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1.
Glutathione S-transferase activity increased in rats with acute pancreatitis: 2.2 times on day 2, 2-fold on day 4, and 1.5
times on day 10. Inducers of microsomal enzymes aroclor 1254 and phenobarbital notably inhibited glutathione S-transferase
activity in animals with experimental pancreatitis on days 2–4 of the disease (3.1–2.5 times in comparison with sham-operated
induced animals). Hence, the activity of enzymes of phase II of liver xenobiotic metabolism is altered in acute pancreatitis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 5, pp. 542–543, May, 2000 相似文献
2.
G. I. Nikonov E. A. Titova K. G. Seleznev 《Bulletin of experimental biology and medicine》1999,128(6):1244-1247
Antiprocoagulant complex isolated from lyophilized medicinal leeches exerted pronounced antithrombotic, thrombolytic, and
hypotensive effects in experimental animals after intravenous injection and showed antithrombotic activity after oral administration
in combination with hirudone, the source of hyaluronidase and inhibitors of digestive proteolytic enzymes. The antiprocoagulant
complex can be used as a specific medicinal preparation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 12, pp. 673–676, December, 1999 相似文献
3.
N. I. Gryazeva A. V. Shurlygina L. V. Verbitskaya E. V. Mel'nikova N. N. Kudryavtseva V. A. Trufakin 《Bulletin of experimental biology and medicine》2000,129(1):44-46
The influence of social status on some immunological characteristics in experimental animals was studied (sensory contact
model). Lactate dehydrogenase activity in blood lymphocytes changed similarly in aggressive and submissive mice probably due
to social stress. The activity of succinate dehydrogenase changed differently and correlated with the type of social behavior.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 53–55, January 2000 相似文献
4.
V. V. Andreev A. A. Kubatiev V. A. Yurkiv N. L. Kol'tsova 《Bulletin of experimental biology and medicine》1976,82(2):1164-1166
In experimentsin vitro after preliminary incubation of fibrinogen with terrilytin clot formation was retarded and subsequent lysis accelerated. Terrilytinin vitro lengthened the recalcification time, reduced thromboplastic activity and fibrinase activity and, at the same time, increased the fibrinolytic activity of blood plasma. In experiments on dogs roentgenovasography revealed considerable thrombolytic activity of terrilytin when injected intravenously into animals with experimental thrombosis of the femoral veins.Pathophysiological Laboratory, Institute of Human Morphology, Academy of Medical Sciences of the USSR. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 8, pp. 936–937, August, 1976. 相似文献
5.
U. R. Farkhutdinov R. R. Farkhutdinov 《Bulletin of experimental biology and medicine》2000,129(3):293-295
Acute experimental pneumonia in animals is accompanied by enhanced production of active oxygen forms by alveolar macrophages
and increased plasma chemiluminescence. Low photosum of chemiluminescence and suppression of bactericidal activity of alveolar
macrophages together with increased blood content of low-molecular-weight peptides are signs of lung destruction.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 3, pp. 344–346, March, 2000 相似文献
6.
N. I. Tsirel'nikov N. P. Voronina 《Bulletin of experimental biology and medicine》1996,121(3):241-243
The activity of alkaline phosphatase of female CBA and BALB/c mice is studied after bilateral adrenalectomy. Interstrain differences
in enzyme activity are revealed in some organs of the control and experimental animals. The expression of new isoforms of
alkaline phosphatase in hypocorticoidism is demonstrated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3 pp. 262–264, March, 1996
Presented by V. P. Kaznacheev, Member of the Russian Academy of Medical Sciences 相似文献
7.
G. B. Kirillicheva M. S. Solov'eva I. G. Baturina A. V. Pronin M. A. Tumanyan 《Bulletin of experimental biology and medicine》1997,124(6):1206-1210
Immunomodulating effect of salmozan injected at different times of the day was assessed by changes in 5-nucleotidase activity
of mouse peritoneal macrophages. The effect of the immunomodulator correlates with the level of 5-nucleotidase activity in
control animals. When this value was high in the control, it was decreased in experimental rats, and vice versa. The effect
of the immunomodulator on the enzyme activity and on immune and neuroendocrine parameters is governed by the “mirror symmetry”
principle.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 12, pp. 658–662, December, 1997 相似文献
8.
Age-related and thymus-dependent regulation of telomerase activity was studied in the bone marrow of normal (physiological
aging) and thymectomized (experimental aging) mice. There was no strong correlation between the age and telomerase activity
in bone marrow cells of normal mice. We observed only small individual differences in telomerase activity. Thymectomy 2-fold
increased telomerase expression in young (2-month-old) and old (24-month-old) animals. Individual differences in telomerase
activity in the bone marrow of thymectomized mice were more pronounced and did not depend on the age. The role of the thymus
in cell aging is discussed.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 6, pp. 654–656, June, 2000 相似文献
9.
O. V. Fidelina O. S. Gorbatyuk I. G. Akmaev 《Bulletin of experimental biology and medicine》1998,125(3):248-250
The activity of nitroxide synthetase (NOS) was studied histochemically and levels of oxytocin and vasopressin immunocytochemically
in rat hypothalamus paraventricular nuclei in on-earth experiments simulating space flight conditions with landing. Colonization
of oxytocin and NOS was found in large-cell neurons of paraventricular nuclei. After 15 days under conditions of simulated
microgravitation followed by 1-day double gravitation and a short-term (1 day) macrogravitation, activities of NOS and content
of neuropeptides increased in large-cell neurons of paraventricular nuclei of experimental animals.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, pp. 282–284, March, 1998 相似文献
10.
P. A. Pirumov N. E. Ordyan V. Yu. Vasil'ev V. G. Shalyapina 《Bulletin of experimental biology and medicine》2000,129(1):86-88
Effects of individual fractions of the liquor preparation from drug addicts, eluted from filters after liquor adsorption session,
on rat behavior in an elevated plus-maze was analyzed. Fraction I activated and fraction IV inhibited orientation and exploratory
activity and increased anxiety of experimental animals. Effects of fraction IV coincided with the effect of total preparation
on rat behavior in an elevated plus-maze, which indicates that this fraction contains substances actively accumulating in
the liquor of drug addicts and partially responsible for functional changes observed during abstinence.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 100–102, January, 2000 相似文献
11.
V. V. Frol'kis B. V. Pugach A. L. Kobzar' 《Bulletin of experimental biology and medicine》1996,121(6):569-571
Myocardial hyperfunction is experimentally modeled by coarctation of the aorta in mature (6–8-month-old) and senescent (26–28-month-old)
Wistar rats. During the emergency phase of cardiac hyperfunction Na,K-ATPase activity is shown to rise reliably in mature
animals, while in old rats it remains unchanged. Cardiomyocyte cytosol and blood plasma from mature (but not old) rats with
experimental coarctation of the aorta activate Na,K-ATPase in membranes from the myocardium of both the mature and old rats.
It is assumed that the activation of Na,K-ATPase during the emergency stage of cardiac hyperfunction is mediated through synthesis
of specific invertors. In senescent animals the synthesis of invertors probably becomes insufficient, while membrane sensitivity
to them is preserved.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 6, pp. 631–633, June, 1996 相似文献
12.
I. P. Anokhina Zh. D. Bespalova T. V. Proskuryakova N. V. Pankratova M. E. Pal'keeva O. B. Petrichenko 《Bulletin of experimental biology and medicine》1998,125(6):573-575
Psychotropic activity of two cholecystokinin analogs Trp-R1-Asp-Phe-NH2 and R2-Trp-R3-Asp-Phe-NH2 is studied using behavioral tests. Both analogs have no effect on motor activity. Trp-R1-Asp-Phe-NH2 in doses of 0.1 and 0.3 mg/kg exhibits anxiogenic activity and impairs learning (only in a dose of 0.1 mg/kg) of experimental
animals. R2-Trp-R3-Asp-Phe-NH2 possesses no anxiogenic activity and in doses of 0.1 and 0.3 mg/kg promotes learning, which attests to its nootropic activity.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 6, pp. 647–650, June, 1998 相似文献
13.
Yu. V. Burov T. N. Robakidze S. A. Sukhanova L. E. Davydova 《Bulletin of experimental biology and medicine》1996,121(3):262-264
A study is made of the effect of thymoptin, a preparation containing a complex of acid peptides from the thymus, on the behavior
of experimental animals. It is found that in a dose of 400 μg/kg the preparation enhances motor activity, raises the body
temperature, augments pain sensitivity, stimulates behavior in the open field test, and facilitates learning and memory processes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121 N
o
3, pp. 285–287, March, 1996
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences 相似文献
14.
V. K. Khugaeva Zh. D. Bespalova 《Bulletin of experimental biology and medicine》1998,126(5):1100-1102
Leu-enkephalin analog reduces cerebral circulation in mild and has no effect in moderate ischemia, while in severe cerebral
ischemia it causes periodic compensatory enhancement of cerebral circulation in experimental animals, instead of its monotonous
reduction, thus ensuring 100% survival during a 6-h period, whereas in the control group 60% animals die within 3 h.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 516–519, November, 1998 相似文献
15.
E. V. Nesterova A. D. Durnev S. B. Seredenin 《Bulletin of experimental biology and medicine》1999,128(6):1254-1258
Acrylamide significantly increased the number of cells with chromosome aberrations in BALB/c and C57B1/6, but not in CBA mice.
No difference was found between the BALB/c and C57B1/6 strains in the clastogenic effect of acrylamide. Within the studied
concentration range acrylonitrile exerted no genotoxic effects. Verapamil significantly potentiated the clastogenic effect
of acrylamide in BALB/c mice, while in C57B1/6 mice potentiation was observed only after the repeated intragastric administration
of verapamil in a dose of 2.5 mg/kg. Acrylonitrile in combination with verapamil also produced a slight clastogenic effect
after single and repeated administrations. Thein vivo comutagenic activity of verapamil depended on the dose, administration route and schedule, and genotype of experimental animals.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 12, pp. 684–689, December, 1999 相似文献
16.
L. F. Panchenko V. Yu. Baronets N. N. Terebilina V. V. Aristova S. V. Litvinova L. V. Kalyuzhnyi 《Bulletin of experimental biology and medicine》1995,120(5):1114-1116
Morphine injected subcutaneously in a dose of 2 mg/kg body weight exerted an analgesic effect in some Wistar rats (morphine-sensitive
animals), as was indicated by a significantly prolonged latency of the tail-flick response, butfailed to produce analgesia
in others (morphine-insensitive animals). In morphine-sensitive rats, the striatum had the highest enkephalinase A activity,
followed in decreasing order by the mesencephalon, hippocampus, pons, cortex, medulla oblongata, and hypothalamus. Thirty
minutes after intraperitoneal administration of naloxone (0.3 mg/kg body weight) to morphine-sensitive rats, enkephalinase
activity fell significantly in the hippocampus, striatum, and cortex, remained unchanged in the pons and medulla oblongata,
and rose significantly in the mesencephalon and insignificantly in the hypothalamus; generally similar differences in enkephalinase
activity from naloxone-untreated morphine-sensitive rats were recorded in the brain structures of morphine-insensitive rats
given saline instead of naloxone.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
11, pp. 492–494, November, 1995
Presented by K. V. Sudakov, Member of the Russian Academy of Medical Sciences 相似文献
17.
I. V. Darmov I. V. Marakulin I. P. Pogorel'skii O. D. Novikova O. Yu. Portnyagina T. F. Solov'eva 《Bulletin of experimental biology and medicine》1999,127(2):200-202
Protective properties of two molecular forms of porin, a protein from the outer membrane ofYersinia pseudotuberculosis, are studied in animals infected with pseudotuberculosis and plague agents. The effect of adjuvant on the protective activity
of porin is investigated. The possibility of using porin as a component of chemical antipseudotuberculosis vaccine is demonstrated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 2, pp. 221–223, February, 1999 相似文献
18.
Rats with low and high resistance to hypoxia are shown to differ in terms of the baseline activity of liver monooxygenases
bothin vivo andin vitro. Low-resistance animals are characterized by a significantly higher rate of elimination of antipyrine, hexenal, and nifedipine,
as evidenced by shorter half-elimination period and higher urinary concentration of metabolites. The concentration of microsomal
cytochromes P-450 and b5 as well as the rates of N-demethylation of amidopyrine, p-hydroxylation of aniline, and hydroxylation
of diazepam are considerably higher in rats with low resistance to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 9, pp. 291–294, September, 1996 相似文献
19.
O. A. Gorukhina R. D. Ilyuk I. V. Mishchenko 《Bulletin of experimental biology and medicine》2000,130(1):665-668
In vivo histoautoradiographic study of cerebral accumulation of exogenous histone after its intracarotid infusion to anesthetized
rats with intact liver and animals with experimental cirrhosis showed that histone penetrates brain capillary endotheliocyte
membranes and gets into the nervous tissue.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 63–66, July, 2000 相似文献
20.
Gorukhina OA Ilyuk RD Mishchenko IV 《Bulletin of experimental biology and medicine》2000,130(7):665-668
In vivo histoautoradiographic study of cerebral accumulation of exogenous histone after its intracarotid infusion to anesthetized
rats with intact liver and animals with experimental cirrhosis showed that histone penetrates brain capillary endotheliocyte
membranes and gets into the nervous tissue.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 63–66, July, 2000 相似文献