类风湿关节炎的治疗进展

类风湿关节炎(rheum atoid arthritis,R A)在我国患病率约为0.32%～0.36%,主要表现为全身多关节的慢性侵蚀性滑膜炎,随病情进展可侵犯关节软骨、软骨下骨、韧带和肌腱等,最终导致关节畸形和功能丧失,严重者可出现全身多系统损害。近十余年来,人们对R A治疗的认识有了重要转变,早...     

Current treatment strategies for rheumatoid arthritis

The management of rheumatoid arthritis has changed considerably during the past 15 years. Current strategies emphasize the need for early diagnosis and therapeutic intervention based on the use of disease-modifying antirheumatic drugs. The advent of agents that are more tailored to inhibit the specific disease processes will profoundly affect management. Immunogenetic studies may eventually assist in identifying subgroups of patients with rheumatoid arthritis who have more aggressive disease and who require a more aggressive treatment approach.     

超声在类风湿性关节炎诊治中的应用进展

超声能准确反映类风湿性关节炎患者关节腔积液、滑膜厚度、滑膜内血流信号、软骨、骨质等情况,相对于其他影像学检查,具有较高特异性及敏感性,且费用低廉,可广泛运用于协助类风湿性关节炎诊断及治疗后的疗效评估,指导临床方案制定。本文就超声在类风湿性关节炎诊治中的作用做一综述。     

Current understanding of rheumatoid arthritis therapy

Progress in understanding the cellular and molecular mechanisms of rheumatoid arthritis (RA), together with the availability of new therapies, has changed the way we think about RA. The paradigm shift in RA therapy has been from controlling symptoms to controlling the disease process with the abrogation of inflammation. Challenges that are still unresolved include the issues in disease prevention, treatment specificity to restore tolerance, approaches to facilitate tissue repair, and treatment optimization to fit the individual patient's disease phenotype and comorbidity context. This review summarizes the pathogenesis-related rationales for the current therapeutic strategies in RA and for emerging therapies and potential approaches to restoring immune tolerance in RA.     

Current knowledge about pathogenesis and treatment of arterial hypertension in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease with a proved high risk of cardiovascular diseases (CVD). An increase of this risk is mainly due to accumulation of conventional factors of CVD development (arterial hypertension - AH), dislipidemia, et cet). Causes of high prevalence of AH in RA, the role of chronic inflammation, effects of antirheumatic drugs with potentially hypertensive effects are outlined and recommendations on AH prevention and treatment in RA patients are given.     

Arthrotec treatment of rheumatoid arthritis

AIM: To try arthrotek, a combined drug, in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: 10 RA women aged 30 to 60 years with endoscopically verified minimal affection of gastroduodenal mucosa (not more than 25 hemorrhages and/or 5 erosions) received arthrotek (1 tablet 3 times a day for 3 months). The efficacy was judged by changes in the joints and gastroduodenal lesions. RESULTS: The 3-month treatment produced positive changes in the main auricular and gastroduodenal symptoms. Side effects (head ache, diarrhea, sleepiness) disappeared after reducing the day dose to 2 tablets. CONCLUSION: Arthrotek proved highly effective against RA. It is also a good gastroprotector promoting healing of gastroduodenal erosions.     

类风湿性关节炎的康复治疗

类风湿性关节炎的患者在成人中约占 0 .1%—0 .3% ,好发年龄在 2 0— 5 0岁 ,男女比例为 1∶4 ,患者中约有 15 %的人病情呈进行性发展 ,可造成关节的高度变形和功能障碍 ,引起严重的残疾。本病主要发生于活动关节 ,且常有各种关节外的症状和体征 ,因此 ,是一种全身性的疾病。1病理目前认为 ,类风湿性关节炎早期表现为滑膜炎 ,可有滑膜充血水肿、纤维变性、肉芽组织形成。此后 ,炎性的肉芽组织在关节软骨形成血管翳 ,破坏吸收软骨组织 ;如果炎症波及到关节软骨下的骨板 ,可破坏关节 ,造成关节松动、不稳定 ,使关节半脱位或全脱位 ,最后 ,肉芽…     

Nutritional treatment of rheumatoid arthritis

This feature focuses on recent nutrition studies that are relevant to clinical medicine. The basis for each discussion is an article from a notable medical or scientific journal. Dr Podell evaluates the findings presented and speculates about their implications for primary care.     

Therapeutic progress II: treatment of psoriasis

Treatment of psoriasis is rapidly changing with improved understanding of the pathogenesis of the disease. Newer topical preparations such as calcipotriol and immunosuppressive agents such as cyclosporin A and FK506 are having a major impact on the therapy of psoriasis. This article reviews the conventional therapies and newer agents used in the treatment of this common dermatosis.