如意金黄散治疗甘露醇及七叶皂甙钠所致静脉炎的临床体会

目的 探讨如意金黄散加蜂蜜外敷治疗静脉炎的疗效.方法 随机将发生静脉炎的30例病人分为治疗组和对照组,治疗组15例采用如意金黄散加蜂蜜调成糊状,外敷于静脉炎处;对照组15例硫酸镁纱布湿敷于静脉炎处.结果 两组的有效率分别为治疗组100%,对照组66.67%.两组病人有效率的差别均有显著性差异.结论 应用如意金黄散加蜂蜜外敷治疗静脉炎明显优于硫酸镁外敷.     

如意金黄散加蜂蜜外敷治疗PICC术后机械性静脉炎的疗效观察

目的观察如意金黄散治疗PICC术后机械性静脉炎的疗效。方法将PICC术后出现机械性静脉炎的肿瘤患者随机分为实验组32例和对照组30例,实验组接受如意金黄散 蜂蜜外敷治疗,对照组接受50%硫酸镁湿敷 TDP灯照射治疗,观察两组机械性静脉炎的治疗效果。结果实验组的总有效率为100%,对照组的总有效率为56.67%,差异有显著性(P<0.01)。结论如意金黄散外敷能有效治疗PICC术后机械性静脉炎。     

如意金黄散加浓茶水治疗化疗性静脉炎的护理

目的探讨如意金黄散加浓茶水治疗化疗性静脉炎的效果。方法化疗性静脉炎患者60例。随机分为实验组（30例）及对照组（30例）。实验组使用如意金黄散适量加浓茶水调匀成糊状,均匀涂于发生静脉炎的部位。对照组使用硫酸镁湿敷于静脉炎处。观察两组疗效。结果实验组治愈率为100%,对照组治愈率为90%。两者之间差异有统计学意义（P〈0.05）。结论如意金黄散加浓茶水治疗化疗性静脉炎具有良好的效果,值得临床推广使用。     

如意金黄散加利多卡因外敷治疗多柔比星所致化疗性静脉炎的临床观察和护理

目的分析研究如意金黄散加利多卡因外敷治疗多柔比星所致化疗性静脉炎的临床疗效和护理对策。方法随机选取该院2011年11月—2012年11月发生静脉炎的40例患者,随机均分为治疗组和对照组,各20例,对照组采用静滴多柔比星,观察组应用如意金黄散加利多卡因外敷治疗。结果如意金黄散加利多卡因外敷治疗多柔比星所致化疗性静脉炎的有效率高于50%硫酸镁。结论如意金黄散加利多卡因外敷治疗多柔比星所致化疗性静脉炎的效果,能减少化疗药物对于病人血管的损伤,临床疗效显著。     

紫金锭外敷治疗化疗所致静脉炎的疗效观察

目的:探讨紫金锭外敷治疗化疗致静脉炎的疗效。方法:随机将发生静脉炎的156例病人分为治疗组和对照组,治疗组78例采用紫金锭外敷于静脉炎处,对照组78例采用50%硫酸镁外敷于静脉炎处。结果:两组显效率、总有效率分别为:治疗组80.77%和92.31%;对照组15.39%和61.54%,经χ2检验,P<0.05,表明两组病人的显效率和总有效率的差别均有显著性差异。结论:应用紫金锭外敷治疗化疗所致静脉炎的效果明显优于50%硫酸镁外敷。     

双柏散与硫酸镁外敷治疗输液性静脉炎的对照研究

目的 探讨双柏散外敷治疗静脉输液所引发的静脉炎的临床疗效.方法 随机将60例输液性静脉炎患者分为对照组和观察组,对照组(30例)用50%硫酸镁湿热敷外渗处;观察组(30例)用双柏散湿热敷外渗处,观察其治愈率、显效率及有效率,4 d为1疗程.结果 观察组的治愈率、显效率、有效率、总有效率分别为36.7%、46.7%、13.3%、96.7%;对照组分别为13.3%、26.7%、46.7%、86.7%,两组比较有统计学差异(P＜0.05).结论 双柏散湿敷是治疗输液性静脉炎的有效方法 ,值得临床推广.     

绿茶如意金黄散外敷治疗局部皮肤变态反应的疗效观察

目的：探讨绿茶如意金黄散外敷治疗局部皮肤变态反应的疗效。方法：将120例并发局部皮肤变态反应的肿瘤患者随机分为实验组和对照组（均60例）。实验组用绿茶冲调如意金黄散呈糊状,外敷于局部皮肤变态反应处;对照组用皮炎平软膏涂于患处。结果：实验组和对照组治愈率分别为96.7%、63.3%;有效率分别为76.7%、33.3%,治疗组治愈率和有效率均明显高于对照组（圴P〈0.05）。结论：绿茶如意金黄散外敷治疗局部皮肤变态反应明显优于皮炎平软膏外涂,值得临床应用。     

中药联合蜂蜜治疗化疗药物所致静脉炎疗效观察

目的:观察中药金黄散联合蜂蜜外敷治疗化疗药物所致静脉炎的临床效果.方法:将72例化疗药物所致静脉炎的患者随机分为2组,治疗组36例用蜂蜜调和金黄散外敷治疗,对照组36例用25％的硫酸镁溶液湿敷治疗,并比较效果.结果:治疗组总有效率100％,对照组总有效率48.2％,2组疗效比较(P＜0.01)差异有统计学意义.结论:中药金黄散联合蜂蜜外敷治疗化疗药物所致静脉炎有显著效果.     

鲜芦荟配合硫酸镁混合液外敷治疗静脉炎的临床研究

目的 探讨鲜芦荟配合硫酸镁混合液外敷治疗对静脉炎的价值.方法 对96例运用鲜芦荟配合硫酸镁混合液和87例单纯运用50%硫酸镁溶液湿敷治疗不同程度静脉炎患者进行临床研究.结果 鲜芦荟配合硫酸镁混合液外敷治疗静脉炎的治愈率58.33%,总显效率88.54%,总有效率100%,单纯使用50%硫酸液外敷治疗静脉炎的治愈率25.29%,总显效率59.77%,总有效率95.40%,芦荟配合硫酸镁混合液治疗组治愈率、总显效率以及总有效率均显著高于单纯50%硫酸镁溶液治疗组,差异有统计学意义(P<0.05).结论 鲜芦荟配合硫酸镁混合液外敷治疗静脉炎能显著提高药物引起的静脉炎的治疗效果.     

金黄散洗剂治疗丹毒和疖或痈的疗效观察

目的观察金黄散洗剂治疗丹毒、疖或痈临床疗效与不良反应。方法 60例丹毒患者随机分为实验组和对照组,每组30例,两组患者治疗前均用青霉素钠800万U静脉滴注,1次/d;50%硫酸镁湿敷,2次/d;微波照射,2次/d,每次30min,对照组采用如意金黄散,1次/d外敷,实验组采用金黄散洗剂,2次/d外擦,两组患者均10d为一个疗程。60例疖或痈患者随机分为实验组和对照组,每组30例,两组患者治疗前均用1:10 000的高锰酸钾溶液清洗,对照组采用如意金黄散,1次/d外敷,实验组采用金黄散洗剂,2次/d外擦,两组患者均7d为一个疗程。结果丹毒实验组、对照组总有效率分别为96.67%、76.67%,两组差异有统计学意义(P0.05),对照组不良反应发生率6.67%,实验组无不良反应发生。疖或痈实验组、对照组总有效率分别为93.33%、73.33%,两组差异有统计学意义(P0.05),对照组不良反应发生率10%,实验组无不良反应发生。结论金黄散洗剂作用迅速,使用方便,临床疗效明显优于如意金黄散。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.