甲状腺功能减退症患者甲状腺功能与血脂变化的临床意义分析

目的 分析甲状腺功能减退症患者甲状腺功能与血脂变化的临床意义。方法 选取60例已明确诊断为甲状腺功能减退症的患者设为观察组,另选取60例健康体检者设为对照组。检测比较两组血脂指标和甲状腺功能指标。结果 两组甘油三酯水平比较差异无统计学意义(P>0.05);观察组高密度脂蛋白胆固醇(1.05±0.68)mmol/L低于对照组的(1.50±1.02)mmol/L,低密度脂蛋白胆固醇(3.62±1.50)mmol/L高于对照组的(2.44±0.93)mmol/L,差异有统计学意义(P<0.05)。观察组游离三碘甲状腺原氨酸(2.30±1.00)pmol/L、游离甲状腺素(6.96±1.62)pmol/L均低于对照组的(4.36±1.28)、(15.63±3.77)pmol/L,促甲状腺激素(16.30±4.99)μIU/ml高于对照组的(2.16±0.91)μIU/ml,差异有统计学意义(P<0.05)。结论 甲状腺功能减退症患者的血脂明显异常,证实低密度脂蛋白胆固醇和高密度脂蛋白胆固醇可以作为评估甲状腺功能的指标。     

先天愚型患儿甲状腺功能的初步探讨

先天愚型(Down's Syndrome DS)是一种常见的染色体疾病。患者染色体组包含一条额外21号染色体。根据21号染色体的变异情况,分为标准型(Standard DS,SDS)、嵌合型(MosaicDS,MDS)和易位型(Translccation DS,     

镉污染区居民甲状腺功能的初步观察

镉是一种污染环境较广泛的非人体必须金属元素,其危害日益受到人们的重视。有关镉对肺脏、肾脏、骨骼和血液等系统的研究已有很多报道,但镉对甲状腺功能影响的资料不多。国外有镉能影响人的甲状腺功能的零星报道,国内尚未见此类报道。为了解长期生活在镉污染区居民甲状腺功能状况,我们对某市镉污染区女性居民甲状腺功能进行了初步观察,同时作了实验研究。     

体检人群检测甲状腺抗体与甲状腺功能的意义分析

目的 分析体检人群检测甲状腺抗体与甲状腺功能的意义,旨在为相关研究工作提供参考.方法 选择500例体检者为研究对象,并对所有受试者开展甲状腺功能以及甲状腺抗体测定.对比男性以及女性受试者甲状腺抗体阳性率,以及甲状腺功能正常与异常受试者甲状腺抗体阳性率.结果 女性受试者的甲状腺过氧化物酶抗体(TPOAb)阳性率13.75...     

妊娠合并甲状腺功能减退症的甲状腺功能检测结果分析

目的分析化学发光酶免疫分析法(CLEIA)检测妊娠合并甲状腺功能减退症的血清甲状腺功能变化的临床价值。方法回顾性分析41例妊娠合并甲状腺功能减退症的血清甲状腺功能检测结果。结果妊娠合并甲状腺功能减退症发病率有逐年增多趋势;观察组治疗后FT3、FT4、T3、T4均明显高于治疗前、TSH明显于低于治疗前,差异有统计学意义(P<0.05);治疗后与对照组比较,差异无统计学意义(P>0.05);观察组合并多种并发症,分娩后2周新生儿低体质量3例,但无出现先天性甲状腺功能减退症及畸形。结论妊娠合并甲状腺功能减退症对孕妇和胎儿会产生不良的影响,且发病率有逐年增多趋势,应用CLEIA法检测血清甲状腺功能对其早期筛查、治疗有重要的临床价值。     

斑秃病人甲状腺功能的初步研究

目的　探讨斑秃与甲状腺功能的关系。方法　采用放射免疫分析法检测 6 0例斑秃病人和正常人血清中甲状腺FT3 、FT4及促甲状腺素 (TSH)的水平。结果　斑秃病人FT3 、FT4(7 0 7± 1 4 5 pmol/L、17 89± 3 5 7pmol/L)同正常对照组相比明显增高 ,差异有非常显著意义 (P <0 0 1) ,而TSH明显降低 (2 0 9± 1 2 7mIU/L) ,与正常对照相比 ,差异有显著意义 (P <0 0 5 )。结论　甲状腺功能异常与斑秃的发病有一定的关系     

抗甲状腺功能亢进药物治疗青少年甲状腺功能亢进临床分析

目的探讨青少年甲状腺功能亢进的临床特点和抗甲状腺药物治疗青少年甲状腺功能亢进的临床效果。方法选择武汉市第十三医院2006年11月至2009年11月甲状腺功能亢进青少年患者36例。分析其病因和临床表现、实验室检查结果。本组患者34例给予抗甲状腺药物治疗。给予他巴唑每天15～30mg,或者给予丙基硫氧嘧啶每天150～300mg,根据患者症状的缓解情况而后逐渐减量,为才治疗量他巴唑为每天5～10mg,或者丙基硫氧嘧啶每天50～100mg。均治疗1.5～2年。其余2例患者手术治疗。结果本组34例口服抗甲状腺药物患者随访1年,其中24例患者缓解,缓解率为70.5%,停药后症状复发者7例,17例患者治愈,治愈率为50%,其余10例患者不规则服药,症状没有缓解或者在治疗过程中症状反复出现,出现白细胞减少1例停药,肝功能损害1例停药。2例手术治疗患者随访1年,1例痊愈,1例复发。结论抗甲状腺药治疗仍然是治疗青少年甲状腺功能亢进的首选方法,用药安全且不会产生永久性甲状腺功能减退,但要加强家长对患者服药监督。     

男性Graves病患者垂体—性腺功能初步探讨

目的：初步探讨男性Graves病（GD）患者垂体-性腺轴功能及性功能变化。方法：对42例男性GD患者进行性功能评价治疗前及治疗后半年用放免法检测T3、T4、S-TSH及FSH、LH、TT、E2进行对比。结果：男性甲亢患者FSH、LH、T、E2在治疗前升高,已婚者性功能障碍发生率为54.1%,治疗后上述改变随着甲状腺功能正常而正常。结论：GD患者存在下丘脑-垂体-性腺轴功能紊乱,属可逆性。     

药源性甲状腺功能异常

药源性甲状腺功能异常是指应用某些药物而引起的甲状腺疾病,包括甲状腺功能亢进、甲状腺功能减退以及亚临床甲状腺疾病等。引起药源性甲状腺疾病的药物种类繁多,不同药物所致甲状腺功能异常的发生机制不同,临床表现不一。本文主要就引起甲状腺疾病的常见药物种类、发病机制、临床表现及诊治方法进行综述。     

男性HIV感染者甲状腺功能与性激素水平的研究

目的研究HIV感染的男性患者是否存在甲状腺功能障碍及性激素水平变化,观察甲状腺激素变化与性激素变化之间的关系。方法采用放射免疫法测定研究对象的甲状腺激素及性激素,分析两者间的相关性。结果1．21．23％的患者出现一种或多种甲状腺激素的改变,12．77％的发生亚临床甲减。2．T,E2,LH,FSH改变差异显著（P〈0．05）。3．有甲状腺激素值有变化比甲状腺激素值无变化的患者T下降更明显（P〈0．05）。结论1．HIV感染男性患者存在甲状腺激素的紊乱;2．HIV感染男性患者存在性激素的紊乱;3．存在甲状腺激素的紊乱的HIV感染男性患者性激素紊乱更明显。     

Clinical pharmacology of prochlorperazine in healthy young males.

1. The pharmacokinetics and pharmacodynamics of prochlorperazine (PCZ) have been studied in healthy young males following single 12.5 mg i.v. and 50 mg oral doses, and during repeated doses (25 mg twice daily) for 14 days. 2. Oral bioavailability was low and an N-desmethyl metabolite was detected. Plasma clearance was high (0.98 1 kg-1 h) and the volume of distribution was large (12.9 1 kg-1) after i.v. dosing. 3. The terminal elimination half-life of PCZ was 9 +/- 1 h and 8 +/- 2 h after i.v. and single oral dosing, respectively. The urinary recoveries of drug and metabolite were low. 4. Accumulation of PCZ and its metabolite occurred following repeated dosing. The half-life at the end of 14 days therapy was 18 +/- 4 h. 5. Postural tachycardia, decreased salivary flow, impaired psychomotor function and a diminished level of arousal were observed after intravenous PCZ. Similar effects, but of lower magnitude were observed after single oral doses. During chronic dosing postural tachycardia and antihistaminic effects were observed, the latter not being observed after single doses. 6. After single intravenous dosing the maximal drug effects occurred 2-4 h after peak plasma drug concentrations for all measures except for plasma prolactin and self-scored restlessness 7. An antagonist action at dopamine (D2), muscarinic-cholinergic and alpha-adrenoceptors is postulated after single doses, with antihistaminic effects during chronic dosing, possibly indicating the presence of an active metabolite.     

Alcohol, intelligence and violent crime in young males

Research has demonstrated a relationship between alcohol and violent behavior, but proof of a causal connection remains elusive. A recent review concluded that the key task that remained was to identify sub-groups of the population for which alcohol promotes violence. Because alcohol might induce violence by causing cognitive disruption (e.g., misunderstood communication), less intelligent persons could be vulnerable because they start out closer to the lower limit of comprehension. Our objective is to investigate the effect of lower intelligence on the alcohol/violence relationship. This analysis uses data from the Buffalo Longitudinal Study of Young Men to investigate this hypothesis. Males, 16 to 19 years of age (N = 596), were selected from Buffalo, NY, by random digit dialing. High-risk males were oversampled. Two interviews were conducted 18 months apart, including drinking, criminal offenses, and psychological traits. Verbal intelligence was measured by the Ammons Quick Test and visual-motor intelligence by the Trail Making Test. An analysis of covariance was conducted with wave 2 average alcohol consumption and both measures of intelligence as independent variables, violent offending as the dependent variable, and race, wave 1 alcohol and wave 1 violence as covariates. Results show a positive main effect of wave 2 alcohol consumption, but also interactions with both verbal and visual-motor intelligence. These interactions indicate that the prevalence of violence increases significantly at low intelligence and high alcohol consumption levels. A parallel analysis with nonviolent offending as the dependent variable failed to find significant interactions. The combination of heavy drinking and lower intelligence is associated with a synergistic surge of violent behavior.     

Comparison of paracetamol metabolism in young adult and elderly males

Summary Paracetamol metabolism was compared in groups of young adult (mean age 20.8 years) and elderly (mean 79.3 years) males.Apparent oral clearance and half-life and partial metabolic clearances to the glucuronide and glutathione-derived conjugates of paracetamol were not significantly different between the two groups. However, the partial metabolic clearance to paracetamol sulphate was 23.1% lower and renal clearance of unchanged drug was 42.9% lower in the elderly compared to the young adults.Despite the decreased clearance by these pathways, reduction in paracetamol dosage should not be necessary in the elderly.     

Improvement in oxidative status with yogic breathing in young healthy males

The modern living lifestyle is known to produce various physical and psychological stresses and subject the individual to produce oxidative stresses as well. The aim of this study has been to assess the effect of yogic breathing exercises (pranayama) on the oxidatives stress. The study group consisted of 30 young male volunteers, trained for the purpose of this study and an equal number of controls were used. The free radicals and Super oxide dismutase levels were measured before the study and at the end of the study. The free radicals were decreased significantly in the study group but the SOD was increased insignificantly as compared to the control group. Yogic breathing exercises not only help in relieving the stresses of life but also improve the antioxidant status of the individual. An improvement in the antioxidant status is helpful in preventing many pathological processes that are known with impaired antioxidant system of body.     

心理干预在青年女性甲状腺癌患者治疗过程中的应用及分析

目的 探讨心理干预在青年女性甲状腺癌患者治疗过程中的应用效果.方法 随机将90例青年女性甲状腺癌患者分为实验组45例和对照组45例,对照组给予常规护理,实验组在此基础上给予有针对性的综合心理护理干预.分别对两组患者在入院第2天、出院前1天进行焦虑量表(SAS)、抑郁量表(SDS)、心理活动影响因素问卷调查,观察干预效果.结果 实验组患者经积极心理干预后焦虑、抑郁心理与对照组比较,差异有统计学意义(P＜0.05).结论 积极的心理干预可改善患者的焦虑、抑郁情绪,有助于提高患者的生活质量和治疗效果.     

Instrumental analysis of ethanol-induced intoxication in human males

A study was conducted to assess subjective reports of intoxication during the ascending phase of the plasma ethanol curve. Eighteen male social drinkers were divided into three groups and were given either placebo, 0.347 g/kg ethanol or 0.694 g/kg ethanol under double-blind conditions. Subjects reported levels of intoxication both instrumentally, by moving a joystick device, and verbally using an 11-point self-rating scale. Compared to placebo, ethanol produced significantly higher verbal self-rating scores, but there were no differences in the scores between the low-and high-dose ethanol groups. Instrumental responses of ethanol effects did, however, distinguish between the two ethanol treatments. All subjects who received ethanol reliably detected its effects when plasma ethanol levels reached 32 mg/dl, but only the subjects who received the high dose reported episodes of intense well-being or euphoria. Ethanol-induced euphoria occurred while plasma ethanol levels were rapidly rising, and was characterized by multiple, paroxysmal episodes that typically lasted about 3 min each. This study demonstrated that a continuously available instrumental response provided sensitive and reliable measures of rapidly changing behavioral states associated with ethanol-induced intoxication.     

Validity of self-report of illicit drug use in young hypertensive urban African American males

Inaccurate self-reporting is the primary threat to the validity and utility of self-report in the research on illicit drug use. The purpose of this study was to estimate the sensitivity and specificity of self-report of drug use, using urine toxicity screening as a criterion variable, and to explore the individual characteristics associated with false reporting in a sample of urban African American males. Baseline data from urine tests and a questionnaire about self-report of illicit drug use were obtained from 290 hypertensive African American males enrolled in an ongoing hypertension clinical trial. Sensitivity and specificity of self-report were estimated, and multivariate logistic regression analysis was conducted to examine factors associated with true or false reporting of drug use. RESULT: The sensitivity and specificity of self-report were 0.87+/-0.019 and 0.63+/-0.02, respectively. Members of the underreporting group were more likely to be older, more educated, employed, living with family, and having experience with jail. Jail experience (OR, 2.0) and living with friends or family (OR, 1.7) were the two strongest predictors of false reporting. This study further confirms that social desirability and fear of the consequences of drug use are major contributing factors in underreporting of drug use.     

Comparison of the urinary metabolite profile of caffeine in young and elderly males.

The urinary metabolite profile of caffeine was compared in a group of seven healthy young men aged 18-29 years and in a group of five healthy elderly men aged 66-71 years. All subjects were given 5 mg/kg doses of caffeine as an aqueous oral solution or an intravenous infusion on two separate occasions in a randomized crossover design. Urine samples were collected for 24 h after dosing and analysed for caffeine and eleven of its metabolites by high-performance liquid chromatography. The effects of age, route of administration, and order of administration by route on the metabolite profile of caffeine were examined. The route of administration and the order of administration by the two routes were found not to influence the urinary metabolite pattern significantly. The urinary metabolite profile did not vary substantially with age except for the observation that significantly greater amounts of 1-methyluric acid, 7-methyluric acid and 1,7-dimethyluric acid were excreted by the elderly subjects.