北京市门头沟区农村居民颈动脉内中膜增厚检出情况及其影响因素

目的 了解北京市门头沟区农村居民中老年人颈动脉内中膜增厚的检出情况及其影响因素.方法 2010年6月至2012年10月,整群抽取门头沟6个地区年龄在45岁及以上的农村居民3 276例,排除既往有脑卒中病史者357例,对2 919例符合入选标准者进行一般项目和脑卒中常见危险因素现况调查,筛出脑卒中高危人群进行颈动脉彩超检查,并分析颈动脉内中膜增厚的相关危险因素.结果 脑卒中高危人群中颈动脉内中膜增厚检出率为49.1％,且颈动脉内中膜增厚检出率随年龄增长呈上升趋势,差异有统计学意义（X^2=398.570,P＜0.01）;单因素分析结果显示,年龄、高收缩压、高血压病史、高脂血症与IMT增厚有关;经logistic多元回归分析,高盐饮食、糖尿病史、年龄升高、收缩压升高是颈动脉内中膜增厚的危险因素（OR值分别为1.157、1.048、1.027、1.023）.结论 高盐饮食、糖尿病史、年龄升高、收缩压升高是颈动脉内中膜增厚危险因素,颈动脉内中膜增厚检出率与年龄呈正相关,预防颈动脉粥样硬化应关口前移.     

高血压患者颈动脉粥样硬化影响因素分析

[目的]探讨脉压、尿酸、高敏C反应蛋白、血糖对原发性高血压(EH)患者颈动脉粥样硬化的影响。[方法]入选EH患者156例,正常血压对照组150例,对两组的相关临床资料、颈动脉内中膜厚度、颈动脉斑块的发生情况进行分析比较。[结果](1)高血压组患者颈动脉斑块检出率明显高于正常血压组,分别为41.79%和24.62%(χ2=4.38,P﹤0.01)。(2)多因素分析:高血压组患者颈动脉内中膜厚度随着脉压、尿酸、高敏C反应蛋白、血糖的增加而增加。[结论]高血压患者易发生颈动脉粥样硬化,且与心血管病危险因素有关。     

新生儿血压与日龄、胎龄、出生体重的关系

目的通过测量正常新生儿和早产儿生后7 d内的血压,探讨正常足月新生儿和早产儿血压的变化规律,以及血压与日龄、出生体重、胎龄的关系.方法应用美国Omni-TrakTMNVS型监护仪上的DINAMAP测压装置,随机检查50例正常足月新生儿和55例早产儿生后7 d内的血压.结果①日龄、出生体重、胎龄对正常足月新生儿和早产儿收缩压、舒张压、平均动脉压有非常显著的影响,出生体重、胎龄对第1 d收缩压、舒张压、平均动脉压均有显著的影响,正常足月新生儿和早产儿相比,收缩压、舒张压、平均动脉压均有显著差异;②收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)与日龄(X1)、出生体重(X2)、胎龄(X3)的回归方程分别为SBP=32.4+0.7X1+3.7X2+0.6X3(mmHg),DBP=13.1+0.6X1+2.9X2+0.6X3(mmHg),MAP=17.3+0.4X1+2.0X2+0.8X3(mmHg),并得到平均动脉压=舒张压+0.45(收缩压-舒张压)(mmHg).结论生后7 d内正常足月新生儿和早产儿收缩压、舒张压、平均动脉压随日龄而增加.早产儿每日的收缩压、舒张压、平均动脉压低于正常足月新生儿.日龄、出生体重、胎龄与新生儿收缩压、舒张压、平均动脉压有线形依赖关系.     

老年患者血压水平与颈动脉粥样硬化的相关性研究

目的探讨老年高血压患者血压水平与颈动脉粥样硬化的关系。方法将患有原发性高血压120例年龄>60岁的患者,将患者根据收缩压分组:血压严格控制组(血压<130mmHg),血压一般控制组(血压130～139mmHg)。对每位患者进行颈动脉超声检查,记录颈动脉内中膜层的厚度。结果多因素线性回归分析显示,收缩压、总胆固醇、空腹血糖与颈动脉颈动脉内中膜厚度呈正相关,而高密度脂蛋白胆固醇与颈动脉颈动脉内中膜厚度呈负相关。分析显示,收缩压≥140mmHg、总胆固醇为颈动脉粥样斑块形成的危险因素,而高密度脂蛋白胆固醇为其保护性因素。结论血压水平和颈动脉粥样硬化具有显著的相关性,血压水平是老年患者颈动脉粥样硬化及斑块形成的危险因素之一。     

成年人脉压差影响因素及脉压差变化特点

目的探讨成年人脉压差影响因素及其变化特点,为制定脉压差异常的防治措施提供参考。方法收集2011年到河南省郑州市某医院进行常规健康体检的1242名18岁及以上成人的资料并对其随访,用HLM 6.08建立两水平模型。结果纳入相关的人口学特征、基线血压或不同单位来源等指标建立脉压差的截距项预测模型和斜率项预测模型;脉压差随着基线年龄或基线收缩压的增加而增加,β分别为0.17(P0.001)和0.55(P0.001);脉压差随着身高或基线舒张压增加而降低,β分别为-0.10(P=0.002)和-0.55(P0.001);年龄越大或基线舒张压越高的人脉压差随时间增加越快,β分别为0.08(P0.001)和0.07(P=0.005);基线收缩压越高的人脉压差随时间增加越慢(β=-0.22,P0.001)。结论在制定脉压差的防控措施时,应多关注年龄较大、基线收缩压高或基线舒张压低以及身高较低的人群,动态监测其脉压差,防止脉压差的异常升高。     

新生儿血压与日龄、胎龄、出生体重的关系

目的:通过测量正常新生儿和早产儿生后7 d内的血压,探讨正常足月新生儿和早产儿血压的变化规律,以及血压与日龄、出生体重、胎龄的关系。方法:应用美国Omni—Trak~(TM)NVS型监护仪上的DINAMAP测压装置,随机检查50例正常足月新生儿和55例早产儿生后7 d内的血压。结果:①日龄、出生体重、胎龄对正常足月新生儿和早产儿收缩压、舒张压、平均动脉压有非常显著的影响,出生体重、胎龄对第1 d收缩压、舒张压、平均动脉压均有显著的影响,正常足月新生儿和早产儿相比,收缩压、舒张压、平均动脉压均有显著差异;②收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)与日龄(X_1)、出生体重(X_2)、胎龄(X_3)的回归方程分别为SBP=32.4+0.7X_1+3.7X_2+0.6X_3(mmHg),DBP-13.1+0.6X_1+2.9X_2+0.6X_3(mmHg),MAP-17.3+0.4X_1+2.0X_2+0.8X_3(mmHg),并得到平均动脉压=舒张压+0.45(收缩压-舒张压)(mmHg)。结论:生后7 d内正常足月新生儿和早产儿收缩压、舒张压、平均动脉压随日龄而增加。早产儿每日的收缩压、舒张压、平均动脉压低于正常足月新生儿。日龄、出生体重、胎龄与新生儿收缩压、舒张压、平均动脉压有线形依赖关系。     

动态血压监测预测妊娠期高血压疾病的价值

目的 了解动态血压监测对妊娠期高血压疾病的预测价值.方法 对350例孕妇在21～27孕周进行24小时动态血压监测,分析妊娠结局与动态血压监测指标的关系.结果 323例孕妇中有28例发生妊娠期高血压疾病,为妊娠期高血压疾病组,其余295例患者为对照组.妊娠期高血压疾病组患者与对照组比较,24小时血压平均值(收缩压t=13.69、舒张压t=13.58、平均动脉压t=13.80),日均血压值(收缩压t=13.12、舒张压t=9.32)及夜均血压值(收缩压t=10.27、舒张压t=13.56)均有极显著性差异(P＜0.01).以24小时平均舒张压等于8.9kPa为切点预测妊娠期高血压疾病敏感性为85.7%;特异性为94.6%;以24小时平均动脉压等于11.2kPa为切点预测妊娠期高血压疾病敏感性为89.3%;特异性为93.9%.结论 在孕中期,利用动态血压监测的24小时平均舒张压和24小时平均动脉压均可较好的预测妊娠期高血压疾病.     

2007-2010年新疆维吾尔自治区汉族、维吾尔族、哈萨克族35岁以上人群空腹血糖水平与颈动脉内中膜厚度的相关性研究

目的 分析新疆维吾尔自治区汉族、维吾尔族、哈萨克族≥35岁人群FBG水平与颈动脉内中膜厚度(IMT)的相关性.方法 于2007年10月至2010年4月,按照多阶段分层整群随机抽样原则,在新疆维吾尔自治区的7个市(州、地区)选取汉族、维吾尔族、哈萨克族≥35岁常住人群,排除颈动脉内中膜增厚(IMT ＞0.9 mm)者及长期外出、流动人口,共获得有效调查对象13 935名.测量其FBG及颈动脉IMT值,根据FBG值将调查对象分为FBG正常组、空腹血糖受损(IFG)组、糖尿病组.采用方差分析比较不同组别颈动脉IMT的差异,采用多元线性回归模型探讨颈动脉IMT的影响因素.结果 汉族、维吾尔族、哈萨克族男性颈动脉IMT分别为(0.81 ±0.29)、(0.71±0.27)、(0.79 ±0.21)mm(F=88.50,P＜0.05),其糖尿病组颈动脉IMT为(0.82±0.29) mm,高于FBG正常组[(0.77±0.26) mm]和IFG组[(0.79±0.27) mm] (F=7.49,P ＜0.05).汉族、维吾尔族、哈萨克族女性颈动脉IMT分别为(0.72±0.27)、(0.63±0.25) 、(0.77±0.22)mm(F=173.93,P＜0.05),其糖尿病组和IFG组颈动脉IMT分别为(0.75±0.29)、(0.74 ± 0.26) mm,均高于FBG正常组[(0.70±0.25) mm] (F=10.46,P＜0.05).舒张压(β'=0.101,P＜0.05)、TC(β'=0.056,P ＜0.05) 、FBG(β'=0.023,P =0.009)是颈动脉IMT的独立影响因素.结论 新疆维吾尔自治区汉族、维吾尔族、哈萨克族≥35岁人群FBG水平是颈动脉IMT的独立影响因素,且两者呈正相关.     

动态血压监测指标指导临床治疗老年高血压的意义

  目的  通过监测高血压患者的动态血压,分析其对临床老年高血压人群防治工作的应用价值。  方法  监测2017年12月-2018年12月期间519例高血压患者的动态血压,按照60岁为分界点,分成≥ 60岁老年组264例, < 60岁中青年对照组255例,对血压、血压昼夜节律、脉压、血压变异系数、血压负荷值、平均心率、晨峰血压等系列指标进行临床分析。  结果  老年组动态血压昼夜节律异常发生率为76.5%,与对照组比较,舒张压、舒张压负荷值、脉压、24 h平均心率、收缩压变异系数、24 h舒张压变异系数、晨峰舒张压等指标两组间均有差异(均有P < 0.05),且老年组中不同血压节律类型的24 h收缩压、夜间收缩压、夜间舒张压、夜间脉压、白天收缩压负荷值、夜间收缩压负荷值、24 h收缩压变异系数、24 h舒张压变异系数等指标均有差异(均有P < 0.05)。  结论  动态血压监测指标对老年高血压人群临床合理用药有一定的指导价值。     

男性高血压患者血浆睾酮水平与颈动脉内中膜厚度的相关性研究

目的:探讨男性高血压患者的血浆睾酮水平、颈动脉内中膜厚度及其相关性.方法:选取120例老年男性原发性高血压患者,依据有无颈动脉粥样硬化斑块,再分为有斑块组(n=75)和无斑块组(n=45);另选取健康老年男性客户50例为空白组.检测所有受试对象的血浆睾酮(T)水平、颈动脉内中膜厚度,分析指标间的相关性.结果:有斑块组与无斑块组、空白组比较,SBP、DBP、IMT均呈增高趋势,T水平呈降低趋势;原发性高血压患者血压、血浆睾酮与颈动脉内中膜厚度之间,两两均具有一定的相关性,其中,T与SBP、DBP、IMT均呈负相关(P＜0.05或P＜0.01).上述差异均具有统计学意义(P＜0.05或P＜0.01).结论:老年男性原发性高血压患者的血浆睾酮水平与动脉硬化程度具有比较紧密的关系,呈负性相关,其血浆睾酮水平可为疾病评估、激素替代治疗等提供理论参考依据.     

A U-shaped Association Between Blood Pressure and Cognitive Impairment in Chinese Elderly

Objectives

Higher or lower blood pressure may relate to cognitive impairment, whereas the relationship between blood pressure and cognitive impairment among the elderly is not well-studied. The study objective was to determine whether blood pressure is associated with cognitive impairment in the elderly, and, if so, to accurately describe the association.

亚临床甲状腺功能减退与收缩压水平的关系

目的 探讨亚临床甲状腺功能减退(亚临床甲减)与收缩压水平的关系,为高血压防治和病因探索提供证据.方法 检索国内外各类大型数据库中近11年发表的有关亚临床甲减与收缩压水平关系的文献,采用Meta分析方法,利用Stata11软件评价亚临床甲减与收缩压水平之间的关系.计算加权均数差(WMD)及其95%CI,Begg's检验法和Egger's检验法评价发表性偏倚.结果 (1)亚临床甲减病例组与甲状腺功能正常对照组的收缩压水平之间差异有统计学意义(WMD=2.04mmHg,95%CI:0.64～3.45,P＜0.05).(2)亚组分析显示,在促甲状腺激素(TSH)均数差值＜7 mU/L组,亚临床甲减病例组与甲状腺功能正常对照组的收缩压水平之间差异有统计学意义(WMD=2.33 mm Hg,95%CI:0.60～4.06,P＜0.05),在TSH均数差值＞7mU/L组,则无统计学意义;在亚洲组,亚临床甲减病例组与甲状腺功能正常对照组的收缩压水平之间差异有统计学意义(WMD=2.62mmHg,95%CI:1.69～3.55,P＜0.05),而在欧洲组差异无统计学意义;在社区收集组,亚临床甲减病例组与甲状腺功能正常对照组的收缩压水平之间差异有统计学意义(WMD=2.77 mm Hg,95%CI:1.61～3.93,P＜0.05),而在医院收集组差异无统计学意义;在横断面研究组,亚临床甲减病例组与甲状腺功能正常对照组的收缩压水平之间差异有统计学意义(WMD=2.77 mm Hg,95%CI:1.61～3.93,P＜0.05),而病例对照研究组的差异无统计学意义.(3)Begg's检验法和Egger's检验法检验均无统计学意义(P＞0.05),所以没有显著的发表偏倚.结论 亚临床甲减和收缩压水平升高有明显相关性.亚临床甲减是否为收缩压水平升高的危险因素之一,还有待进一步大样本的前瞻性研究证实.积极治疗亚临床甲减,对高血压的预防和治疗有一定意义.

Abstract：

Objective To investigate the association between subclinical hypothyroidism and levels of systolic blood pressure (SBP), so as to provide evidence for the development of prevention strategy and understanding the etiology of hypertension. Methods The articles on the association of subclinical hypothyroidism and systolic blood pressure levels were retrieved by searching international and national databases from 1999 to 2010. The relationship between subclinical hypothyroidism and systolic blood pressure levels was assessed by meta analysis with Stata 11software. The weighted mean difference (WMD) and 95% confidence interval (CI) were calculated,and the publication bias was assessed by Begg's test and Egger's test. Results (1) There was significant difference in SBP levels between patients with subclinical hypothyroidism and normal subjects (WMD= 2.04 mm Hg, 95% CI: 0.64 to 3.45, P＜ 0.05 ). (2) Subgroup analysis indicated that there was significant difference seen in thyroid stimulating hormone (TSH) mean difference values ＜7 mU/L group(WMD=2.33 mm Hg,95%CI:0.60 to 4.06,P＜0.05) but not in the group that TSH mean difference values were ＞7 mU/L. There was significant difference seen in the Asian group (WMD=2.62 mm Hg, 95%CI: 1.69 to 3.55,P＜0.05) in the community group(WMD=2.77mm Hg, 95%CI: 1.61 to 3.93, P＜0.05) but not in the European group and or in the hospital group.There was significant difference in the cross-sectional group (WMD=2.77 mm Hg, 95%CI: 1.61 to 3.93, P＜0.05), but not in the case-control group. (3) Results from both Begg' s test and Egger's test did not show significant difference, indicating that there was no publication bias existed.Conclusion Subclinical hypothyroidism was associated with the elevated systolic blood pressure. In terms of the role of subclinical hypothyroidism that might serve as one of the potential risk factor for the elevated systolic blood pressure. Well designed and large sample-sized prospective studies were necessary to confirm the association between subclinical hypothyroidism and systolic blood pressure.Random controlled trials were also needed to study whether the treatment could lower the risk. Active treatment for subclinical hypothyroidism might be useful for prevention and treatment of hypertension.     

老年高血压患者与健康对照者动态脉压特征的研究

目的研究老年原发性高血压患者动态脉压（PP）的特点并探讨其临床意义。方法对388例高血压患者及167例健康对照者进行24h动态血压监测，并按年龄分为老年高血压组与中青年高血压组，老年健康组与中青年健康组，对各组的动态PP、动态收缩压（SBP）、舒张压（DBP）进行比较。结果（1）在不考虑年龄的情况下，高血压组动态PP、SBP、DBP显著高于健康对照组。（2）无论是老年高血压组还是中青年高血压组，动态PP、SBP、DBP水平均显著高于同年龄健康对照组。（3）老年高血压组动态PP显著高于中青年高血压组，两组间动态SBP比较无明显差异，而老年高血压组动态DBP显著低于中青年高血压组。（4）老年健康对照组与中青年健康对照组比较，动态PP水平显著增高；SBP水平无明显差异；DBP水平显著下降。结论动态PP随增龄而增大。老年高血压与健康对照组动态PP增高主要与动态DBP下降有关。     

Blood pressure responses in healthy older people to 50 g carbohydrate drinks with differing glycaemic effects

The aim of the present study was to determine the effects on blood pressure response of 50 g carbohydrate drinks with differing glycaemic effects in ten healthy elderly subjects (age > 65 years; randomized crossover design). Systolic (SBP), diastolic (DBP) and mean arterial (MAP) blood pressure, heart rate and plasma glucose levels were determined following ingestion of equal volumes (379 ml) of water and 50 g carbohydrate drinks with differing reported glycaemic indices (GI) (surrogate marker for glycaemic effect): (1) low-GI: Apple & Cherry Juice; (2) intermediate-GI: Fanta Orange; (3) high-glucose. Glucose (SBP and DBP P < 0.001; MAP P = 0.005) and Fanta Orange (SBP P = 0.005; DBP and MAP P < 0.001) ingestion caused a significant decrease in BP whilst blood pressure increased (SBP P = 0.008; MAP P = 0.005) from baseline following Apple & Cherry Juice ingestion. Water had no significant effect on postprandial blood pressure. Fanta Orange and Apple & Cherry Juice caused similar (P = 0.679) glycaemic effects, which were significantly greater than water, but lower than glucose (P < 0.001). There was no significant correlation between the glycaemic effect of the carbohydrate drinks and there was no change in blood pressure from baseline (SBP r - 0.123, P = 0.509; DBP r - 0.051, P = 0.784; MAP r - 0.069, P = 0.712). Apple & Cherry Juice and Fanta Orange had similar glycaemic effects, but differing effects on blood pressure. Therefore, it is unlikely that the glycaemic effect of a drink can be used to predict the subsequent cardiovascular response.     

The independent effect of habitual cigarette and coffee consumption on blood pressure

The authors investigated the possible relation between habitual cigarette and coffee consumption and blood pressure (BP) levels in 7506 men and 2095 women. The study population were managers and employees examined in northern Italy between 1986–1988. In particular, the hypothesis of a substantial independence between smoking-BP and coffee-BP was tested. BP levels were corrected for age, body mass index, physical activity, and alcohol consumption by analysis of covariance. Significantly, smoking was inversely related to BP, both in men (SBP, P < 0.001, DBP, P < 0.001) and women (SBP, P = 0.001, DBP, P = 0.012). In particular, the BP of non-smoking men, SBP/DBP, was 131.0/83.5, whereas in male smokers up to and over 20 cigarette/day, BP was 128.1/82.0 and 128.1/82.1 respectively. Coffee consumption was related to BP levels in men (SBP, P < 0.001; DBP, P = 0.009), but not in women (SBP, P = 0.320; DBP, P = 0.982). BP in male subjects was 131.3/83.5 in non-drinkers, 130.7/83.3 in those drinking 1–3 cups/day, 128.4/82.6 and 127.2/81.8 in drinkers of 4–5 and over 5 cups/day, respectively. No significant interactions were demonstrated, thus the relationship between habitual smoking and coffee consumption with BP appears to agree with an additive model.Corresponding author.     

Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-ethnic Study of Atherosclerosis (MESA)

BACKGROUND: Blood pressure (BP) may be implicated in associations observed between ambient particulate matter and cardiovascular morbidity and mortality. This study examined cross-sectional associations between short-term ambient fine particles (particulate matter 相似文献   

老年高血压患者动态脉压(PP)与冠心病并发症及颈动脉粥样硬化的关系研究

目的 探讨老年高血压患者的动态脉压(PP)与冠心病并发症及颈动脉粥样硬化之间的关系.方法 选取2006年12月～2012年1月间于某院门诊或住院治疗的老年高血压患者341例,其中合并冠心病的165例病例为A组,单纯的老年高血压患者176例为B组,监控两组动态脉压,对比观察两组动态PP的差异;另对B组176例病例根据颈动脉内膜中层厚度(IMT),IMT≥0.9 mm为颈动脉内膜中层增厚组,共91例为α组,其余85例为β组,比较两组动态PP的差异.结果 合并冠心病组和颈动脉内膜中层增厚组的24 h APP、dPP、nPP水平明显高于单纯高血压组和颈动脉内膜中层厚度正常组.结论 动态脉压水平对冠心病并发症和颈动脉粥样硬化病变有提示作用,动态脉压越高,冠心病并发症和颈动脉粥样硬化病变发病率越高.     

Seasonal changes in ambulatory blood pressure in employees under different indoor temperatures.

OBJECTIVE--The effect of indoor temperature control on summer and winter ambulatory blood pressure levels at work was studied. METHOD--Ambulatory systolic blood pressure (SBP) and diastolic blood pressure (DBP) were monitored once in summer and once in winter in 101 healthy normotensive subjects aged 28-63 years, engaged in similar physical work, from two plants with and three without air conditioning. Subjects were interviewed about health related habits, and measurements of environmental and occupational conditions were obtained. RESULTS--After controlling for possible confounders, mean SBP and DBP during work were significantly higher in winter than in summer (delta SBP = 3.4 mm Hg, P = 0.035; delta DBP = 3.3 mm Hg, P < 0.003). The seasonal change in SBP and DBP showed an independent association with the presence or absence of air conditioning of the industrial plants (SBP: beta = 0.194, P < 0.0001; DBP: beta = 0.054, P = 0.038). The percentage of subjects with increases of more than 10 mm Hg from summer to winter was higher in plants without than with air conditioning. CONCLUSIONS--(1) In normotensive subjects ambulatory working BP varies by season, with higher values in winter. If validated for hypertensive subjects, it may be necessary to tailor drug treatment to these variations. (2) The findings make it clear that drawing valid conclusions from comparisons of BPs between groups requires controlling for several factors, particularly season of the year. (3) Climatic conditions in the industrial plant influence the magnitude of seasonal variations in BP. Work in plants without air conditioning places a considerable added load on the employee's cardiovascular system.     

多元多水平模型及其在血压影响因素研究中的应用

目的探讨多元多水平模型在血压影响因素研究中的应用。方法利用MLwin2.02软件对获得的数据进行二元三水平模型拟合。结果收缩压和舒张压在地区水平上的相关系数为0.949,在个体水平上的相关系数为0.701;收缩压和舒张压随着年龄的增加而增加,但年龄增大对收缩压的影响幅度更大,β分别为0.720(收缩压)和0.118(舒张压),χ2=4284.56,P<0.001;男性的收缩压和舒张压水平均高于女性,但男性人群尤以舒张压水平升高更为明显,β分别为2.208(收缩压)和3.113(舒张压),χ2=31.35,P<0.001。结论多元多水平模型可以灵活有效地处理层次结构的数据,适合于血压影响因素研究。     

福辛普利治疗老年2型糖尿病合并轻中度高血压的临床疗效

目的评价福辛普利治疗老年2型糖尿病合并轻中度高血压的临床疗效及其安全性。方法23例老年2型糖尿病合并轻中度高血压患者服用福辛普利10～40mg,1/d、疗程6周,采用随机测血压和24小时动态血压监测。同时监测治疗前后空腹血糖、空腹胰岛素、糖化血红蛋白、血脂(TC、TG、HDL、LDL)、肾功(BUN、Cr、BUA)及尿微量白蛋白/尿肌酐变化。结果谷峰比率收缩压为72.6%±8.5%,舒张压为59.5%±8.1%。治疗后,24h平均收缩压、白昼平均收缩压、夜间平均收缩压和血压负荷值均显著下降(P＜0.01),而24h平均舒张压、夜间平均舒张压、24h平均血压、夜间平均血压亦有明显的下降(P＜0.05)。治疗后空腹血糖、糖化血红蛋白及空腹胰岛素均明显降低(P＜0.05),而血脂(TC、TG、HDL、LDL)肾功(BUN、Cr、BUA)无明显改变,尿微量白蛋白/尿肌酐明显降低(P＜0.05)。结论福辛普利是治疗老年2型糖尿病合并轻中度高血压的安全、有效、耐受良好的药物。