双歧三联活菌散剂联合葡萄糖酸锌治疗儿童急性腹泻的疗效及安全性

目的 探讨双歧三联活菌散剂联合葡萄糖酸锌治疗儿童急性腹泻的疗效分析.方法 选择80例急性腹泻患儿,采用随机数字表将患儿随机分为联合组和对照组.两组患儿均常规予以调整饮食、口服或静脉补液,纠正脱水、电解质和酸碱失衡紊乱等基础治疗.联合组在此基础上予以双歧三联活菌散剂联合葡萄糖酸锌治疗,对照组在此基础上予以单纯的双歧三联活菌散剂治疗.结果 联合组患儿治疗后的大便外观、呕吐、腹痛和大便常规恢复正常时间明显短于对照组（P＜0.05）.治疗3d后,联合组患儿的临床疗效明显优于对照组（x2 =7.99,P＜0.01）.两组患儿治疗期间均未出现明显的不良反应.结论 双歧三联活菌散剂联合葡萄糖酸锌治疗儿童急性腹泻疗效确切,能明显改善患儿的腹泻症状,缩短腹泻的病程,安全性较好.     

双歧杆菌三联活菌加蒙脱石散联合赖氨葡锌颗粒治疗小儿腹泻62例疗效观察

目的 观察双歧杆菌三联活菌加蒙脱石散联合赖氨葡锌颗粒对腹泻患儿的治疗效果.方法 选择124例急性腹泻患儿随机分成观察组及对照组各62例.对照组患儿给予双歧杆菌三联活菌加蒙脱石散进行治疗,观察组在上述两种药物基础上加赖氨葡锌颗粒进行补锌调整,观察两组疗效.结果 观察组和对照组总有效率差异有统计学意义(P＜0.05),分别为98.4％和87.0％.观察组腹泻的临床症状改善情况明显优于对照组(P＜0.05).结论 微生态制剂双歧杆菌三联活菌加肠黏膜保护剂蒙脱石散的基础上,对腹泻患儿补锌治疗,能显著提高治疗有效率,明显改善临床症状.     

双歧杆菌三联活菌散治疗儿童抗生素相关性腹泻45例临床观察

目的：观察双歧杆菌三联活菌散治疗儿童抗生素相关性腹泻的临床疗效。方法：将86例抗生素相关性腹泻患儿随机分为治疗组45例、对照组41例,治疗组在常规治疗的基础上加用双歧杆菌三联活菌散,观察两组患儿腹泻情况及治疗效果,并对结果加以分析。结果：治疗组腹泻治愈率达75.56%,总有效率97.78%,与对照组相比显著更优（P〈0.01）。腹泻持续时间,治疗组为（2.46±0.9）d,与对照组相比也显著更优（P〈0.01）。结论：双歧杆菌三联活菌散治疗儿童抗生素相关性腹泻疗效确切。     

双歧杆菌乳杆菌三联活菌片联合推拿疗法治疗小儿腹泻疗效及对患儿免疫功能的影响

目的:探讨对小儿腹泻,临床治疗中采取双歧杆菌乳杆菌三联活菌片+推拿疗法治疗的效果.方法:选取160例腹泻患儿并随机分成研究组与对照组每组各80例,对照组单用双歧杆菌乳杆菌三联活菌片治疗,研究组在对照组的基础上加用中医推拿疗法治疗,对患儿均是进行2周的治疗,做疗效、免疫指标的组间对比.结果:研究组治疗总有效率为95.00％,显著高于对照组82.50％的总有效率(P<0.05);治疗后两组CD+4/CD+8、IgA、IgG及IgM指标水平均较治疗前提高,但相对比之下治疗后的各项指标均表现为研究组较对照组更高,差异显著(P<0.05).结论:采取双歧杆菌乳杆菌三联活菌片联合推拿疗法治疗小儿腹泻的疗效满意,且可显著改善患儿免疫功能,值得推广.     

双歧杆菌乳杆菌三联活菌片联合蒙脱石散治疗小儿腹泻的临床效果及对免疫功能的影响

目的 观察双歧杆菌乳杆菌三联活菌片联合蒙脱石散治疗小儿腹泻的临床效果及对免疫功能的影响.方法 选取2019年3月-2020年8月泰安市妇幼保健院收治的腹泻患儿92例,采用随机数字表分为观察组和对照组,各46例.对照组患儿予蒙脱石散治疗,观察组在对照组基础上加用双歧杆菌乳杆菌三联活菌片口服治疗.比较2组患儿治疗效果、临床...     

双歧杆菌三联活菌散预防婴幼儿呼吸道感染继发腹泻的临床研究

目的:观察双歧杆菌三联活菌散预防婴幼儿急性呼吸道感染继发腹泻的临床疗效.方法:将480例急性呼吸道感染患儿随机分为两组,对照组240例给予抗生素及对症处理,治疗组240例在对照组治疗的基础上加用双歧杆菌三联活菌散口服,分别观察治疗第3 d、第5 d、第7 d时腹泻的发生率及其严重程度,并进行统计学分析.结果:治疗组第3...     

蒙脱石散与双歧杆菌三联活菌散治疗小儿腹泻的效果对比

目的探讨蒙脱石散与双歧杆菌三联活菌散治疗小儿腹泻的效果。方法选取我院诊断为的腹泻的患儿400例,随机分为:200例研究组(接受双歧杆菌三联活菌散治疗)和200例对照组(接受蒙脱石散治疗)。对比两组腹泻治疗疗效及不良反应发生情况。结果研究组和对照组腹泻有效率分别为91%、80%,结果比较有差异(P<0.05);两组服用药物期间均无严重不良反应,无死亡病例。结论本次研究认为双歧杆菌三联活菌散治疗小儿腹泻疗效肯定,安全性好。     

双歧杆菌三联活菌散对轮状病毒性肠炎婴幼儿血清炎症因子的影响及疗效观察

摘 要 目的:探讨双歧杆菌三联活菌散对婴幼儿轮状病毒性肠炎患儿血清炎症因子的影响及疗效。方法：74例婴幼儿轮状病毒性肠炎患儿随机分为观察组(37例)和对照组(37例)。两组患儿均予调整饮食、抗病毒、补液及预防和纠正电解质紊乱和酸碱失衡等常规治疗。观察组加用双歧杆菌三联活菌散温水冲服,连用72 h。观察两组患儿治疗前后血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平变化,比较两组临床疗效及药品不良反应。结果：治疗72h后,两组患儿血清IL-6和TNF-α水平均较前明显下降(P<0.05或P<0.01),且观察组水平明显低于对照组(P<0.05)。观察组临床总有效率明显高于对照组(P<0.05)。两组患儿治疗期间未见药品不良反应。结论：双歧杆菌三联活菌散治疗婴幼儿轮状病毒性肠炎疗效显著,可能与明显降低血清IL-6和TNF-α水平,控制肠黏膜炎症反应,且安全性高。     

双歧杆菌三联活菌对婴幼儿抗生素相关性腹泻的预防作用

目的:探讨双歧杆菌三联活菌对不同年龄组婴幼儿抗生素相关性腹泻(AAD)的预防作用。方法:下呼吸道感染患儿255例,按年龄分为1～12月组120例与12～36月组135例,组内再随机分成预防组与对照组。预防组在抗生素治疗同时服用双歧杆菌三联活菌,对照组抗生素治疗开始不服用双歧杆菌三联活菌,出现腹泻后加服该药,比较两组腹泻发生率的差异。同时比较不同年龄组婴幼儿服用双歧杆菌三联活菌对AAD预防作用的差异。结果:1～12月预防组62例发生腹泻11例,对照组58例发生腹泻23例,差异有统计学意义(P<0.05);12～36月预防组79例发生腹泻3例,对照组56例发生腹泻14例,差异有统计学意义(P<0.05)。对照组两个年龄组间比较,差异无统计学意义(P>0.05);预防组两个年龄组间比较,差异有统计学意义(P<0.05)。结论:双歧杆菌三联活菌可降低婴幼儿AAD的发病率。     

赖氨葡锌颗粒联合双歧杆菌乳杆菌三联活菌颗粒治疗小儿腹泻的疗效观察

目的探讨赖氨葡锌颗粒联合双歧杆菌乳杆菌三联活菌颗粒治疗小儿腹泻的疗效。方法选取2017年4月～2019年4月我院收治的86例腹泻患儿为研究对象,按照随机数字表法分为联合组与对照组,各43例。对照组予以双歧杆菌乳杆菌三联活菌颗粒及儿科常规腹泻治疗,联合组在对照组基础上予以赖氨葡锌颗粒。比较两组患儿治疗5d后临床疗效、腹泻情况(腹泻停止时间、大便性状恢复正常时间、腹痛消失时间)、大便检查(大便镜检正常时间、大便细菌培养正常时间)差异,比较两组患儿治疗3个月后腹泻复发率。结果治疗5d后,联合组患者总有效率高于对照组,差异有统计学意义(P 0.05);联合组患者腹泻停止时间、大便性状恢复正常时间、腹痛消失时间、大便镜检正常时间、大便细菌培养正常时间均短于对照组,差异有统计学意义(P 0.05);治疗3个月后联合组患儿复发率低于对照组,差异有统计学意义(P 0.05)。结论赖氨葡锌颗粒联合双歧杆菌乳杆菌三联活菌颗粒治疗小儿腹泻效果显著,复发率低,值得临床推广。     

The pharmacokinetics of zinc from zinc gluconate: a comparison with zinc oxide in healthy men

OBJECTIVE: Zinc supplementation is beneficial in some clinical conditions such as age-related macula degeneration (AMD). It has been suggested that zinc absorption is influenced by the form in which zinc is ingested. Therefore, the pharmacokinetics of zinc gluconate (organic) were compared with those of zinc oxide (inorganic). METHODS: 12 healthy male subjects aged between 21 and 31 years (24 years median) orally received daily doses of 20 mg metal zinc as zinc gluconate and 17.4 mg metal zinc as zinc oxide under randomized crossover conditions for 14 days each with at least 14 days as a washout. Zinc plasma concentrations were measured by means of inductively coupled plasma-atomic emission spectroscopy. RESULTS: C(max) was found 18.3% (10.3 - 26.3%) higher following multiple-dose administration of zinc gluconate as compared to zinc oxide (mean; 0.95% confidence interval of the relative differences between both treatment conditions; p < 0.05). AUC(0-24h) was noted 8.1% (1.9 - 14.3%) higher after zinc was given as zinc gluconate when compared to zinc oxide (p < 0.05) whereas t(max) did not differ between both treatment conditions. CONCLUSIONS: Zinc absorption in humans could be improved by zinc complexation with gluconate.     

婴幼儿急性腹泻病血锌水平及补锌治疗的临床观察

目的探讨患急性腹泻病的婴幼儿血锌水平变化及在常规治疗的基础上辅以补锌治疗的疗效。方法自2012年9月至2012年12月,分别测定了276例1个月～2岁患急性腹泻病婴幼儿和221例同年龄段健康婴幼儿的血锌水平;将276例急性腹泻病患儿随机分为两组,对照组122例,予以补液、肠黏膜保护剂、微生态制剂等常规治疗;治疗组154例在常规治疗的基础上,加用葡萄糖酸锌,比较两组的疗效。结果急性腹泻病患儿血锌水平明显低于对照组,差异有统计学意义(P<0.05和0.01);补锌治疗组总有效率为90.9%,高于对照组的80.3%,两组差异有统计学意义(P<0.05)。结论急性腹泻病婴幼儿血锌水平降低,在常规治疗的基础上佐以补锌治疗,可显著提高疗效。     

Reaction of the XPA zinc finger with S-nitrosoglutathione

S-Nitrosoglutathione (GSNO) is an intracellular redox signaling molecule, also implicated in nitrosative stress. GSNO actions include modifications of Cys thiols in proteins. In this study, we focused on a GSNO reaction with a Cys4 zinc finger (ZF) sequence of human protein XPA, crucial to the nucleotide excision repair pathway of DNA repair. By using a corresponding synthetic 37-residue peptide acetyl-DYVICEECGKEFMDSYLMNHFDLPTCDNCRDADDKHK-amide (XPAzf) and combining the detection of noncovalent and covalent complexes by ESI-MS with zinc release monitored by the zinc-sensitive chromophore 4-(2-pyridylazo)resorcinol (PAR), we demonstrated that the reaction of XPAzf with GSNO yielded S-nitrosylated intermediates, intrapeptide disulfides, and mixed glutathione disulfides. The reaction started with the formation of a complex of GSNO with ZnXPAzf followed by thiol transnitrosylation reactions and the final formation of disulfides. The results obtained suggest that at low levels/transient exposures, GSNO may act as a reversible regulator of Cys4 ZF activity, whereas transnitrosylation by GSNO, occurring at prolonged exposures, may cause deleterious effects to the functions of Cys 4 ZF proteins. In the case of XPA, this may lead to DNA repair inhibition.     

Metallothionein content and zinc status in various tissues of rats treated with iodoacetic acid and zinc

Metallothionein (MT) content was determined in 11 tissues of saline-treated rats, and 18 h after single IP injections of iodoacetic acid (IA, 15 and 30 mg/kg) or zinc sulfate (20 mg zinc/kg). Zinc increased MT content in eight tissues, being most effective in pancreas, liver, and small intestine. After IA, MT increased in liver, muscle, pancreas, and thymus, the highest amount being in liver. Increased levels of total tissue zinc were observed in those tissues which clearly responded to the treatments with elevated MT levels, such as liver, kidney, small intestine, and pancreas. MT induction by zinc in these tissues was associated with an accumulation of zinc not bound to MT. In the IA-treated rats non-MT zinc accumulated in liver and pancreas.It is concluded that induction of MT by zinc and in particular by organic chemicals such as IA without exogenously supplied metals interferes with zinc homeostasis and the physiological role of MT in liver and extrahepatic tissues of the rat.     

Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans

The comparative absorption of zinc after oral administration of three different complexed forms was studied in 15 healthy human volunteers in a double-blind four-period crossover trial. The individuals were randomly divided into four groups. Each group rotated for four week periods through a random sequence of oral supplementation including: zinc picolinate, zinc citrate, and zinc gluconate (equivalent to 50 mg elemental zinc per day) and placebo. Zinc was measured in hair, urine, erythrocyte and serum before and after each period. At the end of four weeks hair, urine and erythrocyte zinc levels rose significantly (p less than 0.005, p less than 0.001, and p less than 0.001) during zinc picolinate administration. There was no significant change in any of these parameters from zinc gluconate, zinc citrate or placebo administration. There was a small, insignificant rise in serum zinc during zinc picolinate, zinc citrate and placebo supplementation. The results of this study suggest that zinc absorption in humans can be improved by complexing zinc with picolinic acid.     

Ocular toxicity studies with zinc pyridinethione.

Ocular toxicity studies were conducted with orally administered zinc pyridinethione (ZPT) in random source domestic cats, standard beagle dogs, atapetal beagle dogs, and rhesus monkeys. The administration of ZPT to cats resulted in ocular lesions characterized by tapetal degeneration and atrophy. ZPT also caused ocular lesions in standard beagle dogs. The initial lesions consisted of a degeneration of tapetal cells, soon accompanied by intense tapetal inflammation which progressed to retinitis, intraretinal hemorrhage, and subretinal edema, resulting in retinal detachment and blindness. No gross or histopathological ocular lesions occurred in the atapetal beagle dogs or rhesus monkeys. The results of these studies provide strong evidence that the tapetum lucidum is the target tissue for the ocular toxicity of ZPT, since the eyes of animals lacking this choroidal structure are not perceptibly affected by oral administration of this compound. The tapetum lucidum is found in many animals but is not present in humans or most nonhuman primates.