Study objective: To asses the association between alcohol consumption and the risk of colorectal cancer (CRC) in the Chinese population. Design: A population-based prospective cohort study was initiated from the colorectal cancer screening population in Jiashan County in 1989–1990. The drinking habits of individuals were investigated with demographic information. Setting: A cohort study was followed-up from 1st May 1990 to 1st January 2001 and censored at the date of diagnosis of CRC, at death from any causes, or at 1st January 2001, whichever came first, and the person-time was computed. Participants: Two hundred and forty two CRC patients were diagnosed during the study period and 64,100 individuals finished the follow-up. Results: The distribution of sex, smoking status, occupation, education level and marital status were all significantly different among different drinking habits at baseline. When the above factors were adjusted, no significant association was observed between alcohol consumption and the risk of CRC. Exclusion of individuals diagnosed cancer less than 1 year after the examination date did not alter the strength of an alcohol–CRC relationship. Further analysis in sex strata also did not show a significant relationship. Conclusions: Alcohol drinking may not be associated with a higher risk of CRC in the Chinese population.This revised was published online in April 2005. In the previous version the article category was missing. 相似文献
The objective of this study was to estimate the economic costs over the first 2 years of life of Group B Streptococcus (GBS)
disease occurring in infants less than 90 days of age. A cost analysis was conducted using a prospective cohort of children
born between 2000 and 2003 in the Greater London, Oxford, Portsmouth and Bristol areas of England. Unit costs were applied
to estimates of the health and social resource use made by 138 infants diagnosed with GBS disease and 305 non-GBS controls
matched for birth weight and hospital stay and time of birth. The health and social care costs for infants exposed to GBS
disease were analysed in a multiple linear regression model. The mean health and social care cost over the first 2 years of
life was estimated at ￡11,968.9 for infants with GBS, compared to ￡6,260.7 for the non-GBS controls; a mean cost difference
of ￡5,708.1 (bootstrap 95% CI ￡2,977.1, ￡8,391.2, P = 0.03). After adjusting for gestational age and other potential confounders in a multiple linear regression, mean societal
costs was ￡6,144.7 higher among GBS cases than among non-GBS controls (P < 0.001). This study shows that the health and social care costs for infants with GBS disease is, on average, two-fold higher
during the first 2 years of life than for infants without GBS disease. These data should be used to inform policy decisions
regarding the cost-effectiveness of prevention and treatment strategies for GBS disease during early childhood. 相似文献
We studied 85,975 Japanese subjects by questionnaire at baseline (age 45–65 years, no histories of CVD or cancer) in 1995 and 1998, and were followed until the end of 2009 and 2010 in Cohorts I and II, respectively. Dietary magnesium intake was estimated from a self-administered 138 item food-frequency questionnaire. Confounding variables were used for age, smoking, alcohol, body mass index, history of diabetes, medication of antihypertensive drug and anti-lipidemic drug users, regular exercise, public health centers, foods (vegetables and fish), dietary energy and minerals (salt, calcium, and potassium).
