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In vivo analysis of mechanical wall stress and abdominal aortic aneurysm rupture risk 总被引:3,自引:0,他引:3
Fillinger MF Raghavan ML Marra SP Cronenwett JL Kennedy FE 《Journal of vascular surgery》2002,36(3):589-597
OBJECTIVE: The purpose of this study was to calculate abdominal aortic aneurysm (AAA) wall stresses in vivo for ruptured, symptomatic, and electively repaired AAAs with three-dimensional computer modeling techniques, computed tomographic scan data, and blood pressure and to compare wall stress with current clinical indices related to rupture risk. METHODS: CT scans were analyzed for 48 patients with AAAs: 18 AAAs that ruptured (n = 10) or were urgently repaired for symptoms (n = 8) and 30 AAAs large enough to merit elective repair within 12 weeks of the CT scan. Three-dimensional computer models of AAAs were reconstructed from CT scan data. The stress distribution on the AAA as a result of geometry and blood pressure was computationally determined with finite element analysis with a hyperelastic nonlinear model that depicted the mechanical behavior of the AAA wall. RESULTS: Peak wall stress (maximal stress on the AAA surface) was significantly different between groups (ruptured, 47.7 +/- 6 N/cm(2); emergent symptomatic, 47.5 +/- 4 N/cm(2); elective repair, 36.9 +/- 2 N/cm(2); P =.03), with no significant difference in blood pressure (P =.2) or AAA diameter (P =.1). Because of trends toward differences in diameter, comparison was made only with diameter-matched subjects. Even with identical mean diameters, ruptured/symptomatic AAAs had a significantly higher peak wall stress (46.8 +/- 4.5 N/cm(2) versus 38.1 +/- 1.3 N/cm(2); P =.05). Maximal wall stress predicted risk of rupture better than the LaPlace equation (20.7 +/- 5.7 N/cm(2) versus 18.8 +/- 2.9 N/cm(2); P =.2) or other proposed indices of rupture risk. The smallest ruptured AAA was 4.8 cm, but this aneurysm had a stress equivalent to the average electively repaired 6.3-cm AAA. CONCLUSION: Peak wall stresses calculated in vivo for AAAs near the time of rupture were significantly higher than peak stresses for electively repaired AAAs, even when matched for maximal diameter. Calculation of wall stress with computer modeling of three-dimensional AAA geometry appears to assess rupture risk more accurately than AAA diameter or other previously proposed clinical indices. Stress analysis is practical and feasible and may become an important clinical tool for evaluation of AAA rupture risk. 相似文献
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《Journal of vascular surgery》1998,27(4):632-639
Purpose: Risk for rupture of an abdominal aortic aneurysm is widely believed to be related to its maximum diameter. From a biomechanical standpoint, however, risk is probably more precisely related to mechanical wall stress. Many abdominal aortic aneurysms are asymmetric (for example because of anterior bulging with posterior expansion limited by the vertebral column). The purpose of this work was to investigate the effect of maximum diameter and asymmetric bulge on wall stress. Methods: Three-dimensional computer models of abdominal aortic aneurysms were generated. In one protocol, maximum diameter was held constant while bulge shape factor was varied. The shape factor took into account the asymmetric shape of the bulge. In a second protocol, the shape of the aneurysmal wall was held constant while maximum diameter was varied. Wall stress was computed in each instance with a commercial software package and assumption of physiologic intraluminal pressure. Results: Both maximum diameter and the shape factor were found to have substantial influence on the distribution of wall stress within the aneurysm. In some instances the maximum stress occurred at the midsection, and in others it occurred elsewhere. The magnitude of peak stress acting on the aneurysm increased nonlinearly with increasing maximum diameter or increasing asymmetry. Conclusions: Our computer models showed that the stress within the wall of an abdominal aortic aneurysm and possibly the potential for rupture are as dependent on aneurysm shape as they are on maximum diameter. This information may be important in determining severity of individual abdominal aortic aneurysms and in improving understanding of the natural history of the disease. (J Vasc Surg 1998;27:632-9.) 相似文献
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BACKGROUND: Most vascular surgeons practice a selective policy of operative intervention for patients with ruptured abdominal aortic aneurysm (AAA). The evidence on which to justify operative selection remains uncertain. This review examines the prediction of outcome after attempted open repair of ruptured AAA. METHODS: The Medline and EMBASE databases and Cochrane Database of Systematic Reviews were searched for clinical studies relating to the prediction of outcome after ruptured AAA. Reference lists of relevant articles were also reviewed. RESULTS: The last 20 years has seen >60 publications considering variables predictive of outcome after AAA rupture. Four predictive scoring systems are reported: Hardman Index, Glasgow Aneurysm Score, Physiological and Operative Severity Score for Enumeration of Mortality and Morbidity (POSSUM), and the Vancouver Scoring System. No scoring system has been shown to have consistent or absolute validity. Of the remaining data, there are no individual or combination of variables that can accurately and consistently predict outcome. CONCLUSIONS: Little robust evidence is available on which to base preoperative outcome prediction in patients with ruptured AAA. Experienced clinical judgement will remain of foremost importance in the selection of patients for ruptured AAA repair. 相似文献
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The role of the aortic aneurysm diameter aortic diameter ratio in predicting the risk of rupture 总被引:2,自引:0,他引:2
This study was performed to examine the ratio between the size of an infrarenal aortic aneurysm and the normal aorta proximal to it, in the hope of identifying a high-risk group of patients. All patients underwent a computed tomography scan of the abdomen, at which time the diameters of the largest aneurysm and of the normal proximal aorta were measured. The ratio was calculated by dividing the diameter of the normal aorta (in centimetres) into the diameter of the aneurysm. One hundred and thirty patients were assessed. One hundred asymptomatic patients had a mean ratio of 2.0. The 30 symptomatic patients were subdivided into 2 groups; 17 were symptomatic but had no evidence of rupture (mean ratio 2.7), and the remaining 13 had a contained rupture (mean ratio 3.4). There was a significant difference between the asymptomatic patients and the two symptomatic groups (P less than 0.001). The results suggest that the aneurysm/aorta ratio may be helpful in identifying the high-risk aneurysm. Patients with a ratio of 2.7 or greater are likely to become symptomatic, whereas those with a ratio of 3.4 or greater are at risk of rupture. 相似文献
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The relationship between aortic wall distensibility and rupture of infrarenal abdominal aortic aneurysm 总被引:4,自引:0,他引:4
Wilson KA Lee AJ Lee AJ Hoskins PR Fowkes FG Ruckley CV Bradbury AW 《Journal of vascular surgery》2003,37(1):112-117
OBJECTIVE: A more accurate means of prediction of abdominal aortic aneurysm (AAA) rupture would improve the clinical and cost effectiveness of prophylactic repair. The purpose of this study was to determine whether AAA wall distensibility can be used to predict time to rupture independently of other recognized risk factors. METHODS: A prospective, six-center study of 210 patients with AAA in whom blood pressure (BP), maximum AAA diameter (Dmax), and AAA distensibility (pressure strain elastic modulus [Ep] and stiffness [beta]) were measured at 6 months with an ultrasound scan-based echo-tracking technique. A stepwise, time-dependent, Cox proportional hazards model was used to determine the effect on time to rupture of age, gender, BP, Dmax, BP, Ep, beta, and change in Dmax, Ep, and beta adjusted for time between follow-up visits. RESULTS: Median (interquartile range) AAA diameter was 48 mm (41 to 54 mm), median age was 72 years (68 to 77 years), and median follow-up period was 19 months (9 to 30 months). In the Cox model, female gender (hazards ratio [HR], 2.78; 95% CI, 1.23 to 6.28; P =.014), larger Dmax (HR, 1.36 for 10% increase in Dmax; 95% CI, 1.12 to 1.66; P =.002), higher diastolic BP (HR, 1.13 for 10% increase in BP; 95% CI, 1.13 to 1.92; P =.004), and a decrease in Ep (increase in distensibility) over time (HR, 1.38 for 10% decrease in Ep over 6 months; 95% CI, 1.08 to 1.78; P =.010) significantly reduced the time to rupture (had a shorter time to rupture). CONCLUSION: Women have a shorter time to AAA rupture. The measurement of AAA distensibility, diastolic BP, and diameter may provide a more accurate assessment of rupture risk than diameter alone. 相似文献
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Kotsis T Thomas K Tympa A Aliki T Kalinis A Aris K Vasilopoulos I Ioannis V Theodoraki K Kassiani T 《Annals of vascular surgery》2011,25(7):981-981.e5
Although the mortality rate after abdominal aortic aneurysm rupture approximates 90% despite the urgent management, a few cases of chronic rupture and delayed repair have been reported in the world literature; anatomic and hemodynamic reasons occasionally allow for the fortunate course of these patients. We report in this article the case of 76-year-old man with a ruptured abdominal aortic aneurysm who was transferred to our facility 4 weeks after his initial hospitalization in a district institution and who finally had a successful open repair. 相似文献
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《European journal of vascular surgery》1993,7(6):667-674
Hitherto the size of abdominal aortic aneurysms (AAA) has been considered the most important factor in determining the risk of rupture. For this reason most interest had been devoted to physical, echographic and tomographic analyses of the shape of AAA. However, its is known that rupture can also occur in small AAA. Other factors must be considered to have an important role in the natural history of aneurysms. The aim of t his study was to characterise the mechanical stress in the wall of an AAA due to pressure in the presence of atherosclerosis, intraluminal thrombus and anatomical restraints. The Finite Elements Method (FEM) was used to determine wall stress distribution. Due to the simplicity of the AAA structure an axisymmetric model has been built. The results of the structural analysis confirms that maximum stress increases with diameter. These effects may be reduced by the presence of intraluminal thrombus, which in the models reduces maximum stress by up to 30%; however this is not the case for dissecting thrombus. On the other hand atherosclerotic plaques cause stress concentration and a significant increase in maximum wall stress. The risk of rupture can increase by about 200%. Finally the investigation shows the FEM is a versatile tool for studying the mechanics of vascular structures. It enables the influence of various parameters on wall stress to be quantified in diagnostic settings, and so could be useful for predicting the rupture of AAA, although at present such predictions are limited by data leakage and by the approximations used in the model. 相似文献
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Thubrikar MJ Robicsek F Labrosse M Chervenkoff V Fowler BL 《The Journal of cardiovascular surgery》2003,44(1):67-77
AIM: Our goal is to understand how a mural thrombus may influence the pressure transmitted to and the dilation experienced by the abdominal aortic aneurysm (AAA) wall. METHODS: Two intact AAAs with mural thrombus were removed from patients and pressurized to 100 mmHg. The pressure was measured using a micro-tip needle transducer inserted in the aneurysm wall and advanced through the thrombus. In 1 patient with AAA, similar measurements were made in vivo. Also, in vitro, in the two aneurysms the dilation as a function of pressure was measured using the markers on the surface before and after the thrombus was removed. RESULTS: Both, in vitro and in vivo, in the presence of the thrombus the pressure transmitted to the aneurysm wall was 91+/-10% of luminal pressure and at 6 mm from the wall it was 96+/-5%. The aneurysm dilated more in the pressure range of 0-40 mmHg (2-8%) than in the range of 40-100 mmHg (0.4-1.8%). Upon removal of the thrombus these dilations increased significantly to 4-15% and 0.9-3.3%, respectively. Overall, the strains (dilation) in the circumferential and longitudinal directions were similar before the thrombus was removed. CONCLUSIONS: Even though the thrombus allows the transmission of luminal pressure to the aneurysm wall, it may prevent the aneurysm from rupture by diminishing the strain on the wall. Consistent with this, a mechanical model of the thrombus proposed is "a thrombus as a fibrous network adherent to the aneurysm wall". 相似文献
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E Petersen F W?gberg K A Angquist 《European journal of vascular and endovascular surgery》2002,23(2):153-157
PURPOSE: to investigate proteolysis of the abdominal aortic aneurysm (AAA) wall and the association with rupture. METHODS: levels of matrix metalloproteinases (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinases (TIMP-1 and TIMP-2) were measured in the walls of medium-sized (5-7 cm in diameter) ruptured AAA (rAAA) (n =30) and large (> or = 7 cm in diameter) asymptomatic AAA (aAAA) (n=30). RESULTS: MMP-2 levels (median, range) were significantly higher in the walls of large aAAA (165 ng/g AAA tissue, 50-840) than from medium-sized rAAA (110 ng/g AAA tissue, 47-547, p=0.007). MMP-9 levels were significantly higher in the walls of medium-sized rAAA (107 ng/g AAA tissue, 19-582) than from large aAAA (55 ng/g AAA tissue, 11-278, p=0.012). TIMP-1 and TIMP-2 levels were equivalent. There was a positive correlation between MMP-2 and the diameter of aAAA (r=0.54, p=0.002), but a negative correlation with MMP-9 (r= -0.44, p=0.017). No significant correlations were found between aAAA diameter and TIMP-1 or TIMP-2. CONCLUSION: AAA rupture is associated with higher levels of MMP-9. There is no association with TIMP-1 or TIMP-2 levels. MMP-2 levels are positively, whereas MMP-9 levels are negatively, correlated with aAAA size. MMP-9 may play a role in the progression towards rupture, whereas MMP-2 may play a role in expansion. 相似文献
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Di Martino ES Bohra A Vande Geest JP Gupta N Makaroun MS Vorp DA 《Journal of vascular surgery》2006,43(3):570-6; discussion 576
OBJECTIVE: The purpose of this study was to evaluate and compare the biomechanical properties of abdominal aortic aneurysm (AAA) wall tissue from patients who experienced AAA rupture with that of those who received elective repair. METHODS: Rectangular, circumferentially oriented AAA wall specimens (approximately 2.5 cm x 7 mm) were obtained fresh from the operating room from patients undergoing surgical repair. The width and thickness were measured for each specimen by using a laser micrometer before testing to failure with a uniaxial tensile testing system. The force and deformation applied to each specimen were measured continuously during testing, and the data were converted to stress and stretch ratio. The tensile strength was taken as the peak stress obtained before specimen failure, and the distensibility was taken as the stretch ratio at failure. The maximum tangential modulus and average modulus were also computed according to the peak and average slope of the stress-stretch ratio curve. RESULTS: Twenty-six specimens were obtained from 16 patients (aged 73 +/- 3 years [mean +/- SEM]) undergoing elective repair of their AAA (diameter, 7.0 +/- 0.5 cm). Thirteen specimens were resected from nine patients (aged 73 +/- 3 years; P = not significant in comparison to the electively repaired AAAs) during repair of their ruptured AAA (diameter, 7.8 +/- 0.6 cm; P = not significant). A significant difference was noted in wall thickness between ruptured and elective AAAs: 3.6 +/- 0.3 mm vs 2.5 +/- 0.1 mm, respectively (P < .001). The tensile strength of the ruptured tissue was found to be lower than that for the electively repaired tissue (54 +/- 6 N/cm2 vs 82 +/- 9.0 N/cm2; P = .04). Considering all specimens, no significant correlation was noted between tensile strength and diameter (R = -0.10; P = .55). Tensile strength, however, had a significant negative correlation with wall thickness (R = -0.42; P < .05) and a significant positive correlation with the tissue maximum tangential modulus (R = 0.76; P < .05). CONCLUSIONS: Our data suggest that AAA rupture is associated with aortic wall weakening, but not with wall stiffening. A widely accepted indicator for risk of aneurysm rupture is the maximum transverse diameter. Our results suggest that AAA wall strength, in large aneurysms, is not related to the maximum transverse diameter. Rather, wall thickness or stiffness may be a better predictor of rupture for large AAAs. 相似文献
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Severe jaundice after rupture of abdominal aortic aneurysm 总被引:1,自引:0,他引:1
Eight patients after operation for ruptured abdominal aortic aneurysm developed severe jaundice. The jaundice became clinically apparent by the sixth postoperative day, and the average peak total bilirubin level reached 28.4 mg/100 ml, alkaline phosphatase level 8.6 BL units/l, and SGOT 95 Karmen units/ml. In addition to the hepatic dysfunction, all patients developed acute renal failure, seven of eight patients experienced hypovolemic shock, and six of eight patients had respiratory insufficiency requiring ventilatory support. The overall mortality was 83 per cent. The most probable causes for the severe jaundice were increased bile pigment load and hepatocellular dysfunction due to ischemic hypoxic injury of hepatocytes secondary to shock. Morphologically, a picture of cholestasis existed with severe bile-staining of hepatocytes and intracanalicular and intraductal bile thrombi. No evidence of recent or resolving hepatic necrosis was observed. 相似文献
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腹主动脉瘤破裂的外科治疗 总被引:11,自引:1,他引:10
腹主动脉瘤破裂是血管外科最为凶险的疾病之一,如不及时手术修复,病人24h内生存率<50%,3个月内罕有生存者,早期诊断和及时正确的外科治疗是拯救该类病人生命的关键[1]。随着我国人口老龄化,腹主动脉瘤的发病率呈增加趋势,因此重视腹主动脉瘤破裂的外科治疗具重要的临床意义。诊断和复苏正确诊断和评估腹主动脉瘤破裂是及时准确进行外科治疗的前提。对年龄>50岁、有突发性腹痛和或腰背痛、血压降低或休克、腹部搏动性肿块三联征者,诊断不难确立,对这类病人是否行CT和其他辅助检查,较一致的观点是否定的,及时手术控制出血是关键。但腹主动脉… 相似文献