脑内移植治疗顽固性癫痫的临床研究

脑内移植治疗顽固性癫痫的临床研究谢培增何强华王东军姚建立我们自１９９１年１月至１９９６年１１月共收治癫痫且手术病人２２７例，其中癫痫灶切除加脑移植治疗顽固性癫痫６２例，男性３８例，女性２４例，年龄１．５～２３岁，平均１７．５岁。全组病人均为癫痫长期、...     

顽固性癫痫的手术治疗（附18例报告）

顽固性癫痫的手术治疗（附１８例报告）解放军１７４医院脑外科杨明范，黄民权，杨大金我院近４年来采用手术治疗顽固性癫痫１８例，男１１例，女７例，年龄５～４５岁，平均２６岁，病程２～３５年，平均１３年。发作类型：全身性抽搐大发作１４例，精神运动性发作２例，...     

癫痫7例手术体会

癫痫７例手术体会哈尔滨医科大学附属第一医院神经外科杨富明，杨世春，李国忠近几年来，我科应用手术治疗顽固性癫痫７例，男６例，女１例，年龄１５～４６岁，病灶３～１４年，术前多次行脑电图和（或）脑地形图检查，均有棘波及中等异常改变。手术方法：５例行胼胝体前...     

手术治疗顽固性癫痫伴精神障碍64例(摘要)

我院自１９７９年至１９９８年５月采用手术治疗顽固性癫痫伴精神障碍６４例。男性５２例，女性１２例；年龄７～５８岁；病程４～３６年。癫痫发作类型：全身性发作３０例，全身性发作加复杂部分性发作１４例，全身性发作加单纯部分性发作１０例，单纯部分性发作１０例。...     

脑出血急性期并发癫痫15例报告

我院于１９９５～１９９８年收治脑出血患者２１４例,其中并发癫痫者１５例（７％）,现将有关资料分析如下。１　临床资料本组１５例,男９例,女６例。年龄３６～７１岁（平均５８．５岁）,４５～５０岁２例,５１～６０岁１１例。脑出血后距发作癫痫时间：１２小时内４例,１２～２４小时５例,１～２天３例,３～５天２例,６天１例。癫痫发作类型：局限性运动发作６例,大发作９例（其中癫痫连续发作２例）。患者住院６小时～４５天（平均１３．５天）,每个患者在院发作１～３次（平均１．３３次）,３小时～２０天（平均１０．１天…     

多种手术方法联合治疗顽固性癫痫的疗效观察

目的：对顽固性癫痫病人，将几种手术方法联合作用，并对其临床疗效进行评价以探讨不同类型顽固性癫痫最佳的治疗方案。方法：手术治疗顽固性癫痫患31例。单纯部分性发作6例，复杂部分性发作12例，部分发作发展至全身发作10例，强直－阵挛性发作3例。术前均行头皮脑电视频连续监测及头MRI检查，其中14例行SPECT检查。局部致癫痫病灶切除术6例，局部致癫痫病灶切除术＋皮层软膜下横纤维切断术3例，局部致癫痫病灶切除术＋皮层热灼术3例，局部致癫痫病灶切除术＋皮层热灼术＋胼胝体切开术2例，前颞叶切除术＋皮层热灼术10例（海马切除8例，杏仁核切除6例），立体定向核团毁损术6例，迷走神经刺激术1例。结果：31例病人无手术死亡及术后并发症。随访3－12个月，手术总有效率87．1％，优良率为67．7％。结论：多种手术联合治疗顽固性癫痫病人安全有效。     

胼胝体前部切开治疗顽固性癫痫一例

胼胝体前部切开治疗顽固性癫痫一例广东省佛山市第一人民医院外科单国雄我院１９９０～１９９３年采用胼胝体前部切开治疗顽固性癫痫二例，收到良好效果。例１男，２４岁。反复全身抽搐５年，近一年来频频发作。有时连续几天均有发作。入院后经检查和准备后，作右额顶大骨...     

脑电监测下手术治疗顽固性癫痫84例

脑电监测下手术治疗顽固性癫痫８４例闫洪法任传兵夏永勤龚惠云左鸿高新疆１９８８年６月至１９９５年６月在脑电监测下手术治疗顽固性癫痫８４例，其中男５１例，女３３例，年龄６～４８岁，平均２３．６岁。病程２～２５年，平均病程７．６年。发作频率１～２０次／周，...     

顽固性癫痫125例手术治疗(摘要)

我院自１９９０年６月至１９９８年５月期间，术前采用常规脑电图、动态脑电图、脑电地形图、ＣＴ、ＭＲ、ＥＣＴ等检查，术中运用皮层电图监测，对１２５例各型顽固性癫痫病人进行了外科手术治疗，男７８例，女４７例，年龄２．５～５０岁，平均２２岁。病程平均５．６年...     

顽固性癫痫立体定向手术治疗相关问题探讨

顽固性癫痫立体定向手术治疗相关问题探讨陈成雨，丁福忠，刘运振，刘混我院于１９８９～１９９５年底采用脑立体定向术治疗顽固性癫痫３１例，取得了满意的效果，现结合文献就有关的问题进行探讨。临床资料一般资料：本组男２１例，女１０例。年龄５～５５岁，平均１９．...     

The effect of age of onset of PD on risk of dementia

Background Dementia occurs in the majority of patients with Parkinson’s disease (PD). Late onset of PD has been reported to be associated with a higher risk for dementia. However, age at onset (AAO) and age at baseline assessment are often correlated. The aim of this study was to explore whether AAO of PD symptoms is a risk factor for dementia independent of the general effect of age. Methods Two community-based studies of PD in New York (n = 281) and Rogaland county, Norway (n = 227) and two population-based groups of healthy elderly from New York (n = 180) and Odense, Denmark (n = 2414) were followed prospectively for 3–4 years and assessed for dementia according to DSM-IIIR. All PD and control cases underwent neurological examination and were followed with neurological and neuropsychological assessments. We used Cox proportional hazards regression based on three different time scales to explore the effect of AAO of PD on risk of dementia, adjusting for age at baseline and other demographic and clinical variables. Findings In both PD groups and in the pooled analyses, there was a significant effect of age at baseline assessment on the time to develop dementia, but there was no effect of AAO independent of age itself. Consistent with these results, there was no increased relative effect of age on the time to develop dementia in PD cases compared with controls. Interpretation This study shows that it is the general effect of age, rather than AAO that is associated with incident dementia in subjects with PD. Received in revised form: 22 December 2005     

腺垂体功能减退症临床特征变化分析

目的探讨腺垂体功能减退症患者的病因结构变化及临床表现。方法回顾性分析我院2013-01—2016-12住院及门诊78例腺垂体功能减退症患者的临床资料。结果男32例(41.03%),女46例(58.97%);诊断时年龄11~89岁,平均62.5岁;鞍区占位(包括术前及术后)52例(66.67%),席汉综合征8例(10.26%),空泡蝶鞍9例(11.65%),病因不明8例(10.26%),垂体-下丘脑发育不良1例(1.28%)。首次就诊科室:纳差厌食、恶心呕吐就诊于消化内科36例(46.15%)最常见。ACTH+TSH+Gn+G激素缺乏为19例最多,占24.36%,ACTH+TSH+Gn缺乏15例,占19.23%。结论腺垂体功能减退症病因结构发生变化,发病人群、首发症状及受累激素也不同,患者女性多于男性,发病年龄偏高,症状不典型,分布于临床多个科室,其中以低钠血症为首发临床表现就诊消化内科最多。     

Standards of instrumentation of EMG

Standardization of Electromyography (EMG) instrumentation is of particular importance to ensure high quality recordings. This consensus report on “Standards of Instrumentation of EMG” is an update and extension of the earlier IFCN Guidelines published in 1999. First, a panel of experts in different fields from different geographical distributions was invited to submit a section on their particular interest and expertise. Then, the merged document was circulated for comments and edits until a consensus emerged.The first sections in this document cover technical aspects such as instrumentation, EMG hardware and software including amplifiers and filters, digital signal analysis and instrumentation settings. Other sections cover the topics such as temporary storage, trigger and delay line, averaging, electrode types, stimulation techniques for optimal and standardised EMG examinations, and the artefacts electromyographers may face and safety rules they should follow. Finally, storage of data and databases, report generators and external communication are summarized.     

Release of endogenous catecholamines from slices of hypothalamus of rats

The release of endogenous catecholamines from superfused slices of rat hypothalamus was studied under basal conditions and during release evoked by 40 mM K⁺. Catecholamines in superfusates, and in extracts of the tissue after stimulation, were isolated by column chromatography and quantitated by liquid chromatography with electrochemical detection. Norepinephrine (NE) was not consistently demonstrable in superfusate collected under basal conditions, but 40 mM K⁺ caused the release of from 2 to 4 ng/g of tissue per min. The addition of cocaine to the superfusate caused increases in basal and evoked release of NE. Epinephrine (E) could be measured in superfusates of slices from male but not female rats and then only when cocaine was added to the superfusate. Accordingly, the concentration of E in hypothalamus was greater in male rats than in female rats. Dopamine (DA) was not consistently measurable in the spontaneous overflow from slices either in the presence or absence of cocaine. K⁺-evoked release of DA could be demonstrated in slices from female rats. The addition of cocaine increased the evoked release of DA from slices from both sexes. Corticosterone, added to cocaine, had no effects on the efflux of any of the catecholamines. The experiments suggest that neuronal reuptake of all catecholamines is very efficient in the hypothalamus both under basal conditions and during evoked release.     

Effects of prevention of afferentation of the development of the chick optic lobe

BONDY, S. C., M. E. HARRINGTON AND C. L. ANDERSON. Effects of prevention of afferentation on the developmentof the chick optic lobe. BRAIN RES. BULL. 3(5) 411–413, 1978.—The effects of unilateral extirpation of the right optic cup of the three-day incubated chick embryo upon the rate of synthesis and the stability of DNA in the non-innervated optic lobe, have been studied. This surgical procedure prevents innervation of the optic lobe contralateral to the removed eye, while the other optic lobe is normally innervated by retinal ganglion cells of the remaining eye. At the 20th day of incubation, the DNA content of the non-innervated lobe was below that of the paired lobe receiving normal innervation. This deficiency of cell number was caused by two events; death of an excess number of neurons formed early in embryogenesis and a reduced rate of glial proliferation in the later stages of incubation.     

《绵阳市社会心理服务工作管理办法》解读

2018年,国家卫生健康委员会等10部委联合发布《关于印发全国社会心理服务体系建设试点工作方案的通知》,四川省绵阳市被列为全国第一批试点地区。绵阳市人民政府依据《中华人民共和国精神卫生法》等相关法律法规和文件精神,结合前期调查研究和社会心理服务工作的试点实际,编制出台了《绵阳市社会心理服务工作管理办法》,并于2021年12月25日起施行。本文围绕社会心理服务的相关概念、办法总则、重点内容、保障措施等方面进行解读,以期为社会心理服务工作的规范、持续和有效开展提供参考。     

帕金森病运动症状进展分析

目的分析帕金森病(PD)患者运动症状进展特点。方法采用PD统一评分量表(UPDRS)Ⅲ对912例PD患者进行评估。结果与病程1年的患者比较,除病程1~2年的患者外,其他病程患者的UPDRSⅢ评分、强直分、姿势或步态异常分、轴性症状总分、言语分、步态分显著升高(均P0.05),病程5~6年及14年患者的震颤分,病程5~6年、7~8年、9~13年、14年患者的运动迟缓分、姿势分显著升高(P0.05~0.01)。轴性症状进展速度高于UPDRSⅢ评分。结论 PD患者病程早期UPDRSⅢ评分进展快,震颤症状进展独立于其他症状,轴性症状评分较UPDRSⅢ更敏感地反映疾病加重趋势。     

阿立哌唑对精神分裂症患者生活质量的影响

目的:比较阿立哌唑与利培酮对精神分裂症患者生活质量的影响。方法:60例精神分裂患者随机平分为两组各30例,分别给予阿立哌唑和利培酮治疗。疗程8周。用生活质量综合评定问卷-74(GQOLI-74)、阳性与阴性症状量表(PANSS)及副反应量表(TESS)评定疗效及不良反应。结果:阿立哌唑与利培酮均能显著提高精神分裂症患者生活质量,但阿立哌唑在改善GQOLI-74总分、躯体健康及社会功能维度优于利培酮。结论:阿立哌唑治疗有利于提高精神分裂症患者生活质量。     

Frequency of accumulation of filaments in adaxonal cytoplasm of Schwann cells of myelinated fibers of rat spinal roots

Summary The frequency of accumulation of 6-nm filaments in the adaxonal cytoplasm of Schwann cells in the 6th lumbar dorsal and ventral roots was evaluated in 4-, 8-, 26- and 45-week-old Sprague-Dawley rats. The frequency was higher in 4- and 8-week-old (growing) rats than in 26- and 45-week old (mature) rats, and also higher in ventral than in dorsal roots in 4-, 8- and 26-week old rats. There were no clusters on certain groups of myelinated fibers according to the size of transverse axonal area, in both the ventral and dorsal roots. Therefore, this accumulation may reflect certain functions of the adaxonal cytoplasm of Schwann cell during natural growth and maturation of the axon and myelin sheath.     

奥氮平治疗精神分裂症对照研究的Meta分析

目的：探讨奥氮平治疗精神分裂症的疗效和不良反应。方法：应用M eta分析对17篇奥氮平与其他抗精神病药治疗精神分裂症对照研究的文章进行再分析。结果：奥氮平自身对照比较的治疗效应极大（χ^2=141.00，P〈0.05）。治疗2周和治疗结束，奥氮平与对照药疗效比较差异无显著性（P〉0.05）;阳性与阴性症状量表（PANSS）评分比较差异亦无显著性（P〉0.05）。与对照药相比，奥氮平的不良反应显著少于对照药组（P〈0.05或P〈0.01）。结论：奥氮平与对照药的临床疗效相仿，但不良反应明显较少。