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1.
A. A. Kubatiev Z. T. Yadigarova I. A. Rud'ko V. A. Bykov N. A. Tyukavkina 《Bulletin of experimental biology and medicine》1999,128(3):890-891
The effects of diquertin on the content of cyclic nucleotides in human platelets was studied. Diquertin in a concentration
of 5 mM increased the content of cAMP and cGMP in native and thrombin-activated platelets probably due to inhibition of phosphodiesterase.
Increasing the concentration of diquertin above 5 mM did not potentiate this effect. The antiaggregation effect of diquertin
was probably associated with the increase in platelet levels of cyclic nucleotides.
Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny,Vol. 128, No. 9, pp. 267–269, September, 1999 相似文献
2.
Academician V. P. Komissarenko V. N. Slavnov E. V. Épshtein V. D. Malinkovich 《Bulletin of experimental biology and medicine》1977,83(4):480-482
The content of prostaglandins (PG) and cyclic adenosine-3,5-monophosphate (cyclic AMP) in rat tissues was studied by a radioisotope method. The maximal content of both PG and cyclic AMP was found in the same organs, those functioning most actively: the brain, endocrine glands, and small intestine, and the minimal content in adipose tissue. The investigations show close functional interdependence between PG synthesis and adenylate cyclase activity in the tissues of the body.Kiev Scientific-Research Institute of Endocrinology and Metabolism. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 4, pp. 416–418, April, 1977. 相似文献
3.
I. M. Baibekov V. M. Vorozheikin Sh. N. Artykov 《Bulletin of experimental biology and medicine》1992,113(4):571-574
Laboratory of Pathological Anatomy, Tashkent Branch, All-Union Research Center for Surgery, Academy of Medical Sciences. (Presented by Academician D. S. Sarkisov, Academy of Medical Sciences.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 4, pp. 424–427, April, 1992. 相似文献
4.
The effect of cylic AMP, ACTH, and glucose on formation of the enzyme chloramphenicol acetyltransferase by cells ofEscherichia coli CSH-2/R222 andE. coli WZ-78/R222 (cya855) was investigated. Glucose was shown to reduce synthesis of the enzyme inE. coli CSH-2/R222 by inducing catabolite repression; this could be overcome by 5 mM cyclic AMP and 1000 g/ml ACTH. Synthesis of the enzyme inE. coli WZ-78/R222 was resistant to catabolite repression and ACTH did not stimulate the synthesis of chloramphenicol acetyltransferase by this strain.Researh Laboratory of Experimental Immunobiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Zhukov-Verezhnikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 3, pp. 294–295, March, 1976. 相似文献
5.
Single intraperitoneal injection of melatonin in a dose of 1 mg/kg prevented accumulation of cGMP and intensification of lipid
peroxidation in the hippocampus and habenula of rats exposed to acute hypobaric hypoxia (12,000 m). Changes in habenular content
of cGMP suggest that melatonin prevents hypoxia-induced activation of heme-oxygenase.
Translated fromByulleten' Eksperimental" noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 168–171, August, 2000 相似文献
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P. N. Aleksandrov G. I. Podoprigora Academician A. M. Chernukh 《Bulletin of experimental biology and medicine》1977,83(2):178-180
The content of histamine (by the reaction with orthophthalic aldehyde) and serotonin (by Falk's reaction) in mesenteric mast cells of normal and germfree rats was determined microspectrometrically. Reserpine (10 mg/kg, intramuscularly) was shown not to change the histamine content, whereas the serotonin content was reduced by 50%. Injection of cyclic AMP (3.5 mg/kg, intraperitoneally) caused the serotonin content to be increased by 80% and the histamine content by 280–320%.Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR. Research Laboratory of Experimental Biological Models, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny. Vol. 83, No. 2, pp. 175–177, February, 1977. 相似文献
7.
A. I. Abesadze L. I. Atanelishvili L. I. Akhmeteli M. G. Kvernadze M. G. Mdivnishvili 《Bulletin of experimental biology and medicine》1993,115(4):369-371
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N
o
4, pp. 354–356, April, 1993 相似文献
8.
The intracellular content of cyclic 3,5-adenosine monophosphate (AMP) and activity of adenylate cyclase and cyclic AMP phosphodiesterase were determined in the lag period and the exponential and stationary phases of growth of mouse hepatoma 22a. In the stage of transition of the tumor cells from the lag period to the exponential phase of growth, the intracellular cyclic AMP concentration was found to be reduced by half as the result of sudden activation of phosphodiesterase. Later the cyclic AMP content fell more slowly until the cells entered the stationary phase of growth. Since adenylate cyclase activity remained unchanged during growth of the hepatoma 22a, this suggests that an increase in phosphodiesterase activity is the signal for escape of the tumor cells from the resting period and their entry into the mitotic cycle.Laboratory of Biochemical Pharmacology, Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR L. M. Shabad.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny Vol. 84, No. 10, pp. 472–474, October, 1977. 相似文献
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N. A. Igonina S. G. Dzgoev V. A. Evseev 《Bulletin of experimental biology and medicine》1998,126(1):712-714
Intracellular concentration of cAMP and phosphorylation of 15 kD protein in cultured mouse peritoneal macrophages are increased
in the presence of arginine-vasopressin. Vasopressin, decreases adhesion of macrophages to plastic.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 7 pp. 80–83, July 1998 相似文献
10.
V. P. Tumanov E. V. Glushchenko G. G. Serov V. I. Kozlov O. A. Terman 《Bulletin of experimental biology and medicine》1994,117(3):318-320
Using morphometry and radioautography methods, it is found that a single laser irradiation (0.5 and 0.05 J/cm2) of cultured human fibroblasts stimulates their proliferationin vitro. The effect of the laser is realized via intensification of DNA synthesis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, Nno 3, pp. 313–315, March, 1994
Presented by D. S. Sarkisov, Member of Russian Academy of Medical Sciences 相似文献
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The action of ouabain and cyclic AMP on the Ca-accumulating capacity and outflow of Ca2+ ions from loaded rat heart mitochondria was studied by the tetracycline probe method. In the course of the investigations no effect of ouabain on these processes was found. Cyclic AMP did not act on Ca binding by the mitochondrial membrane but it induced rapid liberation of Ca2+ from organelles loaded with these ions.Department of Molecular Pharmacology, Medico-Biological Faculty, N. I. Pirogov Second Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR S. S. debov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 2, pp. 158–160, February, 1977. 相似文献
13.
T. I. Karu L. V. Pyatibrat G. S. Kalendo N. G. Serebryakov 《Bulletin of experimental biology and medicine》1993,115(6):688-690
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N
o
6, pp. 617–618, June, 1993 相似文献
14.
N. K. Berdinskikh Z. D. Savtsova O. L. Sanina S. G. Antonenko A. A. Orlovskii M. Yu. Zaritskaya O. Yu. Yudina 《Bulletin of experimental biology and medicine》1994,118(3):985-987
Exogenous ceruloplasmin is shown to increase the resistance of mice to influenza virus, reduce the immunodepressive effect
of the virus, and improve the biochemical parameters in the acute period of experimental infection. A possible positive effect
of ceruloplasmin on delayed complications of influenza is discussed.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
9, pp. 285–287, September, 1994
Presented by T. T. Berezov, Member of the Russian Academy of Medical Sciences 相似文献
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N. S. Sapronov V. V. Eliseev O. M. Rodionova 《Bulletin of experimental biology and medicine》2000,130(4):964-966
Uridine and uridine-5’-monophosphate prevent myocardial stunning during postischemic reperfusion of isolated rat heart. Uridine-5’-diphosphate
does not prevent postischemic myocardial dysfunction, while uridine-5’-triphosphate aggravates it.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 10, pp. 411–414, October, 2000 相似文献
17.
Isopropylnoradrenalin, cyclic AMP, and dibutyryl-3,5-AMP (DB) lower the partial pressure of oxygen (pO2) in the liver and spleen and increase the oxygen consumption of the body. The time course of these two effects for isopropylnoradrenalin and cyclic AMP correlates closely. The increase in heat production was not accompanied by any significant change in the respiratory quotient. The effects of cyclic AMP were not abolished by pempidine or by dihydroergotamine and were only reduced to some degree by propranolol. The effect of catecholamines on pO2 is evidently mediated through an increase in the O2 consumption as a result of the effect of cyclic AMP; the action of cyclic AMP is basically direct, but in vivo it cannot take place through the adrenoreceptor; the compound 2,3-AMP reduces pO2 and also the O2 consumption.Department of Biochemistry, Krasnoyarsk Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR S. S. Debov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 2, pp. 177–180, February, 1977. 相似文献
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Adrenalin, hydrocortisone, and dibutyryl-cyclic AMP inhibited glycolysis and glycogenolysis in surviving liver slices from albino rats. An inhibitory effect also was found when glucose-6-phosphate (G6P), but not fructore-1, 6-diphosphate, was used as the substrate for glycolysis. This indicates that activity of hexokinase and also, probably, of, phosphorylase and phosphofructokinase, in inhibited under the influence, of these hormones and dibutyrul-cyclic AMP. In a reconstituted cell-free system the hormone had no effect and dibutyryl-cyclic AMP inhibited hexokinase only. For the hormones to exert their effect interaction between them and the cell membrane was essential. Inhibition of glycogen and G6P breakdown to lactic acid in liver slices is not connected with the action of the hormones on the corresponding enzymes (phosphorylase and phosphofructokinase) directly through cyclic AMP and protein kinase. The results are evidence of an additional mechanism modifying the action of cyclic AMP on the activity of the above-mentioned enzymes. Insulin had no, effect in all cases.Laboratory of Biochemistry, Institute of Clinical and Experimental Medicine, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirsk. (Presented by Academician of the Academy of Medical Sciences of the USSR V. P. Kaznacheev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 11, pp. 541–544, November, 1978. 相似文献