Association of VDR Gene Variants with Hyperglycemia in Henan Rural Population

<正>The term hyperglycemia was used to defined an abnormal status in which blood glucose increases and deviates from the normal fasting glucose(NFG),which contains the following statuses: impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus (DM).     

空腹血糖受损下限诊断切割点的建议

糖尿病是一组由于血糖水平过高而引起组织、器官功能及结构异常的疾病。糖调节受损（impaired glucose regulation，IGR）是任何一种类型糖尿病发病过程中的中间阶段。根据空腹和负荷后血糖值，IGR可分为两种高血糖状态——空腹血糖受损（impaired fasting glucose，IFG）和糖耐量受损（impaired glucose tolerance，IGT）。     

Correlation between the amplitude of glucose excursion and the oxidative/antioxidative system in subjects with different types of glucose regulation

Objective To investigate effects of glucose excursion on the oxidative/antioxidative system in subjects with different types of glucose regulation. Methods A total of 30 individuals with normal glucose regulation (NGR), 27 subjects with impaired glucose regulation (IGR) and 27 subjects with newly diagnosed type 2 diabetes mellitus (T2DM) were selected and recruited for 3 days’ continuous glucose monitor system (CGMS) assessment. The data from CGMS was used to calculate the mean amplitude of glycemic excursi...     

A tradational medicine improves hyperinsulinemia in obese subjects

[Methods] Forty of 80 obese women （BMI 36.1±2.8）with impaired glucose tolerance were administrated Bofutsushosan and a place hyper bo, Bofutsushosan treatment on insulinemia in Obese subjects with impaired glucose tolerance, respectively. Plasma glucose and serum insulin levels after overnight fast and during a 75g oral glucose tolerance test wre measured before and after the 24-week diet therapy.     

Intima-Media Thickness of Carotid Artery is Associated with Insulin Sensitivity and Glucose Tolerance in Elderly Chinese

Previous studies have shown that patients with type 2 diabetes and even those with impaired glucose tolerance (IGT) have marked higher risk of atherosclerosis than nondiabetic subjects. The relationship between carotid atherosclerosis intima-media thickness (IMT) with glucose tolerance status and insulin sensitivity was studied in the elderly Chinese subjects.     

PREVALENCE OF IMPAIRED GLUCOSE REGULATION IN THE POPULATION OF TIANJIN

Objective To investigate the prevalence of impaired glucose regulation (IGR) in the population of Tianjin. Methods A cross-sectional study was conducted in Tianjin from June to September in 2005. The multi-phasic stratified cluster sampling method was adopted. Totally, 21 454 people were selected as survey sample. Information on risk factors was collected through face-to-face questionnaire interview. Fasting capillary whole blood glucose level and other clinical indexes were tested. Results The prevalence of impaired fasting glucose (IFG) in the population was 5.61% (5.32% in male, 5.89% in female). The prevalence of impaired glucose tolerance (IGT) was 2.91% (2.59% in male, 3.20% in female) in whole population, and the prevalence of female was significantly higher than that of male (P = 0.04). The prevalences of IFG and IGT increased with the increasing of age. And the prevalences were also influenced by the profession, educational level, and income level. Conclusion The prevalences of IGT and IFG in Tianjin are similar to those in the other big cities of China.     

新型脂肪因子对妊娠期糖尿病胰岛素抵抗的影响

目的:探讨新型脂肪因子视黄醇结合蛋白4(RBP4)对妊娠期糖尿病患者胰岛素抵抗的影响.方法:选取2009年6月至2010年6月我院门诊及住院孕妇85例为研究对象,其中正常孕妇(normal glucose tolerance,NGT)27例,妊娠期糖耐量异常孕妇(gestational impaired glucose...     

糖耐量减低患者高敏C反应蛋白及臂踝脉搏波传导速度分析

糖耐量减低(impaired glucose tolerance,IGT)是一种介于正常血糖和糖尿病之间的异常代谢状态,该阶段发生心血管疾病的危险性显著增高,被认为是冠心病的独立危险因素[1].     

妊娠期糖尿病血糖控制水平与妊娠结局的关系

目的探讨妊娠期糖尿病孕妇血糖控制水平与妊娠结局的关系.方法对60例妊娠期糖尿病(gestational diabetes mellitus,GDM)和47例糖耐量损害(impaired glucose     

糖耐量低减者尿中β2-微球蛋白、视黄醇结合蛋白和微量白蛋白检测的临床意义

葡萄糖耐量低减(impaired glucose tolerance IGT)是介于正常与糖尿病(diabetes mellitus,DM)之间的一种代谢异常的病理过程,表现为餐后高血糖.又称为"无症状DM"、"隐性DM"或"DM前期"等.     

急性冠脉综合征合并糖耐量受损患者临床特点及早期预后

目的 探讨急性冠脉综合征(acute coronary syndrome,ACS)合并糖耐量受损(impaired glucose tolerance,IGT)患者临床特点、近期预后及其相关危险因素.方法 对冠状动脉造影明确ACS诊断且既往无糖尿病患者,且经检测符合入选条件并能按时随访的分为血糖正常(normal glucose regulation,NGR)、IGT、空腹血糖受损(impaired fasting glucose,IFG)3组,搜集一般资料,进行生化及糖耐量试验,行冠状动脉造影、随访临床事件.结果 (1) IGT组双支、三支血管病变数、右冠状动脉病变率、Gensini积分、血管病变程度重较明显,差异有统计学意义(P.＜0.05); (2)住院期间严重出血、死亡及联合终点事件在IGT组明显升高,出院后1月内再发心肌梗死、心力衰竭、卒中、严重出血、死亡及联合终点事件在IGT组明显升高,差异有统计学意义(P＜0.05);结论 ACS合并IGT患者冠脉病变重、近期预后差,应引起高度重视.     

重视糖尿病前期人群的诊断和管理

糖尿病前期的概念包括空腹血糖受损（impaired fasting glucose,IFG）和糖耐量减低（impaired glucose tolerance,IGT）或两者兼有,判断标准IFG为空腹血糖6.1—6.9mmol／L,IGT为口服葡萄糖耐量试验（OGTT）后2h血糖7.8—11.0mmoL／L。美国糖尿病学会（ADA）提出的IFG切点为〉5.6mmol/L,     

高血压合并糖耐量受损患者肾小球滤过率差异分析

目的高血压合并不同糖耐量在临床上颇为常见。文中探索高血压合并不同糖耐量人群肾小球滤过率差异,评估糖尿病合并糖代谢异常患者肾脏损伤的特点。方法通过测定204例高血压病程在10年内合并空腹血糖受损(impaired fast glucose,IFG)、糖耐量异常(impaired glucose tolerance,IGT)、糖调节受损(impaired glucose regulate,IGR)及糖尿病(diabetes mellitus,DM)患者血清肌酐,进一步通过MDRD方程计算其肾小球滤过率(estimate glomerular filltration,eGFR),通过组间比较高血压合并不同糖代谢人群eGFR水平。结果 eGFR水平在IGT、IFG、IGR、DM不同人群均值分别为(87.95±26.27、93.46±18.91、98.94±24.14、105.50±31.09)ml/(min.1.73m2),呈逐渐上升趋势,组间比较IGT组与DM组之间存在统计学差别(P<0.05);以eGFR>125 ml/(min.1.73m2)为高eGFR,共计25例患者,其中IFG 3例,IGT1例,IGR组8例,DM组13例,组内相应比率分别为6.8%、5.9%、8.2%、28.9%,χ2检验比较发现4组间在eGFR上存在统计学差别(P<0.01)。结论高血压病程在10年内的人群合并糖代谢异常患者存在超滤状态;且DM组人群超滤状态发生率高于糖尿病前期人群。     

2型糖尿病对社会造成的负担不容忽视

随着人民生活水平提高、生活模式现代化及人口老龄化，糖尿病已成为影响我们健康的主要杀手。本文论述2型糖尿病和糖耐量低减(impaired glucose tolerance，IGT)的流行病学情况、他们的危害，以及对社会造成的沉重负担。     

空腹血糖受损人群血清CRP表达与血脂变化

空腹血糖受损（impaired fasting glucose,IFG）和糖耐量损害（impaired glucose tolerance,IGT）均为介于正常人与糖尿病患者血糖水平之间的一种中间糖代谢状态,又称为糖调节受损,同属于糖尿病前期。糖调节受损是糖尿病发病的危险因素,是最重要的糖尿病高危人群。血清C反应蛋白（C—reactive protein,CRP）是一种非特异性的炎症标志物,糖尿病患者血清CRP明显升高,又是致动脉粥样硬化的一个危险因素。笔者对我院确诊的IFG36例进行血清CRP及血脂检测,报道如下。     

单纯性糖耐量受损与糖尿病对脑梗死患者预后的影响

目的 探讨单纯性糖耐量受损(impaired glucose tolerance,IGT)与糖尿病(diabetes mellitus,DM)对脑梗死患者预后的影响.方法 224例脑梗死患者根据血糖水平分为3组,正常血糖组59例、IGT组89例和DM组76例.入院时与入院1周后分别采用美国国立卫生院卒中评分量表(nat...     

Effects of Impaired Glucose Metabolism on Heart Rate Variability and Blood Pessure Variability in Essential Hpertensive Patients

In the recent years, researches have demonstrated that impaired glucose metabolism (IGM) could induce cardiovascular autonomic neuropathy (CAN) as well as abnormity in cardiovascular structure and function. Heart rate variability (HRV) is a non-invasive means of de-tecting CAN at early stage, while blood pressure vari-ability (BPV) represents fluctuation of blood pressure in certain periods reflecting the effect of cardiovascular autonomic nervous system on the cardiovascular hemo-dynamic…     

老年人白内障手术并发症与糖耐量异常的关系

糖耐量异常(impaired glucose tolerance，IGT)是一组已有代谢异常并有可能向糖尿病发展的病理生理过程的中间阶段，其对人类健康带来的危害越来越受到重视。本文作者对我院1996—2002年收治的59例老年白内障手术患者的手术并发症与IGT的关系作如下分析。     

妊娠期糖尿病的早期筛查与护理干预

妊娠期糖尿病(gestational diabetes mellitus,GDM)是指妊娠期首次发现或发生的糖代谢异常,约占妊娠合并糖尿病的80%～90%[1].妊娠期糖耐量异常(gestational impaired glucose tolerance,GIGT)为早期血糖稳态的改变,是介于正常血糖和GDM之间的中间状态或过渡阶段.妊娠期糖代谢异常包括GDM和GIGT,1979年WHO将GDM列为糖尿病的一个特殊类型[2].     

社区住院老年心脑血管疾病患者血糖异常情况分析

One hundred and four patients aged of 65 years or above with cardiocerebral vascular diseases admitted from March to September 2008 were enrolled in the study. The fast plasma glucose (FPG) and 2 hours postprandial blood glucose (2 hPG) were tested. For patients with undiagnosed diabetes, if FPG≥7.0 mmol/L, 2 hPG≥11.1 mmol/L, their blood sugar index was checked again; if 2hPG was 7.8 mmol/L to 11.1 mmol/L, FPG from 6.1 mmol/L to 7.0 mmol/L, Oral glucose tolerance test (OGTT) was performed. Among the 104 patients, 30 cases of diabetes were diagnosed previously accounting for 28.8 %; 7 cases were newly diagnosed accounting for 6.8%; 21 cases were diagnosed as impaired glucose regulation accounting for 20.2%, with a total rate of sugar metabolism abnormality of 55.8%. The results indicate that blood glucose index should be regularly checked for elderly patients with cardiocerebral vascular diseases.