Usefulness of hydrogen peroxide enhancement in diagnosis of anal and ano-vaginal fistulas

Our objective was to assess if contrast-enhanced (CE) anal endosonography (AES) with hydrogen peroxide is useful in the diagnosis of anal and ano-vaginal fistulas. A Bruel and Kjaer scanner with a 7.0-MHz transducer was used. After visualization of the fistula tract in non-contrast (NC) AES, hydrogen peroxide was introduced into the fistula tract through the external opening in 22 patients with different types of anal fistulas. Both CE and NC AES revealed 13 transsphincteric, 3 intersphincteric, 2 suprasphincteric and 4 ano-vaginal fistulas. Simple tracts were found in 16 cases and complex in 6 cases in non-contrast AES. The CE AES revealed 19 simple and 3 complex fistulas. Fifteen internal openings visible in NC AES were confirmed in CE AES in 6 cases, which additionally found 11 more internal openings. Surgery confirmed all types of fistulas found in NC and CE AES; however, the latter two found 18 simple and 4 complex fistulas, and 21 internal openings. Both NC and CE AES are able to correctly differentiate types of anal fistulas and are of comparable value in differentiating simple from complex fistulas, although a false-negative result was found in CE AES. In the preoperative assessment of the internal opening, CE AES is superior to NC AES. Electronic Publication     

肛瘘的术前MRI表现与手术结果的对照分析

目的 探讨术前MRI检查对肛瘘诊断及分型的价值.方法 回顾性分析经手术证实的36例肛瘘患者的临床资料及MRI表现,并与手术结果对照分析,总结肛瘘的MRI表现特点及应用价值.结果 36例肛瘘手术显示内口42个,主瘘管45条、瘘管分支15条,外口42个,脓肿16个.与手术结果对照,MRI显示肛瘘内口的准确率为90.5%(38/42个),显示瘘管分支的准确率为80%(12/15条),显示主瘘管、外口及脓肿的准确率均为100%.按照Parks分型,MRI分型符合率为88.9%(32/36例).结论 MRI能准确显示肛瘘内、外口的位置,瘘管的数量及走行,能够对肛瘘进行准确分型.     

3.0T高分辨率磁共振成像在肛瘘诊断及分型中的应用

目的探讨3.0T高分辨MRI在肛瘘术前诊断及分型的应用价值。方法选取经手术证实的51例肛瘘患者的临床资料及MRI表现,并与手术结果对照分析,总结肛瘘的MRI表现特点及应用价值。结果51例肛瘘手术显示内口56个,外口43个,主瘘管51条、瘘管分支14条,脓肿16个。与手术结果对照,术前MRI显示肛瘘内、外口、主瘘管及支管的准确率分别为94.64%(53/56个)、100%(43/43个)、94.12%(48/51条)及85.71%(12/14条),对脓肿显示的准确率为100%(16/16个)。按照Parks分型,51例患者MRI共检出括约肌间型肛瘘23例(45.10%),经括约肌型肛瘘17例(33.33%),括约肌上型肛瘘7例(13.73%),括约肌外型肛瘘4例(7.84%),MRI分型准确率为96.08%(49/51例)。MRI在肛瘘Parks分型上与手术结果一致性高,差异无统计学意义(P>0.05)。结论MRI能准确显示肛瘘内、外口的位置,瘘管的数量及走行,能够对肛瘘进行准确分型。     

磁共振成像对肛瘘分级的价值

目的探讨磁共振成像（MRI）对肛瘘分级价值。方法经手术证实的肛瘘患者26例,全部行MRI检查,检查序列主要包括轴面T1WI、T2WI和轴面、冠状面抑脂T2WI序列。结果 26例肛瘘中,Ⅰ级10例,Ⅱ级6例,Ⅲ级5例,Ⅳ级3例,Ⅴ级2例。MRI诊断26例肛瘘中共有28个瘘管,26个内口,31个外口,14个脓肿,敏感度分别达93%、93%、97%、100%。结论 MRI可以对肛瘘准确分级,对正确的手术治疗非常重要。     

超声、CT及MRI在评价体表窦瘘中的对照研究

目的:探讨CT、MRI及超声检查在体表窦瘘中的应用价值。方法:回顾性分析53例体表窦瘘患者的临床和影像资料,患者术前均行CT、MRI及超声检查,对照手术所见,评价3种影像学方法对体表窦瘘的诊断准确率及对复杂性窦瘘支管、脓肿及内口显示的敏感度。结果:53例中,单纯窦道22例,复杂性窦瘘31例。单纯窦道患者CT、MRI及超声检查的准确率分别为100%、100%、95.45%,其差异无统计学意义(P0.05);复杂性窦瘘患者CT、MRI及超声检查的准确率分别为93.55%、96.77%、70.97%,其差异有统计学意义(P0.05),CT与MRI的准确率优于超声,而CT与MRI的诊断准确率差异无统计学意义(P0.05)。CT、MRI及超声检查对复杂性窦瘘支管的敏感度分别为95.24%、98.41%、55.56%,脓肿的敏感度分别为90.00%、100%、70.00%,内口的敏感度分别为80.00%、80.00%、40.00%。对于支管显示的敏感度,CT与MRI高于超声(P0.05),CT与MRI间差异无统计学意义(P0.05)。对于脓肿及内口显示的敏感度,三者间差异无统计学意义(P0.05)。结论:对于单纯窦道,超声检查方便经济;复杂性窦瘘,CT、MRI检查存在很大优势。     

3.0 T MRI在复杂型肛瘘术前诊断中的应用

目的:探讨3.0T MRI在复杂型肛瘘术前诊断中的应用价值。方法:收集21例经手术治疗的复杂型肛瘘患者的临床及影像资料,患者均行MRI平扫及增强扫描,对比手术结果,评价复杂型肛瘘的MRI分级及MRI诊断主管、支管、内口、脓肿的准确性。结果:复杂型瘘管T1WI可见10条或多条状等或稍低信号,T2WI、T2WI抑脂及SPAIR为高信号,增强扫描示瘘管壁明显强化、脓液不强化。MRI诊断与手术所见对照,显示肛瘘内口、外口、主管、支管和脓肿符合率分别为88.00%、100%、97.37%、70.00%和100%。结论:MRI在复杂型肛瘘术前诊断中具有较大的实用价值。     

Image-guided surgery for anal fistula in a 0.5T interventional MRI unit

PURPOSE: To determine whether MR-guided anorectal surgery is feasible, and to develop techniques for MR-guided anal fistula surgery. MATERIALS AND METHODS: Six patients with pilonidal sinus (PNS), and 21 with suspected anal fistulae were operated on in the GE Signa SPIO 0.5T interventional MRI unit. Procedures were performed with magnet-safe Lockhart-Mummery fistula probes. Preprocedural and intra-operative MRI (IOMRI) techniques were used to identify the extent of the fistula tracts and septic foci, and to ensure the adequacy of the surgical procedure. RESULTS: IOMRI demonstrated the PNS lesions and the adequacy of excision. Imaging failed to demonstrate a fistula in two patients, as confirmed by surgical examination. No images were obtained in one patient due to his size (weight in excess of 100 kg). In 18 patients a fistula tract or abscess was demonstrated and IOMRI was used to assess the adequacy of the surgical procedure. In three patients this demonstrated incomplete drainage of septic foci, which was not obvious on inspection of the surgical field. We believe that in these patients IOMRI prevented an incomplete procedure and the potential requirement for a second operation. Further surgery was performed to rectify this situation. The fistula tract was laid open in 13 patients, and a Seton drain was inserted in five. CONCLUSION: MRI-guided surgery for anal fistula is feasible. IOMRI demonstrates the exact anatomy of the tracts and abscesses, and confirms that all have been adequately treated. We believe it may become particularly useful in surgery for recurrent and complex anal fistulae, and may lead to fewer recurrences.     

CO2激光治疗肛瘘185例报告

为总结ＣＯ２激光治疗肛瘘的方法及经验，应用ＣＯ２激光治疗１８５例肛瘘患者。低位单纯性肛瘘１６５例、低位复杂性肛瘘１４例、高位单纯性肛瘘３例、高位复杂性肛瘘３例。采用布比卡因、亚甲蓝肛管部浸润麻醉，持ＣＯ２激光沿瘘管外壁剔除全部瘘管；或者切开全部瘘管后，用激光光束汽化、凝固管腔内的腐烂组织及管壁的瘢痕组织。高位瘘管应与挂线疗法相结合，范围广泛的肛瘘应分期手术。经１～６年临床观察，痊愈者１８３例（治愈率９８．９％）、复发２例（复发率１．１％）。该法具有止血效果好、抗感染作用强、术后痛苦小、瘢痕小、肛门不变形、操作简单、不需住院等优点。     

质子加权预饱和脂肪抑制序列在肛瘘中的应用价值

目的评价质子加权预饱和脂肪抑制序列(PDW PFS)对肛瘘显示的准确性及图像质量的清晰性,探讨PDW PFS在肛瘘中的应用价值。资料与方法 20例经手术证实的肛瘘患者术前进行MRI检查,序列包括T1WI、T2W频谱选择性衰减反转恢复序列(SPAIR)和PDW PFS。MRI检查前均向患者肛管直肠内置入肛肠水囊以撑开肛管和直肠。获得图像后,观察患者的瘘管、内口和肛周脓肿,评估和比较MRI各序列显示的瘘管、内口、脓腔,并对PDW PFS和T2W SPAIR序列瘘管的信号强度(SI)、信噪比(SNR)及瘘管与周围肌肉的对比噪声比(CNR)进行测量及比较。结果 PDW PFS序列显示瘘管(100%)、内口(95.7%)、肛周脓肿(100%)的准确率较T1WI及T2WSPAIR序列为高。Kruskal Wallis检验显示上述各序列对瘘管(χ2=6.95,P<0.05)及内口(χ2=31.53,P<0.05)的显示具有显著统计学差异,PDW PFS序列显示瘘管及内口最多。PDW PFS序列SI、SNR值和CNR值均显著高于T2W SPAIR序列(P<0.05)。结论 PDW PFS成像技术具有较高的图像SNR和CNR,更易认识辨别瘘管和内口,可以作为一种新的无创性磁共振成像技术应用于肛瘘成像。     

医源性肠外瘘的分型和CT表现

目的:探讨医源性肠外瘘的分型和CT表现.方法:对754例医源性肠外瘘实施了CT检查.参照临床分型,将肠外瘘分为管状瘘、唇状瘘和断端瘘三个类型,并分析其CT征象.结果:管状瘘所占比例最高(占68.70%),表现为内、外口之间不均匀的管道形成;唇状瘘(占31.30%)的CT征象特点是较大的外口,呈唇状改变,无瘘管形成.管状瘘的腹腔和腹膜后脓肿发生率明显高于唇状瘘(P＜0.01),而唇状瘘的肠壁炎性改变发生率较高(P＜0.01).结论:CT检查能够显示医源性肠外瘘的临床分型,对治疗具有指导性作用.     

Preoperative MR imaging of anal fistulas: Does it really help the surgeon?

PURPOSE: To evaluate the accuracy of magnetic resonance (MR) imaging with a quadrature phased-array coil for the detection of anal fistulas and to evaluate the additional clinical value of preoperative MR imaging, as compared with surgery alone. MATERIALS AND METHODS: Fifty-six patients with anal fistulas underwent high-spatial-resolution MR imaging. Twenty-four had a primary fistula; 17, a recurrent fistula; and 15, a fistula associated with Crohn disease. MR imaging findings were withheld from the surgeon until surgery ended and verified, and surgery continued when required. RESULTS: MR imaging provided important additional information in 12 (21%) of 56 patients. In patients with Crohn disease, the benefit was 40% (six of 15); in patients with recurrent fistulas, 24% (four of 17); and in patients with primary fistulas, 8% (two of 24). The difference between patients with or without Crohn disease and between patients with a simple fistula versus the rest was significant (P <.05). The sensitivity and specificity for detecting fistula tracks were 100% and 86%, respectively; abscesses, 96% and 97%, respectively; horseshoe fistulas, 100% and 100%, respectively; and internal openings, 96% and 90%, respectively. CONCLUSION: High-spatial-resolution MR imaging is accurate for detecting anal fistulas. It provides important additional information in patients with Crohn disease-related and recurrent anal fistulas and is recommended in their preoperative work-up.     

肛瘘磁共振成像:探讨自制可调节肛肠水囊在肛瘘分级中的价值

目的:探讨普通MR成像中使用自制可调节肛肠水囊在肛瘘患者分级中的应用价值.方法:18例经手术证实的肛瘘患者于使用自制可调节肛肠水囊前、后均各行一次MRI检查.序列包括T_1 WI横断位和冠状位、T_2 W SPAIR横断位,冠状位及矢状位.放置水囊前后比较瘘管末端位置,并且对瘘管、内口、分支及脓腔进行计数,同时观察瘘管走行.所获结果被用于评估肛瘘MR诊断分级,并同时与手术结果相对照.结果:18名肛瘘患者MRI检查共发现瘘管31根、内口22个、分支19根以及脓腔10个.使用水囊前后MRI对瘘管末端位置的显示有显著不同(χ~2=5.56,P<0.05).使用水囊前,MR显示1例1级低位单纯线形括约肌内肛瘘,1例低位和2例高位2级括约肌内肛瘘伴脓肿或分支,1例3级高位经括约肌肛瘘,6例4级经括约肌肛瘘伴脓肿或分支,其中5例为高位,1例为低位,2例5级高位肛提肌上和经肛提肌肛瘘,另有5例无法确定;使用水囊后,2级高位括约肌内肛瘘伴脓肿或分支上升为3例,4级低位经括约肌肛瘘伴脓肿或分支上升至2例,高位上升至7例,另有1例无法确定,余小变.使用水囊前后,M RI对肛瘘分级与手术的相符率分别为72%(13例)和94%(17例).结论:通过使用自制町凋节肛肠水囊,普通M RI能够获得更多有关瘘管及其走行的信息,有助于肛瘘患者的分级.     

高频线阵型超声诊断肛瘘的价值

目的: 探讨高频线阵型超声诊断肛瘘的价值.材料和方法: 使用GE Logiq 7型彩色超声波诊断仪及10 MHz高频线阵型探头对29例肛瘘患者进行检查, 并与手术结果对照.结果: 超声诊断括约肌间肛瘘17例内口22个、经括约肌肛瘘6例内口8个、括约肌上肛瘘4例、括约肌外肛瘘2例,与手术后诊断比较,肛瘘类型诊断符合率分别为17/17、6/6、3/4和1/2.结论: 高频线阵型超声能较清晰地显示肛瘘瘘管的部位、走行及内口,可为肛瘘的明确诊断和手术方案的制定提供较有价值的信息.     

Assessment of anal fistulas with high-resolution subtraction MR-fistulography: comparison with surgical findings

PURPOSE: To investigate a new MR-imaging protocol defined as subtraction MR-fistulography for the detection of fistula-in-ano. MATERIALS AND METHODS: A total of 36 patients (18 men, 18 women) with the clinical diagnosis of anal fistula or abscess who were scheduled for surgical exploration were preoperatively imaged at 1.5 T in the supine position; coronal STIR sequences and axial T1-weighted three-dimensional FLASH sequences before and after intravenous injection of gadobenate dimeglumine (Gd-BOPTA) were obtained. Image subtraction was routinely used. The image findings were compared with the findings at surgical exploration according to a uniform classification system. RESULTS: A total of 46 fistulas were seen on subtraction MR-fistulography, whereas surgery described 41 fistulas. MRI and surgery concordantly depicted a total number of 40 fistulas, six fistulas were only described by MRI, and one fistula was only seen during surgery. A total of 27 abscesses were detected with MRI, compared to 22 during surgery. A total of 22 abscesses were concordantly diagnosed. Complete agreement between subtraction MR-fistulography and surgery occurred in 32 (89%) of the 36 patients. The four patients in whom both procedures disagreed had complex anal sepsis with multiple fistulas and/or abscesses due to Crohn disease. CONCLUSION: High-resolution subtraction MR-fistulography is an important complement to surgical exploration and especially suitable for investigating complex anal sepsis.     

Role of color Doppler echography in the visualization of perianal fistulae with injections of physiologic solutions

PURPOSE: To prove the diagnostic value of color Doppler US in the evaluation of perianal external fistulae, using an endocavitary probe and a saline solution injection, in order to show the location of the fistulae, their extension, possible secondary tracts, residual abscesses and the relationship with adjacent tissues. MATERIAL AND METHODS: From October 1999 to December 1999, thirty-five consecutive patients (21 males and 14 females, mean age 47.5) affected with Crohn's disease were examined prospectively. These patients presented postoperative recurring external perianal fistulae. From this first group, 10 patients (6 males and 4 females, mean age 45) were selected as the external fistula was open. A biplanar transrectal 7.5 MHz probe was used for the examination. First the external opening of the fistula was cannulated with a soft plastic catheter. Then the probe, covered with a lubricated condom filled with US gel, was introduced into the anal canal (males) or the vagina (females). An initial gray-scale US study was performed. Finally the color-box was positioned on the tract, the Pulse Repetition Frequency (PRF) adjusted and the saline solution introduced. The study was completed with axial and linear scans. RESULTS: The mean examination duration was 31 minutes. Only two patients found the examination annoying because of partial anorectal stricture. The wall layers and their thickness were clearly located and distinguished. Gray-scale US showed the local anatomy in all patients. In 4 patients it depicted the primary fistula as a thin hypoecoic line (40%, three intersphinteric and one transphinteric). Color Doppler US detected the fistula in all patients (100%, seven intersphinteric and three transphinteric). Moreover it showed 2 small secondary tracts in 2 patients. No abscesses were found at the time of the examination. In the patients who underwent a second operation, surgical findings showed a good correlation (90-100%) with color Doppler findings. DISCUSSION AND CONCLUSIONS: This study demonstrated a greater diagnostic value of endosonography with color Doppler and saline solution injection as compared to conventional gray-scale endosonography in the evaluation of fistulae. Since this technique is also cost-effective and well tolerated by most patients we conclude that at present it makes an important diagnostic tool in the preoperative assessment of perianal fistulae.     

双源CT双能量血管成像对颈内动脉海绵窦瘘的诊断价值

目的 探讨双源CT双能量血管成像(DE-CTA)对颈内动脉海绵窦瘘(CCF)的诊断价值.方法 选择14例临床疑诊CCF的患者进行DE-CTA.利用直接能最减影后的数据进行去骨图像重组,同时将能量平均后数据进行非去骨图像重组.由4名多年从事脑血管疾病影像诊断的放射科医师独立分析图像,其中2名评价颈内动脉海绵窦段DE-CTA的图像质量,2名评价瘘口位置、数量、大小及有无异常的颅内静脉扩张,比较各种后处理方法对CCF瘘口及相关病变的显示情况.利用Kappa检验分析2名医师对图像质量评价的一致性.利用t检验及相关性分析评价去骨与非去骨重组图像测得的瘘口大小.结果 14例患者28条颈内动脉颅内段均可以满足影像评价标准.14例患者经行双能量直接去骨颅脑CTA检查均确诊为CCF,其中,病变位于双侧2例,左侧7例,右侧5例.14例患者共16处病变,非去骨及去骨重组图像均发现瘘口16处.去骨及非去骨重组图像测得瘘口的平均大小分别为(0.36±0.10)、(0.35±0.11)mm,两者差异无统计学意义(t=0.29,P＞0.05),且二者测量值之间有很好的相关性(r=0.97,P＜0.05).去骨重组图像发现8例患者13支大脑皮质静脉扩张,非去骨重组图像仅发现6例患者9支大脑皮质静脉扩张.结论 DE-CTA图像多种重组方法相结合对CCF的诊断和治疗方案的制定具有重要价值.

Abstract：

Objective To explore the clinical value of dual-energy CT angiography (DE-CTA) in the diagnosis of carotid cavernous fistula. Methods Fourteen patients suspected of carotid cavernous fistula underwent DE-CTA between Dec. 2008 and Feb. 2010. Image post-processing of DE-CTA was performed with the dedicated software to obtain bone-removal and non bone-removal images. Four experienced radiologists evaluated image quality of DE-CTA, the number, location and size of fistulae and dilation of cerebral veins. The bone-removal and non bone-removal images were compared for displaying of fistulae and other related lesions. Kappa test was used to test the consistency of image quality evaluation between two radiologists. The sizes of fistulae were measured with bone-removal DE-CTA images and non bone-removal DE-CTA images respectively and their results were compared by using student's t-test and the correlation test. Results Twenty-eight intracranial internal carotid arteries of 14 patients showed acceptable image quality. Fourteen cases were diagnosed as carotid cavernous fistula with both bone-removal and non boneremoval DE-CTA images. Two patients presented with bilateral lesions, while 7 patients presented with left lesions and 5 patients had right lesions. Totally, sixteen fistulae lesions were detected in 14 patients. The mean size of fistulae was (0. 36 ±0. 10) mm by bone-removal images, whereas (0. 35 ±0. 11 ) mm by non bone-removal images. There was no significant difference between the two methods ( t = 0. 29, P ＞ 0. 05 ),and good correlation was found between the two methods ( r = 0. 97, P ＜0.05). Thirteen dilated cerebral veins in 8 cases were found by bone-removal images versus 9 dilated cerebral veins in 6 cases by non boneremoval images. Conclusions Image post-processing of DE-CTA is a simple and useful method to identify carotid cavernous fistula. DE-CTA is also useful for therapeutic planning.     

First-line investigation of acute intracerebral hemorrhage using dynamic magnetic resonance angiography

Purpose: To report the initial experience of magnetic resonance (MR) digital subtraction angiography (MR-DSA) in the dynamic assessment of the cerebral circulation in acute non-traumatic intracerebral hemorrhage (ICH).

Material and Methods: Twelve patients with acute ICH were investigated within 6 days of the ictus using a dynamic contrast-enhanced 2-D MR angiogram that produces subtracted images with a temporal resolution of 1-2 frame/s. The MR-DSA examinations were assessed for evidence of an intracranial vascular abnormality and were compared with (i) the routine MR sequences, (ii) non-dynamic time-of-flight MR angiography, and (iii) catheter angiogram performed during the same admission.

Results: All 12 MR-DSA examinations were considered to be technically satisfactory. MR-DSA detected an intracranial vascular abnormality in 7 patients (3 arteriovenous malformations, 2 aneurysms, 1 dural arteriovenous fistula, and 1 venous thrombosis). All abnormalities were confirmed by catheter angiography with the exception of one patient with venous sinus thrombosis found on MR imaging that did not undergo catheter angiography. All four arteriovenous shunts were detected by MR-DSA by virtue of early venous filling.

Conclusion: MR-DSA can be performed satisfactorily in the setting of acute ICH and provides an alternative method to catheter angiography for identifying shunting vascular abnormalities such as arteriovenous malformations and fistulae, as well as large aneurysms and venous occlusions. MR-DSA is a contrast-medium-based technique that does not suffer from the T1 shortening effects of acute hemorrhage that can obscure abnormalities on conventional flow-based non-dynamic techniques.     

DWI联合常规MR扫描对肛瘘的诊断价值

目的:评价DWI联合常规MR扫描对肛瘘的诊断价值.方法:选取20例临床怀疑肛瘘或有肛瘘手术史患者行常规MR扫描及DWI检查,比较肛瘘内、外瘘口,瘘管分支及脓肿的显示率.结果:常规MR扫描序列共显示瘘管22个、内口14个、外口22个、脓肿14个;DWI检查共显示瘘管25个、内口16个、外口23个、脓肿17个.结论:DWI...     

Evaluation of perianal sepsis: comparison of anal endosonography and magnetic resonance imaging

The purpose of this study was to compare prospectively the diagnostic yield of anal endosonography (AES) and magnetic resonance imaging (MRI) in the assessment of perianal fistulae and abscesses. There were 39 patients (14 men, 25 women; mean age, 40 years) who underwent AES, performed with a 10-MHz rotating endoanal probe and MRI at 1.0 T (axial and coronal T2-weighted turbo spin-echo (TSE) and turbo-STIR sequences). Fistulae were classified as subcutaneous, intersphincteric, transsphincteric, high (i.e., high extrasphincteric or suprasphincteric), rectovaginal, and horseshoe and were compared with the surgical findings in all patients. Overall, 58 fistulae (subcutaneous, N = 7; intersphincteric, N = 9; transsphincteric, N = 16; high, N = 17; rectovaginal, N = 5; and horseshoe, N = 4) were detected at surgery. MRI showed a sensitivity of 84% and AES of 60% (P <.05). False-positive diagnoses were made in 6 patients (15%) with MRI and in 15 patients (26%) with AES, for a specificity of 68% and 21%, respectively (P <.05). Our findings show that MRI is superior to AES in the assessment of fistula-in-ano before major surgery. AES should be used only for orientation before minor procedures, such as incision or drainage of subcutaneous fistulae.