苦味西葫芦水提物镇痛作用的实验研究

目的:探讨苦味西葫芦水提物的镇痛作用。方法:采用小鼠甩尾试验和热板试验观察苦味西葫芦水提物的镇痛作用。结果:苦味西葫芦在末次给药后90min没有表现明显的镇痛作用,在150min后表现出一定的镇痛作用,效果好于阳性药卡马西平。结论:苦味西葫芦水提物对热刺激引起的锐痛表现出一定的镇痛作用,且镇痛作用起效迟缓。     

高效液相色谱法测定苦味西葫芦中药西瓜苦苷的含量

目的:建立高效液相色谱法测定苦味西葫芦果实中药西瓜苦苷的方法,分析其果实中药西瓜苦苷的含量。方法:采用Shim-Pack CLC-ODS(150mm×4.6mm,5μm)色谱柱,甲醇-水(52∶48)为流动相,检测波长为238nm,柱温为35℃。结果:药西瓜苦苷在1.6~4.8μg范围内线性关系良好,苦味西葫芦果实中药西瓜苦苷的含量为0.28%,RSD为1.27%。结论:该法稳定、简便,可用于苦味西葫芦药材的质量控制。     

全缘叶紫珠三萜类成分研究

为了对全缘叶紫珠的茎和叶进行化学成分研究, 采用硅胶、凝胶等柱色谱方法分离和纯化化合物, 根据理化性质和波谱方法鉴定化合物结构。从全缘叶紫珠的甲醇提取物中分离得到了15个三萜类化合物, 包括1个新化合物: 2α, 3β, 19α, 23-tetrahydroxy-olean-12-en-28-oic acid-28-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside (1) 和14个已知化合物: oleanolic acid (2)、3-acetyl oleanolic acid (3)、3β-O-acetyl ursolic acid (4)、2α-hydroxy-ursolic acid (5)、2α, 3β, 19α, 23-tetrahydroxy-urs-12-en-28-oic acid (6)、α-amyrin-3-O-β-D-glucopyranoside (7)、pomolic acid (8)、betulinic acid (9)、ursolic acid (10)、2α, 3β, 19α, 23-tetrahydroxy-olean-12- en-28-oic acid (11)、2α-hydroxy-oleanolic acid (12)、hederagenin (13)、2α, 19α-dihydroxy-ursolic acid (14) 和pruvuloside A (15)。所有化合物均为首次从全缘叶紫珠中分离得到, 其中化合物3、4和15为首次从紫珠属中分离得到。     

高效液相色谱法测定苦昧西葫芦中药西瓜苦苷的含量

目的:建立高效液相色谱法测定苦味西葫芦果实中药西瓜苦苷的方法,分析其果实中药西瓜苦苷的含量.方法:采用Shim-Pack CLC-ODS(150mm×4.6mm,5μm)色谱柱,甲醇-水(52:48)为流动相,检测波长为238nm,柱温为35℃.结果:药西瓜苦苷在1.6～4.8μg范围内线性关系良好,苦味西葫芦果实中药西瓜苦苷的含量为0.28%,RSD为1.27%.结论:该法稳定、简便,可用于苦味西葫芦药材的质量控制.     

栝楼属植物化学成分

综述了近年来对栝楼属植物中油脂类、黄酮类、三萜类及甾醇等化学成分的研究概况。     

山楂中三萜类有效成份的提取

目的：山楂中三萜类有效成份的提取。方法：用超声提取及大孔树脂分离各成份。结果：用60％乙醇超声清洗,再用无水乙醇超声提取三萜类主要成份。结论：本方法简单易行,提取效率也较高,适合大规模生产。     

黄芪属植物三萜类化学成分

对黄芪属43种植物中的三萜类化学成分及其结构特征作了较系统的综述。     

灵芝三萜类化合物药理作用研究进展

灵芝 (Ｇａｎｏｄｅｒｍａ)为层菌纲非褶菌目灵芝菌科灵芝属真菌的总称。习惯所称灵芝是指灵芝属中赤芝 [Ｇａｎｏｄｅｒｍａｌｕｃｉｄｕｍ (Ｌｅｙｓｓ .ｅｘＦｒ .)Ｋａｒｓｔ .]的子实体部分 ,其主要成分之一是三萜类化合物。该类化合物有较高的脂溶性 ,分子量一般为 4 0 0～ 6 0 0 ,化学结构较复杂 ,目前已知有 7种不同的母核结构 ,在母核上有多个不同的取代基 ,常见有羧基、羟基、酮基、甲基、乙酰基和甲氧基等。由于化学结构的多样性 ,使三萜类化合物有较广泛的药理活性[1] ,如ｇａｎｏｄｅｒｉｃａｃｉｄβ ,ｇａｎｏｌｕｃｉｄｉｃ…     

苣荬菜全草中的三萜类成分

从苣荬菜Sonchus arvensis L.的干燥全草中分离得到8个化合物,分别为无羁萜(1)、蒲公英萜醇乙酸脂(2)、β-香树酯酮(3)、降香萜烯醇乙酸酯(4)、齐墩果烷(5)、chiratenol acetate(6)、正十六烷酸(7)和正二十七烷醇(8).化合物1～8均为首次从苦苣菜属(Sonchus)植物中分离得到.     

苦味受体抑制剂研究进展

自然界存在多种苦味物质,绝大多数苦味物质通过激活苦味受体而产生苦味.苦味受体抑制剂通过与苦味物质竞争结合位点而起到抑制苦味的作用,在食品和药物掩味方面发挥着重要作用.本文综述了苦味受体抑制剂的生理活性及其在药物中的应用,并根据其化学结构进行了分类.     

Cucurbitane and hexanorcucurbitane glycosides from the fruits of Cucurbita pepo cv dayangua

Phytochemical investigation of the fruits of Cucurbita pepo cv dayangua has led to the isolation of two cucurbitane glycosides: cucurbitacin L 2-O-β-d-glucopyranoside (1), cucurbitacin K 2-O-β-d-glucopyranoside (2) and two hexanorcucurbitane glycosides: 2,16-dihydroxy-22,23,24,25,26,27-hexanorcucurbit-5-en-11,20-dione 2-O-β-d-glucopyranoside (3) and 16-hydroxy-22,23,24,25,26,27-hexanorcucurbit-5-en-11,20-dione 3-O-α-l-rhamnopyranosyl-(1 → 2)-β-d-glucopyranoside (4). Compounds 1, 2 and 3 were isolated from Cucurbita genus for the first time, while compound 4 is a new one. Their structures were determined on the basis of chemical and spectroscopic evidence.     

Cucurbitane and hexanorcucurbitane glycosides from the fruits of Cucurbita pepo cv dayangua

Phytochemical investigation of the fruits of Cucurbita pepo cv dayangua has led to the isolation of two cucurbitane glycosides: cucurbitacin L 2-O-beta-D-glucopyranoside (1), cucurbitacin K 2-O-beta-D-glucopyranoside (2) and two hexanorcucurbitane glycosides: 2,16-dihydroxy-22,23,24,25,26,27-hexanorcucurbit-5-en-11,20-dione 2-O-beta-D-glucopyranoside (3) and 16-hydroxy-22,23,24,25,26,27-hexanorcucurbit-5-en-11,20-dione 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranoside (4). Compounds 1, 2 and 3 were isolated from Cucurbita genus for the first time, while compound 4 is a new one. Their structures were determined on the basis of chemical and spectroscopic evidence.     

New phenolic glycosides from the seeds of Cucurbita moschata

Two new phenolic glycosides were isolated from the seeds of Cucurbita moschata. Their structures were elucidated as (2-hydroxy)phenylcarbinyl 5-O-benzoyl-β-d-apiofuranosyl(1 → 2)-β-d-glucopyranoside (1) and 4-β-d-(glucopyranosyl hydroxymethyl)phenyl 5-O-benzoyl-β-d-apiofuranosyl(1 → 2)-β-d-glucopyranoside (2) on the basis of spectroscopic analysis and chemical evidence.     

铁篱巴果中的三萜成分研究

为研究铁篱巴果的化学成分, 利用柱色谱技术进行分离纯化, 得到3个三萜类化合物, 根据理化性质、光谱数据鉴定其结构为: 22S, 23R-环氧-甘遂烷-7-烯-3α, 24, 25-三醇 (1), 21S, 23R-epoxy-21, 24S, 25-trihydroxy- apotirucalla-7-ene-3-one (2), 21R, 23R-epoxy-21-ethoxy-24S, 25-dihydroxy-apotirucalla-7-ene-3-one (3)。化合物1为新化合物, 化合物2和3为首次从该属植物中分离得到。     

Wound Healing Properties of Triterpenes from Buddleia scordioides in Diabetic Rats

Abstract

The pentacyclic triterpenes 3-O-α-l-rhamnopyranosyl-(1 → 4)-β -d-glucopyranosyl-(1 → 3)-[β -d-glucopyranosyl-(1 → 2)]-β -d- fucopyranosyl-23,28-dihydroxy-oleane-11, 13(18)-diene (1) and 3-O-α-l-rhamnopyranosyl-(1 → 4)-β -d-glucopyranosyl-(1 → 3)-[β -d-glucopyranosyl-(1 → 2)]-β -d-fucopyranosyl-16,23,28-trihydroxy-oleane-11,13(18)-diene (2) isolated from leaves of Buddleia scordioides Kunth (Loganiaceae) were studied for the effect on wound healing, using excision and incision wound modes. Significant increase in granulation tissue, tensile strength, hydroxyproline, total protein, and collagen contents was observed. There was significant reduction in the wound area measurement of the test group compared with that of controls. The efficacious prohealing effect may be due to increased collagen deposition as well as to better alignment and maturation.     

超声提取夏枯草中总三萜类成分的研究

目的:探讨夏枯草中总三萜类成分的提取工艺。方法:采用正交试验设计方案优化夏枯草中总三萜类成分的超声提取工艺。结果:最佳提取工艺为提取温度65℃,85%乙醇,超声30min,10倍溶剂用量,超声提取3次。结论:超声提取既简便又高产,节能且环保。     

New dimeric phthalides from Ligusticum sinense Oliv cv. Chaxiong

A new dimeric phthalide, chaxiongnolide A (1), and a new natural product, chaxiongnolide B (2), together with a known compound Z-ligustilide (3), were isolated from the rhizome of Ligusticum sinense Oliv cv. Chaxiong. Their structures were elucidated by various spectroscopic methods and confirmed by X-ray crystallographic analysis.     

积雪苷霜治疗烧伤创面的临床观察

目的 评估积雪苷霜治疗烧伤创面的疗效.方法 96例烧伤患者随机分成积雪苷霜治疗组和对照组,积雪苷霜组采用积雪苷霜外敷创面,对照组不加外用药,两组全身治疗方案相同.随访评估两组的平均愈合时间.结果 与B组相比,A组平均愈合时间明显缩短(P＜0.05＝.结论 积雪苷霜有助于中小面积烧伤创面的愈合,疗效较好.     

积雪草总苷及其制剂的含量研究.Ⅰ.积雪苷霜软膏中积雪草苷和羟基积雪草苷的HPLC法测定

建立了流动相添加剂-HPLC法测定积雪苷霜软膏中积雪草苷和羟基积雪草苷的含量.采用C_(18)色谱柱,以乙腈-水(30:70,添加β-环糊精4.54 g/L)为流动相,检测波长204nm.积雪草苷和羟基积雪草苷在0.2～20μg范围内线性关系良好,平均回收率为99.20%和98.90%,RSD为1.06%和1.17%.