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1.
The action of ouabain and cyclic AMP on the Ca-accumulating capacity and outflow of Ca2+ ions from loaded rat heart mitochondria was studied by the tetracycline probe method. In the course of the investigations no effect of ouabain on these processes was found. Cyclic AMP did not act on Ca binding by the mitochondrial membrane but it induced rapid liberation of Ca2+ from organelles loaded with these ions.Department of Molecular Pharmacology, Medico-Biological Faculty, N. I. Pirogov Second Moscow Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR S. S. debov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 2, pp. 158–160, February, 1977. 相似文献
2.
L. E. Panin N. I. Shalbueva L. M. Polyakov 《Bulletin of experimental biology and medicine》2000,130(2):769-771
It is shown that apoC-III, but not other apoC proteins, components of very low density lipoproteins (apoC-I, apoC-II, apoC-III),
reduced the rate of mitochondrial respiration in various metabolic states. This effect depended on the dose of apoprotein,
type of oxidized substrate, and the presence of Ca ions in the incubation medium. ApoC-III completely blocked oxidative phosphorylation
during oxidation of palmitoyl carnitine by mitochondria, while the respiration rate in metabolic state 4 remained unchanged.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 184–186, August, 2000 相似文献
3.
V. A. Khazanov S. A. Borodina N. B. Smirnova 《Bulletin of experimental biology and medicine》1999,128(4):1042-1044
Inin vitro experiments, antineoplastic anthracycline antibiotic doxorubicine caused deenergization of rat brain mitochondria due to
oxidation-phosphorylation uncoupling and inhibition of succinate oxidase system. Reduced production and oxidation of succinic
acid is the most early effect of doxorubicin on mitochondrial oxidation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 10, pp. 445–447, October, 1999 相似文献
4.
V. A. Eshchenko 《Bulletin of experimental biology and medicine》1977,83(3):329-331
Injection of dithisone and quinoline compounds into animals leads to the intravital formation of granules of a zinc chelate in the tissues that can be detected in frozen sections. The intensity of the intravital histochemical reaction depends on the complex-forming capacity, dose, and mode of administration of the agent and also on the presence of other ligands reducing its use in the coordination of volume.Department of Pathological Anatomy and Central Research Laboratory, Tomsk Medical Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR I. V. Toroptsev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 3, pp. 292–293, March, 1977. 相似文献
5.
I. A. Komissarova Ya. R. Nartsissov N. M. Burbenskaya 《Bulletin of experimental biology and medicine》1996,122(3):898-900
Correlations between respiration rates in the mitochondria in different states are studied using various oxidation substrates.
Specific features and integration between different functional cycles are substrate-dependent. It is suggested that variations
of the mitochondrial function correspond to specific phases of pathological process.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 9, pp. 282–284, September, 1996 相似文献
6.
V. V. Sirotkin A. Yu. Grishin V. A. Smirnov N. A. Yurina L. N. Lupichev 《Bulletin of experimental biology and medicine》1993,115(2):223-227
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol.115, N
o
2, pp.215–218, February, 1993 相似文献
7.
A. P. Ettinger A. Yu. Tsibulevskii 《Bulletin of experimental biology and medicine》1993,116(2):916-918
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 116, N
o
8, pp. 132–134, August, 1993 相似文献
8.
Heparin used as an anticoagulant in modeled hemorrhagic shock decreases the phosphatidylcholine and increases the phosphatidylethanolamine
contents in the mitochondria. Accumulation of lysophosphatidylcholine in whole mitochondria and their inner membrane is observed
in hemorrhagic shock. At the same time, hemorrhagic shock decreases phosphatidylcholine content in the inner and outer mitochondrial
membranes and increases phosphatidylethanolamine content in the outer membranes. Modification of phospholipid composition
of mitochondrial membranes is a mechanism responsible for impaired energy production in liver mitochondria in hemorrhagic
shock.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 43–45, July, 1997 相似文献
9.
Effect of intraperitoneal administration of spermin on oxidative phosphorylation and calcium capacity of isolated liver mitochondria
was studied in normo- and hypothermic rats. Hypothermia stimulates mitochondrial respiration without decreasing the contingency
and increases calcium capacity. Spermin suppresses mitochondrial respiration, the effect being stronger in hypothermia. In
high doses spermin prevents stimulating effect of hypothermia on respiration and reduces the increase in calcium capacity.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 5, pp. 526–528, May, 1998 相似文献
10.
Yu. N. Korolev L. N. Panova Yu. V. Mashkovtsev 《Bulletin of experimental biology and medicine》1996,121(3):318-321
Structural-adaptive alterations in mitochondria and intercellular junctions are found in the liver against the background
of elevated silicon when mineral siliceous water and silicon solution are applied internally. It is established that an increase
of the number of tight and gap junctions takes place during the period of declining bioenergetic processes in hepatocytes.
As the number and area of mitochondria increase, the extent of the intercellular junctions shrinks. These changes may be considered
to be important components in the mechanism of action of siliceous water.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 348–351, March, 1996
Presented by V. V. Kupriyanov, Member of the Russian Academy of Medical Sciences 相似文献
11.
N. K. Isaev R. E. Uzbekov D. B. Zorov E. V. Stel'mashuk I. V. Viktorov 《Bulletin of experimental biology and medicine》1995,119(4):365-367
It is shown that treating rat cerebellum with glutamate in a neurocytotoxic concentration causes a drop of the mitochondrial
membrane potential in granule cells and leads to ultrastructural alterations of mitochondria in these neurons.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
4, pp. 378–380, April, 1995.
Presented by the late Member of the Russian Academy of Medical Sciences 相似文献
12.
T. K. Dubovaya A. Yu. Tsibulevskii A. I. Deev B. V. Semushin G. V. Cherkesova 《Bulletin of experimental biology and medicine》1996,122(6):1199-1201
A decline in serum albumin content and a tendency toward a decrease in the binding constant of the negatively charged fluorescent
probe 1-anilinonaphthalene-8-sulfonate are observed in acute intoxication with tetrachloromethane. The mean number of binding
sites per albumin molecule increases, therefore, the total concentration of the binding sites for serum albumins remains practically
unchanged. Pretreatment with antioxidant, antihypoxant, or actoprotector increases serum albumin content (tomerzole) and partially
normalizes its conjugational parameters: binding constant (sodium γ-oxybutyrate) and mean number of binding sites per molecule
(dibunol, tomerzole).
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 12, pp. 635–637, December, 1996 相似文献
13.
Effects of some steroid hormones on Ca2+ transport and oxidative metabolism of isolated mitochondria
L. D. Luk'yanova R. A. Eliseev T. N. Makarenko A. I. Matyushin 《Bulletin of experimental biology and medicine》1994,118(6):1307-1310
Effects of prednisolone, estradiol, and testosterone on the transport of Ca2+ and the respiration induced by it in the heart and liver mitochondria of rats were studied. Prednisolone and testosterone
were found to reduce the Ca-accumulating capacity of the mitochondria, the rates of ion entry and exit, and the rate of Ca2+-induced respiration. Estradiol, while inhibiting Ca2+ transport across mitochondrial membrane, did not influence the respiration in the phase of Ca2+ absorption, but accelerated it in the phase of ion exit. These data suggest that due to their lipophilic properties, the
steroids become incorporated in the mitochondrial membrane, thereby changing its viscosity and permeability and limiting the
mobility of transmitter proteins.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 616–618, December, 1994 相似文献
14.
Ya. R. Nartsissov I. A. Komissarova T. D. Soldatenkova Yu. V. Gudkova T. T. Kondrashova 《Bulletin of experimental biology and medicine》1995,120(2):803-804
The effect of ionizing radiation on the activity of succinate dehydrogenase (complex II) and succinate-cytochrome C-oxidoreductase
in peripheral blood lymphocytes is studied on rats exposed to whole-body γ-irradiation in doses of 9.5–10.5 Gy. On day 5 after
irradiation, when the number of lymphocytes is sharply reduced, enzyme activity in the remaining population is found to be
reliably increased. These changes are not related to biological cycles. It is assumed that most of the survivors after high-dose
irradiation are the cell populations maintaining a high level of oxidative phosphorylation in mitochondria.
Translated fromByulleten' Eksperimental'noi Giologii i Meditsiny, Vol. 120, N
o
. 8, pp. 158–159, August, 1995
Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences 相似文献
15.
N. P. Dmitrieva S. B. Stefanov E. A. Amirkhanyan 《Bulletin of experimental biology and medicine》1977,83(4):532-535
Activity of cytochrome oxidase and succinate dehydrogenase in the mitochondria of thyroid gland cells of rats was studied by electron-histochemical and morphometric methods during experimental carcinogenesis. The activity of these enzymes in the mitochondria was shown to vary depending on the stage of malignant transformation: In the early stages it was close to normal, but later (precancer) it fell sharply and approached the level observed in the mitochondria of cancer cells. A marked decrease in the activity of the enzymes studied in the morphologically altered mitochondria of cancer cells may be a qualitative characteristic of these cells.Electron Microscopy Room, N. K. Kol'tsov Institute of Developmental Biology, Academy of Sciences of the USSR. Laboratory of Electron Microscopy, Institute of Poliomyelitis and Virus Encephalitis, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 83, No. 4, pp. 452–455, April, 1977. 相似文献
16.
G. N. Kryzhanovskii G. F. Leskova V. I. Udovichenko 《Bulletin of experimental biology and medicine》1996,121(4):352-355
Considerable regional differences in the phospholipid composition of mitochondrial membranes are found in the brain of cats
in the terminal phase of hemorrhagic shock. The most prominent alteration is noted in the medulla oblongata and consists in
a progressive elimination of phosphatidylcholine. Changes in the main phospholipids in mitochondrial membranes of the cerebral
hemispheres are less pronounced and consist in a drop of phosphatidylinositol and phosphatidylethanolamine. Accumulation of
lysophosphatidylcholine and lysophosphatidylethanolamine is a regular feature of the studied mitochondria. Accumulation of
lysophosphatidylserine is found primarily in mitochondrial membranes of the medulla oblongata.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 4, pp. 387–391, April, 1996 相似文献
17.
18.
R. I. Salganik I. G. Shabalina N. G. Kolosova V. N. Solov'ev N. A. Solov'eva A. R. Kolpakov 《Bulletin of experimental biology and medicine》1995,119(6):605-607
Liver mitochondria of inbred W/SSM rats with inherited increased radical formation reveal the following anomalies: inhibition
of oxidative phosphorylation, a lowered transmembrane potential, and alterations in protein-lipid interaction. The membrane
viscosity and osmotic stability of mitochondria are unaffected.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 628–631, June, 1995 相似文献
19.
L. D. Luk'yanova G. N. Chernobaeva V. E. Romanova 《Bulletin of experimental biology and medicine》1995,120(6):1189-1192
After long-term adaptation to intermittent hypoxia, rats with an initially low resistance to acute oxygen deficiency were
2 to 4 times more resistant to it, while highly resistant rats did not show a significant change in resistance. The adaptation
was accompanied by weakening of the electron-transporting function of the respiratory chain and increasing efficiency of oxidative
phosphorylation in the brain mitochondria oxidizing NAD-dependent substrates, indicating that energy was produced in a more
economical way. The succinate oxidase pathway of oxidation was found to be utilized to only a limited extent as a compensatory
mechanism in animals exposed to intermittent hypoxia over a prolonged period. The effects of adaptation were more marked in
the brain mitochondria of rats initially highly sensitive to oxygen deficiency.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
12, pp. 572–575, December, 1995 相似文献
20.
E. Z. Emirbekov S. P. L'vova A. G. Gasangadzhieva 《Bulletin of experimental biology and medicine》1998,125(4):339-341
Repeated cold stress performed in a cold-tempering mode reduces lipid peroxidation and activates tissue antioxidant system.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 4, pp. 385–387, April, 1998 相似文献