Early cleft lip repair in children with unilateral complete cleft lip and palate: a case against primary alveolar repair

All children with complete unilateral cleft lip and palate will develop some degree of malocclusion regardless whether the alveolar cleft is repaired primarily or bone grafting is deferred. To evaluate the impact of early gingivoperiosteoplasty on occlusal relationships, dental models were obtained in 5-year-old patients who underwent early cleft lip and palate repair with primary boneless bone grafting (Skoog's method) (56 children) and without alveolar intervention (51 children). The Goslon's occlusion grading system was applied to evaluate occlusal relationships in both groups. Patients with early surgical intervention to repair alveolar cleft demonstrated poor occlusal relationship with the Goslon score 4 and 5, which will likely need an orthognathic corrective procedure (50% vs. 19.6% in patients without early primary dissection of the alveolar process). Results reaffirm that an inclusion of the alveolar process into the early primary lip repair adds to the severity of occlusal maldevelopment.     

唇腭裂的牙槽突裂植骨修复术

牙槽突植骨术是唇腭裂序列治疗的一个组成部分,对于恢复上颌牙弓的完整性,保证上颌牙齿的正常萌出,促进上颌骨的垂直向生长及颌骨的稳定性,矫正患侧鼻底塌陷畸形及修复唇侧口鼻腔瘘均有重大意义。总结了保证手术成功的关键,并认为植骨术前后应接受正畸治疗。8～11岁 X 线片示尖牙根形成2/3为最佳手术时间。     

唇腭裂的牙槽突裂植骨修复术

牙槽突植骨术是唇腭裂序列治疗的一个组成部分，对于恢复上颌牙弓的完整性，保证上颌牙齿的正常萌出，促进上颌骨的垂直向生长及颌骨的稳定性，矫正患侧鼻底塌陷畸形及修复唇侧口鼻腔瘘均有重大意义。总结了保证手术成功的关键，并认为植骨术前后应接受正畸治疗。８～１１岁Ｘ线片示尖牙根形成２／３为最佳手术时间。     

三种唇腭裂修复术对唇腭裂患者语音恢复影响研究

目的:探讨三种唇腭裂修复术对语音恢复的影响.方法:选择65例唇腭裂患者,随机分为反向双Z术组、咽后壁瓣成形术组、腭因肌瓣术组,观察吹水泡时间、软腭抬高角度α0、腭最高点与咽后壁的最短距离d(mm)、语音清晰.结果:三组患者术后吹水泡时间、软腭抬高角度α0、腭最高点与咽后壁的最短距离d(mm)、语音清晰度均明显优于术前(P＜0.05),组间比较无显著性特征(P＞0.05).结论:手术方式是恢复唇腭裂患者语音的最佳选择,三项检查是评价腭音闭合不全的有效手段.     

Computed tomography of alveolar bone grafts 20 years after repair of unilateral cleft lip and palate.

The aim of this study was to estimate the clinical condition and amount of remaining grafted bone 20 years after final repair of unilateral cleft lip and palate. Eighteen consecutive patients had computed tomograms (CT) and clinical examination 20 years or more after secondary bone grafting which had been done at ages of 7-11 years. The images were obtained with a spiral CT with 1 mm collimation, and reconstructed as three-dimensional volumes with reformatted cut planes. The area of grafted bone was measured in a plane perpendicular to the curved axis of the alveolar arch and compared with the area corresponding section through the non-cleft side. The clinical examination showed satisfactory results in all. CT indicated a mean cross sectional area of 97 mm2 on the cleft side compared with 157 mm2 on the non-cleft side. The bone mass was significantly less on the grafted cleft side (p < 0.001), but the functional results were satisfactory.     

唇腭裂患者手术后上颌骨发育的评价研究

目的　研究唇腭裂术后患者上颌骨发育特征及手术对发育造成的影响。方法　将 6 0例婴幼儿期手术的完全性唇腭裂患者作为研究对象 ,采用X线头影测量方法进行测量 ,拍摄标准侧位头影测量片 ,并选择 12个标志点及 12个测量项目 ,并与同年龄段正常患者的测量值进行比较分析。结果　单纯唇裂患者与正常对照组比较出现∠SNA [(76 .4± 3.0 6 )° ,P 0 .0 5 ]、N A Pg[(- 4 .8± 6 .31)mm ,P 0 .0 5 ]值变小 ;单纯腭裂及唇腭裂患者出现∠SNA[(74 .5± 4 .0 1)° ,P 0 .0 5 ;(75 .1± 1.0 7)°,P 0 .0 1]、N ANS[(47.3± 2 .4 1)mm ,P 0 .0 1;(49.8± 1.91)mm ,P 0 .0 1]等多项指标均小于正常对照 ,提示不同程度、不同表现形式的上颌骨发育受限。结论　唇腭裂患者术后上颌发育不足是先天及后天因素综合影响的结果。唇裂修复术是影响上颌前后向发育的重要因素之一 ,腭裂修复术是影响上颌骨高度及宽度发育的重要因素之一。     

Facial growth and development during the pubertal period in patients with complete unilateral cleft of lip one palate

The study is based on a long-term cephalometric follow-up of lateral X-ray films of 48 boys with complete unilateral cleft lip and palate during puberty. The configuration of the face was negatively influenced by the reduced depth of the maxilla and limited vertical growth of the upper lip. As compared with the mandible, the maxilla grew less harmoniously in many respects; on the soft profile the depth of the nose increased most intensely. Retrusion of the maxilla led to a deterioration of sagittal intermaxillary relations in almost 92% of patients. In 32% of these patients the deterioration exceeded 3 of the ANB angle, and in 27% a transition from the 1st to the 3rd skeletal class was recorded. 25% of the subjects already belonged in class III at the age of ten years. In 94% of patients during puberty, flattening of the face occurred, which was frequently associated with a sunken upper lip (63%). Due to successful orthodontic treatment it was possible to restore maxillary overjet in 46% of the patients. In subjects who had a maxillary overjet of at least 2 mm at the age of 10 years, it did not change to negative values by the age of 15 years. Patients with more severe impairment of the jaws were treated more frequently by means of fixed appliances, but they did not differ substantially from the other patients in their further development (with the exception of a significant anteinclination of the palate).     

Speech results in adult Swedish patients born with unilateral complete cleft lip and palate.

Sixty-one adult patients (34 men and 27 women) who were operated on for unilateral complete cleft lip and palate (UCLP) were followed up from 1996-2001 by clinical investigation, perceptual speech analysis, and self-estimation of quality of speech. Thirty-four had had a von Langenbeck repair at the age of 8 months (L-8 group), and 27 a Wardill repair at the age of 18 months (W-18 group). Statistical comparisons were made by univariate and multiple logistic regression analyses. The L-8 group had a slightly better general outcome but at the expense of a greater incidence of velopharyngeal flaps. There was no significant difference in hypernasality, being 7/34 (21%) of the patients in the L-8 group, compared with 9/27 (33%) in the W-18 group. Compared with findings reported previously of patients with isolated cleft palate (CP) who were treated and investigated under the same circumstances, the speech outcome in the group with UCLP was found to be significantly better.     

干细胞在唇腭裂患者牙槽突裂中应用的研究进展

干细胞具有自我更新能力及多向分化潜能,已被广泛应用于多个领域。相对于唇腭裂患者牙槽突裂的常规手术治疗方法,干细胞具有来源广泛、取材方便、免疫原性低等优点,整形外科医生已逐渐关注唇腭裂患者牙槽突裂干细胞治疗的研究。该文对胚胎干细胞、人间充质干细胞、颌面部来源干细胞在唇腭裂患者牙槽突裂中应用的研究进展进行了综述。     

An analysis of complications in secondary bone grafting in patients with unilateral complete cleft lip and palate

Aim: The aim of this investigation was to assess the outcome of secondary alveolar bone grafts 6 months after the procedure and examine the possible influence of patient sex, age at surgery, cleft width, and dehiscence of mucosa and sequestered bone at 2 weeks.

Methods: Thirty-nine consecutive patients with unilateral complete cleft lip and palate were reconstructed with secondary alveolar bone grafting. Age at surgery ranged from 7.3–12.5 years (mean?=?8.6). Cleft width varied between 2.2–14?mm (mean?=?7.3). Bone was harvested either from the iliac crest or from the chin. Two-dimensional dental radiographs of the cleft area were taken before and 6 months after surgery.

Results: Two weeks after surgery, 10 patients had minor dehiscence of the sutured gingival tissues and five had bone sequesters. However, only one of the treatments turned out to be unsuccessful with a Bergland index of IV. Twenty-nine patients had an initial uneventful course; but, at a follow-up 6 months later, two patients had a Bergland index of III and four a Bergland index of IV. In three of these cases, there were circumstances that could have contributed to the lack of success; but, in the remaining three, no such circumstances could be identified.

Conclusion: The success rate of secondary bone grafting is high, and initial wound healing problems do not necessarily lead to a failed reconstruction. Failure may be related to factors such as exposed tooth enamel during an operation, postoperative infection, and poor compliance. Still, failed operations occur without any obvious causes.     

Analysis of intracranial relations in patients with unilateral cleft lip and palate using cluster and factor analysis

The present investigation was based on the cephalometric analysis of lateral teleroentgenographic pictures of 48 ten-year-old boys with complete unilateral clefts of the lip and palate. Using cluster and factor analysis, the author investigated the relationships among 75 craniofacial size, shape and position characteristics. Both multivariation methods proved useful in the search for associations between partial cranial structures. They supplemented each other well, and their combined use contributed to the definition of the following basic and specific principles of craniofacial relations and compensatory and adaptive mechanisms in patients with clefts. The maxilla consists of two mutually almost independent parts. The vertical parameters of the anterior upper face are interrelated with the slope of the palate plane; the dentoalveolar component of the upper jaw is formed independently. This fact can be aptly explained by the effect of orthodontic treatment, which contributes substantially to an improvement of the facial configuration. Rotation of the mandible has an impact on the vertical dimensions of the anterior lower, as well as the whole, face and is closely associated with the position of the mandibular body but not with the position of its branch nor with its length. The slope of the mandibular branch correlates with the mental angle, with the gonial angle and the slope of its dentoalveolar component, which is the result of adaptation to a shortening of the maxilla while preserving a positive overjet. Damage to the sagittal intermaxillary and interalveolar relations is primarily due to a reduction in the depth of the maxilla and is associated with the length of the mandibular body, while no relation with its rotation or length of the ramus was found. Solution of the given problem may help to find predictive models of facial development in patients with clefts.     

Craniofacial and occlusal characteristics in unilateral cleft lip and palate patients from four Scandinavian centres.

Craniofacial morphology and dental occlusion were studied at early school age in 15 consecutive patients with unilateral cleft lip and palate from each of four Scandinavian cleft centres. Treatment differed mainly in the techniques of palatal repair. Push-back closure of the palate particularly impaired maxillary development, which resulted in an increased incidence of crossbite and reduced intercanine distance when compared with patients who had been operated on by the von Langenbeck method or in whom the anterior palate had not yet been closed.     

Skeletal stability of Le Fort I osteotomy in patients with unilateral cleft lip and palate.

The skeletal stability of Le Fort I osteotomy was evaluated cephalometrically in 40 consecutive patients with unilateral cleft lip and palate (UCLP) (27 male and 13 female) who were operated on between 1987-1995. Their mean age at the time of operation was 23.7 years (range 16.3-40.4). The one-piece Le Fort I osteotomy was fixed with titanium plates and the osteotomy line was bone-grafted. Neither intermaxillary fixation nor occlusal splints were used postoperatively. Skeletal stability was analysed both horizontally and vertically on cephalograms taken shortly before operation, immediately afterwards, and at six months and at one year postoperatively. The mean maxillary advancement (point A) during the Le Fort I was 3.9 mm (range 0-8.9) and mean vertical lengthening 4.5 mm (range -0.6-10.5). One year postoperatively the mean maxillary horizontal relapse was 20.5% (0.8 mm, range 0-3.7) whereas the mean vertical relapse was 22.2% (1 mm, range 0-5.7). The vertical relapse reduced from 38% to 8.3% between 1987 and 1995, and there was a positive correlation between the amount of maxillary advancement and relapse both horizontally and vertically.     

A 20 year audit of nose-tip symmetry in patients with unilateral cleft lip and palate.

The purpose of this study was to audit the process and outcome in terms of nasal-tip symmetry of the first 20 patients with unilateral complete cleft lip and palate treated by the Pigott alar leapfrog primary nasal correction in the early 1970s and followed for 20 years. Symmetry was assessed using the Coghlan computer-based analysis of frontal and basal views to determine the stability of the correction. The Abyholm technique of alveolar bone grafting was performed in 12 of the 20 patients. Various other secondary procedures have been performed on the nose tip and septum to improve the airway or appearance. Photographs were taken within one year of ages 5, 10, 15 and 20 years, and the lower border of the nose, the alar domes and the nostrils were assessed. To assess the overall change from 5 years to 20 years, both views were available for 17 patients. No significant change was found in the lower border or nostril symmetry, but significant deterioration at the P< 0.01 level was found on the basal view. We assessed the 10, 15 and 20 year views of all 12 patients who had undergone alveolar bone grafting to determine early and late changes. No significant benefit was found from alveolar bone grafting or minor secondary procedures for appearance. Consequently, our criteria for undertaking minor adjustments to improve appearance have become more stringent. We consider that objective reporting of appearance should become essential in peer-reviewed journals.     

Predicting the development of jaws in patients with complete unilateral cleft of the lip and palate

The main objective of this study was to find a predictive multivariate model of jaw development in patients with the most frequent cleft malformation, i.e. complete unilateral cleft lip and palate (UCLP). The prediction is urgently needed from the clinical aspect. It will be possible to detect early adversely developing patients upon whom intensive care and adequate orthodontic treatment could be devoted in good time. The study is based on a long-term cephalometric follow-up of lateral X-rays of 48 boys with UCLP during puberty. Using multivariate methods we investigated the relationship of 75 craniofacial characteristics of size, shape and position during the time interval from 10 to 15 years of age. As the prediction of the development of the jaws in patients with clefts is very complicated, we have attempted to find a reliable predictive system. Sagittal intermaxillary relations can be predicted most accurately in the investigated group by means of the angular dimension Ss-N-Sm (A-N-B angle). We suggest using in clinical practice trinomial equations, the coefficient of determination of which varies round 0.80, and thus the position of the variables can be explained with sufficient accuracy (the coefficient of determination 0.64 is considered in orthodontics a value of predictive significance). The proposed predictive technique was successfully tested in a group of 12 patients with the same diagnosis and therapy.     

牙槽裂植骨同期鼻中隔骨支架植入鼻整形术

目的　研究在牙槽裂植骨修复的同时 ,利用自体髂骨皮质板块 ,修复单侧唇腭裂鼻畸形。方法　 10岁以后的单侧完全性唇腭裂患者 ,采用自体髂骨松质骨移植修复牙槽裂 ,同时采取髂骨内侧骨皮质修整后植入两侧鼻翼软骨内侧脚之间 ,形成鼻中隔前下部的骨性基础支架 ,将分离复位的鼻翼软骨内侧脚提升 ,使软骨穹窿顶超过骨性支架的上缘约 3mm ,将软骨缝合固定于骨性支架。结果　本组 2 4例患者均一期痊愈出院 ,患侧鼻翼基部凹陷、鼻小柱偏斜、鼻尖低平等畸形得到良好的矫正。结论　牙槽裂植骨与鼻畸形整复同期进行互不干扰。鼻中隔前骨性支架对鼻的外形结构有良好的支持作用 ,可以有效地矫正唇腭裂鼻畸形 ;与牙槽裂植骨同期进行 ,取材方便 ,减少了手术及麻醉的次数。