双源CT和3.0T磁共振评价左心室功能的相关性研究

目的 对双源CT(dual-source CT,DSCT)和3.0T磁共振(magnetic resonance imaging,MRI)评价的左心室功能参数进行比较,评价其相关性.方法 心脏病患者20例,行双源CT和3.0T MRI检查,分别计算左心室舒张末期容积(end-diastolic volume,EDV)、收缩末期容积(end-systolic volume,ESV)及射血分数(ejection fraction,EF),以磁共振结果为标准,与双源CT结果进行对比,行相关性分析及一致性检验.结果 双源CT检查结果:EDV、 ESV和EF值分别是(118.80±19.43) ml,(43.65±18.06) ml,(63.75±10.59)%;相对的MRI结果分别是(102.39±19.41) ml,(47.82±19.25) ml,(54.34±11.15)%.DSCT测得的EDV 及EF值分别较MRI高估约16.42 ml(95%可信区间9.59～23.24)和9.41%(95%可信区间6.92～11.90),而DSCT测得的ESV较MRI低估约4.17 ml(95%可信区间-8.69～0.35);其Pearson相关系数(r)分别为EDV/ 0.718(P<0.001),ESV/ 0.868(P<0.001),EF/0.881(P<0.001 ) ;Spearman 秩相关系数 (rs)分别为 EDV/0.736(P<0.001),ESV/0.760(P<0.001),EF/0.645(P=0.002).结论 DSCT和3.0T MRI在评价左心室心功能上有很好的相关性,DSCT在一定程度上可以作为"一站式"的心脏检查工具.     

回顾性心电门控多层螺旋CT对急性肺栓塞右心室功能障碍及溶栓前后右心室功能变化的评价

目的 应用ECG门控MSCT前瞻性对中心型急性肺动脉栓塞(APE)患者右心功能障碍及静脉溶栓前后右心功能变化进行评价.方法 96名可疑APE患者进行了ECG门控MSCT胸痛三联检查,25例确诊为中心型肺栓塞.行胸痛三联检查无心肺疾患且性别、年龄匹配的25例作为对照组.APE患者于静脉溶栓后复查MSCT,评价右心功能恢复情况.测量参数包括横断面舒张期的右心室(RV)及左心室(LV)短轴最大内径,RV及LV舒张末期容积(EDV)、收缩末期容积(ESV)、射血分数(EF)、主肺动脉/主动脉直径比.应用单因素方差分析,如果有统计学意义,则采用两两组间q检验.结果 对照组的右心室EDV、ESV、EF值、收缩末期RV/LV容积比、横断面RV/LV内径比及主肺动脉/主动脉直径比分别为(15O.5±24.1)ml、(71.5±18.5)ml、(53.5±4.2)%、1.08±0.04、1.01±0.04及0.99±0.02,中心型APE患者溶栓前以上各值分别为(190.3±16.2)ml、(128.1±13.2)ml、(32.7±3.6)%、2.00±0.26、1.30±0.09及1.34±0.11,溶栓后分别为(159.2±21.5)ml、(80.7±9.4)ml、(49.2±5.9)%、1.22±0.25、1.02±0.02及1.02±0.11.中心型APE患者与对照组比较,右心室ESV(q=6.28,P<0.01)及EDV均增大(q=7.59,P<0.01),EF减小(q=4.82,P<0.01),收缩末期RV/LV容积比增大(q=6.04,P<0.01),横断面RV/LV内径比(q=4.43,P<0.01)及主肺动脉/主动脉直径比增大(q=4.36,P<0.01),左心室EDV减小.中心型APE患者静脉溶栓后,与溶栓前比较,右心室ESV(q=5.03,P<0.01)及EDV减小(q=6.11,P<0.01),EF增加(q=6.29,P<0.01),收缩末期RV/LV容积比减小(q=4.74,P<0.01),横断面RV/LV内径比(q=3.83,P<0.01)及主肺动脉/主动脉直径比减小(q=3.46,P<0.01),左心室EDV增大(q=4.01,P<0.01).结论 回顾性ECG门控MSCT胸痛三联检查可同时检测APE和测量左右心功能,排除其他胸痛疾病,评价溶栓疗效.     

时间-空间相关成像技术评估中孕期胎儿心功能的初步研究

目的 评估时间-空间相关成像( STIC)技术在中孕期胎儿心功能检查中的应用.资料与方法 110例孕20～27+6周胎儿常规超声筛查心脏无异常,用STIC技术扫描获得胎儿心脏整个心动周期的容积数据,存盘后采用体器官计算机辅助分析软件(VOCAL)进行脱机分析,手动描画出心室舒张末期容积(EDV)、收缩末期容积(ESV).计算心室的每搏量(SV)、心排血量(CO)、射血分数(EF),评价SV、CO、EF与孕龄的相关性.结果 110例胎儿中,94例(85.5％)获得满意的心脏容积数据.左、右心室SV从孕20周的(0.33±0.06) ml和(0.40±0.07) ml增加至孕27+6周的(1.13±0.11) ml和(1.29±0.11) ml,左、右心室CO从孕20周的( 49.66±8.10) ml/min和(59.96±9.43) ml/min增加至孕27+6周的(163.51±17.68) ml/min和(187.57±15.98) ml/min;左、右心室SV和CO随孕龄增加而增加,与孕龄呈正相关(左心室SV及CO r=0.93,P＜0.05.右心室:SV r =0.95,P＜0.05; CO r=0.94,P＜0.05).左、右心室EF分别为(49.48±4.12)％和(51.07±4.00)％,与孕龄无明显相关性(r=0.02、0.04,P＞ 0.05).结论 STIC技术能较为准确客观地测量胎儿心室容积,评价胎儿心功能,有望成为胎儿心功能检查的一种新方法.     

MRI对慢性阻塞性肺疾病患者肺动脉血流和右心功能评估的应用价值

目的 探讨MRI在检测慢性阻塞性肺疾病(COPD)患者肺动脉血流与右心功能评估中的应用价值。方法选取我院COPD患者52例,依据患者有无肺动脉高压划分成观察组(存在肺动脉高压) 22例和对照组(无肺动脉高压) 30例,对比两组左右心室功能、肺动脉血流有关指标水平。结果 观察组右心室ESV、EDV、EF、SV、MM及左心室EF、SV和对照组相比差异有统计学意义(P <0.05),观察组右心室ESV、EDV、MM均高于对照组(P <0.05),右心室EF、SV和左心室EF、SV均低于对照组(P <0.05);两组左心室ESV、EDV和MM相比差异无统计学意义(P> 0.05)。观察组主肺动脉的血流量平均值、血流峰值及顺应性和对照组相比差异有统计学意义(P <0.05),观察组主肺动脉的血流量平均值、血流峰值及顺应性均低于对照组(P>0.05)。结论 MRI作为COPD患者右心功能与肺动脉血流检测中的一项无创影像学技术,能为临床提供参考依据。     

基于CMR致心律失常性右室心肌病心肌纤维化程度与心功能的相关性研究

目的 探讨致心律失常性右室发育不良/心肌病(ARVD/C)心室壁心肌纤维化程度与心室容积及心室功能变化的相关性,以期通过纤维化程度评估患者预后.方法 搜集依据最新ARVD/C诊断指南确诊并行心脏磁共振(CMR)检查患者的影像学资料,定量测量心室容积和功能,包括心室舒张末容积(EDV)、心室收缩末容积(ESV)、每搏输出量(SV)、射血分数(EF)及心室舒张末容积指数(EDVI).并分别计算左心室壁、右心室壁及总体心肌纤维化指数,评估其纤维化严重程度.分析心肌纤维化指数与心脏功能指标间的相关性.结果 共35例患者确诊为ARVD/C且行CMR检查,CMR评估ARVD/C患者的LVEF为(48.39±11.10)％,LVEDVI为(111.14±28.66) mL/m2;RVEF为(33.51±13.19)％,RVEDVI为(174.74±64.36) mL/m2.CMR评估左心室壁心肌纤维化指数为(19.7±28.4)％,右心室壁心肌纤维化指数为(50.9±37.7)％,总体心肌纤维化指数为(26.8±28.9)％.左心室壁心肌纤维化指数与LVEF间呈负相关(r=-0.669,P＜0.01),右心室壁心肌纤维化指数与RVEF间呈负相关且相关程度高(r=-0.874,P＜0.01);总体心肌纤维化指数与LVEF、RVEF间亦均呈负相关,相关系数分别为-0.588(P ＜0.01)、-0.835(P ＜0.01).右心室壁心肌纤维化指数、总体心肌纤维化指数与右心室舒张末容积指数(RVEDVI)间均呈显著正相关,相关系数分别为0.846(P ＜0.01)、0.847(P ＜0.01).结论 CMR可以全面评价ARVD/C患者心肌组织特征变化及心脏功能改变;CMR显示的心室壁心肌纤维化程度与心功能存在相关性,可以间接反映心脏功能的变化情况.     

MRI对慢性高原病患者心脏结构和功能的评价研究

目的探讨心脏磁共振成像(CMRI)对慢性高原病(CMS)患者在心脏结构及功能方面的应用价值。方法选取分析30例CMS患者的CMRI影像学资料,另选取30例健康正常志愿者作为对照组。测定心脏结构参数:前室间隔厚度、左心室舒张末期内径、左心房内径、主动脉根部内径、主肺动脉内径、右心室流出道宽径、右心房横径、右心房长径、右心室横径、右心室长径;另测定左、右心室心功能参数:舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、射血分数(EF)和右心室心肌质量(RVMM),对两组参数进行对比分析。结果在心脏结构方面,CMS组前室间隔厚度、主肺动脉内径、右心室流出道宽径、右心房长径和右心室长径显著对照组(P 0.05);在左、右心功能方面,CMS组RVMM明显对照组(P 0.05),RVSV和RVEF明显对照组(P 0.05)。结论 CMRI可准确评价CMS患者心脏结构及功能,CMS患者以右心结构及功能改变为主。     

双源CT在主动脉瓣置换术前左心功能评价中的应用

目的:以磁共振成像(MRI)为金标准,用双源CT(DSCT)定量评价左心功能,探讨DSCT在主动脉瓣置换术前左心功能评价中的应用价值.方法:选取临床诊断主动脉瓣病变欲行主动脉瓣置换术的患者21例,全部病例均行DSCT和MRI心功能分析检查.由有经验的2位放射科医生独立进行,结果以均数士标准差表示.两种仪器间测量值应用配对样本t检验及相关分析检验,同一仪器测量值的差异相互关系用组内相关系数描述,P ＜0.05为有统计学意义.结果:DSCT和MRI两种方法测量的心功能指标差异无统计学意义,舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、左室射血分数(EF)相关性高,r值(EDV)=0.93,r值(ESV)=0.94,r值(SV)=0.89,r值(EF)=0.85.EDV均值:DSCT＞ MRI;ESV均值:DSCT＞ MRI;SV均值:DSCT＞ MRI; EF均值:DSCT＞ MRI.同一仪器三次测量值的差异相互关系(ICC值):MRI测量的EDV、ESV、SV、EF值的ICC值在0.8～1之间;DSCT测量的EDV、ESV、SV、EF值的ICC值在0.6～0.75之间.结论:DSCT在左心室收缩功能定量评价方面准确、可靠,重复性好,并可在不增加放射剂量的前提下,一次DSCT冠状动脉造影检查同时评估冠状动脉狭窄情况和左心室收缩功能,能够为临床主动脉瓣置换术前评估及制订手术方案提供更多重要的参考信息.     

128层CT冠状动脉成像对左心室功能的评价

目的:应用冠状动脉成像原始数据,了解左心室形态变化,评价整体左心室功能。方法:收集90例患者冠状动脉成像原始数据,行MPR,观察左心室形态和各心肌节段的变化,并应用心功能分析软件自动计算出左心室收缩末期容积(ESV)、舒张末期容积(EDV)和射血分数(EF)。根据冠状动脉、左心室形态及整体左心室功能,将所有患者分为对照组、冠心病组、左心室肥厚组及心功能衰竭组,结合各组左心室形态变化,将左心室ESV、EDV和EF进行统计学比较和分析。结果:对照组患者冠状动脉和左心室形态正常;冠心病组左心室壁局限性增厚7例和变薄13例;左心室肥厚组左心室缩小、心室壁增厚;心功能衰竭组心室扩大、室壁普遍变薄。对照组、冠心病组、左心室肥厚组、心功能衰竭组平均EDV和ESV分别为(133.58±14.91)mL、(51.33±11.06)mL;(130.68±11.53)mL、(56.16±8.24)mL;(97.59±8.18)mL、(29.53±4.78)mL;(229.40±50.64)mL、(171.27±60.64)mL。冠心病组与对照组平均EDV和ESV比较,差异无统计学意义,左心室肥厚组及心功能衰竭组与对照组比较,差异均有统计学意义(P0.001)。对照组、冠心病组、左心室肥厚组、心功能衰竭组EF分别为(61.25±5.83)%、(56.37±6.79)%、(68.94±5.36)%和(26.33±8.30)%,差异均有统计学意义。结论:应用冠状动脉成像原始数据,结合冠状动脉及左心室形态改变,无创评价左心室整体功能,实用而可行,可为临床提供更多有价值的信息。     

MSCT、超声心动图与MRI评价左心功能的比较研究

目的以磁共振成像(MRI)为对照标准,应用64层螺旋CT(MSCT),定量评价左心功能,探讨MSCT和MRI心功能评价指标的相关性及MSCT在冠心病左心功能评价中的应用价值;比较同组病例的超声心动图和心脏MRI的左心功能指标,探讨两种方法心功能指标的相关性。资料与方法临床拟诊冠心病的患者32例(均自愿参加),均行心脏MSCT、MRI和超声心动图检查。结果MSCT和MRI两种方法的心功能指标差异无统计学意义,舒张末期容积(EDV)、收缩末期容积(ESV)、每搏输出量(SV)、左室射血分数(EF)、心肌质量(MM)相关性高(r值=0.78~0.92);超声心动图和MRI两种方法的心功能指标差异亦无统计学意义,EDV和SV相关性高(r值分别为0.63和0.69);ESV和EF值相关性中等或低(r值分别为0.41和0.34)。EDV、ESV均值:MSCT>MRI>超声心动图;SV均值:MSCT>MRI和超声心动图;EF均值:超声心动图>MRI>MSCT。结论MSCT在左心功能定量评价方面准确、可靠,一次MSCT冠状动脉造影检查可以同时评估冠状动脉狭窄情况和左心室功能。超声心动图也具有重要的临床应用价值,但是MSCT用于定量评价左心功能较超声心动图更准确。     

实时三维超声心动图在评估心梗患者左心功能的应用价值

目的:本研究以磁共振成像(MRI)检查结果为标准,应用实时三维超声心动图(real time 3-dimensional echocardiography,RT-3DE),定量评价左心室收缩功能,并比较同组病例的二维超声心动(two-dimensionalechocardiograp hy,2D)的心功能指标,探讨实时三维超声心动图在心梗患者心功能评价中的应用价值.方法:临床诊断心梗患者33例,均行心脏MRI、二维超声心动图、实时三维超声心动图.结果:RT-3DE和MRI两种方法的心功能指标差异无统计学意义,收缩末期容积(ESV)、舒张末期容积(EDV)、每搏输出量(SV)、左室射血分数(EF)相关性高(r=0.81～0.87);2D和MRI两种方法测量的心功能指标差异没有统计学意义,EDV、SV相关性较高(r值分别为0.61、0.67);ESV和EF值相关性中等或较低(r值分别为0.41和0.33).结论:RT-3DE能够准确、可靠的定量评价左心功能,用于定量评价心梗患者左心室收缩功能较2D更准确.     

Assessment of global left and right ventricular function using dual-source computed tomography (DSCT) in comparison to MRI: an experimental study in a porcine model

OBJECTIVE: We sought to evaluate the ability of retrospectively ECG-gated dual-source computed tomography (DSCT) to assess left (LV) and right ventricular (RV) functional parameters in comparison to 1.5 T magnetic resonance imaging (MRI). MATERIALS AND METHODS: Ten domestic pigs (60 kg) underwent both contrast-enhanced cardiac DSCT and cardiac MRI using standardized examination protocols under general anesthesia. From manually drawn endocardial and epicardial contours, LV and RV end-systolic (ESV) and end-diastolic volume (EDV), stroke volume (SV), ejection fraction (EF), myocardial mass (MM), peak filling rate (PFR), peak ejection rate (PER), time to peak ejection (TPE), and time to peak filling (TPF) were calculated by means of dedicated analysis software. LV and RV functional parameters were analyzed using Bland-Altman plots, Student t test, and Pearson's correlation coefficient. RESULTS: Both left and right ESV and EDV, SV and EF determined with DSCT correlated well with MR imaging results (left, r = 0.98/0.92/0.82/0.98; right, r = 0.90/0.94/0.96/0.94). PER, PFR, TPE, TPF, and MM showed only a moderate to low correlation (left, r = 0.67/0.37/0.23/0.35/0.57; right, r = 0.78/0.69/0.12/0.11/0.44). PER and PFR were significantly underestimated by DSCT when compared with MRI. CONCLUSIONS: Retrospectively ECG-gated DSCT correctly depicts end-systole and can accurately determine LV and RV volumes, SV, and EF in comparison to MRI. DSCT showed a significant underestimation of PER and PFR in comparison to MRI.     

Comparison of electron beam computed tomography with magnetic resonance imaging in assessment of right ventricular volumes and function

OBJECTIVE: Intraindividual comparison of right ventricular volumes and function using electron beam computed tomography (EBT) and magnetic resonance imaging (MRI). METHODS: Twenty-seven patients with a known cardiac history were referred for evaluation of ventricular function parameters. The following standardized protocols were used: contrast-enhanced multislice mode EBT and gradient echo sequence MRI. Right ventricular end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) were calculated using a slice summation method. Interobserver variability was calculated. RESULTS: The correlation between the 2 methods was: r = 0.901 for EDV, r = 0.938 for ESV, r = 0.823 for SV, and r = 0.953 for EF. Electron beam computed tomography overestimated EDV and ESV slightly when compared with MRI (P < 0.05). No significant differences (P > 0.05) were found between SV and EF. Mean values determined by EBT and MRI were as follows: 168.6 +/- 62.3 mL and 153.7 +/- 59.1 mL for EDV, 104.7 +/- 60.4 mL and 95.1 +/- 54.8 mL for ESV, 63.2 +/- 19.3 mL and 58.7 +/- 19.8 mL for SV, and 40.2% +/- 14.1% and 40.2% +/- 13.6% for EF, respectively. Interobserver variability ranged between 1.0% and 3.2%. CONCLUSION: Electron beam computed tomography shows good agreement with a close correlation and an acceptable interobserver variability for right ventricular volumes and global function, with a small but significant overestimation of EDV and ESV when compared with MRI.     

Accuracy of different reconstruction intervals to quantify left ventricular function and mass in cardiac computed tomography examinations

PURPOSE: To compare the accuracy of cardiac dual-source CT (DSCT) reconstructions obtained at 5% and 10% of the cardiac cycle and MRI for quantifying global left ventricular (LV) function and mass in heart transplant recipients. MATERIAL AND METHODS: We prospectively included 23 heart transplant recipients (21 male, mean age 60±11.7 years) who underwent cardiac DSCT and MRI examinations. We compared LV parameters on cardiac DSCT reconstructions obtained at 5% (0%-95%) and 10% (0%-90%) intervals of the cardiac cycle and on double-oblique short-axis MR images. We determined ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and myocardial mass using commercially available semiautomated segmentation analysis software for DSCT datasets and conventional manual contour tracing for MR studies. RESULTS: Using different reconstruction intervals to quantify LV parameters at DSCT resulted in non-significant differences (P>.05). Compared to MRI, DSCT slightly overestimated LV-EDV, ESV, and mass when both 5% (11.5±25.1ml, 6.8±10.9ml, and 28.3±21.6g, respectively) and 10% (mean difference 15.3±26.3ml, 7.4±11.5ml, and 29.3±18.7g, respectively) reconstruction intervals were used. DSCT and MRI estimates of EF and SV were not significantly different. CONCLUSION: In heart transplant recipients, DSCT allows reliable quantification of LV function and mass compared with MRI, even using 10% interval reconstructions.     

Improved reproducibility of right ventricular volumes and function estimation from cardiac magnetic resonance images using level-set models.

This study aims to assess whether an alternative method, that is based on volumetric surface detection (VoSD) without tracing and is totally free of geometric assumptions, can improve the reproducibility of right ventricular (RV) volume quantification from cardiac magnetic resonance (CMR) images, in comparison with a conventional disk-area technique. In a sample of 23 patients, with wide variability of RV end-diastolic volume (EDV: 47-131 ml), end-systolic volume (ESV: 20-76 ml), and ejection fraction (EF: 29-73%), using the standard method (Argus, Siemens) as the reference, the VoSD method showed good agreement for EDV, ESV, and EF estimations (correlation coefficient: 0.91, 0.94, and 0.94; Bland-Altman biases: 1 ml, 1 ml, and 0%; limits of agreement: +/-16 ml, +/-11 ml, and +/-11%, respectively). An analysis of the reproducibility of the two methods showed lower intraobserver variability for the VoSD method than for the conventional method, as evidenced by the coefficient of variability (CoV) values (2-6% vs. 8-15%; P < 0.05). In addition, the VoSD method showed improved interobserver reproducibility (7-10% vs. 8-15%), but the difference was statistically significant only for EF estimation variability (8 vs. 15%, P < 0.05). In conclusion, the newly developed VoSD technique allows accurate measurements of RV volumes and function, and appears to be more reproducible than the conventional methodology.     

Assessment of left ventricular myocardial function using 16-slice multidetector-row computed tomography: comparison with magnetic resonance imaging and echocardiography

Objective To assess functional parameters using multidetector-row computed tomography (MDCT) and echocardiography and to compare the results with magnetic resonance imaging (MRI). Materials and methods End-diastolic-volume (EDV), end-systolic-volume (ESV), stroke-volume (SV), ejection-fraction (EF), and myocardial mass (MM) were calculated based on CT data sets from 52 patients. Echocardiography was performed in 24 of the 52 patients. The results from MDCT and echocardiography were compared with MRI. Results A strong correlation between MDCT and MRI (r=0.66–0.90) was found for all parameters. Echocardiography revealed a low or moderate correlation (0.05–0.59). Compared to MRI the average differences with MDCT were for EDV 15.1 ml, ESV 10.6 ml, SV 4.5 ml, EF 1.8%, and MM 8.2 g, for EDV determined by echocardiography 36.2 ml, ESV 6.8 ml, and EF 13.9%. Bland-Altman analysis revealed acceptable limits of agreement between MRI and MDCT. Conclusions MDCT enables reliable quantification of left ventricular function. Echocardiography was found to have only a moderate agreement of functional parameters with MRI.     

肺心病患者左右心功能的MRI研究

目的探讨MRI评价肺心病患者左、右心功能的应用价值。资料与方法前瞻性研究18例经肺功能实验、临床检查、X线、心电图、超声心动图等影像学检查证实为合并慢性阻塞性肺病(COPD)的肺心病患者,另选取18名健康志愿者作为对照组。采用1.5 T MRI仪测量两组左、右室心功能及右室心肌质量。采用独立样本t检验测量两组间差异是否有统计学意义。结果 2例肺心病患者MRI检查时由于屏气时间长、不能配合而排除。与对照组比较,16例肺心病患者右室(right ventricle,RV)舒张末期容积(end-diastolic volume,EDV)、右室收缩末期容积(end-systolic volume,ESV)及右室心肌质量(myocardial mass,MM)明显增加(P<0.05),而右室射血分数(ejec-tion fraction,EF)明显减低(P<0.01)。左室EDV及EF显著减低(P<0.01)。结论肺心病患者随着肺动脉压升高,超过右心室的代偿能力,促使右心室扩大和右心功能衰竭,同时左心功能损伤。MRI左右心功能的测量可以评价肺心病的严重程度,为临床提供治疗的客观依据。     

Assessment of global left ventricular function: comparison of cardiac multidetector-row computed tomography with angiocardiography

OBJECTIVE: Evaluation of left ventricular function using electrocardiogram (ECG)-gated multidetector row CT (MDCT) by using 3 different volumetric assessment methods in comparison to assessment of the left ventricular function by invasive ventriculography. METHODS: Thirty patients with suspected or known coronary artery disease underwent MDCT coronary angiography with retrospective ECG cardiac gating. Raw data were reconstructed at the end-diastolic and end-systolic periods of the heart cycle. To calculate the volumes of the left ventricle, 3 methods were applied: The 3-dimensional data set (3D), the geometric hemisphere cylinder (HC), and the geometric biplane ellipsoid (BE) methods. End-diastolic volumes (EDV), end-systolic volumes (ESV), the stroke volumes (SV), and ejection fractions (EF) were calculated. The left ventricular volumetric data from the 3 methods were compared with measurements from left ventriculography (LVG). RESULTS: The best results were obtained using the 3D method; EDV (r = 0.73), ESV (r = 0.88), and EF (r = 0.76) correlated well with the LVG data. The EDV volumes did not differ significantly between LVG and the 3D method (P = 0.24); however, ESV, SV, and EF differed significantly. The ESV were significantly overestimated (P < 0.01), leading to an underestimation of the SV (P < 0.01) and the EF (P < 0.01). The HC method resulted in the greatest overestimation of the volumes. The EDV and the ESV were 31.8 +/- 37.6% and 136.4 +/- 92.9% higher than the EDV and ESV volumes obtained by LVG. Bland-Altman analysis showed systematic overestimation of the ESV using the HC method. CONCLUSION: MDCT with retrospective cardiac ECG gating allows the calculation of left ventricular volumes to estimate systolic function. The 3D method had the highest correlation with LVG. However, the overestimation of the ESV is significant, which led to an underestimation of the SV and the EF.     

Measurement of ventricular volumes and function: a comparison of gated PET and cardiovascular magnetic resonance.

The aim of this study was to compare cardiac volume and function assessment using PET with the reference technique of cardiovascular magnetic resonance (CMR). METHODS: Left ventricular (LV) and right ventricular (RV) end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fractions (EF) were measured in 9 patients using both CMR and PET with inhaled C(15)O. RESULTS: Correlation between the techniques was generally reasonable (r values ranged from 0.63 to 0.99). Best agreement was seen for ESV (LV and RV). With PET, there was a tendency to underestimate LV EF and EDV, and RV EDV and SV. Agreement was worst for LV SV. Percentage difference between CMR and PET measurements ranged from -2% to 15%; Bland-Altman limits of agreement ranged from 24% to 75%. CONCLUSION: Although small systematic differences exist, the agreement between PET and CMR suggests useful information regarding function, and volumes may be obtained from a standard PET protocol.