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C Benedetto M Barbero L Rey M Zonca M Massobrio G Rocca T F Slater 《British journal of obstetrics and gynaecology》1987,94(12):1165-1169
The aim of this study was to investigate the production of prostacyclin (PGI2) and thromboxane B2 (TXB2) by incubated samples of umbilical arteries and veins taken at different distances (2, 10, 20, 30 cm) from the placenta to provide additional information relevant to the haemodynamics of umbilical blood flow. The production of PGI2, and 6-keto-PGF1 alpha (the stable metabolite of PGI2), was higher in both veins and arteries as the distance from the placenta at which the vessels were sampled was increased. A similar correlation between production by venous rings and distance from the placenta was observed for TXB2, but there was no apparent gradient of TXB2 production by the samples of arterial rings. No statistically significant variations were discernible in the ratio of 6-keto-PGF1 alpha:TXB2 (approximately 50 in the veins and approximately 20 in the arteries) in relation to the sampling distance. The significance of these high ratios is discussed in relation to umbilical blood flow and fetal well-being and development. 相似文献
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O. YLIKORKALA U.-M. MÄKILÄ L. VIINIKKA 《BJOG : an international journal of obstetrics and gynaecology》1983,90(3):251-254
Summary. Serial plasma samples collected before and after vacuum curettage followed by methylergometrine injection in 10 women were assayed for 6-keto-prostaglandin Flα (6-keto-PGF1α ). The mean 6-keto-PGFlα concentration was 97.2 (SE 8.8) pg/ml before cervical dilatation. The concentration rose to 128.2 (SE 13.5) pg/ml (P < 0.10) immediately and to 133.3 (SE 17.8) pg/ml (P < 0.05) 1 h after curettage and returned to the initial value within 5 h. Neither methylergometrine nor anaesthesia, nor non-gynaecological surgery, caused changes in the level of plasma 6-keto-PGFlα . The capacity of the platelets to produce thromboxane A2 during spontaneous clotting of blood did not change during vacuum curettage, anaesthesia and non-gynaecological surgery, nor after methylergometrine. The evidence suggests that the pregnant myometrium and/or intrauterine tissues capable of generating prostacyclin (PGI2 ) in vitro may release PG12 also in vivo . 相似文献
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O. YLIKORKALA Associate Professor H. PAATERO Registrar L. SUHONEN Senior Resident L. VIINIKKA Senior Lecturer 《BJOG : an international journal of obstetrics and gynaecology》1986,93(9):950-954
Summary. To study the role of the antiaggregatory and vasodilatory prostacyclin (PGI2 ) during human delivery, serial urine samples collected from 13 women delivered vaginally and from eight delivered abdominally were assayed for 6-keto-prostaglandin F1α (6-keto-PGF1α a breakdown product of PGI2 ) by high-performance-liquid-chromatography and radioimmunoassay. In women delivered vaginally the mean urinary 6-keto-PGF1α concentration was 41.9 (SE 8.3) ng/mmol creatinine, before the onset of labour and increased progressively to a maximum of 186.5 (SE 47.6) ng/mmol creatinine 2 h after delivery irrespective of the use of oxytocin and epidural analgesia. In women delivered by caesarean section under epidural anaesthesia, the urinary 6-keto-PGF1α rose from 33.4 (SE 4.2) ng/mmol creatinine to 2153 (SE 314) ng/mmol creatinine 2 h after section. In both groups the increased levels had fallen by 24 h postpartum to levels below those found before delivery. In neonatal urine 6-keto-PGF1α concentrations were some 12–30 times higher than those in postpartum urine. Thus, vaginal and abdominal delivery is accompanied by significant increases in maternal PGI2 release, perhaps in the myometrium and/or intrauterine tissues. This may be of significance in the regulation of fetoplacental blood flow and in the prevention of intra- and postpartum thrombosis. 相似文献
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S. C. BELL Lecturer in Reproductive Biochemistry M. W. HALES Chief Technician S. R. PATEL Research Technician P. H. KIRWAN Lecturer J. O. DRIFE Senior Lecturer A. MILFORD-WARD Director 《BJOG : an international journal of obstetrics and gynaecology》1986,93(9):909-915
Summary. The levels of pregnancy-associated endometrial α1 - and α2 -globulins (α1 - and α2 -PEG), the two major proteins synthesized and secreted by the endometrium in vitro have been assayed in 210 amniotic fluid specimens obtained at termination of pregnancy or by amniocentesis, or at delivery. α1 -PEG was undetectable until week 10 and thereafter rose to peak levels between weeks 20 and 24. Levels fell 15-fold by week 35 but substantial amounts were still present at parturition. α2 -PEG was present at highest levels during early pregnancy, at weeks 6–15, but thereafter levels rapidly fell until during weeks 31–42 α2 -PEG was detectable in only 3 of 25 specimens. During weeks 15–20, when α2 -PEG levels fell and α1 -PEG levels rose, a high correlation was observed between the week of gestation and the log of the ratios of the concentration of these proteins. These observations provide the opportunity to assess the role of endometrial and decidual dysfunction in the aetiology of pregnancy disorders. 相似文献
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Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre-eclampsia 总被引:1,自引:1,他引:0
K. A. LOUDEN Formerly Trent Regional Health Authority Research Registrar F. BROUGHTON PIPKIN Professor of Reproductive Physiology S. HEPTINSTALL Senior Lecturer S. C. FOX Laboratory Technician J. R. A. MITCHELL Foundation Professor E. M. SYMONDS Foundation Professor Head of Department 《BJOG : an international journal of obstetrics and gynaecology》1991,98(12):1239-1244
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M. A. LUMSDEN Research Fellow R. W. KELLY Biochemist D. T. BAIRD Professor 《BJOG : an international journal of obstetrics and gynaecology》1983,90(12):1135-1140
Summary. Menstrual fluid was collected in a contraceptive diaphragm from 16 women with primary dysmenorrhoea and 12 matched control subjects without dysmenorrhoea. Prostaglandins F2α (PGF2α ), E2 (PGE2 ) and 6-oxo-prostaglandin F1α (6-oxo-PGFlα ) were extracted and measured using gas-chromatography: mass spectrometry (GC:MS). The concentrations of both PGF2α and PGE2 were higher on days 1 and 2 in the dysmenorrhoea group than in the control group and the concentration of PGF2α was higher on day 1 than on day 2 in the dysmenorrhoea group. The concentrations of 6-oxo-PGF1α (the stable metabolite of PGI2 ) were low in both groups. These results confirm suggestions that PGF2α is important in the aetiology of dysmenorrhoea and also indicate that PGE2 may be involved. 相似文献
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Andrew Korda Rodney P. Shearman Ian D. Smith 《The Australian & New Zealand journal of obstetrics & gynaecology》1972,12(3):166-169
Summary: Fourteen pregnancies between the 12th and 19th weeks of gestation were terminated by intra-uterine administration of prostaglandin F2α . In 7 patients the method of administration was transcervically into the extra-ovular space; in the other 7, administration was directly into the amniotic sac. The methods of administration, the doses used, the side effects and results are discussed. The findings indicate that intra-amniotic administration is the procedure of choice: firstly, because of the incidence of genital tract infection after transcervical administration; secondly, because 3 patients in the transcervical group had incomplete abortions and required anaesthesia for curettage; and finally, the induction-abortion interval was significantly less when the drug was administered into the uterine cavity. 相似文献
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A. C. ROY S. M. M. KARIM S. R. KOTTEGODA S. S. RATNAM 《BJOG : an international journal of obstetrics and gynaecology》1984,91(9):908-912
Summary. Plasma levels of thromboxane (TX) A2 and prostacyclin (PGI2 ), as measured by radioimmunoassay of their respective stable metabolites TXB2 and 6–keto PGF1α , were studied in six molar pregnancies immediately before, immediately following and 24 h after evacuation of the uterus. The mean (SD) levels for TXB2 were 150 (41), 137 (32) and 125 (25) pg/ml respectively, and for 6–keto PGF1α the respective values were 225 (52), 226 (127) and 213 (49) pg/ml. There was no significant difference in the levels of prostanoids between the samples taken at the various time intervals. The concentration of these prostanoids in molar intravesicular fluid was also determined. Their respective mean (SD) pg/ml values were 3682 (760) for TXB2 and 2969 (744) for 6–keto PGF1α . In 15 normal pregnancies of equivalent gestation, the mean amniotic fluid levels of TXB2 and 6–keto PGFlα were 34 (17) and 146 (86) pg/ml respectively. The ability of molar trophoblast to generate the prostanoids from [14 C]arachidonic acid in vitro was also demonstrated. Mean (SD) values for TXB2 and 6-keto PGF1α were 12.2 (2.6) and 13.2 (1.8) pg/mg protein/min, respectively. It is likely that the high concentrations of prostanoids in vesicular fluid reflect the synthesizing ability of the villus vesicles. The mole contributes little to the circulatory prostanoids possibly because its villi are deficient in blood circulation. 相似文献
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A. G. AHMED A. KLOPPER 《BJOG : an international journal of obstetrics and gynaecology》1983,90(4):312-316
Summary. The Schwangerschaftsprotein 1 (SP1 ,)α values in blood measured by rocket immunoelectrophoresis are affected by the addition of anticoagulants. When compared with values in serum, those in heparin plasma were much higher, while those in sequestrene ethylenediaminetetra acetic acid), sodium citrate and fluoride oxalate were lower. On the other hand, SP1 and SP1 β concentrations were not significantly affected in heparin or sequestrene and were only slightly depressed in sodium citrate and flouride oxalate. The effect of heparin on SP1 α in serum was dosedependent. We surmise that SP1 α forms a complex with heparin and that it may be involved in the coagulation system in pregnancy. 相似文献