蒲地蓝消炎口服液治疗162例小儿急性扁桃体炎与急性咽炎的疗效

目的:观察蒲地蓝消炎口服液治疗小儿急性扁桃体炎、急性咽炎的疗效。方法:选择280例小儿急性扁桃体炎、急性咽炎的患儿随机分成两组,治疗组予口服蒲地蓝消炎口服液0岁～1岁,每次1/3支,每日3次;1岁～3岁,1/2支,每日3次;3岁～5岁,每次2/3支,每日3次;5岁以上,每次1支,每日3次。对照组口服头孢克洛分散片,按20mg/(kg·d)～40mg/(kg·d),分3次服。每8h1次,疗程均为7d。结果:经统计学处理两组在咽痛、咽充血、咽肿胀减轻,体温下降及全身不适缓解等方面的差异,治疗组较对照组差异有显著性(P<0.05或P<0.01);治疗组总有效率91.3%,对照组总有效率81.3%,差异有显著性(P<0.05)。结论:蒲地蓝消炎口服液治疗小儿急性扁桃体炎、急性咽炎有较好疗效,其疗效明显优于头孢克洛分散片。     

万应胶囊治疗慢性咽炎的随机对照研究

目的　评价万应胶囊与熊胆丸治疗慢性咽炎的疗效。方法　根据随机对照原则 ,将 2 6 4例慢性咽炎患者随机分成万应胶囊组和熊胆丸组 ,各 1 32例。万应胶囊组使用万应胶囊口服 ,一日 2次 ,一次 2片 ,共 1 0 d。熊胆丸组采用口服熊胆丸 ,一次 4片 ,一日 2次 ,共 1 0 d。对各型慢性咽炎分别在治疗后的 3、5、1 0 d进行疗效观察。结果　各型慢性咽炎在治疗 3、5 d后万应胶囊组治疗的总有效率略高于熊胆丸组 (P>0 .0 5 ) ,治疗 1 0 d以后 ,万应胶囊组治疗的总有效率明显高于熊胆丸组治疗的总有效率 (P<0 .0 5 ) ,其中慢性肥厚型咽炎治疗 1 0 d后的有效率高于熊胆丸组肥厚型咽炎治疗后的有效率 (P<0 .0 5 )。结论　与熊胆丸相比 ,万应胶囊对慢性咽炎更有效 ,对慢性肥厚型咽炎最为有效     

咽炎合剂的制备与临床应用

目的：制备咽炎合剂并观察其临床疗效。方法：用煎煮法制备咽炎合剂,将98例急性咽炎和258例慢性咽炎各随机分为治疗组和对照组,急性咽炎治疗组给予咽炎合剂20-30ml,餐后口服,1日3次,咽部症状较重者,晚睡前加服1次;对照组患者给予复方硼砂溶液15Hd,含漱、1日3次,利巴韦林分散片150m鼽口服、1日3次。两组疗程均为7d。慢性咽炎对照组患者给予华素片、1片、含服、1日4次,复方硼砂溶液15ml、含漱、1日3次;治疗组给予咽炎合剂15—20ml、餐后口服、1日3次。两组疗程均为15d。观察临床疗效。结果：急性咽炎治疗组和对照组的总有效率比较无显著差异性（P＞O．05）,但痊愈和显效之和比较有显著差异性（P〈0．05）。治疗组和对照组的总有效率间有显著差异性（P〈0．05）。结论：咽炎合剂组方合理,制备工艺简单,质量符合中国药典合剂项下有关的各项规定;对急、慢性咽炎的治疗效果良好,使用方便。     

还原型谷胱甘肽治疗药物性急性肾损害

目的　探讨还原型谷胱甘肽治疗药物性急性肾损害的临床疗效。方法　将 66例因肾毒性药物所致急性肾损害患者随机分为 2组 ,观察组 ( 3 8例 )用还原型谷胱甘肽治疗 ,每日用量 12 0 0mg ,静脉滴注 ,1次 /d ,2～ 4周 ;对照组( 2 8例 )用复方氨基酸 9AA(肾安 )治疗 ,2 5 0ml/d ,静脉滴注 ,1次 /d ,2～ 4周。 2组其他治疗相同。结果　 2组中对急性肾衰总有效率分别为 95 %和 5 9% (P <0 0 5 ) ;对尿蛋白、尿 β2 -微球蛋白、血尿总有效率分别为 83 %、89%、89%和45 %、3 6%、5 4% (P <0 0 5 )。结论　还原型谷胱甘肽治疗药物性急性肾损害有明显的疗效。     

博乐欣与氯丙咪嗪治疗强迫症的对照研究

目的 :本文旨在探讨 5 -HT抑制博乐欣治疗强迫症疗效及副作用与氯丙咪嗪比较。方法 :选择符合诊断标准的强迫症 36例 ,随机分成A、B两组。A组口服博乐欣 ,初始剂量 5 0mg/d ,1～ 2周内加到 1 0 0～ 2 5 0mg/d ;B组服安拿芬尼 ,初始剂量 5 0mg/d ,1～ 2周内加到1 0 0～ 2 5 0mg/d ;观察 8周后疗效及副作用。结果 :A组显效 1 2例 ,有效 6例 ,总有效率6 6 6 9% ;B组 ,显效 1 3例 ,有效 4例 ,总有效率 72 2 2 % ,两组比较无显著差异。结论 :博乐欣是一种安全有效的抗强迫症的新药     

复方血栓通胶囊治疗缺血性视网膜病变疗效观察

目的　观察复方血栓通胶囊治疗缺血性视网膜病变的疗效。方法　将 5 6例缺血性视网膜病变患者随机分为对照组 (2 8例 )和观察组 (2 8例 ) ,观察组口服血栓通胶囊每次 3粒 ,3次 /d ,连服 4周为一疗程。对照组口服复方丹参片每次 3片 ,3次 /d ,连服 4周为一疗程。两组病例均给予口服维生素B1、复方芦丁片、ATP、肌苷等辅助药物 ,有高血压、糖尿病等原发病的患者同时在内科医师指导下治疗原发病。两组治疗前各项主要指标具有可比性 (P >0 0 5 )。结果　观察组有效率为 82 % ,对照组有效率为 5 7% ,两组比较差异有显著性 (P <0 0 5 )。结论　复方血栓通囊治疗缺血性视网膜病变无明显不良反应 ,疗效完全可靠 ,值得推广应用     

复方新诺明片联合复方玄驹胶囊治疗慢性前列腺炎80例分析

目的:观察复方新诺明片联合复方玄驹胶囊治疗慢性前列腺炎疗效。方法:将160例慢性前列腺炎患者分为治疗组与对照组,每组80例。两组均给予复方新诺明片0.96 g,2次/d,口服,治疗组加用复方玄驹胶囊3粒,3次/d,口服,均4周为1个疗程。结果:治疗4周后,治疗组总有效率高于对照组总有效率(P<0.05)。结论:复方新诺明片联合复方玄驹胶囊治疗慢性前列腺炎疗效好。     

咽立爽治疗急性咽炎的疗效观察

1998年 1月至 1999年 8月我们用贵州中信药厂生产的咽立爽口含滴丸治疗急性咽炎 15 3例 ,效果满意 ,现报告如下。1　资料与方法1.1　临床资料　急性咽炎 2 46例 ,均符合诊断标准 [1 ] ,随机分为治疗组和对照组。治疗组 15 3例 ,男 85例 ,女 6 8例 ,12～ 6 3岁 ,平均 31.4岁。对照组 93例 ,男 5 3例 ,女 40例 ,10～6 5岁 ,平均 34 .5岁。全部病例均在起病 1周内就诊。1.2　方法　治疗组 :口含咽立爽 4粒 ,每日 3次 ,1周为一疗程。对照组 :口服头孢氨苄每日 3次 ,每次 0 .5 g,1周为一疗程。1.3　疗效评定标准　痊愈 :咽部症状消失 ,咽部充血、…     

复方鳖甲软肝片与和络舒肝胶囊治疗肝纤维化疗效比较

①目的比较复方鳖甲软肝片(FFBJRGP)与和络舒肝胶囊(HLSG JN)治疗肝纤维化的疗效。②方法将100例肝纤维化患者随机分成两组,FFBJRGP治疗组52例,每次FFBJRGP 4粒,口服,3次/d,连续6个月;HLSG JN治疗组48例,每次HLSG JN 5粒,口服,3次/d,连续6个月。③结果FFBJRGP组显效率为5 9.6 1%,有效率为2 5.0 0%,总有效率为8 4.6 1%,HLSG JN组显效率为52.08%,有效为22.91%,总有效率为74.99%,两组有显著性差异。④结论FFBJRGP治疗肝纤维化优于HLSG JN。     

弗莱莫星可溶片治疗小儿急性细菌性呼吸道感染的疗效观察

用弗莱莫星可溶片治疗小儿急性细菌性呼吸道感染 5 0例观察疗效 ,弗莱莫星 2 5～ 5 0mg/ (kg·日 )分二次口服 ,并用头孢氨苄做对照 ,疗程均为 3～ 6天。结果弗莱莫星总疗效为 94% ,明显优于头孢氨苄对照组。提示弗莱莫星是治疗小儿急性细菌性呼吸道感染的安全、有效制剂     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.