斑块切除加自体睾丸鞘膜移植术治疗阴茎硬结症

目的:探讨斑块切除+自体睾丸鞘膜移植术治疗阴茎硬结症的临床疗效。方法:选取2013年1月至2015年12月收治的10例经药物保守治疗12个月以上无效、处于稳定期6个月以上、阴茎弯曲60°、不能完成性交的阴茎硬结症患者,行阴茎硬结切除+自体睾丸鞘膜移植修补缺损。结果:10例患者术后随访期6~24个月,所有患者术后阴茎均能正常勃起,无手术侧睾丸萎缩、扭转或坏死。患者对阴茎外形满意,未觉阴茎有明显缩短。结论:斑块切除+自体睾丸鞘膜移植术是治疗阴茎硬结症造成的阴茎勃起畸形的一种安全、简便、经济和有效的手术方式。     

睾丸鞘膜移植治疗阴茎Peyronies病(附4例报告)

目的 探讨睾丸鞘膜移植治疗严重的阴茎Peyronies病的临床疗效及术后对性功能的影响.方法 回顾性分析2007年6月至2009年4月4例严重阴茎Peyronies病患者的临床资料,均经药物保守治疗12个月以上无效,阴茎勃起后弯曲畸形,而行阴茎硬结切除自体睾丸鞘膜移植修补缺损治疗.结果 所有患者均得到半年以上的随访,患者术后阴茎均能恢复正常勃起,无勃起疼痛感,能进行满意的性生活,无手术侧睾丸萎缩、扭转或坏死.结论 睾丸鞘膜移植术治疗阴茎Peyronies病造成的阴茎勃起畸形是一种安全、简便、经济和有效的手术方式.     

体外冲击波治疗阴茎海绵体硬结症

〔德国泌尿外科学会 .UrologeA2 0 0 4 ,4 3:5 97(德文 )〕　　阴茎海绵体硬结症 (IPP)主要症状是阴茎斑块、阴茎疼痛和偏斜 ,少数病例伴有勃起功能障碍 (ED)。形态学基础是阴茎海绵体白膜斑块形成 ,发病机理尚不清楚 ,故尚无针对病因的药物、仪器和手术疗法。标准疗法如口服药物、斑块内用药、电离子透入疗法和局部放疗等 ,不能肯定其疗效 ,纠正阴茎偏斜或假体植入作为治疗伴有ED的最后手段。1990年临床开始应用体外冲击波(ESWT)治疗IPP ,此期间 14个工作组刊登了 2 0篇原著 ,但对其疗效机理仍不清楚 ,有些学者认为疼痛减轻是直接破…     

复层睾丸鞘膜替代治疗阴茎白膜peyronie病1例

1　病例摘要患者男性 ,37岁。因阴茎背部结节增生 ,致阴茎勃起时向上呈 4 5°角弯曲、疼痛、影响正常性交 3月。局部体检 :勃起时 ,左阴茎海绵体背侧可触及 4cm× 1.5cm的块状硬结 ,并向背侧弯曲 ,尿道开口正常。否认有阴茎外伤史。B超 :勃起时 ,左侧阴茎海绵体白膜有 4cm× 1.5cm的钙化斑 ,周围血流少。手术治疗 :硬膜外麻醉 ,术中用止血带阻断阴茎血流 ,7号针刺入左侧阴茎海绵体内 ,注入生理盐水 5 0mL ,见阴茎向背部成角弯曲。在弯曲处 ,环形切开背侧包皮长约 3cm ,纵行分离至阴茎白膜 ,避免损伤血管及神经 ,充分暴露左侧阴茎白膜硬结。…     

阴茎体白膜两侧睾丸鞘膜移植阴茎增粗术实验研究

目的:探讨犬阴茎体白膜两侧自体睾丸鞘膜移植阴茎增粗术的治疗效果及手术并发症。方法:取5只雄性杂种狗自体睾丸鞘膜移植于阴茎白膜两侧的纵形切口,以扩大阴茎白膜腔、增大阴茎海绵体容积、增粗阴茎;手术前后进行疲软及勃起状态下阴茎海绵体周径的测量及两侧阴茎海绵体动态灌注测压(DIC);术后3个月行组织学检查。结果:施行5只10侧,术后3个月勃起状态下阴茎海绵体周径平均增加21.1%,疲软状态下增粗不明显,DIC参数与术前相比无统计学差异;无其他严重并发症;组织学检查移植物内轻度炎性反应和纤维化,其上有白膜的重新形成。结论:该手术方法使勃起状态下阴茎增粗效果显著,是一种安全的、真正针对勃起组织的阴茎增粗方法。     

颊粘膜替代斑块治疗阴茎硬结症(附27例报告)

目的:评价使用颊粘膜替代阴茎斑块治疗阴茎硬结症的临床效果。方法:27例阴茎硬结症患者,年龄24～72岁,平均53岁,病程1～13年,勃起时阴茎弯曲的角度为30～80度。阴茎硬结位于阴茎背侧根部15例,阴茎背侧中部6例,阴茎冠状沟下3例,阴茎腹侧中部3例。硬结数目:1枚24例,2枚2例,3枚1例。硬结大小:0.7cm×0.7cm～1.6cm×1.0cm,采用手术切除阴茎海绵体白膜斑块,自体颊粘膜移植物替代治疗,并进行随访。结果:本组27例患者矫形满意,口腔疼痛多在1周内消失。3例面颊部水肿明显,5～7d后消失。无血肿、感染、口腔麻木及张口紧缩感。24例获得随访,随访6个月～7年,平均31个月,21例患者阴茎伸直,3例稍有弯曲,弯曲角度<15度,不影响阴茎有效勃起及正常性生活,无阴茎缩窄及凹痕感,无局部阴茎白膜膨出,2例阴茎长度术后有缩短(<1cm),3例仍有阴茎勃起疼痛。结论:颊粘膜弹性好,不挛缩,可在男科治疗阴茎硬结症中广泛使用。     

斑块磨削和改良Nesbit技术治疗阴茎硬结症

目的 :探讨斑块磨削和改良Nesbit技术治疗阴茎硬结症的疗效。　方法 :11例阴茎硬结症病人行斑块磨削和改良Nesbit技术治疗 ,并进行随访。　结果 :11例均获得了满意的治疗效果。 9例术前无勃起功能障碍者术后均获得了满意的性生活 ;8例伴有阴茎勃起时弯曲者中 ,2例由于斑块范围过大 ,术中矫正不彻底 ,仍残留有轻微弯曲 ;5例伴有勃起疼痛的病人术后均获改善 ,仅 1例有轻微的间歇疼痛 ;但以上情况均不影响性生活。　结论 :斑块磨削和改良Nesbit技术治疗阴茎硬结症操作方便 ,近期治疗效果好 ,术后并发症少 ,复发率低 ,远期疗效需进一步观察     

大隐静脉补片治疗阴茎硬结症

目的探讨大隐静脉补片治疗阴茎硬结症的应用。方法对3例患者将阴茎硬结斑块“H”型切开，伸直阴茎，大隐静脉补片修补白膜缺损。结果随访6月以上，全部患者术后阴茎勃起良好。结论斑块切开结合大隐静脉移植可作为治疗阴茎硬结症的理想手术方法。     

Functional tissue engineering of autologous tunica albuginea: a possible graft for Peyronie's disease surgery

OBJECTIVES: The aim of the present study was to generate a tissue engineered type of mechanically stable graft suitable for surgical replacement of the tunica albuginea penis. METHODS: Porcine fibroblasts isolated from open fascia biopsies were seeded on decellularized collagen matrices and then cultivated in a bioreactor under continuous multiaxial stress for up to 21 days (n=12). Static cultures without mechanical stress served as controls. Cell proliferation, cell alignment, and de novo synthesis of extracellular matrix proteins (proteoglycans, procollagen I, elastin) in these grafts was evaluated by hematoxylin-eosin, pentachrome, and immuno-staining. Additionally, the enzymatic isolation of porcine fibroblasts from X4mm skin punch biopsies (n=8) was evaluated. RESULTS: Mechanically strained cultures of fibroblasts showed a homogeneous multilayer matrix infiltration and a regular cell alignment in the direction of strain axis after 7 days, as well as a de novo production of extracellular matrix proteins compared to the static control. A large amount of viable fibroblasts was easily obtained from small skin punch biopsies. CONCLUSION: This study shows that continuous multiaxial stimuli improve proliferation and extracellular matrix synthesis of mature fibroblasts reseeded on a biological matrix making this a feasible autologous tissue engineered graft for penile surgery. For the clinical setting fibroblasts harvested from small skin biopsies can be a comfortable cell source.     

Tunica vaginalis autografting in Peyronie's disease

Surgical excision of the indurated penile plaque and tunica vaginalis autografting was done in 3 patients. Preoperatively, their chief complaints had not been impotence but penile angulation or pain. Postoperatively, all of them improved and erectile failure was not seen, although hypesthesia of glans developed in all patients. One patient complained of impotence. The patients had been followed from 2 months to 9 months. As prosthesis is not prevailing in Japan and tunica vaginalis is easy to procure and handle, tunica vaginalis autografting is recommended.     

Novel and simple method for isolating autologous mesothelial cells from the tunica vaginalis

OBJECTIVE: To report the development of a new method of isolating autologous mesothelial cells from the tunica vaginalis that are easily obtained and generally free from the effects of abdominal cancer, and to investigate whether transplanting these mesothelial cells is effective in preventing postoperative adhesions. MATERIALS AND METHODS: The tunica vaginalis was resected from male Lewis rats, and mesothelial cells were collected by enzymatic disaggregation. To investigate the efficacy of mesothelial cells in preventing adhesion, harvested cells were transplanted into a rat intestinal hernia adhesion model. RESULTS: Cells isolated from the tunica vaginalis were homogenous, polygonal when confluent, expressed cytokeratin and vimentin, and the cell surface was covered with microvilli, which is the characteristic appearance of endogenous mesothelial cells. The transplantation of autologous mesothelial cell sheets reduced peritoneal adhesion. CONCLUSION: We developed a new method of obtaining autologous mesothelial cells from the tunica vaginalis. These cells may provide a valuable option for treating patients at risk of postoperative adhesions.     

Corporoplasty with small soft axial prostheses (VIRILIS I?) and bovine pericardial graft (HYDRIX?) in Peyronie's disease

The surgical techniques used by Austoni and Egydio in the treatment of Peyronie''s disease are based on geometric principles. The aim of this paper is to report our multicentric experience and technical changes to Austoni''s original technique, focusing on several tips and tricks to make this technique easy to perform, even by less experienced practitioners. We performed operations in three different Italian institutions. We implanted a small soft Virilis I® axial prostheses (Ø 7 Fr.), using a bovine pericardium collagen matrix patch (Hydrix®) to cover the defect in the tunica albuginea. Sixty patients with a mean age of 58 years (range 44–76 years) underwent surgery between September 2005 and January 2010. After surgery, mean lengthening of the shaft was 2 cm (range 1.2–2.3 cm) with complete correction of penile recurvatum. Thirty-nine patients resumed sexual activity 60 days later, 14 after 90 days and 7 after 120 days. The international index of erectile function (IIEF) score was 15.5 before surgery and it improved to 23 at 12 and 24 months after surgery. Furthermore, the visual analogue scale (VAS) showed good results in terms of the recovery of natural sexual intercourse (over 80% of couples) and of the original length and girth of the penis. The soft implant we used takes advantage of erection that occurs spontaneously, using the residual erection of the spared cavernous tissue. The method is easy to learn and reproducible, and the use of pericardium speeds up the operation, while also covering large defects of the tunica albuginea that result from complex recurvatum.     

Penile corporoplasty using tunica albuginea free graft from proximal corpus cavernosum: a new technique for treatment of penile curvature in Peyronie's disease

OBJECTIVES: In Peyronie's disease, any kind of plication technique for correcting penile deformities is associated with penile shortening in addition to the disease-related shrinkage. To minimize penile shortening we describe a new technique of penile corporoplasty using a free graft from the tunica albuginea. PATIENTS AND METHODS: From October 2001 to February 2003 we treated 18 patients with the new technique. All patients had stable Peyronie's disease with relevant curvature and sufficient erectile rigidity without any signs of inflammatory disease. Penile corporoplasty was performed by incision of the plaques to produce straightening. The resulting gap was covered with a free graft of tunica albuginea removed from the crural segment of the corpora cavernosa. RESULTS: In a preliminary follow-up of 16 patients, 12 penises were straight and 4 had a residual curvature less than 20 degrees. Two patients needed sildenafil for sufficient penile rigidity. Fourteen of 16 patients were satisfactory with the result of penile straightening. No severe perioperative complication was noted. CONCLUSION: The technique of penile straightening using a free tunica albuginea graft is effective and avoids additional shortening of the penis. As the results are preliminary, the study is continued to gain experience with a larger number of patients.     

Use of tunica vaginalis patch graft for repair of traumatic testicular rupture.

Early exploration of patients with testicular rupture has become the standard of care in traumatic testicular injuries. We report on a case of traumatic rupture of the testicle diagnosed by ultrasonography, with a large testicular defect that could not be closed primarily. This was managed successfully with a free graft of tunica vaginalis. The affected testicle is palpably normal three months postoperatively. This technique may represent a valuable adjunct in managing major testicular ruptures.     

Corporoplasty using tunica albuginea free grafts for penile curvature: surgical technique and long-term results

PURPOSE: A Nesbit or plication procedure for correcting penile deformities is associated with penile shortening, especially in patients with excessive curvature and/or rotation. On the other hand, grafting procedures are associated with poor postoperative results due to graft shrinkage and veno-occlusive dysfunction. To minimize penile shortening and preserve potency we describe a new surgical technique combining the Nesbit procedure with tunica albuginea free grafting. Long-term functional results and patient satisfaction are reported. MATERIALS AND METHODS: We treated 17 potent patients with a mean age plus or minus standard deviation of 46.1 +/- 14.5 years, including 4 with congenital penile deviation and 13 with stabilized Peyronie's disease. Opposite the point of maximal curvature a typical Nesbit procedure was performed. The excised tunica albuginea segment consequently served as a free graft. A symmetrical incision was made at the opposite site and the preserved elliptical tunica albuginea graft was placed in the defect. Further elliptical excisions and grafting followed as needed to correct the deformity. RESULTS: At a mean followup of 39.5 +/- 13.7 months (range 18 to 62) all patients reported penile straightening and functional erection, while ultrasonography of the corpora cavernosa revealed no changes in graft ultrastructure. There was penile shortening in 8 patients (47%) but only 2 (11.7%) considered it significant. All patients with a minimum 2-year followup were positive in regard to recommending the operation to others or repeating it if necessary. CONCLUSIONS: The newly described technique may be considered as a treatment option in patients with excessive penile curvature since shortening of the penile shaft is eliminated by 50% compared with the result of the Nesbit procedure. Tunica albuginea seems to be an appropriate grafting material since it prevents postoperative corporeal veno-occlusive dysfunction.