Fixed drug eruption

The enigma of fixed drug eruption has fascinated dermatologists for over eighty years. The clinical features and investigative studies suggest that many immunopathogenic mechanisms may be involved. Fixed drug eruption offers a unique opportunity to study the early events of inflammation and the factors controlling localizations of skin disease.     

Fixed drug eruption induced by sulfaguanidine

INTRODUCTION: Fixed drug eruption is a lesion induced by drugs. The family of drugs usually incriminated are sulfonamides, tetracyclines and pyrazols. We describe nine cases of fixed drug eruption induced by sulfaguanidine, a sulfonamide with local action. CASE REPORTS: All the patients presented one or more fixed drug eruption reactivation lesions induced by sulfaguanidine as self-medication for diarrhea. The number of lesions increased in 7 cases after reactivation. The delay in occurrence of the fixed drug eruption decreased during the different episodes. The lesions predominated on the hands in 8 cases of 9. DISCUSSION: The sulfaguanidine must be added to the list of drug-induced fixed drug eruptions with limited absorption from the gastrointestinal tract.