Effect of Yiqi Jianpi Bushen Recipe (益气健脾补肾方) in Reducing Nephrotoxicity of Cisplatin

Ｃｉｓｐｌａｔｉｎ（ＣＤＤＰ）ｉｓａｗｉｄｅｌｙｕｓｅｄａｎｔｉ ｃａｎ ｃｅｒｄｒｕｇ．ＩｔｓｍｅｃｈａｎｉｓｍｉｓｔｈｒｏｕｇｈｂｉｎｄｉｎｇＣＤ ＤＰｗｉｔｈＤＮＡｔｏｉｎｔｅｒｆｅｒｅｔｈｅｃｅｌｌｕｌａｒＤＮＡｒｅｐｌｉｃａｔｉｏｎ，ｓｏａｓｔｏｉ     

A Disccussion on TCM Mediated Biotherapy of Leukemia

ＡＤｉｓｃｃｕｓｓｉｏｎｏｎＴＣＭＭｅｄｉａｔｅｄＢｉｏｔｈｅｒａｐｙｏｆＬｅｕｋｅｍｉａＡＤｉｓｃｃｕｓｓｉｏｎｏｎＴＣＭＭｅｄｉａｔｅｄＢｉｏｔｈｅｒａｐｙｏｆＬｅｕｋｅｍｉａＬｉＤａ（李达）（ＬａｎｇｆａｎｇＭｕｎｉｃｉｐａｌＩｎｓｔｉｔｕｔｅ...     

Distinguishment of A 42 Capsomere Structure of Icosohedral Virion from A 32 One by Electron Microsco

ＤｉｓｔｉｎｇｕｉｓｈｍｅｎｔｏｆＡ４２ＣａｐｓｏｍｅｒｅＳｔｒｕｃｔｕｒｅｏｆＩｃｏｓｏｈｅｄｒａｌＶｉｒｉｏｎｆｒｏｍＡ３２ＯｎｅｂｙＥｌｅｃｔｒｏｎＭｉｃｒｏｓｃｏｐｅＣｎｅｎＢｉｎｇｙｉｎｇ（陈丙莺）；ＺｈｏｕＴｏｎｇ（周）（Ｄｅｐａｒｔｍｅ...     

Role of Traditional Chinese and Western Medicines that Inhibit Aldose Reductase in The Treatment of Diabetic Neuropathy

Ｄｉａｂｅｔｉｃｎｅｕｒｏｐａｔｈｙ（ＤＮ）ｉｓｏｎｅｏｆｃｏｍ ｍｏｎｄｉａｂｅｔｉｃｃｏｍｐｌｉｃａｔｉｏｎｓ，ｗｈｉｃｈｈａｓａｈｉｇｈｉｎｃｉｄｅｎｃｅｏｖｅｒ 90 %ｉｎｔｈｅｌｏｎｇ ｔｅｒｍｃｏｕｒｓｅ．Ｐａｔｈｏｌｏｇｉｃａｌｃｈａｎｇｅｓｍａｙｉｎｖｏｌｖｅｓｅｎｓｏｒｙｎｅｒｖｅ，ｍｏｔｏｒｎｅｒｖｅａｎｄａｕｔｏｎｏｍｉｃｎｅｒｖｅ．Ｔｈｅｐａｔｈｏｇｅｎｅｓｉｓｉｓｓｔｉｌｌｐａｒｔｌｙｕｎｄｅｒｓｔｏｏｄ．Ｒｅｃｅｎｔｒｅｓｅａｒｃｈｅｓｓｈｏｗｅｄｔｈａｔｔｈｅｏｃｃｕｒ…     

Study on the Role of Mast Cells in the Development of Liver Fibrosis During Diethylnitrosamine （DEN）－induced Hepatocarcinogen

ＳｔｕｄｙｏｎｔｈｅＲｏｌｅｏｆＭａｓｔＣｅｌｌｓｉｎｔｈｅＤｅｖｅｌｏｐｍｅｎｔｏｆＬｉｖｅｒＦｉｂｒｏｓｉｓＤｕｒｉｎｇＤｉｅｔｈｙｌｎｉｔｒｏｓａｍｉｎｅ（ＤＥＮ）－ｉｎｄｕｃｅｄＨｅｐａｔｏｃａｒｃｉｎｏｇｅｎｅｓｉｓｉｎＲａｔｓＸＵＸｉａｎ...     

Clinical Study of Jinmaitong Composita(复方筋脉通) on Diabetic Peripheral Neuropathy

Ｄｉａｂｅｔｉｃｐｅｒｉｐｈｅｒａｌｎｅｕｒｏｐａｔｈｙ（ＤＮ）ｉｓｏｎｅｏｆｔｈｅｍｏｓｔｃｏｍｍｏｎｄｉａｂｅｔｉｃｃｏｍｐｌｉｃａ ｔｉｏｎｓ．Ｉｔｓｐａｔｈｏｇｅｎｅｓｉｓｉｓｓｔｉｌｌｕｎｃｌｅａｒ,ｓｏｎｏｄｅｆｉｎｉｔｅｌｙｅｆｆｅｃｔｉｖｅｍｅｄｉｃｉｎｅｈａｓｂｅｅｎｆｏｕｎｄ．ＣｌｉｎｉｃａｌｓｙｍｐｔｏｍｓｏｆＤＮｃｏｕｌｄｂｅｓｉｇｎｉｆｉｃａｎｔｌｙｒｅｌｉｅｖｅｄｂｙＪｉｎｍａｉｔｏｎｇｃｏｍｐｏｓｉｔａ（ＪＭＴＣ,复方筋脉通）,ａｔｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅ…     

Clinical Study of Blastocyisasis in Children of Fuzhou District

ＣｌｉｎｉｃａｌＳｔｕｄｙｏｆＢｌａｓｔｏｃｙｉｓａｓｉｓｉｎＣｈｉｌｄｒｅｎｏｆＦｕｚｈｏｕＤｉｓｔｒｉｃｔＷｕＢｉｎ（吴斌）；ＺｈａｏＺｉｑｉｎｇ（赵子庆）；ＨｕａｎｇＭｉａｏｈｕｉ（黄妙辉）ａｎｄＳｕＱｉｎｇｐｉｎｇ（苏庆平）（ＴｈｅｌｓｔＡｆ...     

Influence of Buyang Huanwu Decoction (补阳还五汤) on Activity of Blood Platelet Activating Factor Receptor in Rabbit

ＢｕｙａｎｇＨｕａｎｗｕＤｅｃｏｃｔｉｏｎ（ＢＹＨＷＤ）ｉｓａＣｈｉｎｅｓｅｔｒａｄｉｔｏｎａｌｍｅｄｉｃａｍｅｎｔｗｈｉｃｈｈａｓｂｅｅｎｕｓｅｄｉｎｃｌｉｎｉｃａｌｐｒａｃｔｉｃｅｆｏｒａｌｏｎｇｔｉｍｅ．ＩｔｉｓｃｏｍｐｏｓｅｄｏｆｒａｗＲａｄｉｘＡｓｔｒａｇａｌｕｓ120ｇ,ＲａｄｉｘＡｎｇｅｌｉｃａＳｉｎｅｎｓｉｓ6ｇ,ＲａｄｉｘＰａｅｏｎｉａＲｕｂｒａ4．5ｇ,ＲｈｉｚｏｍａＬｉｇｕｓｔｉｃｕｍＷａｌｌｉｃｈｉｉ,ＳｅｍｅｎＰｅｒｓｉｃａ,ＦｌｏｓＣａｒｔｈａｍｕｓａｎｄＬｕｍｂｒｉｃｕｓ…     

Progress in Immunopharmacologic Study of Yupingfeng Powder(玉屏风散)

ＹｕｐｉｎｇｆｅｎｇＰｏｗｄｅｒ（ＹＰＦＰ,玉屏风散）,ａｒｅｃｉｐｅｗｈｉｃｈｃｏｎｓｉｓｔｓｏｆＲａｄｉｘＡｓｔｒａｇａｌｕｓ,ＲｈｉｚｏｍａＡｔｒａｃｔｙｌｏｄｅｓＡｌｂａａｎｄＲａｄｉｘＳｉｌｅｒｉｓｉｓｏｒｉｇｉｎａｌｌｙｆｒｏｍｔｈｅｂｏｏｋ“ＥｘｐｅｒｉｅｎｃｅｓｏｆＺＨＵＤａｎｘｉ”（ｗｒｉｔｔｅｎｂｙＺＨＵＤａｎｘｉ,ａｆａｍｏｕｓｄｏｃｔｏｒｉｎｔｈｅＹｕａｎＤｙｎａｓｔｙ）．ＦＺＫｏｎｇ,ＹＨＳｈｅｎ,ｅｔａｌｆｏｕｎｄｔｈａｔＹＰＦＰｈａｄａｃｔｉｏｎｏｎａｎｔｉｂａｃｔ…     

Analysis of Drug Resistance Spectra and Conjugative Plasmid Carrying Rates of P.aeruginosa and Acinetobacter

ＡｎａｌｙｓｉｓｏｆＤｒｕｇＲｅｓｉｓｔａｎｃｅＳｐｅｃｔｒａａｎｄＣｏｎｊｕｇａｔｉｖｅＰｌａｓｍｉｄＣａｒｒｙｉｎｇＲａｔｅｓｏｆＰ．ａｅｒｕｇｉｎｏｓａａｎｄＡｃｉｎｅｔｏｂａｃｔｅｒＷｅｎｇＹａｌｉ（翁亚丽）Ｌｉｕｙａｎｙａｎ（刘雁雁）Ｊｉａ...     

无创双水平正压通气对重叠综合征膈肌疲劳及近期肺动脉压的影响

目的:探讨无创双水平正压通气(BiPAP)治疗重叠综合征(OS)对近期肺动脉压力(PAP)及膈肌疲劳的改善情况。方法:26例OS患者均在常规治疗基础上进行无创双水平正压通气治疗24 h,检测治疗前、后静息状态下肺阻抗血流图,同步电阻抗呼吸仪描记胸、腹部呼吸运动曲线。结果:BiPAP治疗后患者平均PAP较治疗前明显改善(P<0.01),PAP大于20 mmHg病人4例,较治疗前(20例)显著减少(P<0.01);OS患者膈肌疲劳发生率高达73.8%,而治疗后检出率降至15.4%。结论:无创双水平正压通气治疗OS能显著降低患者近期肺动脉压,改善膈肌疲劳。     

Effect of Shenmai Injection on L-type Calcium Current of Diaphragmatic Muscle in Rats

Diaphragmaticmuscleisanimportantrespiratorymuscle,anddiaphragmaticfatiguecanleadtomanydisorders .Onlyintherecent 2 0 yearshavethesys temicresearchesbeen performedtoinvestigatethefunctionofdiaphragmanditspathophysiology .Di aphragmaticfatiguecanbeinducedby…     

The effect of neferine on foam cell formation by anti-low density lipoprotein oxidation

Summary Oxidatively modified low density lipoprtein (LDL) plays an important role in atheroslerosis (AS) development. To investigate the role of neferine (Nef) in anti-LDL oxidation and foam cell formation, the lipoprotein was derived and subjected to three different treatments: N-LDL (normal LDL), Cu²⁺+LDL and Cu²⁺ + Nef+LDL. The LDLs were put at 25 C for 24 h and the thiobarbituric acid reactive substance (TBARS) values were determined. They were 0. 57 ±0. 02, 6. 01 ±0. 22 and 2. 26±0.13 nmol/mg protein, respectively. The difference was very significant (P<0. 01) for each two groups byt test. Mouse peritoneal macrophage (MΦ) were exposed to 50 μg protein/ml of Cu²⁺+LDL and Cu²⁺+Nef+LDL at 37 °C for 60 h. The tryglyceride (TG) and total cholesterol (TC content in MΦ were assayed. The results showed that Cu²⁺+ LDL was more efficient than Cu²⁺+Nef+ LDL in stimulating lipid accumulation in MΦ(P <0. 001). The study demonstrated that Nef could inhibit Cu²⁺-mediated LDL oxidation and thereby inhibiting macrophage-derived foam cell formation.     

创伤性膈疝23例诊治体会

目的：总结创伤性膈疝的诊断和治疗方法。方法：对２３例例创伤性膈疝进行回顾性分析。除５例直接急诊手术外,全部进行Ｘ线检查,１６例有阳性发现。陈旧性膈疝６例。本组均进行手术治疗,经胸１１３例,经腹７例,经腹加腹部切口手术２例,胸腹联合手术２例,结果：治愈２０例,死亡３例,结论：诊断主要依据Ｘ表现,生膈疝一经诊断,尽早手术可减少其病死率。     

Effect of Anti-inflammatory Agent No.6 for injection on the cAMP content of rat peritoneal macrophages

Summary The effect of Anti-inflammatory Agent No.6 for injection (AI-6) on the cAMP content of rat peritoneal macrophages (Mϕ) was studied in the present work. It was demonstrated in in vitro studies that AI-6, while showing no effect on the basal cAMP level in resident peritoneal Mϕ, significantly facilitated the formyl Methionyl-Leucyl-Phenylalanine-induced increase in the intracellular cAMP concentration (control: 34.01 ±3.48 pmol/10⁷ cells, test; 41.68±2.76 pmol/10⁷ cells;P< 0.05). In vivo, AI-6 was found to increase the intracellular cAMP concentration of fetal calf serum(FCS)-elicited rat peritoneal Mϕ (control: 28.5±3.17 pmol/mg protein, test: 41.01±4.13 pmol/mg protein;P< 0.01). The possible effect of the drug-induced changes in cAMP level on Mϕ function is discussed. Project supported by the Science Fund of the Chinese Academy of Sciences.     

Detection of abnormalities in dyspneic patients using a new lung imaging modality

Background Although chest radiography is a useful examination tool,it has limitations.Because not all chest conditions can be detected on a radiograph,radiography cannot necessarily rule out all irregularities in the chest.Therefore,further imaging studies may be required to clarify the results of a chest radiograph,or to identify abnormalities that are not readily visible.The aim of this study was to compare traditional chest radiography with acoustic-based imaging （vibration response imaging） for the detection of lung abnormalities in patients with acute dyspnea.Methods The current investigation was a pilot study.Respiratory sounds throughout the respiratory cycle were captured using an acoustic-based imaging technique.Consecutive patients who presented to the emergency department with acute dyspnea and a normal chest radiograph on admission were enrolled and underwent imaging at the time of presentation.Dynamic and static images of vibration （breath sounds） and a dynamic image score were generated,and assessments were made using an evaluation form.Results In healthy volunteer controls （n=61）,the mean dynamic image score was 6.3±1.9.In dyspneic patients with normal chest radiographs （n=51） and abnormal chest radiographs （n=48）,the dynamic image scores were 4.7±2.7 and 5.1±2.5,respectively （P ＜0.05）.The final assessment of the vibration images indicated abnormal findings in 15％,86％ and 90％ of the participants in the above groups,respectively （P ＜0.05）.Conclusions In patients with acute dyspnea who present with normal chest radiographs,respiratory sound analyses often showed abnormal values.Hence,the ability of acoustic-based recordings to offer objective and noninvasive measurements of abnormal sound transmission may be useful in the clinical setting for patients presenting with acute dyspnea.     

Large bowel obstruction complicating a posttraumatic diaphragmatic hernia

Posttraumatic diaphragmatic hernia is a rare cause of large bowel obstruction, and can present weeks or years after the initial trauma. Herein, we report the case of a 28-year-old man who presented with signs and symptoms of bowel obstruction nine months after he had a stab wound to his left chest. Chest radiography showed multiple air-fluid levels in the right upper quadrant, an air-fluid level in the left thoracic cavity and significant free air under the diaphragm. Exploratory laparotomy revealed a contaminated abdomen with perforations in the caecum and proximal transverse colon, and a 4 cm × 4 cm defect in the left posterolateral (septal) aspect of the diaphragm, which was closed with a nonabsorbable suture. Posttraumatic diaphragmatic hernias should be part of the differential diagnosis for patients with bowel obstruction, especially if there is a history of trauma. Radiography is useful in facilitating a quick diagnosis.     

Placental Isoferritin Action in Pathogenesis of Pre-eclampsia and/or Intrauterine Growth Retardation and Its Earlier Predictive Value

Pre- eclampsia and intrauterine growth retarda-tion(IUGR) are major sources of clinical morbidityand mortality in pregnant women and prenatal in-fants.Their mechanisms are not completely clear.The imbalance of maternal- fetal immune interactionwas demonstrated to play a role in them[1] .Recentlyplacental isoferritin (PLF) was demonstrated to be asignificant immune regular factor in pregnant im-mune inhibition[2 ] ,butitsrole in pathogenesisof pre-eclampsia and/or IUGR is unknown.In this s…     

M型超声评价2型糖尿病患者膈肌运动异常

目的  探讨应用M型超声评价2型糖尿病（T2DM）患者膈肌运动异常。方法  将67例T2DM患者根据糖尿病病程分为两组,病程>10年为A组（32例）,病程≤10年为B组（35例）,正常对照组为C组（36例）。应用M型超声分别在平静呼吸,用鼻子用力深快呼吸,深呼吸时测量膈肌运动幅度,同时获得肺功能相关指标：一秒用力呼气量（FEV1）、一秒用力呼气容积预测值[FEV1（%） of predicted]、用力肺活量（FVC）、用力肺活量预测值[FVC（%） of predicted]、一秒用力呼气量占用力肺活量的百分数（FEV1/FVC）和肺活量（VC）,并分析膈肌运动与肺功能的相关性。结果  平静呼吸时A、B、C组膈肌运动幅度差异无统计学意义（P >0.05）;用鼻子用力深快呼吸和深呼吸时膈肌运动幅度比较：A组<B、C组（P <0.05）,B组<C组（P <0.05）。A组FEV1<B、C组（P <0.05）,B组与C组间比较差异无统计学意义（P >0.05）;A、B、C组[FEV1（%） of predicted]、FVC、[FVC（%） of predicted]、FEV1/FVC（%）及VC组间比较差异无统计学意义（P >0.05）。A、B、C组在深呼吸时膈肌运动幅度均与FEV1、FVC及VC呈正相关（P <0.05）。结论  M型超声评价膈肌运动具有直接、便捷、非侵入性等优点,可以为糖尿病患者合并膈肌运动异常提供客观的诊断依据。

     

Effects of intraoperative autologous blood donation and tepid temperature cardiopulmonary bypass on blood system

We have reported previously that routine cardiopulmonary bypass (CPB) causes platelet count reduced and platelet function h....dlil. Modificationsto routine CPB should be made in order to reduce theharmful non--physiological low temperatUre of CPB tothe blood system and reduce postoperative non--surgical bleeding and blood transfusion needed. The present clinical experiment was designed to investigateintraoperative autologous blood donation and tepidtemperature CPB and compared with routi…