非血管化髂骨移植同期种植重建下颌骨节段缺损的临床研究

目的：研究非血管化髂骨移植同期种植重建下颌骨节段缺损的方法及临床效果。方法：选取下颌骨节段缺损的病人，通过非血管化髂骨移植建立下颌骨连续性，同期植入牙种植体。结果：移植的骨块成活，植入的种植体可以实现骨结合并完成种植义齿修复，行使功能。结论：此方法可以实现下颌骨的功能重建。     

非血管化髂骨移植修复下颌骨部份缺损

目的 总结应用非血管化髂骨移植同期修复不同类型下颌骨缺损的临床经验.方法 对1996年1月～2006年1月136例应用非血管化髂骨移植同期修复下颌骨部份缺损的病例进行回顾性研究,按HCL分类法对下颌骨缺损分类,分析不同类型的下颌骨缺损应用非血管化髂骨移植同期修复术后的效果,植骨区并发症及移植骨吸收情况.结果 总体移植骨成活率89.7%,其中L类缺损成功率最高.术后总体感染发生率16.9%,其中H类缺损感染率最高.术后6个月植入骨均有不同程度的吸收,以H类缺损骨吸收最明显.结论 非血管化髂骨移植是修复下颌骨节段性缺损的简单有效的方法,以L类缺损最适宜.     

ITI种植体即刻植入血管化髂骨修复下颌骨缺损12例分析

目的:种植体植入血管化髂骨修复下颌骨缺损已成为一种常规治疗方法。本研究对一组ITI种植体即刻植入血管化髂骨后的效果进行评价。方法:对2000～2004年间12例患者共36枚ITI种植体植入血管化髂骨的情况进行研究。髂骨瓣移植完成即刻种植体植入,3～5个月愈合期后进行修复负载。结果:种植体植入髂骨后初期稳定性良好,经1年观察,垂直骨吸收<1m m,进入稳定状态。在观察期间无种植体失败。结论:血管化髂骨是下颌骨缺损修复安全的种植床。种植体支持的固定义齿和覆盖义齿修复,是下颌骨缺损可靠的修复方法。     

种植体—血管化髂骨移植早期修复下颌骨缺损的咀嚼效率测定

对５例血管化髂骨移植一期植入种植体修复下颌骨缺损患者，义齿修复后分别采用吸光度法和过筛称重法进行咀嚼效率测定，结果显示其咀嚼效率可恢复至正常人的６０．７－９６．６％，表明种植体应用于血管化骨移植修复下颌骨缺损早期恢复患者的咀嚼功能。     

自体髂骨游离移植加同期种植修复牙槽缺损初步观察

目的：利用自体髂骨游离移植同期种植修复牙槽缺损。方法：13例牙槽嵴萎缩患者行自体髂骨游离移植同期植入29枚种植体。结果：移植骨存活，植入的29枚种植体与移植骨结合良好，义齿修复一年后种植体无松动、脱落。结论：采用该方法可早期修复牙槽缺损，但仍需进一步观察长期效果。     

自体髂骨游离移植同期人工牙种植修复下颌骨缺损二例报告

两例因下颌骨良性肿瘤行下颌骨部分切除的病例，采用自体髂骨游离移植，同期骨内种植体植入，用以修复颌骨缺损及牙列缺损，治疗效果良好，为非血管化移植骨上同期植入牙种植体可以达到骨愈合提供了直接证据。     

即刻植骨同期种植体植入修复下颌骨缺损

目的：探讨下颌骨缺损即刻植骨同期种植的可行性。方法：对6例下颌骨部分切除的患者，行下颌骨缺损即刻植骨同期种植术。其中2例行血管化腓骨双层折叠移植，另4例为非血管化髂骨移植。同期植入种植体共19颗。结果：6例术后均一期愈合，X线显示种植体周围骨结合正常。结论：下颌骨缺损血管化和非血管化骨移植同期种植术是可行的，但由于同期种植的复杂性，要求在适应症的选择及手术操作上应更加严格。     

骨移植种植体一期植入的研究进展

因肿瘤或外伤造成下颌骨缺损，其外形及功能的一期整复问题一直困扰着人们。近来，用髂骨移植种植体一期植入修复下颌骨缺损，重建面部外形，恢复咀嚼功能等，国内外做了零星报道。但对牙种植体植入移植骨后能否与移植骨发生骨结合、结合时间、影响结合的因素以及移植骨能否改建形成牙力轨道等都未见报道。本文就血管化骨移植及游离骨移植愈合的组织学差异，以及两类骨移植种植体一期植入的现状、优缺点和应用前景做一综述。     

下颌骨缺损自体骨移植术后种植修复

目的：下颌骨缺损自体骨移植术后采用种植义齿修复。方法：6例髂骨移植患者，3例直接植入种植体；2例经颌骨骨块上置法植骨后植入种植体；1例经牵引成骨术增高牙槽突后植入种植体。2例腓骨移植患者，分别经腓骨上置法移植和牵引成骨术增高牙槽突后植入种植体。结果：8例患者最终都植入种植体，其中3例已完成上部义齿修复。结论：下颌骨缺损自体骨移植术后，常有牙槽突骨量不足，需行牙槽突Ⅱ期重建。上置法植骨和牵引成骨术能成功地重建牙槽突缺损骨量。     

血管化髂骨移植与下颌骨的功能重建

目的 寻求下颌骨大范围缺损的修复和功能重建的方法。方法 ７例患者用旋髂深务管为蒂的游离髂骨移植同期植入纯钛螺旋状骨内种植体。结果 术后６个月Ｘ线显示：种植体与移植骨块有结合。义齿修复后,随访６－３６个月,种植体无松动。Ｘ线片未见种植边缘骨吸收;恢复了咀嚼、语言、外形等,结论 该方法能较好地解决下颌骨大范围缺损的功能性重建。     

柠檬精油对牙周致病菌抑制作用及其安全性初步研究

目的:探讨柠檬精油对牙周致病菌的体外抗菌活性及对细胞增殖的影响。方法:采用微量液体稀释法测定柠檬精油对Pg、Fn、Aa、Pi的最小抑菌浓度(minimal inhibitory concentration,MIC)及最小杀菌浓度(minimum bactericidal concentration,MBC);以较低浓度的MIC为标准稀释LEO作为实验组,采用MTT法测定柠檬精油对HUVECs的毒性作用,明确抑菌浓度下LEO的安全性。结果:柠檬精油对牙周主要致病菌均有抑菌作用,Pg、Fn、Aa、Pi的MIC分别是9.0 g/L、4.5 g/L、4.5 g/L、9.0 g/L,Aa、Fn的 MBC是9.0 g/L,Pg、Pi的MBC未测得。1/2MIC、1/20MIC浓度的LEO能够抑制人脐静脉内皮细胞的生长,而低于1/200MIC浓度的LEO则对人脐静脉内皮细胞的生长没有影响,其中1/200MIC浓度的LEO作用明显优于0.02%的CHX。结论:体外环境中,柠檬精油对牙周致病菌Pg、Fn、Aa、Pi具有抗菌活性,低浓度应用对机体相对安全。     

Oral cancer: molecular technologies for risk assessment and diagnosis

Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.     

Computer-assisted planning for maxillofacial prosthodontic rehabilitation

Computerized tomography (CT) planning and the use of CT derived surgical templates for implant placement have shown promise for restoring function within months after surgical reconstruction of acquired post-oncologic defects.     

Stimulated whole saliva components in children with Down syndrome

The authors report on the components of stimulated whole saliva from children with Down syndrome—including pH, flow rate, sialic acid and protein concentrations, and amylase and peroxidase activity. Saliva samples were collected from 35 children aged 6–10 years. Of the participants, 17 had Down syndrome and 18 did not. To stimulate saliva production, the children chewed a piece of parafilm for 10 minutes before the sample was collected. Soon after collecting the saliva sample, the authors measured pH using a portable pH-meter. Sialic acid levels were determined with a thiobarbituric acid assay. Protein content was determined with Folin's phenol reagent. Amylase was assayed and the authors measured the maltose produced by the breakdown of starch and peroxidase using ortho-dianisidine.
No statistically significant difference was observed in levels of sialic acid (free and total) between the two groups. Protein concentration was about 36% higher in the group with Down syndrome. However, the salivary flow rate, pH, and amylase and peroxidase activities were lower among the children with Down syndrome.     

Effect of Pingyangmycin on human venous malformation endothelial cells

Purpose: Venous malformations are common vascular anomalies with a propensity of the head and neck. Intralesional injection of Pingyangmycin (PYM, bleomycin A5 hydrochloride) is a widely used sclerotherapy method for the treatment of venous malformation.     

牙髓再生的研究现状

目前,根管治疗术在临床上已得到了广泛的应用并成功的保存了患牙,但其仍有许多术后并发症。随着组织工程技术在口腔领域的应用,构建一种组织工程化牙髓进行牙髓-牙本质复合体的再生治疗成为可能。近年来国内外已有很多关于牙髓再生的研究,并且已经取得了一定成果。本文将对目前国内外牙髓再生的研究进展现状作一综述。     

Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life

Dysphagia is one of the most important complications encountered in amyotrophic lateral sclerosis (ALS). Our aim was to determine whether oropharyngeal dysphagia impacted the quality of life (QoL) of patients with ALS. Thirty consecutive patients were recruited (31–82 years, 18 men). Swallowing function was evaluated using a standardised videofluoroscopic barium swallow. All the patients completed a specific questionnaire on quality of life in dysphagia (SWAL‐QoL) immediately after the videofluoroscopy. The results of dysphagia outcome severity scale separated 14 patients with oropharyngeal dysphagia and 16 with normal swallowing function. There was no difference in the average age, weight and body mass index of the two groups (dysphagic patients: 68 ± 11 kg versus non‐dysphagic patients: 69 ± 14 kg). Most of the dysphagic patients had a bulbar affection based on their Norris scores which determine the importance of cranial nerves illness (20 ± 8), significantly lower than those of the non‐dysphagic patients (35 ± 5) (P < 0·0001). There was no difference in the neurological peripheral symptoms evaluated by Amyotrophic Lateral Sclerosis Functional Rating Scale scores (dysphagic patients: 26 ± 7 versus non‐dysphagic patients: 27 ± 8) (ns). The swallowing quality of life questionnaire revealed that the dysphagic patients had significant burden (P < 0·001). They were affected by the necessity to applied a food selection (P < 0·01), by the increase in eating duration (P < 0·05) and described a decrease in eating desire (P < 0·05). They complained of fear regarding the risk of dysphagia (P < 0·05). They also described difficulties with oral communication (P < 0·001). All of those complained about dysphagia which impacted directly mental health (P < 0·05) and social life (P < 0·05). In conclusion, oropharyngeal dysphagia is a common symptom accompanying ALS, which alters the patient's QoL, especially social health.     

替牙期骨性Ⅲ类错牙合患者颞下颌关节特征的锥形束CT研究

目的:采用锥形束CT(CBCT)研究替牙期骨性Ⅲ类错牙合患者颞下颌关节的影像学特征,探讨Ⅲ类功能状态下,颞下颌关节的生长、改建机制。方法:从就诊于昆明医科大学附属口腔医院正畸科的患者中选取符合纳入标准的替牙期骨性Ⅲ类错牙合患者及骨性Ⅰ类错牙合患者各20名,使用NNT viewer 5.3图像处理软件进行三维重建及线距和角度的测量,并进行统计学分析。结果:替牙期骨性Ⅲ类错牙合患者组和替牙期骨性Ⅰ类错牙合患者组对比结果为:矢状面双侧关节前间隙偏小、双侧关节上间隙偏小、双侧关节结节斜度偏小;冠状面双侧关节内间隙偏小,双侧关节上间隙偏小,双侧关节外间隙偏小,右侧髁状突角度偏小;横截面右侧髁状突前后径偏小。结论:替牙期骨性Ⅲ类错牙合患者颞下颌关节发育不充分,呈现髁状突,关节窝深度,关节结节斜度;冠状面关节内、外间隙均较小的特征。骨性Ⅲ类错牙合患者髁状突在关节窝中处于前置近关节窝顶位置。骨性Ⅲ类错牙合患者颞下颌关节影像学特征与其功能状态相适应。     

拔牙位点保存用复合温敏凝胶的构建及体外表征

目的:制备多壁碳纳米管/羟基磷灰石/壳聚糖复合温敏凝胶,探讨其作为拔牙位点保存材料的理化性能。方法:采用原位沉积方法制备多壁碳纳米管/羟基磷灰石(MWNT/ HA简称HAC)复合无机材料,将其分散至壳聚糖温敏凝胶中,制备壳聚糖/多壁碳纳米管/羟基磷灰石(CS /MWNT/HA简称CS/HAC)复合温敏凝胶,以成胶时间、孔径、孔隙率、机械强度及降解性能为指标优化配方设计,并表征复合温敏凝胶的微观形貌及理化性能。结果:以10 g/L的HAC作为补强成分加入到壳聚糖溶液中,能够在不影响成胶并保证一定孔隙率(84%)的前提下,提高材料的机械性能(抗压强度0.441 MPa),所获复合温敏凝胶具有适宜的临床操作时间(12 min),并具有可控的降解速率。结论:负载HAC的复合温敏凝胶具有良好的成型性,并具有较好的机械性能,在拔牙位点保存领域具有良好的应用前景。