复明片治疗老年性白内障的临床研究

目的:观察与研究复明片治疗老年性白内障的临床效果.方法:采用世界卫生组织(WHO)施行的年龄、视力、晶状体混浊的有关标准,对218例患者随机分为治疗组和对照组,治疗组采用复明片、维生素及白内停治疗,对照组采用维生素及白内停治疗.结果:3个疗程(3 mo)的结果显示,治疗组总有效率90.9%,总显效率29.2%,对照组总有效率26.7%,总显效率2.5%.两者比较差异有非常显著性意义(χ2=102.758,P=0.000),治疗组治疗后裸眼视力情况、晶状体混浊改善情况等均优于对照组.结论:复明片治疗老年性白内障具有良好的临床疗效,是一种积极主动的防盲治盲的有效措施.     

麝珠明目滴眼液对老年性白内障疗效观察

麝珠明目滴眼液对老年性白内障疗效观察湖北咸宁地区医院眼科（４３７１００）徐济兰老年性白内障是眼科常见多发病，目前尚无特效药物治疗。最近，我们应用卢氏“麝珠明目滴眼液”治疗该病８０例（１００眼），效果较好。现报告如下：临床资料１一般资料门诊随机选择早、...     

复明片治疗未成熟期老年性白内障临床观察

目的:观察复明片治疗未成熟期老年性白内障的临床疗效.方法:117例(234眼)随机分为治疗组和对照组.其中治疗组74例(148眼),对照组43例(86眼).治疗组用复明片,对照组用障眼明片.对治疗前后视力、晶状体混浊程度、肝肾阴虚症状等进行评估.结果:有效以上病例,治疗组54例(108眼),总有效率为73.0%,对照组27例(53眼),总有效率为61.6%.有效率治疗组高于对照组.但统计学Ridit分析法处理,u=1.460,P＞0.05,两组差异无显著性.结论:复明片对未成熟期老年性白内障的治疗是有效的.     

复明片联合人工泪液局部滴眼治疗肝肾阴虚型干眼症

目的:观察复明片配合人工泪液局部滴眼治疗肝肾阴虚型干眼症的临床疗效。方法:将符合肝肾阴虚型干眼症诊断标准的患者,随机分为治疗组和对照组。治疗组采用口服复明片和局部滴用玻璃酸钠滴眼液治疗;对照组采用单纯滴用玻璃酸钠滴眼液治疗。根据临床症状和基础泪液分泌试验、泪膜破裂时间、角膜荧光素钠染色等检查进行评分。随机抽取干眼症患者60例,治疗组和对照组各30例60眼,治疗观察2mo。结果:两组治疗后BUT,SⅠt、角膜荧光素染色与治疗前比较,差异均有统计学意义(P<0.05或P<0.01),且治疗后治疗组上述指标变化程度明显优于对照组(P<0.01);治疗组总有效率93.3%,对照组总有效率75.0%,治疗组疗效明显优于对照组(P<0.01)。结论:复明片联合人工泪液局部点眼治疗干眼症疗效较单纯使用人工泪液滴眼疗效好。     

强力珍珠滴眼液治疗四种眼疾疗效观察

用新制剂强力珍珠滴眼液（亦名眼宝）治疗视疲劳症、慢性结膜炎、角结膜干燥症、老年性白内障，四种眼病共１５０例进行临床疗效观察。结果：显效７２例（４８％），有效４１例，总有效率７５．３３％，显效对照组（用原珍珠明目滴眼液治疗）显效９例（７．４％），有效２９例，总有效率３１．１５％。经统计学处理，各病种两组间疗效均具有显著性差异，表明治疗组疗效明显优于对照组。     

祛障穴冷冻治疗老年性未成熟期白内障的临床研究

目的:观察祛障穴冷冻治疗老年性未成熟期白内障的疗效。方法:老年性未成熟期白内障患者138例(260眼)随机分为2组,观察组98例(186眼)采用祛障穴冷冻治疗,对照组40例(74眼)用白内停滴眼液治疗进行比较。结果:观察组总有效率为83.9%,对照组为71.6%(P <0.05)。结论:祛障穴冷冻治疗老年性未成熟期白内障有一定的疗效。     

激光光凝联合施图伦滴眼液治疗糖尿病视网膜病变疗效分析

目的探讨激光光凝联合施图伦滴眼液治疗糖尿病视网膜病变（DR）的临床疗效。方法 68例99眼单纯期糖网患者,随机分为A、B两组,A组观察组34例50眼,采用激光光凝联合施图伦滴眼液治疗,B组对照组34例49眼,单纯采用激光光凝治疗。结果观察组在接受治疗的50眼中,视力提高43眼（86.0%）：对照组在接受治疗的49眼中,视力提高26眼（53.0%）。黄斑区水肿消退,观察组50眼中,水肿消退47眼（94.0%）,对照组49眼中,水肿消退26眼（53.1%）,两组比较P〈0.05,观察组优于对照组。结论激光光凝与施图伦滴眼液结合治疗糖尿病视网膜病变及黄斑水肿,临床效果明显优于单纯激光治疗。     

和血明目片治疗球结膜下出血50例

目的:观察和血明目片治疗球结膜下出血的临床疗效,寻求缩短球结膜下出血病程、提高疗效的治疗方法。方法:将就诊的82例球结膜下出血患者随机分成两组,和血明目片组(50例50眼):口服和血明目片5片,每日3次;维生素C组(32例32眼):口服维生素C0.2g每日3次,并进行临床观察。结果:随访1mo,和血明目片组治愈40例,7例有效,3例无效,总有效(治愈+有效)率为94%;维生素C组治愈16例,9例有效,7例无效,总有效(治愈+有效)率78%。两组有效率差异有统计学意义(P=0.015<0.05)。结论:和血明目片治疗球结膜下出血疗效显著,可明显缩短病程,方法简单,未发现不良反应,安全可靠,疗效确切,值得在临床治疗中应用推广。     

麝珠明目滴眼液对PRK术后角膜上皮下混浊并发激素性高眼压的影响

目的：探讨准分子激光屈光性角膜切削术(PRK)术后非激素类药物代替激素的有效性及安全性。方法：对PRK术后发生一级以上Haze的患者分组，13只眼使用氟美童眼液(氟组)、22只眼在使用氟美童眼液的基础上加用麝珠明目滴眼液(氟 麝组)、对于有Haze及眼压增高的病例只使用麝珠明目滴眼液(麝组)，于术后3月、6月随访视力、Haze、屈光度。结果：氟美童组术后3月haze的情况与眼压增高伴haze组(麝组)有显著性差异，其余组间比较无显著性差异。6个月时haze观察各组均有效，组间比较无显著性差异。结论：麝珠明目滴眼液可明显减轻激素类眼液的副作用，可望成为防治角膜Haze的一种新药。     

和血明目片治疗视网膜静脉阻塞的临床观察

目的:探究和血明目片治疗视网膜静脉阻塞的疗效。方法:将92例93眼患者随机分为两组,治疗组50例51眼给予和血明目片治疗,对照组42例42眼给予血塞通片治疗。根据视力恢复情况、荧光血管造影、自觉症状有无改善进行观察。结果:治疗组治愈17眼,有效27眼,无效7眼,总有效率86%。对照组治愈8眼,有效17眼,无效17眼,总有效率60%。结论:和血明目片能促进视网膜出血渗出吸收,恢复视网膜功能,提高视网膜静脉阻塞患者的视功能。经比较,和血明目片在提高视力,改善眼底方面的疗效优于血塞通片(P<0.05)。     

复明片联合马来酸噻吗洛尔滴眼液治疗开角型青光眼

目的：探讨复明片联合马来酸噻吗洛尔滴眼液治疗开角型青光眼的临床疗效。

方法：选择2017-04/2018-07于本院接受治疗的82例147眼开角型青光眼患者作为研究对象,根据治疗手段不同分为对照组41例72眼及观察组41例75眼。对照组予以马来酸噻吗洛尔滴眼液进行治疗,观察组在对照组基础上予以复明片治疗。观察两组患者临床疗效,对治疗前后眼压、血液流变学进行比较分析。

结果：治疗12wk后,观察组与对照组间的临床总有效率(94.7% vs 80.6%)比较有差异(P<0.05); 两组患者眼压均明显低于治疗6wk后及治疗前(P<0.05),且观察组眼压显著低于对照组(P<0.05); 对照组PSV、EDV及RI与治疗前无差异(P>0.05); 观察组PSV、EDV显著高于治疗前(P<0.05),而RI显著低于治疗前(P<0.05),且两组PSV、EDV及RI比较有差异(P<0.05)。两组患者总不良反应发生率比较无差异(P>0.05)。

结论：复明片联合马来酸噻吗洛尔滴眼液可有效改善患者的临床疗效,降眼压作用显著,同时对患者眼部血液流变学改善效果良好,安全可靠。     

白内障术前滴用氧氟沙星滴眼液对结膜囊细菌培养的影响

目的:观察老年性白内障患者术前应用氧氟沙星滴眼液对结膜囊细菌培养的影响。方法:老年性白内障患者30例60眼,随机分成两组:对照组15例30眼,3g/L氧氟沙星点眼组15例30眼,平均点眼5次,l滴/次。观察点药前,点药l,2,3d,结膜囊内细菌的变化。结果:点药前,点药1,2,3d,结膜囊内细菌落积分的变化:对照组,51,51,33,42;3g/L氧氟沙星点眼组,51,30,9,0。配对t检验统计分析,点药3d,P=0.043。结膜囊内细菌检出率的变化:对照组,60%,60%,40%,50%;3g/L氧氟沙星点眼组,60%,30%,10%,0。χ2检验,点药3d,P<0.01。结论:老年性白内障患者术前应用氧氟沙星滴眼液点眼,3d可以达到结膜囊内无细菌。     

玻璃酸钠联合rhEGF滴眼液治疗白内障摘除术后干眼的疗效

目的:探讨玻璃酸钠滴眼液联合重组人表皮生长因子(rhEGF)滴眼液治疗白内障囊外摘除术后干眼的临床疗效。方法:选择白内障囊外摘除术后有干眼症状的患者42例60眼,随机分为治疗组和对照组两组,每组21例30眼治疗组采用玻璃酸钠滴眼液联合rhEGF滴眼液滴眼,对照组单独使用玻璃酸钠滴眼液。记录患者用药前和用药后2,4wk的干眼症状评分,裂隙灯下观察泪膜破裂时间(BUT)、泪液分泌试验(SchirmerⅠtest,SⅠt)、荧光素染色(FL)情况。结果:治疗前两组干眼症状评分、BUT,SⅠt,FL无显著性差异(P>0.05),用药后2,4wk,治疗组干眼症状评分、BUT,SⅠt,FL与对照组比较,均有显著性差异(P<0.01)。结论:玻璃酸钠滴眼液联合rhEGF滴眼液治疗白内障囊外摘除术后干眼疗效优于单独使用玻璃酸钠滴眼液。     

更昔洛韦眼用凝胶与更昔洛韦滴眼液治疗带状疱疹角膜炎的疗效比较

目的:探讨更昔洛韦眼用凝胶和更昔洛韦滴眼液治疗带状疱疹角膜炎的疗效比较。方法:将68例68眼带状疱疹角膜炎患者随机分为更昔洛韦凝胶组(观察组)36例,更昔洛韦滴眼液(对照组)32例,两组患者均给予滴眼6次/d,并全身抗病毒综合治疗。结果:更昔洛韦凝胶组和滴眼液组之间总有效率无明显差异(P>0.05),但在病情痊愈时间上,凝胶组要短于滴眼液组,结果有统计学差异(P<0.05)。结论:更昔洛韦眼用凝胶与滴眼液治疗带状疱疹角膜炎在疗效上无明显差异,但是更昔洛韦凝胶能明显缩短病程。     

地夸磷索钠联合清润养目口服液治疗白内障术后干眼

目的:探讨地夸磷索钠滴眼液联合清润养目口服液治疗白内障超声乳化摘除术联合人工晶状体植入术后干眼的临床疗效。方法:选取2020-09/2021-01就诊于我院眼科的白内障术后干眼患者57例65眼作为研究对象,采用随机数字表法分为对照组(28例32眼,使用3%地夸磷索钠滴眼液治疗)和观察组(29例33眼,使用3%地夸磷索钠滴眼液联合清润养目口服液治疗)。比较两组患者术前1d,术后1wk(治疗前),1mo(治疗后)眼表疾病指数(OSDI)量表评分、非侵入性泪膜破裂时间(NIBUT)、泪液分泌试验(SⅠt)、角膜荧光素钠染色(CFS)评分、中医症状评分等指标。结果:治疗后,观察组和对照组总有效率分别为88%、75%,两组患者OSDI评分、NIBUT、SⅠt均较治疗前明显改善(P<0.05),观察组治疗后NIBUT、SⅠt、CFS评分、中医症状评分均优于对照组(P<0.05)。治疗期间,两组患者均无不良反应发生。结论:地夸磷索钠滴眼液联合清润养目口服液可改善白内障术后干眼的主观症状及客观临床指标,为白内障围手术期干眼的眼表管理提供了新的治疗方案。     

Comparison of Trans-scleral Fixation of PMMA and Foldable Intraocular Lens in Children

Purpose: To observe the difference of the effects of PMMA and foldable intraocular lenses (IOLs) trans-sclerally fixed in pediatric eyes.Methods: Thirty-two children (43 eyes) who had undergone trans-scleral fixation of IOL were retrospected, of whom 5 children were implanted PMMA IOL in both eyes, 6 children were implanted PMMA IOL in one eye and foldable IOL in the other eye, 12 children were implanted foldable IOL in one eye and 9 chilrden were implanted PMMA IOL in one eye. Mean age was 5. 3 years ( range 2. 5 ~ 12 years ). Twelve children had traumatic cataract and the others congenital cataract before lens extraction. Results: Foldable group (18 eyes ): Mean follow-up was 12. 1 months. Visual acuity (VA): compared with the best corrected VA before IOL fixation, postoperative best corrected VA improved in 16 eyes, remained unchanged in 2 eyes. In 14 eyes, one or two stitches were needed to seal the incision. Complications: Severe anterior chamber reaction was seen in 3 eyes. Intraocular bleeding was     

An alternative method of steroid-induced lens opacification in brown norway rat eyes applying systemic pulse administration

PURPOSE: To confirm whether long-term administration of prednisolone sodium succinate (prednisolone) alone is able to induce cataract in rat eyes. MATERIALS AND METHODS: A 1% solution of prednisolone was administered topically as eye drops to Brown Norway rat eyes, and a systemic pulse administration of 10 mg/kg/day was given via the tail vein. Both administration methods were applied in different combinations. Eighty-three 6-week-old male rats were divided into 8 groups: group 1 = control; group 2 = topical instillation every day; group 3 = single pulse; group 4 = single pulse + eye drops; group 5 = 3 times pulse; group 6 = 3 times pulse + eye drops; group 7 = 3 times pulse per 2 months; group 8 = 3 times pulse per 2 months + eye drops. Observations for changes of lens transparency were made by slitlamp microscopy and documented by an anterior eye segment analysis system (Nidek EAS-1000) from the onset of drug administration to a maximum period of 16 months. RESULTS: Lens opacity in the shallow anterior and posterior lens layers developed from the tenth month following commencement of prednisolone administration. The incidence of anterior and/or posterior cortical cataract at the sixteenth month was 15% in group 2, 12.5% in group 5, 25% in group 6, 17.9% in group 7 and 35.3% in group 8. The lenses of groups 1, 3 and 4 maintained their transparency throughout the observation period. Light scattering intensity in groups 8 and 7 was the highest, followed by groups 6 and 5, then groups 2, 4, 3 and 1. CONCLUSION: Cortical cataract was successfully induced in Brown Norway rat eyes by sustained administration of prednisolone succinate alone applied as systemic pulse.     

Cataract--clinic and pathology

Clinicopathological studies were performed on 156 lenses of human senile cataract obtained by cataract operations between 1970 and 1988. It became clear that the aging influences the functional destruction of the equatorial region, the pathological changes of the bow area, and changes of the extralens environment. After operation for the atrophic type of the posterior subcapsular cataract, aftercataract easily develops on the intraocular lens and this requires treatment. Long-term observations were carried out in 180 Wistar male rats under the same laboratory condition and histological studies were performed. The similarities between the senile Wistar rat cataract and the human senile cataract indicate that the Wistar rat cataract is useful as a model for studying the human senile cataract. These rats were initially classified into six groups (control, vitamin E diet, EPC eye drops, catalin eye drops and reduced catalin eye drops). To study the effects of the agents (vitamin E, ARI, EPC, catalin, reduced catalin) on the cataract in senile Wistar rats the mean cell density of lens epithelia were measured at 2 or 3-month intervals. There were no statistically significant differences in treated groups and the control group. The results suggest that these agents affect another factor of lens apart from the proliferative activity of lens epithelial cell. Effects of anti-cataract agents were investigated using cultured lens epithelial cells. When cultured rat lens epithelial cells were incubated in medium containing selenite, super-oxide dismutase (SOD) activity and GSH in the cells markedly decreased, and GSSG was markedly increased. When cultured rabbit lens epithelial cells were incubated in medium contained selenite and glutathione, SOD activity was maintained normal level. When cultured lens epithelial cells were incubated in medium contained selenite and pirenoxin, SOD activity also maintained a normal level. These results suggest that both glutathione and pirenoxin are effective as anti-cataract agents. Cataracts in spontaneously hypertensive rats (SHR) was investigated on male of Wistar-Kyoto rats (WKY), stroke resistant SHR (SHRSR) and stroke-prone SHR (SHRSP) rats aged 3 to 9 months. Cataracts in these rats were classified as follows: Type 0: no opaciiy, Type 1: nuclear opacity, Type 2: posterior subcapsular opacity, Type 3: nuclear opacity associated posterior subcapsular opacity and Type 4: complete opacity in both lenses. Incidence of cataract in WKY was 2.6%, SHRSR, 76.8% ant SHRSP, 88.2%. Incidence of nuclear opacity was remarkably higher in SHRSP (48.5%). In SHR aged from 3 to 5 months, nuclear opacity was ahead of the appearance of posterior subcapsular opacity which was increased during aging.(ABSTRACT TRUNCATED AT 400 WORDS)     

Impact of cataract on the results of frequency-doubling technology perimetry

PURPOSE: To determine the effect of cataract on the results of frequency-doubling technology (FDT) perimetry. DESIGN: Consecutive cohort study. PARTICIPANTS: Forty-four patients with normal ophthalmic examinations, with the exception of cataract, scheduled to undergo phacoemulsification and posterior chamber lens implantation were prospectively identified and completed the study. METHODS: All subjects underwent FDT perimetry using the full-threshold C-20 strategy. Both eyes were tested within 1 month before cataract surgery and up to 3 months after surgery. The unoperated fellow eyes served as controls. MAIN OUTCOME MEASURES: Changes in visual acuity (VA), mean deviation (MD), and pattern standard deviation (PSD) were evaluated. For each subject, the change in MD and PSD in the eye that underwent cataract surgery was adjusted for change in the control eye that is thought to occur due to a learning effect. RESULTS: Among the eyes that underwent cataract surgery, the median preoperative VA was 20/60 (range, 20/30-20/800) and the mean preoperative MD was -4.00+/-3.72 decibels (dB). Postoperatively, the median VA improved to 20/30 (range, 20/20-20/70) and the mean postoperative MD was -0.26+/-3.09 dB (P<0.001). Among the control eyes, MDs were -1.74+/-3.71 dB preoperatively and -0.94+/-3.85 dB postoperatively (P = 0.019). The adjusted improvement in MD among eyes that underwent cataract surgery was 2.94+/-3.44 dB (P<0.001). There was no significant change in PSD. Preoperative VA correlated significantly with preoperative MD (r = 0.39, P = 0.01). The improvement in VA correlated significantly with the adjusted improvement in MD (r = 0.38, P = 0.01). CONCLUSIONS: Cataract has an adverse effect on the MD but not the PSD in FDT perimetry. Among eyes with visually significant cataract, the MD correlates significantly with VA. After cataract surgery, the change in VA correlates significantly with the adjusted change in MD.