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Pharmacologic blockade of the renin‐angiotensin‐aldosterone system (RAS) has antihypertensive, anti‐atherogenic, antioxidant, and anti‐inflammatory effects. Treatment with angiotensin‐converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) has been demonstrated to prevent atrial fibrillation and new‐onset diabetes, and provide cardiac, cerebral, and renal protection. Combination therapy with ACEIs and ARBs, compared with monotherapy, provides enhanced reno‐ and cardioprotection, although available data indicate that combination RAS blockade may be beneficial only in select patient groups, such as those with diabetes mellitus, chronic kidney disease, or heart failure (HF). In certain high‐risk patients, the use of ARBs provides comparable efficacy to that observed with ACEIs. The efficacy of these agents may stem from pleiotropic effects beyond blood pressure (BP) reduction. Several studies demonstrate achievement of clinical endpoints without significant effects on BP. Copyright © 2009 Wiley Periodicals, Inc. 相似文献
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Farzana Afroze Sumon Kumar Das Shahnawaz Ahmed Monira Sarmin Nusrat Jahan Shaly Soroar Hossain Khan Abu Sadat Mohammad Sayeem Bin Shahid Lubaba Shahrin Haimanti Saha Tahmina Alam Abu Syed Golam Faruque K. M. Shahunja Mohammod Jobayer Chisti Tahmeed Ahmed 《Tropical medicine & international health : TM & IH》2020,25(8):1032-1042
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Anne Roivainen Riitta Parkkola Timo Yli‐Kerttula Pertti Lehikoinen Tapio Viljanen Timo Mttnen Pirjo Nuutila Heikki Minn 《Arthritis \u0026amp; Rheumatology》2003,48(11):3077-3084
Objective
To compare positron emission tomography (PET) and magnetic resonance imaging (MRI) in the evaluation of inflammatory proliferation of synovium.Methods
Ten patients (mean ± SD age 36 ± 13 years) with inflammatory joint disease and with clinical signs of inflammation of the joint were studied. A new tracer for cellular proliferation, methyl‐11C‐choline (11C‐choline), and a widely used tracer for the detection of inflammation and cancer, 2‐18F‐fluoro‐2‐deoxy‐D ‐glucose (18F‐FDG), were applied for PET imaging, and the results were compared with the findings from gadolinium diethylenetriaminepentaacetic acid–enhanced MR images. The uptake of 11C‐choline and 18F‐FDG in the inflamed synovium was measured and expressed as the standardized uptake value (SUV) and the kinetic influx constant (Ki) obtained from graphic analysis, and these values were compared with quantitative values on MRI. Synovial volumes were measured on the coronal contrast‐enhanced T1‐weighted MR images using the standard software of the MR imager.Results
All patients showed high accumulation of both 11C‐choline and 18F‐FDG at the site of arthritic changes, where quantification of the tracer uptake was performed. The SUV of 11C‐choline was 1.5 ± 0.9 gm/ml (mean ± SD; n = 10) and the SUV of 18F‐FDG was 1.9 ± 0.9 gm/ml (n = 10) (P = 0.017). The Ki of 11C‐choline (mean ± SD 0.048 ± 0.042 minute−1) was 8‐fold higher than the Ki of 18F‐FDG (0.006 ± 0.003 minute−1) (P = 0.009). Both the uptake of 11C‐choline and the uptake of 18F‐FDG correlated highly with the volume of synovium; the highest correlation was observed with the Ki of 11C‐choline (r = 0.954, P < 0.0001).Conclusion
In the use of PET scans,11C‐choline can be regarded as a promising tracer for quantitative imaging of proliferative arthritis changes. Nevertheless, subsequent prospective studies with larger numbers of patients are necessary to further characterize the relationship between the findings on PET imaging and the clinical and functional measures of inflammation.5.
J.J.M.L. Hoffmann 《International journal of laboratory hematology》2001,23(3):193-196
This report describes a case of spurious neutropenia caused by EDTA‐dependent in vitro agglutination of neutrophils. After raising the temperature of the sample to 37°C the agglutination was irreversible, but it resolved completely after addition of kanamycin. Previously this method has been shown to be effective in EDTA‐dependent pseudo‐thrombocytopenia, but this is the first report demonstrating successful application in EDTA‐dependent pseudo‐neutropenia. 相似文献
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Safety and efficacy profile of bioresorbable‐polylactide‐polymer‐biolimus‐A9‐eluting stents versus durable‐polymer‐everolimus‐ and zotarolimus‐eluting stents in patients with acute coronary syndrome 下载免费PDF全文
Milosz Jaguszewski MD PhD Manuela Dörig Antonio H. Frangieh MD Jelena‐Rima Ghadri MD Victoria Lucia Cammann Johanna Diekmann L. Christian Napp MD Fabrizio D'Ascenzo MD Yoichi Imori MD Slayman Obeid MD Willibald Maier MD Thomas F. Lüscher MD Christian Templin MD PhD 《Catheterization and cardiovascular interventions》2016,88(6):E173-E182
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One‐year outcome from an all‐comers population of patients with ST‐segment elevation myocardial infarction treated with biolimus‐eluting stent with biodegradable polymer 下载免费PDF全文
Fabrizio Tomai MD FACC FESC Leonardo De Luca MD PHD FACC Luca Altamura MD Francesco Versaci MD FACC Mauro Pennacchi MD Igino Proietti MD Anna S. Ghini MD PHD Pierfrancesco Corvo MD Giovanni De Persio MD Alessandro Petrolini MD Antonella Tommasino MD Gennaro Sardella MD 《Catheterization and cardiovascular interventions》2015,85(3):352-358
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G. DINCOL M. AGAN O. DOGAN R. DIZ‐KUCUKKAYA B. USLU 《International journal of laboratory hematology》2006,28(6):419-422
We report a 19‐year‐old woman who was presented with B‐symptoms, massive splenomegaly, hepatomegaly and hypersplenism. She underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen showed a vaguely micronodular and diffuse proliferation of lymphoid cells in the white pulp that also involved the red pulp. On immunohistochemical staining, this proliferation consisted predominantly of CD3+, CD7+ small T cells with the presence of a minor populat?on of CD15?,CD30?, CD20+ large atypical B cells. A liver biopsy also showed a similar morphology to that seen in the spleen. After splenectomy, only the pancytopenia improved. A combined immunochemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) was utilized, which resulted in a complete remission. 相似文献
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Costantino Mancusi Maria Viviana Carlino Alfonso Sforza 《Echocardiography (Mount Kisco, N.Y.)》2019,36(9):1755-1764
Point‐of‐care ultrasound is a useful tool for clinicians in the management of patients. Particularly in emergency department, the role of point‐of‐care ultrasound is strongly increasing due to the need for a rapid assessment of critically ill patients and to speed up the diagnostic process. Hand‐carried ultrasound devices are particularly useful in emergency setting and allow rapid assessment of patient even in prehospital setting. This article will review the role of point‐of‐care ultrasonography, performed with pocket‐size devices, in the management of patients presenting with acute onset of undifferentiating dyspnea, chest pain, and shock in emergency department. 相似文献
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Patient‐Reported Outcomes of Elderly Adults with Chronic Hepatitis C Treated with Interferon‐ and Ribavirin‐Free Regimens 下载免费PDF全文
Zobair M. Younossi MD MPH Maria Stepanova PhD Fatema Nader MSBM Linda Henry PhD 《Journal of the American Geriatrics Society》2016,64(2):386-393
The purpose of the study was to assess the effect of different treatment regimens for chronic hepatitis C on patient‐reported outcomes (PROs) of individuals aged 65 and older with chronic hepatitis C. PRO data from eight multinational multicenter Phase 2 and 3 clinical trials were included. Of 3,120 participants in these clinical trials, 229 were aged 65 and older (67.8 ± 3.2, 57% male, 75% treatment‐naïve, 22% cirrhotic), and 90 of those received ledipasvir plus sofosbuvir (LDV + SOF), 119 received SOF plus ribavirin (SOF + RBV), and 20 received pegylated IFN, SOF, and RBV (IFN + SOF + RBV). Participants aged 65 and older had slightly more pretreatment PRO impairment in their physical functioning than younger individuals (?3.1% on a normalized 0–100% PRO scale, P < .001). Despite this, these participants experienced significant PRO improvement during treatment with IFN‐free RBV‐free regimens (up to +8.0%, P < .001), similar to improvements in younger participants. In contrast, participants aged 65 and older experienced substantial decline in PROs while receiving IFN‐ or RBV‐containing regimens (up to ?18.9% in IFN + SOF + RBV, ?10.4% in IFN‐free SOF+RBV, P < .001), and some were greater than in the younger group. Nevertheless, after achieving sustained viral clearance at Posttreatment Week 12, PROs in participants aged 65 and older improved regardless of the regimen (up to +10.4%, P < .001). In multivariate analysis of the cohort aged 65 and older, the use of IFN and RBV was consistently associated with PRO impairment during treatment. The use of an IFN‐ and RBV‐free anti‐HCV regimen in older adults with hepatitis C results in significant improvement of PROs. 相似文献
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Intensive point‐of‐care ultrasound training with long‐term follow‐up in a cohort of Rwandan physicians 下载免费PDF全文
Patricia C. Henwood David C. Mackenzie Joshua S. Rempell Emily Douglass Damas Dukundane Andrew S. Liteplo Megan M. Leo Alice F. Murray Samuel Vaillancourt Anthony J. Dean Resa E. Lewiss Stephen Rulisa Elizabeth Krebs A. K. Raja Rao Emmanuel Rudakemwa Vincent Rusanganwa Patrick Kyanmanywa Vicki E. Noble 《Tropical medicine & international health : TM & IH》2016,21(12):1531-1538
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Five‐year follow‐up of polymer‐free sirolimus‐ and probucol‐eluting stents versus new generation zotarolimus‐eluting stents in patients presenting with st‐elevation myocardial infarction 下载免费PDF全文
Roisin Colleran MB BCH Sebastian Kufner MD Yukinori Harada MD Daniele Giacoppo MD Salvatore Cassese MD PhD Janika Repp MD Jens Wiebe MD Raphaela Lohaus MD Annalena Lahmann MD Simon Schneider MD Tareq Ibrahim MD Karl‐Ludwig Laugwitz MD Adnan Kastrati MD Robert A. Byrne MB BCH PhD for the Intracoronary Stenting Angiographic Results: Test Efficacy of Sirolimus‐ Probucol‐Eluting Versus Zotarolimus‐Eluting Stents Investigators 《Catheterization and cardiovascular interventions》2017,89(3):367-374
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Clinical characteristics and outcomes of patients with community‐acquired,health‐care‐associated and hospital‐acquired empyema 下载免费PDF全文
Yasuko Koma Sayaka Inoue Nao Oda Naoya Yokota Koji Tamai Yusuke Matsumoto Nobuhiko Okada Akiko Otsuka Nariyasu Nakashima Daiki Masuya Hirofumi Matsuoka Harukazu Yoshimatsu Yujiro Suzuki 《The clinical respiratory journal》2017,11(6):781-788
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Isolated Roux‐en‐Y anastomosis of the pancreatic stump in a duct‐to‐mucosa fashion in patients with distal pancreatectomy with en‐bloc celiac axis resection 下载免费PDF全文
Ken‐ichi Okada Manabu Kawai Masaji Tani Seiko Hirono Motoki Miyazawa Atsushi Shimizu Yuji Kitahata Hiroki Yamaue 《Journal of hepato-biliary-pancreatic sciences》2014,21(3):193-198