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B A Pawson H C Cheung R J Han P W Trown M Buck R Hansen W Bollag U Ineichen H Pleil R Rüegg 《Journal of medicinal chemistry》1977,20(7):918-925
The syntheses of the ring and four side-chain dihydroretinoic acids and/or their esters, 3-7, are described. The syntheses of several other retinoids containing a substituted aromatic ring are also included. The biological activity of the compounds was evaluated in vivo in a chemically induced mouse skin papilloma test and in vitro in two vitamin A deficient assays. The activity observed for 1a, 1c, and 2a in the former test was partially retained in the dihydro derivatives 4b, 4c, and 6b. Similar results were found in the in vitro assays. 相似文献
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《Expert opinion on therapeutic patents》2013,23(10):1427-1429
Furan sulphonic acid derivatives are claimed to inhibit formation of amyloid β-sheets and/or protect against neuronal cell loss and/or inhibit the release of cytokines, such as IL-1β, IL-6 and TNF-α. Thus, these compounds may be useful for the treatment of neurodegenerative diseases, autoimmune diseases and inflammatory diseases. 相似文献
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D. N. Ismatov U. M. Azizov M. K. Nurullaeva S. I. Iskandarov 《Pharmaceutical Chemistry Journal》1991,25(7):498-502
Translated from Khimiko-farmatsevitcheskii Zhurnal, Vol. 25, No. 7, pp. 56–59, July, 1991. 相似文献
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