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1.
Aty Widyawaruyanti Subehan Surya Kant Kalauni Suresh Awale Maria Nindatu Noor Cholies Zaini Din Syafruddin Puji Budi Setia Asih Yasuhiro Tezuka Shigetoshi Kadota 《Journal of natural medicines》2007,61(4):410-413
Two new prenylated flavones, artocarpones A and B (1 and 2), and seven known isoprenylated flavonoids, artonin A (3), cycloheterophyllin (4), artoindonesianin E (5), artoindonesianin R (6), heterophyllin (7), heteroflavanone C (8), and artoindonesianin A-2 (9), have been isolated from the stem bark of Artocarpus champeden. Their structures were determined by spectroscopic analysis. Among the compounds isolated, 8 had the most potent inhibitory activity against the growth of Plasmodium falciparum 3D7 clone, with an IC50 value of 1 nmol L−1. 相似文献
2.
Seong Su Hong Chul Lee Chang Hee Lee Mieon Park Moon Soon Lee Jin Tae Hong Heesoon Lee Mi Kyeong Lee Bang Yeon Hwang 《Archives of pharmacal research》2009,32(4):501-504
A new sesamin type furofuran lignan, (−)-sesamin-2,2′-diol (1), along with two known flavonoids (2 and 3) and three phenolic compounds (4–6) were isolated from the aerial parts of Isodon japonicus. The structures of these compounds were determined by analysis of spectroscopic data (1D-, 2D-NMR, HRMS and CD) and by comparison
of the data with those of related metabolites. 相似文献
3.
Nine known compounds, butyrospermol (1), lupeol (2), stigmast-4-en-3-one (3), stigmast-4-ene-3,6-dione (4), (+)-methyl abscisate (5), methyl indole-3-carboxylate (6), vanillin (7), methyl (E)-caffeate (8), and methyl (E)-ferulate (9), and two new compounds, methyl (E)-feruloylglycolate (10), and methyl-7,8-dihydro-(S)-7-methoxyferulate (11), have been isolated from the roots of Ligularia dentata Hara (Compositae). The structures were elucidated on the basis of spectral data. 相似文献
4.
Ono M Mishima K Yamasaki T Masuoka C Okawa M Kinjo J Ikeda T Nohara T 《Journal of natural medicines》2009,63(1):86-90
A new lignan glucoside (1) was isolated from the stems of Callicarpa japonica Thunb. var. luxurians Rehd. (Verbenaceae), along with six known lignan glucosides and three known triterpenoids. The chemical structure of 1 was characterized as (+)-lyoniresinol 3α-O-(6″-3,5-dimethoxy-4-hydroxybenzoyl)-β-d-glucopyranoside on the basis of spectroscopic data. In addition, the radical-scavenging effect of four lignans on the stable
free radical 1,1-diphenyl-2-picrylhydrazyl was examined. Among the tested compounds, three compounds, including 1, showed almost the same scavenging activity as that of α-tocopherol. 相似文献
5.
Three new prenylated xanthones, 1,3,5-trihydroxy-6,7-[2′-(1-methylethenyl)-dihydrofurano]-xanthone (1), 1,3,5-trihydroxy-6,7-[2′-(1-hydroxy-1-methylethyl)-dihydrofurano]-xanthone (2), and 1,3,5-trihydroxy-6-O-prenyl-xanthone (3), together with eight known compounds were isolated from the leaves of Hypericum ascyron. Compound 3 has an O-prenyl moiety, and therefore represents the first reported xanthone to have an O-prenyl moiety from genus Hypericum. The structures of the isolated compounds were established based on spectroscopic data and on a comparison with values for
previously identified analogues. 相似文献
6.
Tanaka H Hattori H Tanaka T Sakai E Tanaka N Kulkarni A Etoh H 《Journal of natural medicines》2008,62(2):228-231
A new Erythrina alkaloid, 10-hydroxy-11-oxoerysotrine (1), has been isolated from the flowers of Erythrina herbacea together with five known compounds: erytharbine (2), 10,11-dioxoerysotrine (3), erythrartine (4), erysotramidine (5) and erysotrine-N-oxide (6). The structure of the new compound was elucidated on the basis of its spectral data, including 2-D NMR and mass (MS) spectra.
The new compound is a rare C-10 oxygenated Erythrina alkaloid. The antioxidant activities of the isolated compounds 1–6 were evaluated by scavenging with peroxynitrite. 相似文献
7.
A new kaempferol trioside [kaempferol 3-O-rutinoside 7-O-β-d-apiofuranoside, (1)] was isolated together with nine phenolic compounds, trans-tiliroside (2), caffeic acid (3), chlorogenic acid (4), 3-O-caffeoylquinic acid (5), 4-O-caffeoylquinic acid (6), 3-O-coumaroylquinic acid (7), 4-O-coumaroylquinic acid (8), 3,5-di-O-caffeoylquinic acid (9) and 4,5-dicaffeoylquinic acid (10) from the leaves of Solidago altissima L. The structure elucidations of the compounds were based on the analyses of spectroscopic data. 相似文献
8.
Nazemiyeh H Rahman MM Gibbons S Nahar L Delazar A Ghahramani MA Talebpour AH Sarker SD 《Journal of natural medicines》2008,62(1):91-95
Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures
of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear
magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations. 相似文献
9.
Tzong-Huei Lee Yuan-Hsiang Chiang Chin-Hui Chen Pi-Yu Chen Ching-Kuo Lee 《Journal of natural medicines》2009,63(2):209-214
A new flavonol galloylrhamnoside, kaempferol 3-O-(2″,3″-di-O-galloyl)-α-l-rhamnopyranoside, and a new lignan glycoside, hinokinin 7-O-β-d-glucopyranoside were isolated from the leaves of Koelreuteria henryi, along with 18 known compounds, including six flavonol glycosides (3–8), three lignans (9–11), four chlorophyll derivatives (12–15), two steroids (16, 17), and three aromatic compounds (18–20). The structures were determined on the basis of spectral analysis and chemical evidence. The scavenging effect of 1–8 and 20 on the stable free radical 1,1-diphenyl-2-picrylhydrazyl was examined. Compounds 1, 5, 6, and 20 showed more potent activity than that of trolox. 相似文献
10.
Rawiwun Kaewamatawong Nijsiri Ruangrungsi Kittisak Likhitwitayawuid 《Journal of natural medicines》2007,61(3):349-350
From the stem of Polyalthia parviflora, four compounds were isolated, including p-hydroxyphenylethyl p-coumarate (1), p-hydroxyphenylethyl ferulate (2), dehydrodiscretamine (3) and (−)-discretamine (4). Complete 1H and 13C NMR assignments were obtained for 1, 3 and 4 for the first time. 相似文献
11.
Yamasaki T Kawabata T Masuoka C Kinjo J Ikeda T Nohara T Ono M 《Journal of natural medicines》2008,62(1):47-51
Two new phenyldihydronaphthalene-type lignan glucosides, vitecannasides A (1) and B (2) were isolated from the fruit of Vitex cannabifolia Sieb. et. Zucc. (Verbenaceae) along with the six known lignan derivatives (3–8), four known iridoid glucosides (9–12), three known flavonoids (13–15), and one known phenylbutanone glucoside (16). Their chemical structures were determined on the basis of spectroscopic data as well as chemical evidence. The scavenging
effect of 1, 2, and 11–16 on the stable free radical 1,1-diphenyl-2-picrylhydrazyl was examined. Compounds 1, 2, 14, and 15 exhibited stronger activity than that of l-cysteine. Especially, 14 and 15 showed more potent activity than that of α-tocopherol. 相似文献
12.
Toru Yamasaki Chikako Masuoka Toshihiro Nohara Masateru Ono 《Journal of natural medicines》2007,61(3):318-322
A new phenylethanoid glycoside, named acetyl forsythoside B (1), was isolated from the fruits of Callicarpa japonica Thunb. var. luxurians Rehd. (Verbenaceae) along with forsythoside B (2), brandioside (3), poliumoside (4), actioside (5), and apigenin 7-galacturonide (6). The structures of 1–6 were determined on the basis of spectroscopic data. In addition, the antioxidative activity of 1–4 and 6 was evaluated by the ferric thiocyanate method. All of the tested compounds except 6 exhibited almost the same activity as 3-tert-butyl-4-hydroxyanisole. The radical-scavenging effect of 1–6 on the stable free radical 1,1-diphenyl-2-picrylhydrazyl was also examined. Compounds 1–5 showed almost twice the activity compared to α-tocopherol. 相似文献
13.
Hitomi Sakai Rie Kakuda Yasunori Yaoita Masao Kikuchi 《Journal of natural medicines》2007,61(2):226-228
Seven secoiridoid glycosides, secologanin dimethyl acetal (1), n-butyl vogeloside (2), n-butyl epi-vogeloside (3), (7R)-n-butyl morroniside (4), hydrangenoside A (5), hydrangenoside C (6), and hydrangenoside A dimethyl acetal (7), have been isolated from the leaves of Hydrangea macrophylla subsp. serrata (Thunb.) Makino (Saxifragaceae). The structures were elucidated on the basis of spectral data. 相似文献
14.
Jian Hua Liu Jiang Jiang Qin Hui Zi Jin Xiao Jia Hu Ming Chen Yun Heng Shen Shi Kai Yan Wei Dong Zhang 《Archives of pharmacal research》2009,32(5):661-666
A new triterpenoid, bruceajavanin C (1), together with bruceosides A and B (2 and 3), bruceines D and E (4 and 5), yadanziosides A and G (6 and 7), (20R)-O-(3)-α-L-arabinopyranosylpregn-5-ene-3β,20-diol (8), and α-D-glucopyranoside, (3β, 20R)-3-hydroxypregn-5-en-20-yl (9) were isolated from the aerial parts of Brucea javanica. The structure of 1 was elucidated on the basis of 2D-NMR spectroscopic analysis. In addition, compounds 1, 3, 4, 5, and 6 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. 相似文献
15.
Saroyobudiono H Juliawaty LD Syah YM Achmad SA Hakim EH Latip J Said IM 《Journal of natural medicines》2008,62(2):195-198
A new oligostilbenoid derivative, diptoindonesin F (1), along with five known oligostilbenoids, (−)-ampelopsin A (2), (−)-α-viniferin (3), ampelopsin E (4), (−)-vaticanol B (5), and (−)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new compound was determined based on the analysis of spectroscopic data, including UV, IR, NMR 1-D
and 2-D, and mass spectra. Cytotoxic properties of the isolated oligostilbenoids were evaluated against murine leukemia P-388
cells with the result that compounds 2 and 4 showed the highest cytotoxicity. 相似文献
16.
Jun Li Makoto Tanaka Katsuki Kurasawa Tsuyoshi Ikeda Toshihiro Nohara 《Journal of natural medicines》2007,61(2):222-223
The constituents of the flower buds of Magnolia kobus DC. and M. salicifolia MAXIM. have been investigated. We isolated and identified six bis-tetrahydrofuran-type and three tetrahydrofuran-type lignan
derivatives from M. kobus, and one bis-tetrahydrofuran-type lignan and eight phenylpropanoid-type derivatives from M. salicifolia. The structures of these compounds were elucidated on the basis of chemical and spectroscopic evidence. 相似文献
17.
A novel norlignan derivative, crassifogenin C (1), and a known compound, curcapital (2), were isolated from the ethanolic extract of the rhizomes of Curculigo crassifolia. Their structures were elucidated on the basis of spectroscopic evidence and comparisons with literature data. Curcapital
(2) was isolated from this plant for the first time. The free radical scavenging activity of the isolated compounds along with
crassifoside E (3) and crassifoside F (4), which were reported previously, was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. All compounds showed strong
radical scavenging activity. The primary structure-activity relationship is also discussed. 相似文献
18.
A novel gallate of tannin, (−)-epigallocatechin-(2β→O→7′,4β→8′)-epicatechin-3′-O-gallate (8), together with (−)-epicatechin-3-O-gallate (4), (−)-epigallocatechin (5), (−)-epigallocatechin-3-O-gallate (6), and (+)-gallocatechin-(4α→8′)-epigallocatechin (7), were isolated from the tea plant Camellia
sinensis (L.) O. Kuntze var. sinensis (cv., Yabukita). The structure of 8, including stereochemistry, was elucidated by spectroscopic methods and hydrolysis. The compounds, along with commercially
available pyrogallol (1), (+)-catechin (2), and (−)-epicatechin (3), were examined for toxicity towards egg-bearing adults of Caenorhabditis
elegans. The anthelmintic mebendazole (9) was used as a positive control. Neither 2 nor 3 were toxic but the other compounds were toxic in the descending order 8, 7 ≈ 6, 9, 4, 5, 1. The LC50 (96 h) values of 8 and 9 were evaluated as 49 and 334 μmol L−1, respectively. These data show that many green tea polyphenols may be potential anthelmintics. 相似文献
19.
Jun-Mian Tian Ying-Tong Di Xian-Wen Yang Zhu-Lin Gao 《Journal of Asian natural products research》2013,15(3):228-232
Three new lignan glycosides, mananthosides I–K (1–3), were isolated from the ethanolic extract of the aerial part of Mananthes patentiflora. The structure elucidation of these compounds was mainly established on the basis of 1D NMR, 2D NMR and HR-MS spectroscopic analysis. 相似文献
20.
Phan Van Kiem Nguyen Xuan Nhiem Nguyen Xuan Cuong Tran Quynh Hoa Hoang Thanh Huong Le Mai Huong Chau Van Minh Young Ho Kim 《Archives of pharmacal research》2008,31(11):1477-1482
By various chromatographic methods, two new phenylpropanoid esters of sucrose named hidropiperosides A (1) and B (2), and three known compounds as vanicosides A (3), B (4), and E (5) were isolated from the methanolic extract of the whole plant of Polygonum hydropiper L. (Polygonaceae). Their structures were elucidated by extensive spectroscopic methods including 1D-and 2D-NMR experiments,
as well as ESI-MS analysis. All the isolated compounds were tested for their antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl
(DPPH) radical scavenging assay system. Among them, compounds 2 and 3 showed significant antioxidant activity with their SC50 values of 23.4 and 26.7 μg/mL, respectively. 相似文献