共查询到20条相似文献,搜索用时 31 毫秒
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Linda Fogelstrand MD PhD Anna Staffas Msc Carina Wasslavik Bsc Helene Sjögren PhD Stefan Söderhäll MD PhD Britt‐Marie Frost MD PhD Erik Forestier MD PhD Sofie Degerman PhD Mikael Behrendtz MD Jesper Heldrup MD Kristina Karrman MD Bertil Johansson MD PhD Mats Heyman MD PhD Jonas Abrahamsson MD PhD Lars Palmqvist MD PhD 《Pediatric blood & cancer》2014,61(3):424-430
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High hyperdiploid acute lymphoblastic leukemia (ALL)—A 25‐year population‐based survey of the Austrian ALL‐BFM (Berlin‐Frankfurt‐Münster) Study Group
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Bettina Reismüller Manuel Steiner Herbert Pichler Michael Dworzak Christian Urban Bernhard Meister Klaus Schmitt Ulrike P?tschger Margit K?nig Georg Mann Oskar A. Haas Andishe Attarbaschi Austrian ALL‐BFM Study Group 《Pediatric blood & cancer》2017,64(6)
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Treatment for childhood acute lymphoblastic leukemia in Taiwan: Taiwan Pediatric Oncology Group ALL‐2002 study emphasizing optimal reinduction therapy and central nervous system preventive therapy without cranial radiation
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Meng‐Ju Li Hsi‐Che Liu Hsiu‐Ju Yen Tang‐Her Jaing Dong‐Tsamn Lin Chao‐Ping Yang Kai‐Hsin Lin Iou‐Jih Hung Shiann‐Tarng Jou Meng‐Yao Lu Chih‐Cheng Hsiao Ching‐Tien Peng Tai‐Tsung Chang Shih‐Chung Wang Ming‐Tsan Lin Jiann‐Shiuh Chen Te‐Kau Chang Giun‐Yi Hung Kang‐Hsi Wu Yung‐Li Yang Hsiu‐Hao Chang Shih‐Hsiang Chen Ting‐Chi Yeh Chao‐Neng Cheng Pei‐Chin Lin Shyh‐Shin Chiou Jiunn‐Ming Sheen Shin‐Nan Cheng Shu‐Huey Chen Yu‐Hsiang Chang Wan‐Ling Ho Yu‐Hua Chao Rong‐Long Chen Bow‐Wen Chen Jinn‐Li Wang Yuh‐Lin Hsieh Yu‐Mei Liao Shang‐Hsien Yang Wan‐Hui Chang Yu‐Mei Y. Chao Der‐Cherng Liang 《Pediatric blood & cancer》2017,64(2):234-241
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Very long survival in complete cytogenetic remission in an adolescent with lymphoid blast crisis of chronic myeloid leukemia after treatment with intensive ALL‐directed chemotherapy combined with continuous imatinib
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Alexey Maschan Galina Novichkova Natalia Miakova Marina Persiantseva 《Pediatric blood & cancer》2016,63(12):2243-2245
An 11‐year‐old male was diagnosed with chronic‐phase chronic myeloid leukemia (CML) in 1998 and received therapy with interferon‐α2b and low‐dose cytarabine. In 6 years, he progressed to lymphoid blast crisis and received induction chemotherapy with prednisolone, vincristine, daunorubicin, and l ‐asparaginase concomitantly with imatinib 400 mg/day, and continuation with vincristine + prednisolone, cytarabine + etoposide, vincristine + l ‐asparaginase, cyclophosphamide + etoposide, and 6‐mercaptopurine + methotrexate. Complete molecular response (MR) was achieved and therapy was continued with imatinib 800 mg/day. He relapsed to chronic‐phase CML after interruption of imatinib and regained MR after its restart. The patient is alive 17.5 years after CML diagnosis and 11.5 years after lymphoid blast crisis. 相似文献
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Uwe Kordes MD Andrea Richter MD Rene Santer MD Hansjörg Schäfer MD Dominique Singer MD Josef Sonntag MD Ulrike Steuerwald MD Reinhard Schneppenheim MD Gritta Janka MD 《Pediatric blood & cancer》2010,54(5):758-760
We report a Caucasian neonate with chronic non‐spherocytic hemolytic anemia due to a class I G6PD deficiency. A novel mutation missense mutation in exon eight of the G6PD gene was detected (c.827C>T p.Pro276Leu). Bilirubin peaked on day 5 at 24 mg/dl with a conjugated bilirubin of 17 mg/dl. Jaundice resolved within 4 weeks. A detailed work‐up failed to reveal other specific factors contributing to cholestasis. Severe hemolytic disease of the newborn may cause cholestasis even in the absence of associated primary hepato‐biliary disease. Pediatr Blood Cancer 2010;54:758–760. © 2010 Wiley‐Liss, Inc. 相似文献
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Chika Yamasaki Atsushi Uchiyama Hidehiko Nakanishi Kenichi Masumoto Hiroyuki Aoyagi Yosuke Washio Satsuki Totsu Ken Imai Satoshi Kusuda 《Pediatrics international》2012,54(4):465-470
Background: The long‐term effects of hydrocortisone (HDC) used for very‐low‐birthweight (VLBW) infants with chronic lung disease (CLD) are not fully understood. The aim of this study was to examine the short‐term clinical effects and long‐term impact of a physiological replacement dose of HDC on acute deterioration of CLD in VLBW infants. Methods: This prospective case–control study included 110 of the 174 VLBW infants admitted to our facility between 2003 and 2006 who were followed up to a corrected age of 18 months. Infant deaths and infants with congenital deformities were excluded from the study. The infants were classified into the following three groups: infants with CLD and treated with HDC (1–2 mg/kg/dose) due to progressive deterioration in oxygenation (CLD treatment group; n= 24); infants with CLD but not treated with HDC (CLD untreated group; n= 40); and infants without CLD (non‐CLD group; n= 46). Results: The fraction of inspired oxygen (FIO2) in the CLD treatment group improved significantly after treatment (P < 0.01). There were no significant differences among the three groups in terms of growth and neurodevelopmental quotient at the corrected age of 18 months following adjustment for birthweight, sex, and presence of light‐for‐date infants. There were also no significant intergroup differences in all three areas of developmental quotient. Conclusions: Physiological doses of HDC replacement are effective in treating acute deterioration in oxygenation in VLBW infants with CLD. Furthermore, this treatment modality did not adversely affect the growth and development of infants at the corrected age of 18 months. 相似文献
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L Rautava U Häkkinen E Korvenranta S Andersson M Gissler M Hallman H Korvenranta J Leipälä M Peltola O Tammela L Lehtonen for PERFECT Preterm Infant Study Group 《Acta paediatrica (Oslo, Norway : 1992)》2010,99(7):1073-1079
Aim: We aimed to study the effect of prematurity, time of birth and level of birth hospital on morbidity and the use of health care services at age 5. Methods: This national study included all very‐low‐birth‐weight infants (VLBWI, <32 gestational weeks or birth weight ≤1500 g) born in Finnish level II or III hospitals in 2001–2002 (n = 918), and full‐term controls (n = 381). Parental questionnaires and register data were used to compare morbidity, and the use of health care services between VLBWI and full‐term controls, and within VLBWI according to the time of birth and birth hospital level. Results: Cerebral palsy, retinopathy of prematurity, other ophthalmic problems, respiratory infections, asthma or chronic lung disease, and inguinal hernia were overrepresented in VLBWI compared with the controls. VLBWI had more outpatient and inpatient days than the controls. The time of birth and birth hospital level were not associated with the use of services or with prematurity‐related morbidity. Conclusion: Although morbidity and the use of health care services were increased in the surviving VLBWI, the average use of services was relatively small at age 5. In surviving VLBWI, the time of birth and the birth hospital level did not affect morbidity or the use of services. 相似文献
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Aims: It remains questionable what birth weight for gestational age percentile cut‐offs should be used in defining clinically important poor or excessive foetal growth. We aimed to evaluate the optimal birth weight percentile cut‐offs for defining small‐ or large‐for‐gestational‐age (SGA or LGA). Methods: In a birth cohort‐based analysis of 17 979 120 non‐malformation singleton live births, U.S. 1995–2001, we assessed the optimal birth weight percentile cut‐offs for defining SGA and LGA. The 25th–75th percentile group served as the reference. Primary outcomes are the risk ratios (RR) of neonatal death and low 5‐min Apgar score (<4) comparing SGA or LGA versus the reference group. More than 2‐fold risk elevations were considered clinically significant. Results: The 15th birth weight cut‐off already identified SGA infants at more than 2‐fold risk of neonatal death at pre‐term, term or post‐term, except for extremely pre‐term births <28 weeks (continuous risk reductions over increasing birth weight percentiles). LGA was associated with a reduced risk of low 5‐min Apgar score at pre‐term, but an elevated risk at term and post‐term. The 97th cut‐off identified LGA infants at 2‐fold risk of low 5‐min Apgar at term. Conclusion: The commonly used 10th and 90th birth weight percentile cut‐offs for defining SGA and LGA respectively seem largely arbitrary. The 15th and 97th percentiles may be the optimal cut‐offs to define SGA and LGA respectively. 相似文献
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Mitsuo Okubo Eriko Nishida Akiko Watanabe Naoto Nishizaki Kaoru Obinata Fumihiro Azuma Mika Matsuhashi Naoko Watanabe‐Okochi Nelson Hirokazu Tsuno Kazunori Miyake Minoru Yamaguchi Koyo Yoshida Akimichi Ohsaka 《Pediatric blood & cancer》2019,66(3)
Maternal antibodies against human platelet antigen (HPA) and/or human leukocyte antigen (HLA) cause fetal and neonatal alloimmune thrombocytopenia (FNAIT) in 0.09‐0.15% of live births. Severe cases account for 5‐31% and the frequency of multiple kinds of alloantibodies is 6.9‐9% of FNAIT. We present a case of severe FNAIT associated with anti‐HPA‐5b, anti‐HLA‐A31, and anti‐HLA‐B55 antibodies, successfully treated with immunoglobulin and platelet transfusion. The anti‐HLA‐B55 antibody was detected in the newborn's serum, but disappeared on the 20th day, which was followed by an increase of the platelet count. These findings suggested the potential involvement of an anti‐HLA antibody in the pathogenesis of FNAIT. 相似文献
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Report and review of described associations of Mayer‐Rokitansky‐Küster‐Hauser syndrome and Silver–Russell syndrome
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Mary B Abraham Karen Carpenter Gareth S Baynam Deborah JG Mackay Glynis Price Catherine S Choong 《Journal of paediatrics and child health》2015,51(5):555-560
Silver–Russell syndrome (SRS) and Mayer‐Rokitansky‐Küster‐Hauser (MRKH) syndrome are described in isolation. However, their co‐occurrence has only been rarely reported. Here, we present a case report of an adolescent with SRS who was diagnosed with MRKH during the evaluation of primary amenorrhoea. Multiplex ligation‐dependent probe amplification analysis showed a normal methylation pattern and normal dosage at 11p15.5. A PubMed search for all peer‐reviewed publications (original articles and reviews) using the key words Silver–Russell syndrome, Mayer‐Rokitansky‐Küster‐Hauser syndrome, genetics, hypomethylation and reproductive anomalies identified three cases of SRS with MRKH, two of which were associated with significant hypomethylation of the H19 imprinting control region of the 11p15.5 locus. This report highlights the association between SRS and MRKH. The absence of hypomethylation and normal dosage at 11p15.5 suggests these two rare entities share alternative aetiopathogenic mechanisms. 相似文献