than that in the CTL group (AUCQRS5, P = 0.003) or ILE group (AUCQRS5, P = 0.045). During the first minute, seven of the animals in the NaHCO3 group vs. two in the ILE or 0 in the CTL group recovered more than 30% of the sinus QRS previously lengthened by ropivacaine (P = 0.003). Sodium bicarbonate reversed the electrophysiological toxicity of ropivacaine faster than ILE and control groups. 相似文献
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Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. PM-loaded CLEs (PM-CLEs) were prepared through emulsifying/high-pressure homogenisation and characterised by particle size, ζ potential and morphology. The resulting PM-CLEs possessed a particle size of 192?nm and ζ potential of 45?mV around. In vitro release illustrated that PM was released less from CLEs. Corneal bioadhesion test showed that PM-CLEs exhibited an enhanced ocular residence time. Improved anti-infective activity was achieved in the model of fungus-induced keratitis. Furthermore, PM-CLEs demonstrated predominant cellular uptake and internalisation in the corneal epithelial cells. These results provide proof of concept that CLEs are promising bioadhesive carriers for ophthalmic delivery of PM. 相似文献
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人参皂苷C-K静脉乳剂的制备及理化性质考察 总被引:2,自引:0,他引:2
目的研究人参皂苷C K静脉乳剂的处方及制备工艺 ,并对其理化性质进行考察。方法以人参皂苷C K为原料 ,以精制豆磷脂为乳化剂 ,加入适量的辅助乳化剂、稳定剂 ,用正交实验法优化乳剂的处方及工艺 ;用加速实验法考察乳剂的理化性质。结果制备的乳剂符合《中华人民共和国药典》对静脉乳剂的要求 ,经过影响因素试验确定了乳剂的储存条件。结论制备的乳剂性质稳定 ,为乳剂的进一步开发奠定了基础 相似文献
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Marina Gallarate Michele Trotta Luigi Battaglia Daniela Chirio 《Journal of microencapsulation》2013,30(5):394-402
AbstractA method to produce solid lipid nanoparticles (SLN) from W/O/W multiple emulsions was developed applying the solvent-in-water emulsion-diffusion technique. Insulin was chosen as hydrophilic peptide drug to be dissolved in the acidic inner aqueous phase of multiple emulsions and to be consequently carried in SLN. Several partially water-miscible solvents with low toxicity were screened in order to optimize emulsions and SLN composition, after assessing that insulin did not undergo any chemical modification in the presence of the different solvents and under the production process conditions. SLN of spherical shape and with mean diameters in the 600–1200 nm range were obtained by simple water dilution of the W/O/W emulsion. Best results, in terms of SLN mean diameter and encapsulation efficiencies, were obtained using glyceryl monostearate as lipid matrix, butyl lactate as a solvent, and soy lecithin and Pluronic®F68 as surfactants. Encapsulation efficiencies up to 40% of the loaded amount were obtained, owing to the actual multiplicity of the system; the use of multiple emulsion-derived SLN can be considered a useful strategy to encapsulate a hydrophilic drug in a lipid matrix. 相似文献