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庚型肝炎病毒感染对慢性丙型肝炎的影响 总被引:1,自引:0,他引:1
研究慢性丙型肝炎患者中庚型肝炎病毒(UGV)的感染及其对丙型肝炎临床表现、肝功能和对干扰素应答的影响。以HGV的5′非编码区引物建立了检测HGV RNA的RT-PCR法,检测51例慢性丙型肝炎病人中的HGV感染。结果51例病人中,11例为HGV RNA阳性。慢性丙型肝炎病人的临床表现与是否感染HGV不相关,肝功能试验结果也无统计学差异。29例接受干扰素治疗的病人中,有6例病人(20.7%)合并HGV感染。HGV阳性组6人中1例完全应答,HGV阴性组23人中,有3例完全应答,在这有限的病例中,两组应答率没有统计学差异。提示在我国丙型肝炎病人中,混合HGV较为常见,HGV感染对丙型肝炎的临床表现无明显影响,也不影响其对干扰素的应答。 相似文献
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血液透析患者丙型肝炎病毒感染的研究 总被引:20,自引:0,他引:20
为调查血液透析患者丙型肝炎病毒(HCV)感染情况,并探讨相对危险因素,对1994年12月~1995年6月在北京协和医院血透中心进行血液透析的80例患者及1995年新入学的30例研究生(健康对照)进行研究。采用第二代ELISA检测人类免疫缺陷病毒(HIV)和HCV抗体,逆转录巢式双聚合酶链反应(PCR)法检测HCVRNA。追查80例血液透析患者,24例HCV抗体阳性,56例HCV抗体阴性患者中,2例HCVRNA阳性,即80例血液透析患者HCV感染率32.5%(26/80)。Mantel-Haenszel法分析显示,血透患者HCV感染与输血、透析时间、肾移植及手术史有关。9例HCVRNA阳性病人的透析液中,3例检出HCVRNA。表明血液透析患者HCV感染率明显高于普通人群,主要危险因素是输血和免疫功能低下,透析设备和环境污染是不容忽视的危险因素。 相似文献
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丙型肝炎病毒感染与膜性肾病及膜增殖性肾炎的研究 总被引:2,自引:1,他引:2
目的:了解我国膜性肾病(MN),膜增殖性肾炎(MPGN)的丙型肝炎病毒(HCV)感染率,HCV感染与冷球蛋白血症及肾脏病关系,以期阐明HCV在MN及MPGN中的作用。方法:前瞻性观察46例健康工作人员以及1996年5月至1997年11月期间67例MN12例HPGN患者血清HCV抗体HCV-RNA的阳性率,血清冷球蛋白浓度及冷沉淀物的中的HCV抗体及HCV-RNA阳性率,并结合肾组织HCV抗原沉积特 相似文献
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POLYARTHRITIS ASSOCIATED WITH HEPATITIS C VIRUS INFECTION 总被引:2,自引:0,他引:2
Two cases of polyarthritis associated with hepatitis C infectionare reported. In Patient 1, stiffness and polyarthritis occurredduring the acute stage of hepatitis. The arthritic symptomslasted for 4 months. A transient polyarthritis recurred 4 yrlater. The persistent presence of anti-hepatitis C viral antibodieswas noted. Hepatitis C viral RNA (HCV RNA) was identified inthe serum using the polymerase chain reaction proving that thepatient was a carrier. In Patient 2, polyarthritis occurredassociated with chronic hepatitis C liver disease. Synovialiopsy showed infiltration of mononuclear cells HCV RNA was demonstratedin both serum and SF. These cases suggest an aetiologic associationbetween arthritis and hepatitis C antigenaemia. KEY WORDS: Polyarthritis, Hepatitis C virus carrier, Chronic antigenaemia 相似文献
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为研究筛查抗-HCV控制HCV感染的作用,在献血员(简称血员)筛查抗-HCV前(1990年11月~1992年2月)调查5个城市血站和4个县单采血浆站,血员抗-HCV阳性率:献浆血员为55.5%,全血血员为10.2%。其中合格和不合格献浆血员分别为46.2%和91.6%,合格和不合格全血血员分别为5.8%和42.3%,说明血员HCV感染率高,血员不合格主要与HCV污染有关。筛查血员抗-HCV1年后,调查3个城市中心血站和4个县医院供血基地,合格血员抗-HCV阳性率:献浆血员降至4.0%、全血血员降至0.2%,分别比筛查前降低91.3%和96.6%,P<0.001。义务血员抗-HCV阳性率0.5%。筛查抗-HCV前后首次献血员86人,抗-HCV皆阴性。说明筛查血员抗-HCV既可控制HCV感染,又可提高供血质量。 相似文献
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HCV感染的慢性肝病患者肝组织HCV RNA和HCV C33c检测 总被引:1,自引:0,他引:1
为探讨丙型肝炎病毒在肝组织分布和致病机理,用地高辛标记的 HCV5'-NC区cDNA探针和抗HCV C33c单克隆抗体对24例HCV感染的慢性肝病患者肝组织进行了原位核酸杂交和免疫组化研究,发现HCV RNA和C33 c阳性信号主要定位于肝细胞浆,HCV感染的阳性肝细胞呈散在、局灶和弥漫三种形式分布,与丙氨酸转氨酶水平、肝组织学类型没有明显联系:HCV感染的细胞周围有较多的淋巴细胞和单核细胞浸润。 相似文献
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在无国产抗-HCV试剂供应的1990和1991年,甲地观察输血者90名(不筛查ALT),乙地筛查ALT观察输血者64名。输血后HCV感染率甲地45.6%,乙地18.8%,p<0.01;其中输血后丙型肝炎发生率甲地41.1%,乙地14.1%P<0.01,甲地观察二年未发现抗-HCV阴转;输血距抗-HCV阳转甲地38.4±11.8天,乙地42.9±15.9天;输血后ALT异常率甲地44.4%,乙地21.9%,输血距ALT异常甲地48.2±16.8天(观察二年ALT异常率27.8%),乙地51.9±20.9天。输抗-HCV阳性、阴性血受血者,其HCV感染率88.2%(45/51)和7.8%(8/103)。既往HCV隐性感染的受血者,输后丙型肝炎发病率52.9%(11/22),同时发现3例输血后抗-HCVS/CO值渐低,2例阴转,似有HCV中和性抗体存在。 相似文献
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HEPATITIS C VIRUS AND ESSENTIAL MIXED CRYOGLOBULINAEMIA 总被引:2,自引:0,他引:2
CACOUB P.; MUSSET L.; FABIANI F. LUNEL; PERRIN M.; LEGER J.-M.; HUONG DU L THI; WECHSLER B.; BLETRY O.; OPOLON P.; HURAUX J.-M.; PIETTE J.-C.; GODEAU P. 《Rheumatology (Oxford, England)》1993,32(8):689-692
Clinical and laboratory evidence of liver involvement are frequentlyfound in essential mixed cryoglobulinaemia (EMC). We lookedfor evidence of hepatitis C virus (HCV) infection in 37 patientswith EMC. Anti-HCV antibodies (Ab) were found in 16/37 (43%)patients with EMC using the ELISA 2 test and the RIBA 2 test.The 16 anti-HCV-Ab positive patients (group 1) were comparedto the 21 anti-HCV-Ab negative patients (group 2). Group 1 patientshad more frequent cutaneous involvement (P = 0.02), clinical,biological and histologic hepatic involvement (P<0.01), higherserum cryoglobulin and lower CH50 levels (P<0.001). Serumhepatitis B virus markers were infrequent in both groups andno patient from either group had detectable serum HBV DNA. Thesepreliminary results suggest that HCV may be another cause ofmixed cryoglobulinaemia. KEY WORDS: Hepatitis C virus, Cryoglobulinaemia 相似文献
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A. Zampieron H. Jayasekera M. Elseviers E. Lindley J.‐Y. DeVos R. Visser M. Harrington 《Journal of Renal Care》2006,32(1):42-44
An analysis of the literature showed a high prevalence of HCV in the European dialysis population in the nineties. The prevalence was similar in most countries in northern Europe, but infection was more common in France, Italy, Spain, Portugal and Greece (1) and in Eastern European countries (2). The reported prevalence of anti‐HCV‐positive patients in the EDTA registry was 21% in 1992 and 18% in 1993 (3) ranging from 1% in Finland to 42% in Egypt (4). The incidence of HCV, in new patients starting renal replacement therapy, ranged from 3% to 7% (5,6) and reported seroconversion rates during dialysis treatment varied between 1% (7) and 16% (8) per year. 相似文献
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丙型肝炎病毒感染者肝组织中病毒抗原表达的免疫组化研究 总被引:1,自引:0,他引:1
为探讨丙型肝炎病毒(HCV)在肝组织中的表达状况,应用免疫组化方法以多克隆人抗-HCV和单克隆鼠抗-HCV-NS_3检测一组HCV感染者石蜡包埋肝组织中HCV抗原(Ag)和HCV-NS_3,并对抗原检出与血清HCV标志的关系进行分析。结果:HCVAg和HCV-NS_3检出率分别为38.3%(23/60)和30.0%(18/60);所有HCV-NS_2,阳性者均同时表现HCVAg阳性;阳性颗粒定位于肝细胞胞浆;阳性细胞分布呈散在、弥漫状和簇状,周围多天坏死及炎性细胞浸润;不同血清HCV标志模式间抗原检出率存在明显差别。研究结果对认识HCV致病机理有一定意义。 相似文献
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中国藏族和维吾尔族人群丙型肝炎病毒基因型分析 总被引:4,自引:0,他引:4
目的与方法根据不同基因型丙型肝炎病毒(HCV)核心区基因序列,合成一条通用引物和四条型特异性引物用于RT/PCR扩增反应,所得不同长度的扩增产物分别对应于HCVⅠ、Ⅱ、Ⅲ、Ⅳ的基因型,用此方法对采自西藏的69例藏族和新疆的81例维吾尔族的丙型肝炎病毒阳性血清进行了分析。结果藏族的69例中3例为Ⅰ型(3/69,4.3%),33例为Ⅱ型(33/69,47.8%),4例为Ⅲ型(4/69,5.8%),29例为混合型(29/69,42.1%);维吾尔族的81例中8例为Ⅰ型(8/81,9.9%),14例为Ⅱ型(14/81.17.3%),3例为Ⅲ型(3/81,3.7%),56例为混合型(56/81,69.1%),这同我国内地汉族人群中丙型肝炎病毒基因型分布明显不同。结论 HCV基因型的分布有一定的地区特异性。 相似文献
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HEPATITIS B INFECTION AMONG STD CLINIC PATIENTS IN SYDNEY 总被引:2,自引:0,他引:2
P. J. CHRISTOPHER E. B. CREWE P. T. MAILER A. M. MURPHY 《Internal medicine journal》1984,14(4):491-494
Evidence of current or past infection with hepatitis B has been studied in 809 patients attending clinics for sexually transmitted diseases in Sydney by assaying serological markers. Prevalence rates were 13.9% among male heterosexuals; 13.5% among female heterosexuals; 30.7% among female prostitutes; 64.3% among male homosexuals and 47.1% among male bisexuals. The prevalence was 80% for male homosexuals aged 36 years or more. Vaccination should be considered for persons at high risk of sexual transmission of hepatitis B, and it is the immunization of this group that is likely to have a major impact on this disease. 相似文献