酒精依赖者视觉诱发电位的研究

目的：本研究旨在通过对酒精依赖者模式翻转视觉诱发电位（ＰＲＶＥＰ）的研究，为了解酒精依赖者的生理和心理功能损害提供客观指标。方法：酒精依赖者６２人，正常对照者４０人，采用日本产Ｎｅｕｒｏｐａｃｋ－２型诱发电位仪，分别对其进行模式翻转视觉诱发电位（ＰＲＶＥＰ）记录。结果：与正常对照组相比，酒精依赖者ＰＲＶＥＰ波潜伏期延长，波幅降低，主波群异常，晚成份出现率低，周期不明显及侧性优势现象消失，差异具有显     

白化病视觉诱发电位检查的研究进展

白化病（Albinism）是一组与黑色素合成、分解有关的基因突变而导致的以眼、皮肤、毛发黑色素缺失为临床特征的遗传性疾病。临床上通常根据黑色素缺乏的部位及有无其他系统异常,分为三型;即眼白化病（仅有眼部黑色素的缺失）、眼皮肤白化病（同时存在眼、全身皮肤及毛发的黑色素     

帕金森病患者的视觉诱发电位研究

目的:观察帕金森病(PD)患者视觉诱发电位(VEP)的改变及其临床意义。方法:选取昆明医学院第一附属医院神经内科2008年1月～2010年3月期间收治的48例帕金森病患者作为观察组,同时选取45例在昆明医学院第一附属医院神经内科健康体检的志愿者作为对照组,应用丹麦Dantec公司生产的Keypoint4导诱发电位仪对两组受试者进行视觉诱发电位(VEP)的检测并进行比较。结果:观察组视觉诱发电位的P100潜伏期为(116.8±11.2)ms,P100波幅为(6.52±2.87)μV,对照组视觉诱发电位的P100潜伏期为(104.8±10.1)ms,P100波幅为(7.68±3.02)μV,两组P100潜伏期经比较,差异有统计学意义(P<0.05),两组P100波幅差异不显著;观察组P100潜伏期与病程及病情严重程度均呈正相关(P<0.05)。结论:帕金森病患者的视觉诱发电位有一定程度的改变,提示帕金森病患者可伴有视觉传导通路的损害,视觉诱发电位可作为患者疾病早期诊断及病情发展、判断预后的客观的评价标准。     

视觉诱发电位与优势眼

目的:研究正常儿童优势眼视觉诱发电位特征。方法:对47名正常儿童进行全视野刺激多导视觉诱发电位研究。结果:优势眼视觉诱发电位以0_z电极为代表,P_(100)潜伏期较非优势眼缩短(P<0.01),而N_(75)—P_(100)峰峰值较非优势眼增大(P<0.05)。结论:中枢神经系统存在偏利现象,这种偏利现象可能与控制视神经髓鞘优先形成的某种遗传机制有关,或是中枢神经系统突触的局部构造、突触效能的差异。     

弱视儿童图形视觉诱发电位分析

弱视是妨碍儿童视觉发育的严重眼病之一。近年来 ,视觉诱发电位 (ＶＥＰ)已成为研究弱视发病机理 ,进行临床诊断和评价预后的一项重要手段。笔者于 1996年 9月至 1998年9月对 34例弱视儿童进行图形视觉诱发电位 (Ｐ ＶＥＰ)检测分析 ,现报告如下。1　 对象和方法研究对象 :34例弱视儿童中 ,单眼弱视 18例 ,男 10例 ,女 8例 ,共 18眼 ,年龄 3～ 14岁 ,弱视眼视力 0 0 7～ 0 6 ;双眼弱视 16例 ,男 7例 ,女 9例 ,共 32眼 ,年龄 4～ 14岁 ,视力 0 1～ 0 7。弱视依文献 [1]分度 ,两组患者中 ,轻度弱视 10眼 ,中度 16眼 ,重度 2 4眼。以同年龄…     

非枕叶癫痫患者视觉诱发电位的表现

目的：研究非枕叶癫痫患者视觉传导通路可能的损害及其机制.方法：应用诱发电位仪对非枕叶癫痫中的难治性癫痫患者（第一组）、非枕叶癫痫中的非难治性癫痫患者（第二组）及健康志愿者（第三组）共3组进行视觉诱发电位（VEP）检测,观察其N75波潜伏期（LN75）、P100波潜伏期（LP100）、N75波幅（AN75）、P100波幅（AP100）等指标.结果：第一、二组的LN75、 LP100均较第三组延长,差异有统计学意义（P〈0.05）,而第一、二组间的LN75和LP100比较差异均无显著意义（P〉0.05） 第一组的AP100较第三组升高,差异有统计学意义（P〈0.05）,而第一、二组间比较差异无显著意义（P〉0.05） 三组间比较AN75比较差异均无统计学意义（P〉0.05）.结论： 非枕叶癫痫患者存在视觉传导异常,表现为LN75、LP100延长,AP100的升高 而其中的难治性癫痫患者与非难治性癫痫患者的视觉传导异常程度比较差异无统计学意义.     

视觉诱发电位P100潜伏期的临床意义

本探讨了视觉诱发电位（Visually evoked cortical potentials VEP)P100潜伏期延长的临床意义。检测对象为临床眼科病例，其中视神经炎25例30只眼睛，多发性硬化症15例30只眼睛，青光眼20例30只眼睛。以正常人25例50只眼睛作为对照组。提示：所有视神经病变P100潜伏期都延长，黄斑部正常的视神经疾病其P100潜伏期也延长。P100潜伏期的延长能够反映视神经障碍。     

不同颜色单色光产生的稳态视觉诱发电位的比较

人的视网膜上的视锥细胞是明视条件下视觉形成的感应器，可分为红锥细胞、绿锥细胞、蓝锥细胞。每类锥细胞有不同的光谱吸收特性。用10Hz的脉冲分别驱动红、绿、蓝三种发光二极管，使其产生同样强度的单色光，用这些单色光分别对10个受试者的双眼进行刺激，用128道的脑电系统对受试者的脑电进行记录。通过对所有电极处的稳态视觉诱发电位（Steady—state visually evoked potential，SSVEP）进行频谱分析，发现不同类视锥细胞输出的信号在视觉初级皮质激发的神经网络分布基本一致，但在各自网络引起的反应强度有差别：蓝光最强，红光次之，绿光最弱。     

A new and simple technique for the generation of visual evoked potentials in freely moving animals

A new and simple technique for the generation of visual evoked brain-potentials (VEP) by the aid of a light-emitting diode (LED) is presented. The method allows the generation of VEPs in freely moving animals under constant stimulation conditions and prevents moreover any acoustic disturbances.     

Occipital cortex activation studied with simultaneous recordings of functional transcranial Doppler ultrasound (fTCD) and visual evoked potential (VEP) in cognitively normal human subjects: Effect of healthy aging

We evaluated effect of aging, gender and eye (sighting) dominance on relationship between visual evoked flow response (VEFR) and visual evoked potential (VEP), which refers to neurovascular coupling. The VEFR was defined as a percentage increase of the ratio of mean blood flow velocity in the contralateral (according to the side of dominant eye processing) posterior cerebral artery P2 segment to those in ipsilateral middle cerebral artery from the baseline during half-field stimulation. Vasoneural coupling index (CI) was defined as “100 × VEFR/VEP P100 amplitude”. Compared to the healthy elderly subjects (n: 19; female/male: 6/13, mean age: 69.7 ± 7), younger participants (n: 28; female/male: 16/12; mean age: 31.1 ± 4.7) had significantly higher VEFR for both sides: 18.9 ± 6.7% versus 11.2 ± 6.7%, p < 0.001 and 17.3 ± 7.7% versus 11.8 ± 5.5%, p: 0.007, for the hemisphere contralateral to dominant and nondominant eye (D and ND side), respectively. Albeit absence of any correlation between their latencies, VEP and VEFR amplitudes were well correlated. However, this was significant only for younger subjects and more evident in D side. The CI was higher in young subjects compared to those in old ones (6.49 ± 2.79 versus 4.75 ± 2.35, respectively, p = 0.007). But, this age-related trend remained as borderline when sides were analyzed individually: In the young subjects CI was 5.99 ± 2.21 and 6.96 ± 3.22 for D and ND sides, while those were 4.27 ± 2.60 and 5.19 ± 2.07 in old ones. This study confirmed diminished visual evoked flow in relation with advancing age, and suggested that “weakened” neurovascular coupling (as evidenced by a decreased VEP and VEFR correlation along with decreased CI) as one of the underlying mechanisms.     

帕金森病患者VEP、BAEP及SEP的测定

目的：研究帕金森病（PD）患者视觉诱发电位（VEP）、脑干听觉诱发电位（BAEP）及体感诱发电位（SEP）的变化并推测其发生机制。方法：选择2008年1月至2013年1月在昆明医学院第一附属医院神经内科门诊及住院的80例PD患者作为PD组,50例健康对照者作为对照组。应用神经电生理检查仪分别对PD患者和健康者进行VEP、BAEP和SEP检测,并进行比较。结果：PD组VEP的P100潜伏期（115．1±10．6）ms较健康对照组（103．2±9．0）ms明显延长（P〈0．01）,P100波幅（6．25±3．02）弘V较健康对照组（7．70±2．62）pV增高（P〈0．05）;PD组BAEP的I、Ⅱ、Ⅲ波的潜伏期和Ⅲ-V及I—V峰间期较对照组明显延长（P〈0．05）;SEP各波潜伏期及波幅两组比较差异无显著意义。结论：PD患者的VEP和BAEP均有不同程度的改变,提示PD患者可能伴有脑干听觉传导通路与视觉俜导诵略的桶害．     

一种基于两种不同范式的混合型脑-机接口系统

混合模式脑机接口是脑-机接口研究的一个新方向,它为进一步提高脑-机接口系统性能提供了可能。现有的混合模式脑-机接口所采用的范式通常需要借助较强的视觉刺激,容易引起受试者疲劳等问题。本研究提出将运动想象和运动起始时刻视觉诱发电位两种无需强烈视觉刺激的范式以串行的方式相结合,通过运动起始时刻视觉诱发电位控制字符的输入,通过运动想象控制界面的开关和允许输入下一字符,实现了一种可用于字符输入的混合模式脑-机接口系统。为了验证系统的可行性,共完成了5例实验。实验中受试者首先进行两种范式的训练,然后进行开关系统界面和输入字符的测试。实验结果显示,经过一定训练的受试可以较好地完成系统的操作,运动想象单步操作平均时间最短为3.9 s,字符输入的正确率最高可达93.3%。除了不容易令受试者产生疲劳外,本系统相比单一感觉模式的脑-机接口也具有可完成任务种类多、控制方式灵活等优势。     

基于ANFIS的自适应噪声消除方法在视觉诱发脑电信号的单次提取中的应用

本研究将基于自适应模糊神经网络(ANFIS)的噪声消除方法应用于视觉诱发脑电信号的单次提取。通过数字仿真和实际临床应用的结果验证了该方法的有效性。经与目前临床通用的相干平均法比较，在波形整体和P100潜伏期的提取上，效果显著。     

A technique for processing coronary hemodynamic data with a small hybrid computing system

This report describes the program for utilizing a small hybrid computing system to process coronary arterial flow and pressure signals obtained from chronically instrumented, conscious animals and discusses the advantages and disadvantages of the hybrid approach. Extensive analog preprocessing using parallel logic facilitates formation of data during the experiment and minimizes later editing. Moreover, it allows the digital portion of the program to be much smaller and more general than similar applications using only digital systems. Final output consists of an ink-jet recording of the analog signals, a printout of the digital results, and CalComp plots.     

Abnormal B.A.E.P. in a family with Moebius syndrome: evidence for supranuclear lesion

A family with Moebius syndrome is presented. Neurological lesions in the affected members are various: complete VI and VII cranial nerves palsy associated with mental retardation in the proband; left convergent strabismus and mental retardation in a brother of the proband and only mental retardation in a sister of the proband. The brainstem auditory evoked potentials (B. A.E.P.), investigated in the proband and his affected sister, are abnormal. The presence of the anomaly after the 3rd wave is consistent with a disfunction of the auditory tract at a supranuclear level. The mental deficiency and the supranuclear site of the acoustic lesion are an indication for a more general involvement of C.N.S. than cranial nerve nuclei alone.
Karyotype and dermatoglyphics of the three affected subjects were normal. The authors hypothesized the same disorganogenetic factor acting very early (4th-6th week of gestational age) on the metamerization process of limb buds mesoderm and brainstem gray matter.     

A dynamic nonlinear time domain model for reconstruction and compression of cardiovascular signals with application to telemedicine

A new nonlinear time domain model is proposed in this paper for signals of cardiovascular origin. An equation of the dynamic nonlinear model has been obtained by considering a masking function, which is modulated by a harmonic series with the baseline drift incorporated into the model. Signal reconstruction using model parameters has established the effectiveness of the model for signal compression. Improvement has been effected by using neural networks for reducing the time for optimizing the initial parameters. An improved adaptive optimization step size algorithm has also been implemented. Results show that the technique is able to provide reasonable compression with low error between the original and reconstructed signals. One of the main advantages of the model is its potential of being used for compression of many different types of biosignals transmitted in parallel. Incorporation of the compression model into a telemedicine system has led to considerable saving in transmission time for patient data.