腹腔镜下骶前神经切断术治疗子宫内膜异位症痛经

子宫内膜异位症是妇科常见疾病之一。而痛经又是子宫内膜异位症的主要症状 ,严重者常影响日常生活与工作。腹腔镜下骶前神经切断术治疗盆腔痛有损伤小、恢复快、疗效确切之优点 ,现将手术方法及治疗效果介绍如下。1　资料与方法1 1　一般情况　 8例患者年龄 2 5～ 34岁 ,平均 2 9 4岁。病程最短 3年 ,最长 10年 ,平均 6 8年。术前诊断均为子宫内膜异位症。诊断依据[1] :①病史 :8例均为典型的继发性、进行性加剧之痛经 ;②妇科三合诊检查 :8例均有子宫骶骨韧带明显的触痛或结节 ;③Ｂ超 :2例有卵巢巧克力囊肿者 ,Ｂ超声像图均符合子宫内膜…     

腹腔镜下骶前神经切断术联合病灶电灼术治疗子宫内膜异位症的临床观察

子宫内膜异位症是妇科常见病，而痛经又是子宫内膜异位症的主要症状之一，严重者常影响日常工作与生活。目前，用药物或物理治疗子宫内膜异位症痛经的效果均不理想。近年来，随着腹腔镜手术技术的进步及其在妇科领域的广泛应用，使腹腔镜下骶前神经切断术日臻成熟，应用于临床取得了较好的疗效。我院从2000年3月至2003年10月，在腹腔镜下行骶前神经切断术联合病灶电灼术治疗子宫内膜异位症痛经患者21例，现将结果报道如下。     

腹腔镜子宫骶神经切断术治疗子宫内膜异位症疼痛的多中心前瞻性对照研究

目的:研究、评价腹腔镜子宫骶神经切断术(LUNA)治疗子宫内膜异位症疼痛的安全性和有效性。方法:应用多中心随机对照的前瞻性研究方法,收集82例中、重度痛经患者的临床资料,分析比较同时行LUNA对子宫内膜异位症保守手术后各种疼痛缓解率的影响,并评价手术的安全性。结果:71例患者纳入分析,LUNA组51例,对照组20例。LUNA组术后痛经缓解率90.2%,高于对照组的60.0%(P=0.02);LUNA组性交痛术后缓解率85.7%,高于对照组的50.0%(P=0.048);LUNA组慢性盆腔痛(CPP)缓解率100%,高于对照组的71.4%(P=0.041),差异均有统计学意义。手术安全性:LUNA组患者手术时间延长,术后肛门排气时间延长,但两组术中出血量、术后体温、住院时间、总住院费用以及手术费用均无统计学差异。所有研究对象均无手术并发症发生。结论:内异症保守手术同时行LUNA手术,术后2年内能有效的缓解内异症的各种疼痛。     

腹腔镜下骶前神经切断术治疗子宫内膜异位症痛经

子宫内膜异位症(内异症)是妇科的常见病，目前对其痛经的治疗方法仍不理想。我院于1999年1月～2001年12月在腹腔镜下行骶前神经切断术治疗内异症痛经患者28例，效果较满意，报告如下。     

经阴道骶棘韧带固定术治疗子宫脱垂的疗效分析

目的：观察经阴道骶棘韧带固定术（SSLF）治疗子宫脱垂的临床疗效。方法：33例子宫脱垂患者患者随机分为两组,研究组采用经阴道骶棘韧带固定术,对照组采用腹腔镜高位宫骶韧带悬吊术,对比两组的手术时间、出血量、治疗效果及尿道感染的发生率、住院费用。术后随访对比两组子宫脱垂的复发率、术后症状。结果：在手术时间、术中出血量、治疗有效率、尿道感染发生率、1年复发率及随访症状方面,两组之间比较差异无统计学意义（P〉0．05）,在住院费用方面VSSLF比腹腔镜下骶棘韧带固定术低（P〈0．05）。结论：对子宫脱垂这种疾病,经阴道的骶棘韧带固定术和腹腔镜高位宫骶韧带悬吊术这两种术式都能达到较好效果,而VSSLF经济、简易,器械要求不高,值得推广。     

浸润宫骶韧带的后腹膜子宫内膜异位症腹腔镜治疗的技术及疗效

为评价腹腔镜手术治疗子宫内膜异位症(内异症)浸润宫骶韧带而引起盆腔疼痛的疗效,选择内异症浸润宫骶韧带的患者除外累及邻近脏器如乙状结肠、输尿管、直肠阴道隔等。术前行乙状结肠镜、直肠超声、静脉肾盂造影及妇科三合诊,以了解内异灶累及范围。术前常规准备。术时先分解盆腔粘连,     

腹腔镜下神经切断术治疗原发性痛经

传统的治疗原发性痛经的药物如口服避孕药及非甾体类消炎药能缓解多数患者的痛经程度,但仍有部分患者对药物治疗无反应.目益增多的研究证据表明,可以采用神经切断术用于药物治疗无效的顽固性痛经.有限的临床证据显示,腹腔镜下子宫神经消融术能够改善原发性痛经患者痛经症状,但其疗效可能逐渐消退;而腹腔镜下骶前神经切断术能更有效地缓解药...     

腹腔镜下骶前神经溶解术治疗子宫内膜异位症引起的盆腔痛

腹腔镜下骶前神经溶解术治疗子宫内膜异位症引起的盆腔痛@Soysal ME @刘素萍     

小开腹术辅助阴式子宫切除术

1993年11月～1994年4月间对26例患子宫肌瘤合并子宫内膜异位症(内异症)的经产妇行小开腹术辅助阴式子宫切除术。阴道部分的手术步骤与传统的阴式子宫切除相同,环切宫颈周围组织,钳夹宫骶韧带、主韧带,切断并结扎。自前或后腹膜进入     

神经纤维束状浸润与深部浸润型子宫内膜异位症疼痛相关性研究

目的探讨深部浸润型子宫内膜异位症(DIE)宫骶韧带病灶及阴道直肠隔病灶中神经纤维束状浸润(NFBI)情况及其与患者疼痛的相关性。方法收集2012-06-01—2015-01-01在中山大学附属第一医院妇科行手术治疗的64例DIE患者,采用免疫组化的方法分别检测宫骶韧带病灶和阴道直肠隔病灶中神经纤维蛋白基因产物9.5(PGP9.5)和GAP-43染色阳性的神经纤维。根据是否存在神经纤维束状浸润分为两组:NFBI阳性组和NFBI阴性组。比较两组患者痛经、肛门坠胀痛、性交痛和慢性盆腔痛程度,并探讨二者之间新生神经纤维密度的差异。结果宫骶韧带DIE病灶中NFBI阳性组痛经、肛门坠胀痛和慢性盆腔痛评分均比NFBI阴性组高,差异有统计学意义(均P0.05);性交痛评分两组差异无统计学意义(P=0.12)。阴道直肠隔DIE病灶中NFBI阳性组痛经、肛门坠胀痛、性交痛和慢性盆腔痛评分均比NFBI阴性组高,差异均有统计学意义(均P0.05)。宫骶韧带DIE病灶和阴道直肠隔DIE病灶中NFBI阳性患者的新生神经纤维(GAP-43染色阳性的神经)密度均比NFBI阴性患者高,差异均有统计学意义(P=0.001,P=0.007)。结论深部浸润型子宫内膜异位症病灶中神经纤维束状浸润与患者疼痛的严重程度相关,其原因之一可能是刺激新生神经纤维生长增加。     

Effectiveness of presacral neurectomy in women with severe dysmenorrhea caused by endometriosis who were treated with laparoscopic conservative surgery: a 1-year prospective randomized double-blind controlled trial

OBJECTIVE: The purpose of this study was to assess the effectiveness of presacral neurectomy in women with severe dysmenorrhea caused by endometriosis that was treated with conservative surgical intervention. STUDY DESIGN: One hundred forty-one sexually active women of fertile age with chronic severe dysmenorrhea caused by endometriosis were treated with conservative laparoscopic surgery. Patients were assigned randomly to not receive (group A) or receive (group B) presacral neurectomy. At 6 and 12 months after the surgical procedures, the cure rate was evaluated in each patient. The frequency and severity of dysmenorrhea, dyspareunia, and chronic pelvic pain were also evaluated at the same time intervals. RESULTS: The cure rate was significantly higher in group B compared with group A at a follow-up examination at 6 months (87.3% vs 60.3%) and 12 months (85.7% vs 57.1%). At follow-up visits, the frequency and severity of dysmenorrhea, dyspareunia, and chronic pelvic pain were significantly lower in both groups compared with baseline values; in particular, significantly lower values were observed in group B versus group A for the severity. CONCLUSION: Presacral neurectomy improves the cure rate in women who are treated with conservative laparoscopic surgery for severe dysmenorrhea caused by endometriosis.     

Surgical interruption of pelvic nerve pathways in dysmenorrhea: a systematic review of effectiveness

OBJECTIVES: To assess the effectiveness of surgical interruption of pelvic nerve pathways in primary and secondary dysmenorrhea. Data sources. The Cochrane Menstrual Disorders and Subfertility Group Trials Register (9 June 2004), CENTRAL (The Cochrane Library, Issue 2, 2004), MEDLINE (1966 to Nov. 2003), EMBASE (1980 to Nov. 2003), CINAHL (1982 to Oct. 2003), MetaRegister of Controlled Trials, the citation lists of review articles and included trials, and contact with the corresponding author of each included trial. REVIEW METHODS: The inclusion criteria were randomized controlled trials of uterosacral nerve ablation or presacral neurectomy (both open and laparoscopic procedures) for the treatment of dysmenorrhea. The main outcome measures were pain relief and adverse effects. Two reviewers extracted data on characteristics of the study quality and the population, intervention, and outcome independently. RESULTS: Nine randomized controlled trials were included in the systematic review. There were two trials with open presacral neurectomy; all other trials used laparoscopic techniques. For the treatment of primary dysmenorrhea, laparoscopic uterosacral nerve ablation at 12 months was better when compared to a control or no treatment (OR 6.12; 95% CI 1.78-21.03). The comparison of laparoscopic uterosacral nerve ablation with presacral neurectomy for primary dysmenorrhea showed that at 12 months follow-up, presacral neurectomy was more effective (OR 0.10; 95% CI 0.03-0.32). In secondary dysmenorrhea, along with laparoscopic surgical treatment of endometriosis, the addition of laparoscopic uterosacral nerve ablation did not improve the pain relief (OR 0.77; 95% CI 0.43-1.39), while presacral neurectomy did (OR 3.14; 95% CI 1.59-6.21). Adverse events were more common for presacral neurectomy than procedures without presacral neurectomy (OR 14.6; 95% CI 5-42.5). CONCLUSION: The evidence for nerve interruption in the management of dysmenorrhea is limited. Methodologically sound and sufficiently powered randomized controlled trials are needed.     

Presacral neurectomy for chronic pelvic pain

Over an eight-year period, 50 presacral neurectomies were performed at Madigan Army Medical Center for chronic pelvic pain failing response to medical management. Each hospital record was reviewed and 45 patients answered a questionnaire grading the severity of their pain from 0 to 10 for dysmenorrhea, dyspareunia, and other pelvic pain before and after surgery. The results showed success rates of 73% in relieving dysmenorrhea, 77% in relieving dyspareunia, and 63% in relieving other pelvic pains. The addition of a bilateral uterosacral ligament resection to the presacral neurectomy did not increase the success rate. There was an 18% lateral pelvic pain recurrence rate, and no recurrence of dysmenorrhea. Complications occurred in 4%.     

Pelvic denervation for chronic pain associated with endometriosis: fact or fancy?

The efficacy of presacral neurectomy and amputation of the uterosacral ligaments in the treatment of chronic pelvic pain has been debated for decades. These procedures used to be done mainly in women with normal pelves, but more recently they have been performed during conservative surgery for treatment of endometriosis. In the 1980s the rapid spread of laparoscopic surgery has led to an increasing number of endoscopic denervations in patients with chronic pelvic pain associated with endometriosis. However, an analysis of literature data has failed to prove that presacral neurectomy and amputation of the uterosacral ligaments are effective and did not demonstrate better results with the use of lasers rather than electrocoagulation. Moreover, no valid comparison has yet been made between laparotomy and laparoscopic methods.     

Presacral neurectomy for the treatment of pelvic pain associated with endometriosis: a controlled study.

OBJECTIVE: Our objective was to evaluate the efficacy of presacral neurectomy combined with conservative surgery for the treatment of pelvic pain associated with endometriosis. STUDY DESIGN: In a randomized, controlled study performed in a tertiary institution 71 patients with moderate or severe endometriosis and midline dysmenorrhea were randomly assigned to conservative surgery alone (n = 36) or conservative surgery and presacral neurectomy (n = 35). Main outcome measures were relief of dysmenorrhea, pelvic pain, and deep dyspareunia after surgery according to a multidimensional and an analog pain scale. RESULTS: Presacral neurectomy markedly reduced the midline component of menstrual pain, but no statistically significant differences were observed between the two groups in the frequency and severity of dysmenorrhea, pelvic pain, and dyspareunia in the long-term follow-up. After presacral neurectomy, constipation developed or worsened in 13 patients and urinary urgency occurred in three and a painless first stage of labor in two. CONCLUSION: Presacral neurectomy should be combined with conservative surgery for endometriosis only in selected cases.     

The efficacy of presacral neurectomy for the relief of midline dysmenorrhea

The present study was undertaken to evaluate prospectively the efficacy of presacral neurectomy for the treatment of midline dysmenorrhea. All patients had moderate to severe dysmenorrhea and stage III-IV endometriosis. Of the patients undergoing presacral neurectomy (N = 17), only two had a recurrence of pain. The remainder of the patients undergoing presacral neurectomy remain pain-free at 42 months of follow-up. Of the patients undergoing resection of endometriosis but not presacral neurectomy (N = 9), none received relief of midline pain. Relief of lateral pain, back pain, and dyspareunia was variable in both groups. Our findings corroborate previous retrospective studies showing that presacral neurectomy is highly effective in the treatment of dysmenorrhea. We speculate that the most common reasons for failure of presacral neurectomy are inappropriate selection of patients and incomplete resection of the presacral nerve plexus.     

Laparoscopic presacral neurectomy. Results of the first 25 cases

Since the 1960s, medical therapy utilizing nonsteroidal antiinflammatory drugs and oral contraceptives with the addition of danazol and gonadotropin releasing hormone have become the treatment of choice for chronic pelvic pain and dysmenorrhea. The surgical approach to this problem, incorporating interruption of the superior hypogastric nerve plexus (presacral neurectomy), therefore, has become less popular. Investigations, however, have demonstrated that 20-25% of patients treated medically for this problem fail to show an improvement. As a result, attention has turned once again toward surgical treatment for those who have failed to respond to medical management. Laparoscopic uterosacral nerve ablation, or laparoscopic uterine nerve ablation, appears to offer hope in this regard and represents a return to a surgical approach for conservative management of severe, disabling dysmenorrhea and pelvic pain in women who have failed medical treatment. Since there has been such an emphasis on outpatient treatment and surgery, a laparoscopic approach to the classic presacral neurectomy was devised and implemented.     

Long-term effectiveness of presacral neurectomy for the treatment of severe dysmenorrhea due to endometriosis

STUDY OBJECTIVE: To assess the long-term effectiveness of presacral neurectomy (PSN) in women with severe dysmenorrhea due to endometriosis treated with conservative laparoscopic surgical intervention. DESIGN: Randomized, controlled trial (Canadian Task Force classification I). SETTING: University-affiliated department of obstetrics and gynecology. PATIENTS: One hundred forty-one sexually active women of reproductive age. INTERVENTION: Conservative laparoscopic surgery without (group A) or with (group B) PSN. MEASUREMENTS AND MAIN RESULTS: At entry and 24-months after surgical procedures, cure rates; frequency and severity of dysmenorrhea, dyspareunia, and chronic pelvic pain; and quality of life were evaluated. At follow-up visit, the cure rate was significantly (P<0.05) higher in group B (83.3%) than in group A (53.3%). The frequency and severity of dysmenorrhea, dyspareunia, and chronic pelvic pain were significantly (P<0.05) lower in both groups compared with baseline values, and only severity was significantly (P<0.05) lower in group B. A significant (P<0.05) improvement in quality of life was observed after surgery in both groups and was significantly (P<0.05) increased in group B compared with group A. CONCLUSION: PSN improves long-term cure rates and quality of life in women treated with conservative laparoscopic surgery for severe dysmenorrhea due to endometriosis.     

Laparoscopic uterosacral ligament resection for dysmenorrhea associated with endometriosis: results of a randomized,controlled trial

OBJECTIVE: To evaluate the efficacy of laparoscopic resection of the uterosacral ligaments in women with endometriosis and predominantly midline dysmenorrhea. DESIGN: Randomized controlled trial. SETTING: Two academic departments.One hundred eighty patients undergoing operative laparoscopy as first-line therapy for stage I to IV symptomatic endometriosis. INTERVENTION(S): Operative laparoscopy including uterosacral ligament resection or conservative surgery alone. MAIN OUTCOME MEASURE(S): Proportion of women with recurrence of moderate or severe dysmenorrhea 1 year after surgery. RESULT(S): No complications occurred. Among the patients who were evaluable 1 year after operative laparoscopy, 23 of 78 (29%) women who had uterosacral ligament resection and 21 of 78 (27%) women who had conservative surgery only reported recurrent dysmenorrhea. The corresponding numbers of patients at 3 years were 21 of 59 (36%) women and 18 of 57 (32%) women, respectively. Time to recurrence was similar in the two groups. Pain was substantially reduced, and patients in both groups experienced similar and significant improvements in health-related quality of life, psychiatric profile, and sexual satisfaction. Overall, 68 of 90 (75%) patients in the uterosacral ligament resection group and 67 of 90 (74%) patients in the conservative surgery group were satisfied at 1 year. CONCLUSION(S): Addition of uterosacral ligament resection to conservative laparoscopic surgery for endometriosis did not reduce the medium- or long-term frequency and severity of recurrence of dysmenorrhea.     

Pelvic denervation procedures: A current reappraisal

The introduction of minimally invasive techniques over recent years has led to the resurgence of pelvic denervation procedures such as presacral neurectomy and uterine nerve ablation being performed for women with dysmenorrhea and pelvic pain. Women who have failed medical therapy with persistent and debilitating symptoms may certainly benefit from these procedures. However, presacral neurectomy and uterine nerve ablation are distinct procedures that require appropriate patient selection in order to optimize pain relief. Whereas presacral neurectomy may be effective for both primary dysmenorrhea and endometriosis-related pelvic pain, the role of uterine nerve ablation should be reserved for patients with primary dysmenorrhea only, as evidenced by several randomized trials.