乳腺导管造影诊断溢液性乳腺疾病的临床实用价值

目的探讨乳腺导管造影诊断溢液性乳腺疾病的临床实用价值。方法 120例女性溢液性乳腺疾病患者,年龄22～65岁,平均年龄43岁。临床症状以乳头溢液为主。回顾分析乳腺导管造影资料,所有病例均行超声、患侧乳腺钼靶平片＋导管造影检查,并做病理组织检查。比较乳腺导管造影诊断的差异。结果 120例中,超声发现病灶108例,阳性率为90.00%;乳腺钼靶平片发现病灶102例,阳性率为85.00%;乳腺导管造影发现病灶117例,阳性率为97.50%。超声、钼靶平片、导管造影检查诊断良、恶性肿瘤灵敏度分别为80.00%、85.00%、90.60%,3组比较差异有统计学意义（χ2=31.46,P〈0.005）。手术病理证实：单纯导管内乳头状瘤37例,导管内乳头状瘤伴导管扩张33例,纤维囊性乳腺病伴导管扩张21例,导管内癌及乳头状瘤癌变29例。结论乳腺导管造影在诊断溢液性乳腺疾病中具有定位、定性的实用价值,对临床是否确定手术及切除范围提供了可靠、重要的诊断依据。     

乳腺导管内乳头状瘤超声诊断回顾性分析

回顾性分析乳腺导管内乳头状瘤超声图像特点及误诊原因,提高诊断准确率。方法 回顾性分析我院经手术病理证实的50例乳腺导管内乳头状瘤患者的彩色多普勒超声图像特点,根据声像图特征分为5型,观察超声图像分型、血流信号分类及BI-RADS分类标准。结果 50例患者共65个病灶,37个病灶超声诊断与病理结果相符合,诊断准确率为56.92%。其中Ⅰ型:导管扩张伴导管内实性结节,19个病灶,2个误诊;Ⅱ型:导管扩张伴远端中断处实性团块,5个病灶,1个误诊;Ⅲ型:囊实性混合回声团块,15个病灶,5个误诊;Ⅳ型:实性团块而无导管扩张,24个病灶,19个误诊;Ⅴ型:单纯导管扩张,2个病灶,2个误诊。彩色血流信号结果:23个病灶表现为0级;19个病灶表现为Ⅰ级;10个病灶表现为Ⅱ级;13个病灶表现为Ⅲ级。BI-RADS分类结果:2类2个病灶;3类59个病灶;4A类3个病灶;4C类1个病灶。结论 乳腺导管内乳头状瘤的超声表现有多种类型,诊断时应结合临床表现,运用多种超声成像方法综合诊断,以便进一步提高诊断准确率。     

高频超声诊断乳腺导管内乳头状瘤的价值分析

目的：探析高频超声诊断乳腺导管内乳头状瘤的临床价值。方法选取我院2013年5月~2014年5月经过手术证实的33例乳腺导管内乳头状瘤患者进行高频超声诊断,回顾分析超声图像特征。结果高频超声诊断检出率为90.91%%,误诊率为6.06%。结论高频超声诊断乳腺导管内乳头状瘤能够清晰显示病灶大小、部位、形态、血供情况与内部回声,操作简单、安全可靠、无创无痛,值得临床广泛应用。     

乳腺超声检查中BI-RADS分级诊断标准对乳腺原位癌的诊断价值

目的 探究应用BI-RADS分级诊断标准来诊断乳腺原位癌的超声诊断价值,以提升超声工作者对规范乳腺诊断标准认识和运用,提高彩色多普勒超声对乳腺原位癌的诊断能力。方法 选取2015年5月~2018年5月在我院通过手术及病理结果证实为乳腺原位癌的患者37例,系统回顾了根据病灶所显示出的不同声像图特征,综合分析采用BI-RADS超声分级诊断,探讨误诊主要原因。结果 37例乳腺原位癌病例中,超声诊断准确率为75.36%（28/37）,4例未定,5例误诊,其中1例误诊为导管内乳头状瘤,1例误诊为导管浸润癌,1例误诊为导管局部扩张,2例误诊为瘤样增生。结论 彩色多普勒超声诊断仪采用BI-RADS分级诊断方法,较大提高了乳腺原位癌的检出率,联合其它辅助检查可明显提高检出率,在指导临床对患者乳腺疾病的评估起到重要作用。     

纤维乳管镜对病理性乳头溢液的诊疗价值

目的探讨纤维乳管镜对病理性乳头溢液的临床诊疗价值。方法回顾性分析北京市通州区妇幼保健院乳腺外科2018年10月至2019年6月313例病理性乳头溢液患者病例资料。结果 313例病理性乳头溢液患者行纤维乳管镜检查,其中124例为占位性病变行手术治疗。术后病理发现导管原位癌6例,小叶原位癌1例,非典型增生5例,导管内乳头状瘤病5例,多发导管内乳头状瘤6例,导管内乳头状瘤38例,纤维腺瘤4例,乳腺腺病9例,乳腺增生症50例。结论纤维乳管镜可直接诊断病理性乳头溢液的病因。纤维乳管镜引导下导丝定位手术更能准确切除导管内病灶。纤维乳管镜能发现仅仅表现为乳头溢液的早期乳腺癌。     

乳腺恶性导管内乳头状病变28例临床病理分析

目的探讨乳腺恶性导管内乳头状病变的临床病理学特征、诊断、鉴别诊断及预后。方法回顾性分析28例乳腺恶性导管内乳头状病变的临床表现,观察其组织病理学及免疫表型特征,收集随访资料并复习相关文献。结果 28例患者均为女性,平均年龄55.7岁,主要表现为乳头溢液和乳腺肿块。组织学类型:导管内乳头状癌22例、包膜内乳头状癌2例及实性乳头状癌4例。镜检:肿瘤呈乳头状或实体状,可见纤细的纤维血管轴心。肿瘤细胞形态多一致,细胞核级别低。免疫组化标记示大部分患者肿瘤细胞ER和PR均呈强阳性,HER-2、CK5/6均呈阴性;结节内CK5/6、p63、SMA均呈阴性。实性型者部分可表达CD56、Syn、CgA。Ki-67增殖指数平均为5.3%。27例获得随访资料,随访10~79个月,患者均存活。结论乳腺恶性导管内乳头状病变好发于老年女性,组织学形态多样,诊断需结合临床、组织学形态及免疫表型,应与导管内乳头状瘤鉴别。该肿瘤具有较为惰性的生物学行为,预后较好。     

超声鉴别诊断乳腺典型髓样癌与不典型髓样癌的价值分析

目的分析病理证实的乳腺髓样癌及不典型髓样癌的超声及病理资料,证明超声诊断乳腺髓样癌价值。方法回顾性分析114例乳腺髓样癌病灶病理资料,将其分为髓样癌组及不典型髓样癌组,分析其超声声像图中病灶的形态、大小、边缘、边界、内部回声、血流情况等,探讨两组超声声像图的差异。结果乳腺典型髓样癌病灶93例,不典型髓样癌病灶21例,两组的超声声像图上各特征均无明显统计学差异。超声诊断典型髓样癌和不典型髓样癌良恶性的准确性分别为83.87%、85.71%。结论超声对鉴别乳腺髓样癌良恶性方面具有诊断价值,但在鉴别髓样癌与不典型髓样癌方面价值有限。     

超声引导下导丝定位切除术治疗触诊阴性乳腺病灶的价值

目的探讨超声引导下导丝定位切除术治疗触诊阴性乳腺病灶的临床应用价值。方法选择133例超声探及但临床触诊阴性的乳腺病灶,在超声引导下将定位导丝置入乳腺病灶内,根据定位导丝的位置切除病变及其周围部分正常组织,并送检病理检查。结果133例患者共136个结节,导管内乳头状瘤9例,乳腺增生症伴纤维腺瘤样结构形成25例,非典型增生4例,乳腺增生症35例,纤维腺瘤53例,乳腺浸润性癌8例,导管原位癌2例。结论超声引导下导丝定位切除术治疗触诊阴性乳腺病灶具有定位准确、操作简单、微创等优点,该技术的应用对于乳腺癌的早期诊断及早期治疗具有重要价值。     

乳腺导管内乳头状肿瘤的形态学和免疫表型特征

目的观察乳腺导管内乳头状肿瘤（intraductal papillary neoplasms,IDPN）的形态学和免疫表型特征,并探讨其诊断。方法根据WHO分类（2003）和Tavassoli等（1999、2003）有关标准,筛选出乳腺导管内乳头状肿瘤41例,对上述病例进行HE形态观察和免疫组化检测,选用的一抗有CK5、CK34βE12、CK8、CD34、SMA、p63、CD10。结果（1）导管内乳头状瘤19例,镜检为扩张的导管或小管内含纤维-脉管轴心的乳头状病变,由腺（系）上皮和肌上皮覆盖轴心形成双层构型。其中16例伴腺（系）上皮普通性增生,2例〈10％的乳头覆盖上皮呈不典型增生（AH）改变。腺（系）上皮CK5 17例（89．5％）中～强阳性;CK34βE1216例（84．2％）中～强阳性。肌上皮SMA、p63、CD10均阳性。（2）非典犁导管内乳头状瘤4例,3例伴发于囊内乳头状癌,1例作为主要诊断。表现为≥10％而〈90％的乳头覆盖上皮呈AH改变。其AH区域CK5均阴性,3例CK34βE12阴性～弱阳性。（3）导管内乳头状癌21例,其中①2例仅表现为≥90％的乳头区肌上皮层完全缺乏;②1例仪表现为〉90％的乳头覆盖上皮呈低级导管原位癌（DCIS）样改变;③8例兼具上两种特征;④10例乳头覆盖上皮呈中～高级别DCIS样改变。符合②及③者CK5均阴性,CK34βE12 6例（66．7％）阴性～弱阳性;符合④者CK5、CK34βE12 8例（80％）均阴性～弱阳性。结论IDPN是一组良恶性不同的病变,各自的HE形态和免疫表型均有差异,应采用HE形态和免疫组化相结合的综合标准进行诊断。     

乳腺结节90例临床分析

目的 探讨乳腺结节的诊治.方法 回顾性分析2009年2月至2009年10月经我科手术治疗的术前行磁共振检查的90例乳腺结节临床资料.结果 90例患者中36例确诊为乳腺纤维腺瘤(占40%),23例为乳腺增生症(占25.6%),20例为乳腺浸润性导管癌(占22.2%),其中男性1例,女性19例,粘液性乳头状腺癌2例(2.2%),囊肿5例(5.6%),其中1例为男性,分叶状肿瘤1例(1.1%),囊性乳头状癌1例,为男性(1.1%),导管内乳头状癌1例(1.1%),浸润性神经内分泌癌1例(1.1%).25例恶性肿瘤,仅1例导管内乳头状癌磁共振未提示.结论 乳腺MR平扫+动态增强对明确乳腺结节良恶性准确率较高,手术是治疗结节的首选方法[1].我科诊治术前行磁共振检查的90例乳腺结节患者,现报告如下:     

Mammary Paget's disease: evidence of diverse origin of the disease with a subgroup of Paget's disease developing from the superficial portion of lactiferous duct and a discontinuous pattern of tumor spread

The pattern of spread of intraductal carcinoma associated with mammary Paget's disease has not been well studied. The purpose of this study was to examine the site of origin and the pattern of tumor spread with a three-dimensional view by serial sectioning of the tissue blocks from 19 cases of Paget's disease. Intraductal carcinoma in the superficial portion of the lactiferous ducts was seen in continuity with the overlying epidermis with Paget's disease in all 19 cases. In seven cases that had adequate tissue sampling, five showed a continuous pattern of the intraductal carcinoma within the superficial as well as the deep breast tissue. In the remaining two cases, a portion of benign duct was identified between the intraductal carcinoma in the superficial lactiferous duct and the deep breast tissue. This discontinuous pattern of spread of the intraductal carcinoma was also identified in the foci of carcinoma in deep tissue. In the five cases in which the tumor involved the skin and only the superficial portions of the lactiferous duct, the leading edge of the intraductal carcinoma was seen orientated in the direction of the nipple towards the deep breast tissue. Our study of Paget's disease demonstrated that in addition to tumor spread along the lactiferous ducts from intraductal carcinoma in the deep tissue towards the nipple, there was a group of Paget's disease arising from the nipple. These lesions included: (i) lesions limited to the areolar tissue; and (ii) lesions with intraductal carcinoma involving the duct system in both superficial and deep breast tissue with and, possibly, without skip areas pattern of spread. Although certain cases of Paget's disease may appear superficial, an independent associated carcinoma in deep breast tissue has to be ruled out.     

Assessment of utility of ductal lavage and ductoscopy in breast cancer-a retrospective analysis of mastectomy specimens.

Early detection of breast lesions continues to be an important goal in the management of breast cancer. At present, mammographic imaging in addition to physical examination is the main screening method for the detection of cancer. Fiberoptic ductoscopy and duct lavage are being recently used to evaluate patients at risk for breast cancer. Both techniques examine the nipple and central duct area to identify intraductal lesions. In this study, we examined the frequency of involvement of these structures in mastectomy specimens as a surrogate marker to estimate the utility of these methods in breast cancer patients. The presence and type of involvement of the nipple and central duct area was retrospectively evaluated in 801 mastectomy specimens from a 4-year period that had been performed for infiltrating or in situ carcinoma. Atypical proliferation or cells, when seen in the ducts of this region, was considered as evidence of nipple involvement, even if definite evidence of malignancy was lacking. The review of 801 mastectomies showed nipple and central duct involvement in 179 (22%) cases. Among the 665 cases of infiltrating carcinoma, 17% did not have an intraductal component. The relative rarity of nipple and central duct in mastectomy specimens and the lack of an in situ component in many cases raise questions about the utility of fiberoptic ductoscopy and duct lavage as methods for screening of breast cancer. Additionally, as these methods examine only 1-2 ducts of the 15-20 ducts that open at the nipple, they might fail to detect focal abnormalities.     

对女性盆腔囊性和囊实性包块的彩色多普勒超声和MSCT诊断的临床研究

目的总结对比彩色多普勒超声与多层螺旋CT（MSCT）对女性盆腔囊性和囊实性包块诊断的影像学特点,提高彩色多普勒超声和MSCT对盆腔囊性和囊实性包块的诊断准确率。方法 39例新疆女性盆腔囊性和囊实性包块患者,年龄27～62岁,平均年龄39.5岁。术前分别行彩色多普勒超声和MSCT检查,进行影像学诊断,术后经手术和病理全部证实,并回顾性对比分析彩色多普勒超声和MSCT的影像学诊断和定位准确率。结果 39例患者中5例为女性盆腔包虫（2例单囊型,3例多囊型,且1例伴包虫囊肿破裂）,MSCT诊断正确率为80%（4例）,定位准确率为100%（5例）,彩色多普勒超声诊断正确率为60%（3例）,定位准确率为40%（2例）;25例为囊实性卵巢囊腺瘤（7例为单囊型,18例为多囊型）,MSCT诊断正确率为88%（22例）,定位正确率为84%（21例）,彩色多普勒超声诊断正确率60%（15例）,定位正确率为52%（13例）;4例为较大子宫肌瘤囊性变,MSCT和彩色多普勒超声均100%正确诊断,MSCT定位正确率75%（3例）,彩色多普勒超声定位准确率50%（2例因肌瘤较大,位置特殊而定位失败）;5例为卵巢囊腺癌,MSCT诊断正确率为80%（4例）,定位准确率为80%（4例）,彩色多普勒超声诊断正确率为60%（3例）,定位准确率为60%（3例）。结论彩色多普勒超声和MSCT对女性盆腔囊性和囊实性包块的定性诊断具有较高的价值,但MSCT定位较彩色多普勒超声更为准确。     

Pattern of distribution of intraductal and infiltrating ductal carcinoma: a three-dimensional study using serial coronal giant sections of the breast

The purpose of this study was to establish the 3-dimensional (3D) structure of the breast tissue and to study the distribution and relationship between the intraductal and infiltrating components of ductal carcinoma and other proliferative epithelial lesions of the breast. Thirty mastectomy specimens with infiltrating carcinoma less than 3.0 cm in diameter were serially cut in the coronal plane. Each giant section was divided into small sections for routine processing. Using Photoshop (Adobe) and PowerPoint (Microsoft) software programs, the routinely stained sections were scanned and assembled to reestablish complete giant sections of the breast and subsequently the 3D structure. Intraductal and infiltrating ductal carcinomas, epithelial hyperplasia with atypia, and marked epithelial hyperplasia without atypia were mostly confined to a single duct (27 cases), resulting in an increase in size of the involved breast segment. Three remaining cases included a case of Paget's disease with tumor appearing to spread from one duct system to another system through the epidermis and two cases with multiple separate foci of carcinomas located in different quadrants and accompanied by ductal spread in different lactiferous ducts. Both intraductal and infiltrating carcinomas were often located in the superficial segments (near the subcutaneous tissue) (28 cases). The infiltrating components were often located adjacent to area of pure intraductal carcinoma and were often peripheral (nearer the chest wall than the nipple). Intraductal carcinomas showed a "fanned out" pattern of distribution, frequently extended toward the nipple (with involvement of the nipple or subareolar tissue in 7 cases), and occasionally were seen in the breast tissue peripheral to the infiltrating carcinoma. Multiple ducts with intraductal carcinoma could be seen to be connected with each other with serial sections. However, in at least 6 cases, foci of intraductal carcinomas were separated from each other by segments of duct with benign epithelium. Breast carcinoma often arise from the breast segment close to the subcutaneous tissue. Infiltrating carcinoma lesser than 3.0 cm in diameter is usually located adjacent to the area of pure intraductal. The pattern of spread of intraductal carcinoma has a pyramid-like shape, with the summit toward and occasionally extending up to the nipple. These findings should be considered in the surgical strategy for segmental resections of breast carcinomas.     

乳腺良恶性病变中CD10表达及意义

目的 探讨CD10免疫标记乳腺肌上皮细胞的可行性。方法 收集50例乳腺良恶性病变的石蜡包埋标本(腺瘤、纤维腺瘤、叶状肿瘤、纤维囊性病、导管内乳头状瘤、乳头腺瘤、导管内癌、小叶内癌、浸润性导管癌、浸润性小叶癌)，采用免疫组化(S-P法)检测CD10在上述病变中的表达。结果 在乳腺良性病变中，CD10阳性的肌上皮细胞连续地环绕在普通型增生的小导管的周围。但在囊性扩张或不典型上皮增生的导管周围，CD10阳性细胞不连续，甚至不见阳性细胞。导管原位癌的癌细胞巢外周的阳性细胞由完整到不完整，甚至完全缺失。在浸润性癌中癌巢周围不见阳性细胞，在早期浸润性癌中可见残存的阳性细胞。除少许癌细胞和肌纤维母细胞表达CD10外，其余癌细胞、肌纤维母细胞、血管平滑肌细胞和上皮细胞均不表达CD10。结论 CD10标记肌上皮细胞具有较高的敏感性和特异性，可以作为肌上皮细胞的有效标记物。     

实时超声弹性成像技术结合血清促甲状腺激素在甲状腺微小乳头状癌诊断中的价值*

目的：探讨实时超声弹性成像技术联合促甲状腺激素（ TSH）在老年甲状腺微小乳头状癌（ PTMC）诊 断中的价值。方法：选取本院接受手术治疗的甲状腺微小结节患者及健康体检者。术前所有患者均进行实时超 声弹性成像技术检查,以病理诊断为“金标准”,分析实时超声弹性成像技术诊断甲状腺微小乳头状癌的准确 率、特异度及灵敏度。比较良恶性结节的弹性成像评分,采用化学发光法检测所有受试者血清TSH水平。结果： 经术后病理检查有60.00% 患者确诊为良性结节（ 共85 个良性结节,占58.62%）,有40.00% 患者确诊为恶性结 节（ 共60 个恶性结节,占41.38%）。实时超声弹性成像技术诊断甲状腺微小乳头状癌的灵敏度为92.50%,特异度 为83.08%,准确性为88.28%。实时超声弹性成像诊断与病理诊断有较高的一致性。 恶性组1 ～ 2 分的比例显著 低于良性组,3 ～ 4 分的比例显著高于良性组,差异具有统计学意义。良性组和恶性组血清TSH水平均显著高于 对照组,恶性组血清TSH水平显著高于良性组,差异具有统计学意义。受试者工作特征（ ROC）曲线结果显示, 超声弹性成像联合TSH检测其ROC曲线下面积为0.869,95%CL（0.789 ～ 0.949）,联合诊断最佳截点为TSH= 2.16（ mIU/L）,此时诊断敏感度为0.646,诊断特异度为0.575。超声弹性成像诊断老年甲状腺微小乳头状癌ROC 曲线下面积为0.814,95%CL（0.721 ～ 0.907）,联合诊断曲线下面积高于超声弹性成像。结论：实时超声弹性成 像联合血清TSH检测对甲状腺微小状乳头癌具有较高诊断价值,且联合检测诊断价值高于实时超声弹性成像。     

The routine immunohistochemical evaluation in Paget disease of the nipple

Paget disease (PD) of the nipple with coexisting intraductal (DCIS) and invasive carcinoma of the breast comprises 0.6-1.8% of all malignant epithelial neoplasms of this organ. Unlike invasive ductal carcinoma, there are many controversies concerning histological features of PD and the significance of the immunohistochemical characteristics of this neoplasm, which limits the optimal treatment protocols. Therefore, we decided to verify the immunohistochemical markers of PD basing on the retrospective analysis of postoperative material from 69 patients treated surgically. Microscopic examination revealed partial (7 cases) or total (62 cases) replacement of the squamous epithelium of the nipple with nests of atypical glandular cells spreading in an area ranging from 0.2 to 2.5 cm. DCIS coexisting with the PD lesions was present in all examined patients, and infiltrating carcinoma occurred in 31 (44.9%) patients. Both intraepidermal and DCIS components presented c-erbB2 overexpression. Positive estrogen and progesterone receptor staining was observed only in 7 (10.1%) and 2 (2.7%) tumours, respectively. Ki-67 proliferation index of PD cells ranged from 10% to 30%, whereas in DCIS it varied from 4% to 20%. The value of Ki-67 index exceeding 25% in the intraepidermal component of PD was associated with worse overall survival rate.     

乳腺导管内乳头状肿瘤187例临床病理及免疫组织化学特征

目的 探讨乳腺导管内乳头状肿瘤(IDPN)的诊断方法和标准.方法 收集187例IDPN患者的临床和病理资料,结合目前认可的2003年WHO乳腺和女性生殖系统肿瘤病理学和遗传学分类标准、Page等和Tavassoli的诊断标准,对其形态学特点进行分析,并对其中53例行CD10、p63、CK14、CK5/6、CK7、乳珠蛋白-1(MGB1)及p53免疫组织化学EnVision法染色分析.结果 187例IDPN患者中导管内乳头状瘤(IDPMa) 128例,不典型导管内乳头状瘤(A-IDPMa) 16例,导管内乳头状癌(IDPCa) 43例.IDPN在形态学上表现为不同程度的上皮细胞和间质增生,以及继发病变等,这些使病灶呈现异常复杂的多样性.免疫组织化学肌上皮标记(CD10和p63)染色在IDPMa、A-IDPMa及IDPCa的表达依次减少,组间比较差异均有统计学意义(均P＜0.001).基底型角蛋白(CK5/6和CK14)染色显示良性病变的表达呈镶嵌状阳性表达,在A-IDPMa的不典型区和IDPCa中表达明显减少或缺如,两者相比差异有统计学意义(P＜0.001).腺腔上皮标志物CK7染色各组间比较差异无统计学意义(P=0.06).MGB1在IDPCa组染色明显减少(P值分别为0.002和0.007),p53染色各组均呈阴性.结论 IDPN是一组组织学改变复杂的疾病,应注意其诊断标准的掌握.肌上皮、基底型角蛋白和腺腔上皮标志物联合应用在该组复杂病变中有很好的诊断和鉴别诊断价值.     

131I-SPECT配2.5mA X射线球管装置显像在分化型甲状腺癌131I去除治疗后的临床应用

目的 探讨单光子发射计算机断层显像（SPECT）/X线计算机断层显像（CT）在131I去除治疗分化型甲状腺癌（DTC）后的临床应用.方法 对119例接受甲状腺全切或部分切除术后的DTC患者（其中男性22例,女性97例）,用131I去除残余甲状腺组织（简称去除治疗）5 ～7d后,行131I-SPECT配2.5mA X射线球管装置和131I全身扫描（131I-WBS显像）,所有结果均通过病理、其他影像检查（B超、CT）和临床随访一年,确定DTC转移灶397处.结果 119例病人经131 I-SPECT配2.5mA X射线球管装置融合显像检查发现DTC转移或复发灶377处,占95％ （377/397）,假阴性有9处,占2％（27/397）,假阳性病灶11处,占3％ （11/397）.131I-WBS显像检查发现DTC转移灶或复发灶324处,占82％（324/397）,假阴性有64处,占16％（64/397）,假阳性病灶9处,占2％（9/397）.从病灶检出数目看,差异具有统计学意义（t=-8.445,P＜0.0I）.结论 131 I-SPECT配2.5mA X射线球管装置显像在131I去除治疗后能够精确定位DTC复发和转移,准确鉴别病灶和生理显像或污染的影响,提高DTC术后病灶的检出率,明确病灶的具体部位及摄碘情况,有助于对DTC进行再分期,为患者的进一步治疗提供临床依据.