共查询到20条相似文献,搜索用时 31 毫秒
1.
Takako Nakano Hitoshi Hotokezaka Megumi Hashimoto Irin Sirisoontorn Kotaro Arita Takeshi Kurohama M. Ali Darendeliler Noriaki Yoshida 《The Angle orthodontist》2014,84(6):1079
Objective:To investigate differences in the amount of tooth movement and root resorption that occurred after tipping and bodily movement of the maxillary first molar in rats.Materials and Methods:Ten-week-old female Wistar rats were divided into two groups according to type of tooth movement and subdivided into four subgroups according to the magnitude of applied force. Nickel-titanium closed-coil springs exerting forces of 10, 25, 50, or 100 g were applied to the maxillary left first molars to induce mesial tooth movement. We designed a novel orthodontic appliance for bodily tooth movement. Tooth movement distance and root resorption were measured using microcomputed tomography and scanning electron and scanning laser microscopy.Results:The amount of tooth movement in the bodily tooth movement group was less than half that in the tipping tooth movement group. The greatest amount of tooth movement occurred in the 10-g tipping and 50-g bodily tooth movement subgroups, and the amount of tooth movement decreased with the application of an excessive magnitude of force. Conversely, root resorption increased when the heavier orthodontic force was applied in both groups. Root resorption in the tipping tooth movement group was approximately twice that in the bodily tooth movement group.Conclusions:Root resorption in the tipping tooth movement group was more pronounced than that in the bodily tooth movement group. Although the amount of tooth movement decreased when extremely heavy forces were applied, root resorption increased in both the tipping and bodily tooth movement groups in rats. 相似文献
2.
Apical root resorption of maxillary first molars after intrusion with zygomatic skeletal anchorage 总被引:3,自引:0,他引:3
The aim of this study was to evaluate radiographically the apical root resorption of maxillary first molars after their intrusion was done using zygomatic miniplates as skeletal anchorage in open-bite cases. The study group comprised 16 consecutively treated open-bite cases who had received special titanium miniplates in their zygomatic bones for use as anchorage to apply orthodontic intrusive forces to the maxillary posterior region. The control group consisted of 16 patients, who were matched regarding age, sex, and treatment duration but who had undergone fixed orthodontic treatment without intrusion mechanics for molars. Tooth lengths were measured on pretreatment, and posttreatment panoramic radiographs of all patients and mesiobuccal and distobuccal roots of left and right maxillary first molars were measured on-screen using a software program. The difference between the pre- and posttreatment tooth lengths was defined as apical root resorption. Comparison of the differences in root resorption of the two groups using the t-test for independent samples showed a statistically significant difference (P = .004) only for mesial roots on the right side. But because the mean difference in apical root resorption was only 0.5 mm, it was concluded that the apical root resorption of maxillary first molars after intrusion was done using zygomatic skeletal anchorage was not clinically significant. 相似文献
3.
Root resorption and tooth movement in orthodontically treated, calcium-deficient, and lactating rats 总被引:5,自引:0,他引:5
Previous studies have shown that chronic dietary deficiency of calcium can result in more rapid orthodontic tooth movement. The purposes of this study were to confirm that finding in a calcium-deficient, lactating rat model and to quantify the degree to which the area of root surface resorption is affected by these conditions. Thirty-five adult female Sprague-Dawley rats were divided into two groups: (1) nonlactating animals on a control diet and (2) lactating animals on a calcium-deficient diet. A 60-gm orthodontic force designed to tip maxillary molars mesially was applied for varying times. At sacrifice, tooth movement was quantified by measuring the space created between maxillary molars; percent bone ash was measured for each humerus, and root surface resorption was estimated by means of a morphometric technique to measure the area of cratering on the mesial roots of first molars. Both groups showed a typical two-phased tooth movement cycle lasting for 10 days, although the magnitude of movement was significantly greater (p less than 0.001) in the test animals. The "humerus" test from animals exhibited a significantly decreased (p less than 0.001) fat-free dry weight, ash, and percent ash weight. The test group also displayed a significantly reduced percent area of root surface resorption (p less than 0.05) by 7 and 10 days following appliance activation. These findings confirm earlier observations that lactation, coupled with calcium deficiency, will produce decreased bone density which is consistent with increased parathyroid hormone secretion.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
4.
Orthodontic tooth movement in the prednisolone-treated rat 总被引:15,自引:0,他引:15
Adverse effects of corticosteroids on bone metabolism raise concerns as to whether steroid treatment may influence orthodontic movement. This study examined the effect of prednisolone on orthodontic movement using an established rat model. The corticosteroid treated group (N = 6) was administered prednisolone (1 mg/kg) daily, for a 12-day induction period; the control group (N = 6) received equivalent volumes of saline. On day 12, an orthodontic appliance was placed which exerted 30 g of mesial force to the maxillary first molar. Animals were sacrificed on day 24 and tooth movement was measured. Sagittal sections of the molars were stained with haematoxylin and eosin, and for tartrate-resistant acid phosphatase (TRAP) activity. While there were no significant differences in the magnitude of tooth movement between the 2 groups, steroid-treated rats displayed significantly less root resorption on the compression side and fewer TRAP-positive cells within the PDL space on the same side. This suggests steroid treatment suppressed clastic activity. 相似文献
5.
Force magnitude and duration effects on amount of tooth movement and root resorption in the rat molar 总被引:2,自引:0,他引:2
Gonzales C Hotokezaka H Yoshimatsu M Yozgatian JH Darendeliler MA Yoshida N 《The Angle orthodontist》2008,78(3):502-509
OBJECTIVE: To test the hypothesis that there is no difference in the effect of different continuous moderate to very heavy forces on root resorption or amount of tooth movement. MATERIALS AND METHODS: In the study, 10, 25, 50 and 100 g mesial force were applied to the maxillary first molars of rat using nickel titanium closed-coil springs for 3 days, 14 days, and 28 days. The molars were extracted and the surface areas of the root resorption craters were measured using scanning electron microscope. The depths of the root resorption craters were measured using a three-dimensional laser scanning microscope. Tooth movement of the maxillary first molar was measured in relation to the maxillary second molar on digitized lateral cephalometric radiographs. RESULTS: Three days after force application, the tooth movement was not proportionally related to force magnitude. However, 14 days of force application resulted in significantly more tooth movement in the 10, 25, and 50 g force groups than in the 100 g force group. A force application of 10 g produced significantly more tooth movement at 28 days than all the other three force applications. The largest and deepest resorption craters were observed in the disto-buccal root followed by disto-palatal, middle-buccal, middle-palatal, and mesial root. Root resorption and tooth movement increased over time from 3 to 28 days. As heavier forces were applied, greater root resorption occurred. CONCLUSION: The hypothesis is rejected. The light mesially oriented forces, as applied in this study, produced more tooth movement and less root resorption compared with heavier forces. 相似文献
6.
Orthodontically induced root and alveolar bone resorption: inhibitory effect of systemic doxycycline administration in rats 总被引:5,自引:0,他引:5
The aim of the present study was to investigate the effect of systemic administration of low-dose doxycycline (DC) on orthodontic root resorption. The effect on alveolar bone, the cell population involved, and the amount of tooth movement were also evaluated.Fifty-six 40-50-day-old male Wistar rats were used. Six animals served as untreated controls. Six animals were only administered DC for 7 days, by means of a mini-osmotic pump implanted subcutaneously. In 44 animals the maxillary first molar was mesialized by a fixed orthodontic appliance exerting 50 g force upon insertion. In 28 of these animals DC was administered at the time of appliance insertion and throughout the experiment. The animals were sacrificed 7, 10 or 14 days after force application and block sections processed for analysis. An area including the mesial aspect of the distopalatal root and the adjacent inter-radicular alveolar bone was histomorphometrically evaluated. The root resorption area, absolute alveolar bone area, distance between first and second molars, number of odontoclasts, osteoclasts, mononuclear cells on the root, tartrate-resistant acid phosphatase (TRAP)-positive cells on the root, bone, and in the periodontal ligament (PDL) were compared between DC-treated and non-DC-treated animals.The results revealed a significant reduction in root resorption, the number of odontoclasts, osteoclasts, mononuclear cells on the root surface, and TRAP-positive cells on the root and bone for the DC-administered group. The absolute alveolar bone area was greater, whereas the distance between the first and second molars did not differ between groups. In conclusion, systemic administration of low-dose DC in rats may have an inhibitory effect on orthodontically induced resorptive activity. 相似文献
7.
Tengku BS Joseph BK Harbrow D Taverne AA Symons AL 《European journal of orthodontics》2000,22(5):475-487
Orthodontic tooth movement may be enhanced by the application of a magnetic field. Bone remodelling necessary for orthodontic tooth movement involves clastic cells, which are tartrate-resistant acid phosphatase (TRAP) positive and which may also be regulated by growth hormone (GH) via its receptor (GHR). The aim of this study was to determine the effect of a static magnetic field (SMF) on orthodontic tooth movement in the rat. Thirty-two male Wistar rats, 9 weeks old, were fitted with an orthodontic appliance directing a mesial force of 30 g on the left maxillary first molar. The appliance incorporated a weight (NM) or a magnet (M). The animals were killed at 1, 3, 7, or 14 days post-appliance insertion, and the maxillae processed to paraffin. Sagittal sections of the first molar were stained with haematoxylin and eosin (H&E), for TRAP activity or immunohistochemically for GHR. The percentage body weight loss/gain, magnetic flux density, tooth movement, width of the periodontal ligament (PDL), length of root resorption lacunae, and hyalinized zone were measured. TRAP and GHR-positive cells along the alveolar bone, root surface, and in the PDL space were counted. The incorporation of a SMF (100-170 Gauss) into an orthodontic appliance did not enhance tooth movement, nor greatly alter the histological appearance of the PDL during tooth movement. However significantly greater root resorption (P = 0.016), increased width of the PDL (P = 0.017) and greater TRAP activity (P = 0.001) were observed for group M at day 7 on the compression side. At day 14 no differences were observed between the appliance groups. 相似文献
8.
Clinical orthodontists frequently reactivate appliances following decay. Studies of tooth movement and tissue responses following reactivations indicate that linear tooth movement and rapid recruitment of osteoclasts can be achieved if reactivation is timed to coincide with the latter part of the bone remodeling cycle initiated by the first activation. Both can be delayed if reactivations are timed for the early part of the previous cycle. The objective of this study was to examine tooth movement, root resorption, and osteoclast recruitment following appliance reactivation after the first activation had decayed. Bilateral orthodontic appliances were activated with 40 cN in 144 rats to mesially tip the maxillary molars. After 16 days, rats were randomized into two groups of 72. In group 1, appliances were reactivated in precisely the same manner as the first activation. In group 2, appliances were sham-reactivated. Rats were sacrificed at 1, 3, 5, 7, 10, and 14 days. Orthodontic movement was measured cephalometrically; changes in osteoclasts and root resorption were assessed at both compression and tension sites histomorphometrically; tartrate-resistant acid phosphatase (TRAP) was measured in alveolar bone and serum biochemically. Orthodontic tooth movement was linear in group 1, but osteoclasts required 3 to 5 days to appear. There were no group- or time-related differences in root resorption. Bone TRAP levels were elevated in both groups but dropped significantly (p<0.01) in group 2 at day 7. Appliance reactivations that followed decay of the first activation produced efficient tooth movement without increased risk of root resorption, but these changes were not accompanied by rapid osteoclast recruitment at compression sites. Timing appliance reactivations for the latter portion of the previous bone remodeling cycle could have significant clinical advantages because the delay period seen in tooth movement following a single activation or short-term reactivation can be avoided. 相似文献
9.
目的:了解不同矫治力作用下大鼠牙齿移动距离及牙根吸收情况,探索应用Micro?CT研究正畸牙齿移动过程中矫治力对牙根吸收的影响。方法10周龄健康雄性SD大鼠64只(220~270 g),分别施以10 g (10 g力组)、30 g力(130 g力组)拉右侧上颌第一磨牙向近中移动建立实验动物模型,以对侧同名牙为对照牙。于加力后第3、7、14、28天处死动物,使用Micro?CT扫描上颌第一磨牙及周围牙槽骨,测量上颌第一磨牙近中移动距离,计算加力28 d上颌第一磨牙近中根的表面凹陷体积,进行统计学分析。结果加力后发生牙齿移动,10 g力组在加力14 d内,牙齿移动量小于30 g力组(P =0.039),在加力28 d时大于30 g力组(P<0.05)。加力28 d,10 g力组、30 g力组的牙根表面凹陷总体积高于对照组(P=0.004),30 g力组产生的牙根表面凹陷总体积高于10 g力组(P<0.001)。结论 Micro?CT可以对牙齿移动及牙根吸收进行可靠评价及量化分析。加力后28 d,10 g力组移动量较30 g力组大,相应产生牙根吸收较30 g力组少。 相似文献
10.
Simone P. Friedrichsdorf Emily Zaniboni Alyne Simes Victor E. Arana-Chavez Gladys C. Dominguez 《The Angle orthodontist》2019,89(6):936
Objectives:To investigate the effects of irradiation lasers and light-emitting diode (LED) light on root resorption in rat molars during orthodontic tooth movement (OTM).Materials and Methods:Twenty-one 12-week-old Wistar male rats were divided into three groups: OTM only (control [CG]), OTM and LED irradiation (DG), and OTM and low laser irradiation therapy (LG). The distance between the first and second molars was used to evaluate the amount of tooth movement. The mesial surfaces of the distopalatal roots were analyzed by scanning electron microscopy, and the area of the resorption was calculated.Results:Statistical analysis showed a decreased amount of tooth movement in the exposed DG or LG compared with CG, which was statistically significant (P = .031 and P = .004, respectively). However, when the DG and LG groups were compared, no statistically significant differences were found (P = .504). The root resorption areas were similar between CG and DG. However, statistically significant differences were found between LG and CG (P = .014) and LG and DG (P = .038).Conclusions:Phototherapy did not enhance tooth movement, while infrared laser irradiation did increase root resorption. 相似文献
11.
REN Yi-jin JC. Maltha AM Kuijpers-Jagtman 《口腔医学研究》2004,20(3):282-285
目的:比较研究幼鼠和成年鼠正畸牙齿移动过程中的牙根吸收。材料与方法:本研究包括两组大鼠,其中幼鼠30只(年龄约6周),成年鼠30只(年龄约9~12个月)。大鼠上颌牙一侧用于实验侧,另一侧用于对照。实验侧的三颗磨牙用结扎丝颌粘接剂固为一个整体,在超弹性拉簧作用下(力值为0.1牛顿)向切牙侧移动。1,2,4,8和12周时给予大鼠过量麻醉剂,材料用于组织学研究。上颌第一磨牙的近中颊侧根为根吸收研究对象。压力侧和张力侧的牙根吸收程度在显微镜下进行长度测量。实验侧与对照侧,压力侧与张力侧,幼鼠与成年鼠之间的牙根吸收程度分别以实验时间为参照,在统计学手段下进行了组间和组内分析和比较,以探讨牙齿移动时间和年龄因素对于牙根吸收的影响。结果:实验侧的牙根吸收在幼鼠与成年鼠之间在1,2,4,8周时均没有统计学差异。而在第12周时,成年鼠实验侧牙根吸收大于幼鼠(P<0.05)。成年鼠实验组压力侧的牙根吸收明显大于对照组压力侧,而在幼鼠组没有发现这一差异。两组年龄幼鼠的实验组其压力侧和张力侧的牙根吸收均高度相关。结论:相对于对照侧,正畸牙齿移动并没有在幼鼠的实验侧诱发更多的牙根吸收。在成年鼠,长期的正畸作用力倾向于诱发更多的牙根吸收。这些研究结果表明对于正畸成年病人的后期治疗要更加注意防止牙根吸收。 相似文献
12.
目的 应用CBCT研究无托槽隐形矫治及传统固定矫治器正畸拔牙对前牙区牙根及牙槽骨的变化情况.方法 选择成人拔牙矫正的患者60例,随机分为无托槽隐形矫治器组及传统固定矫治器组(N=30).正畸治疗前后拍摄CBCT,测量两组正畸患者上下颌中切牙、侧切牙、尖牙的牙根长度及牙槽骨的厚度变化情况.结果 固定矫治器组较无托槽隐形矫... 相似文献
13.
Periodontal healing following orthodontic movement of rat molars with intact versus damaged periodontia towards a bony defect 总被引:1,自引:0,他引:1
Nemcovsky CE Sasson M Beny L Weinreb M Vardimon AD 《European journal of orthodontics》2007,29(4):338-344
The aim of this research was to determine whether orthodontic tooth movement influences periodontal healing. In 16 male Wistar rats, 12 week of age, a bony defect was created mesial to both maxillary first molars, not including the attachment apparatus (group 1), and in 15 animals, the defect included the periodontal ligament (group 2). In both groups, the right first molar was moved mesially (orthodontic side) for 2 weeks followed by a 1-week retention period; the contralateral molar was not moved (control side). Histomorphometric analysis was performed. The results within and between the different treatment groups and sides were statistically compared by t-test and analysis of variance with repeated measures on logarithmic transformation. Junctional epithelium was significantly larger at the control than at the orthodontic side of both groups (P = 0.024), and significantly larger in group 2 than in group 1 (P < 0.001). A significantly (P = 0.034) larger pocket depth was found at the control side in group 1. Supracrestal connective tissue was larger at the control than at the orthodontic side for both groups and significantly larger in group 2 than in group 1 (P = 0.004). Root resorption was found infrequently only at the orthodontic side in both groups (five out of 31 cases). The principal findings suggest favourable effects of orthodontic tooth movement on restraining epithelial apical down-growth and decreasing pocket depth. Orthodontic treatment could not completely avoid formation of a long epithelial attachment. Therefore, periodontal regenerative surgery might be indicated prior to orthodontic tooth movement. Orthodontic movement, shortly after periodontal surgery, had no detrimental effect on periodontal soft tissue healing or on diminished but non-inflamed periodontal tissues. 相似文献
14.
目的 本研究通过对拔牙创的骨改建进程及矫治力对牙齿移动的影响进行研究,为临床医生选择理想的矫治力和牙齿移动时机,缩短矫治时间提供依据。方法 取SD大鼠36只,随机分为3组,全麻下拔除一侧上颌第一磨牙,3月后拔除另一侧上颌第一磨牙。在拔牙后不同的时间制作口内矫治器,分别以0·30、0·60、1·36 N的力牵上颌第二磨牙向拔牙区移动,分别在施力前及施力后的第1、3、5、7、10、14天拍摄X线片,利用图像处理技术, 测量牙齿移动距离,以置入的拔髓针校正放大率。结果 ①牙齿向新鲜拔牙区移动的速度明显大于向已愈合拔牙区移动的速度。②无论向新鲜拔牙区移动还是向已经愈合的拔牙区移动,0·30 N力组牙齿移动的距离在各时间点与0·60 N、1·36 N力组牙齿移动的距离之间存在显著的统计学差异;而0·60 N与1·36 N力组牙齿移动的距离之间基本上从第5天开始差别不大。③加力后牙齿移动周期一般包括三个阶段:瞬时运动;迟滞期;后期移动阶段。大约在第14天时,由于矫治力衰减,牙齿停止移动。结论 ①牙齿向新鲜拔牙区移动速度快,而向已经愈合的拔牙区移动速度慢。②在矫治过程中,中等力较为合适;即使使用较大的力,也不一定引起较大的牙齿移动。 相似文献
15.
Nemcovsky CE Beny L Shanberger S Feldman-Herman S Vardimon A 《Journal of periodontology》2004,75(7):1013-1019
BACKGROUND: The influence of orthodontic tooth movement with diminished periodontal support is unclear. The aim of the present study was to evaluate bone healing in surgical defects following orthodontic tooth movement with and without periodontal ligament (PDL) and root surface damage. METHODS: The study comprised 33 adult male Wistar rats, divided into two groups: group 1 (n = 14) with bony defect and no root damage and group 2 (n = 19) with periodontal bony defect including root/PDL damage on the mesial root of the maxillary first molar. One week after a surgical defect was created, orthodontic protraction of the right maxillary first molar was initiated in both groups. After 2 weeks of protraction, retention of 1 week was established; at the end of this period block sections were made. Histomorphometric analysis through light microscopy of decalcified tissue was performed. Results were statistically analyzed using independent samples t test and analysis of variance (ANOVA) with repeated measures. RESULTS: Differences between groups in total area of bone defect and bone apposition were not statistically significant. Bone apposition calculated as percentage of the bone defect was significantly (t-test) greater (P = 0.002) in group 2 (46.21%) than in group 1 (24.95%). Within each group, area of bone apposition was significantly (ANOVA) greater in the distal than in the mesial quadrants of the bony defect (P = 0.006) and in the apical than the occlusal ones (P = 0.021). CONCLUSION: Following orthodontic tooth movement, periodontal bony defects showed enhanced bony healing compared with alveolar bone defects with no direct association with the periodontal attachment apparatus. 相似文献
16.
Villa PA Oberti G Moncada CA Vasseur O Jaramillo A Tobón D Agudelo JA 《Journal of endodontics》2005,31(1):61-66
Pulpitis, external root resorption, and pain may be experienced during orthodontic movement. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been suggested to control these changes. The purpose of this study was to observe pulp-dentinal reactions, root resorption, tooth pain, and tooth movement after the application of a 4-ounce intrusive orthodontic force to human maxillary first premolars in patients given the NSAID nabumetone. Thirty-four maxillary first premolars were evaluated. A placebo was prescribed to 17 patients after an intrusive force was activated and reactivated for an 8-week period on the right side. The same procedure was repeated on the left side after patients were given nabumetone. Pulp-dentinal reactions and external root resorption were evaluated by histology. Pain and movement were also evaluated. Nabumetone was found to be useful in reducing pulpitis, external root resorption, and pain caused by intrusive orthodontic movement, without altering tooth movement in response to the application of orthodontic force. 相似文献
17.
The major goals of this study were to determine the effects of different doses of thyroxin on the rate of orthodontic tooth movement and the force-induced root resorption. In this study fifty male Sprague--Dawley rats were divided into five groups: a normal group with no intervention; a control group in which appliances were placed and 10 ml/kg i.p./day normal saline was injected; and three thyroxin groups in which appliances were placed and 5, 10 and 20/microgram/kg i.p./day L-thyroxin were administered, respectively. A fixed orthodontic appliance consisting of a 5 mm closed-coil spring was ligated between the maxillary incisor and maxillary first molar to deliver an initial force of 60 gm. The results showed that administration of 20/microgram/kg i.p./day L-thyroxin significantly increased the amount of orthodontic tooth movement (p < 0.001). The extent of root resorption as seen from scanning electron micrographs decreased with thyroxin administration. 相似文献
18.
目的:观察釉基质蛋白衍生物对大鼠正畸牙移动后早期复发和牙根吸收的影响.方法:选用20只10周龄雄性SD大鼠,实验组和对照组各10只,在左上第一磨牙施加100 g力,使其近中移动,加力14d后拆除装置.自拆除加力装置起,实验组局部注射釉基质蛋白衍生物,对照组不注射任何药物.分别于拆除装置后当天及第14天分别行Micro-CT活体扫描,分析牙根吸收陷窝以及牙移动距离的变化.采用SPSS19.0软件包对数据进行统计学分析.结果:拆除装置14 d后,实验组与对照组牙根吸收陷窝体积修复量分别为(0.0295±0.0052) ×1 07 μm3、(0.0189±0.0086)×107 μm3;牙移动后复发距离及复发百分率分别为(0.089±0.005)mm、(64.76±3.63)%和(0.127±0.010)mm、(92.28±1.90)%.统计学分析表明,拆除装置14 d后,牙根吸收陷窝体积修复量、牙移动后复发距离及复发百分率均有显著差异(P<0.05).结论:一定浓度的釉基质蛋白衍生物可在一定程度上加强大鼠正畸移动后牙根吸收后修复效应,减弱牙移动后早期复发. 相似文献
19.
External apical root resorption of posterior teeth in asthmatics after orthodontic treatment. 总被引:8,自引:0,他引:8
S McNab D Battistutta A Taverne A L Symons 《American journal of orthodontics and dentofacial orthopedics》1999,116(5):545-551
External apical root resorption is an undesirable sequela of orthodontic treatment, resulting in loss of tooth structure from the root apex. It has been proposed that systemic factors, such as the inflammatory mediators produced in asthma, may enter the periodontal ligament and act synergistically to enhance root resorption. The aim of this study was to determine if asthmatic patients exhibited a higher incidence or severity of external apical root resorption compared with healthy (no medical conditions) patients after fixed orthodontic treatment. Records were obtained from patients treated with fixed appliances; 99 were healthy and 44 had asthma. Using OPGs (panoral films), posterior external apical root resorption was measured on all first and second premolars, mesiobuccal and distobuccal roots of the upper first molars, and mesial and distal roots of the lower first molars, giving 4 measurements per quadrant. A 4-grade ordinal scale was used to determine the degree of external apical root resorption. Combined tooth analysis (adjusted for treatment time, appliance, and extractions) showed that asthmatics had significantly more external apical root resorption of posterior teeth after treatment compared with the healthy group (P =.0194). Tooth-by-tooth analysis (adjusted for treatment time, appliance, extractions, headgear, overbite, overjet, sex, and age at start of treatment) found the upper first molars were most susceptible to external apical root resorption. Although the incidence of external apical root resorption was elevated in the asthma group, both asthmatics and healthy patients exhibited similar amounts of grade 2 (moderate) and grade 3 (severe) resorption. 相似文献
20.
Jerome J Brunson T Takeoka G Foster C Moon HB Grageda E Zeichner-David M 《Journal of the California Dental Association》2005,33(12):951-959
Tooth movement results from alveolar bone resorption/deposition following application of orthodontic forces, and root resorption can be an undesirable complication associated with this process. No treatment for external root resorption is available to date. OBJECTIVE: To determine if COX-2 inhibitors like Celebrex are effective in protecting root resorption associated with orthodontic forces. METHODS: A force of 80 grams was applied to the left maxillary first molars of 7-week-old female Wistar rats using nickel titanium closed coil springs attached to the cervical area of the incisors with 0.010 stainless-steel ligature wires. Twenty animals were divided into three experimental groups: one receiving no treatment, the second receiving 25mg/kg, and the third receiving 50 mg/kg of celecoxib (Celebrex) in their drinking water. Rats were maintained on a soft diet and euthanized two weeks after initial placement of the force. Paraffin-embedded sections of the right (control) and left (experimental) maxillae were stained with H&E and the areas of root resorption were examined by counting the number of lacunaes in the roots. RESULTS: No difference in the distance of tooth movement (0.5 mm/two weeks) was seen in all three groups. The rats that received the low dose of Celebrex showed no statistically significant difference in root resorption than that of the rats that received no dose. The rats that received the high dose of Celebrex showed a lower number of lacunaes (mean = 3.5) than that of the control group (mean 10.2; p=0.02). CONCLUSIONS: Administration of Celebrex during the application of orthodontic forces does not interfere with tooth movement and appears to offer some slight protection against root resorption. 相似文献