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1.
Tsieh Sun Klaus Dittmar Prasad Koduru Myron Susin Saul Teichberg Judith Brody 《American journal of hematology》1996,51(4):282-288
An unusual case of low-grade B-cell lymphoproliferative disorder with peripheral lymphocytosis and splenomegaly followed for 4 1/2 years is reported. During this period, the phenotype of the tumor cells in the blood changed from that of hairy cell leukemia (HCL)/chronic lymphocytic leukemia (CLL) to HCL/prolymphocytic leukemia (PLL), to PLL. The lymphoid population in the blood showed a mixture of hairy cells, villous lymphocytes, small lymphocytes, and prolymphocytes, corresponding to the phenotypes at various stages. Although relatively specific markers for CLL, HCL, and PLL, such as CD5, CD11c, CD22, CD25, and FMC-7, were positive at various stages, all these markers have also been demonstrated in a large study series of splenic lymphoma with villous lymphocytes (SLVL). In addition, the histologic pattern of the bone marrow biopsy and splenectomy specimen were not typical for HCL. This case can therefore be classified either as HCL variant or as SLVL. As SLVL assumes various cytologic and histologic patterns, which overlap with different lymphoproliferative disorders, especially HCL variants, this entity appears to represent a heterogeneous group of lymphomas/leukemias that may evolve into each other. The absence of activation of c-myc and bcl-2 oncogenes as well as mutation of p53 tumor suppressor gene, together with the presence of only one single rearranged band for both heavy chain and κ light chain genes in our case suggest that these morphologically different lymphoid tumors may belong to the same family. © 1996 Wiley-Liss, Inc. 相似文献
2.
The immunophenotype of splenic lymphoma with villous lymphocytes and its relevance to the differential diagnosis with other B-cell disorders 总被引:6,自引:2,他引:6
Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade disorder that regularly presents with peripheral blood involvement. We describe the immunophenotype of the circulating cells from 100 SLVL patients whose disease has been characterized on clinical, morphologic, and histologic grounds. Cells from all cases expressed B-cell antigens (CD19 and CD37) and/or HLA-Dr and showed light chain restriction (kappa/lambda: 1.5/1) with moderate to strong intensity of membrane Ig staining. Cells from most cases (> 80%) were CD24+, FMC7+, and expressed strongly membrane CD22. The monoclonal antibodies CD10, CD23, and CD38 were positive in one-third of the cases; CD11c in 47%; and CD25 in 25% of cases. A minority of cases (< 20%) were positive with HC2, B-ly-7, and CD5. However, none of the 19 CD5+ cases had the phenotype characteristic of chronic lymphocytic leukemia (CD5+, CD23+, FMC7-, weak surface Ig and membrane CD22). None of the 17 CD25+ cases had the immunophenotype typical of hairy cell leukemia (CD25+, CD11c+, HC2+, B-ly-7+). HC2 and B-ly-7 were the most useful reagents to distinguish SLVL from hairy cell leukemia. Our findings demonstrate that SLVL has a distinct immunologic profile and that monoclonal antibodies are important for the differential diagnosis between this disease and other B-lymphoproliferative disorders with which SLVL can be confused. 相似文献
3.
The presence of biclonal gammopathy [immunoglobulin (Ig)Mk + IgAλ] and platelet antibodies in a patient with chronic hepatitis
C virus (HCV) infection is reported. A type-II cryoglobulinemia (IgMk and polyclonal IgG) has also been detected. The IgAλ
monoclonal component still persists after removal of the cryoprecipitate. Two populations of atypical lymphoid cells with
plasmocytoid features in bone marrow have been detected. They express IgM with k restriction and IgA with λ restriction, respectively.
These cells are CD19+, CD5+, bcl2+, and Ki67–. Liver biopsy shows lymphoid infiltrates with features of B follicles. Thrombocytopenia
with platelet antibodies but without splenomegaly is also present. This case is interesting because two hematologic extrahepatic
manifestations simultaneously occur in a patient with HCV infection. Moreover the association between HCV and biclonal gammopathies
has never been reported.
Received: 5 October 1999 / Accepted: 5 January 2000 相似文献
4.
Kuwayama M Machii T Yamaguchi M Yamaguti K Kitani T Kanakura Y 《International journal of hematology》2000,71(2):167-171
A 30-year-old Japanese man with splenomegaly and lymphocytosis was examined in 1985. Blood analysis revealed that some of the lymphocytes had short-surface villi with polar distribution. The cells showed Ig lambda+, CD5+, CD11c+, CD19+, CD22+, CD23+, CD24+, FMC7+ phenotype. A small M peak was detected in the serum. Splenic lymphoma with villous lymphocytes (SLVL) was diagnosed on the basis of these findings. Remission was induced and was maintained with low-dose chlorambucil for more than 10 years. In 1996, the patient developed splenomegaly and lymphadenopathy with "B" symptoms and a high serum lactase dehydrogenase (LDH) level. Large blastoid cells with prominent nucleoli were observed in the bone marrow; later, a small number appeared in the peripheral blood. The bone marrow cells showed a complex chromosomal abnormality involving del(7)(q32). Southern blot analysis of immunoglobulin gene rearrangements in SLVL cells that had been cryopreserved in 1986 and of bone marrow cells in 1996 showed 2 rearranged bands in each cell sample; 1 band showed identical sizes in the 2 samples, and the other showed different sizes. These findings suggest that the blastoid cells were derived from SLVL cells through transformation. After this transformation, the disease followed a highly aggressive course. Various chemotherapeutic agents had little effect, and the patient died 3 months later. 相似文献
5.
Tsieh Sun Myron Susin Judith Brody Klaus Dittmar Saul Teichberg Robert Weiner Jen H. Lin Norbert Felber 《American journal of hematology》1994,45(1):39-50
Splenic lymphoma with villous lymphocytes (SLVL) is a relatively new entity with only a few reports published. We report seven cases of SLVL with detailed clinicopathologic and comprehensive immunophenotypic studies to further characterize this lymphoma, which is frequently confused with hairy cell leukemia and other low-grade B-cell lymphoid neoplasms. The diagnostic criteria we used include 1) prominent splenomegaly, 2) insignificant or no lymphadenopathy, 3) lymphocytosis without leukopenia, 4) presence of circulating villous lymphocytes, 5) characteristic cytologic and histologic features, and 6) specific phenotypic and cytochemical findings. Our studies show that SLVL does not represent a pure entity but rather a morphologically heterogeneous group of low-grade lymphomas with various cytologlc and histologic features. Although immunophenotyping is helpful in differential diagnosis, multiparameter studies are necessary to confirm the diagnosis. In our series, only two patients died of SLVL, who probably developed transformation to a higher-grade lymphoma. © 1994 Wiley-Liss, Inc. 相似文献
6.
Gruszka-Westwood AM Matutes E Coignet LJ Wotherspoon A Catovsky D 《British journal of haematology》1999,107(3):600-604
Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade B-cell lymphoproliferative disorder characterized by splenomegaly and circulating villous lymphocytes. The relationship between SLVL and splenic marginal zone lymphoma (SMZL), a disorder with identical splenic histology to SLVL, is not clear. Previous studies have failed to show a consistent karyotypic abnormality in SLVL whereas trisomy 3 has been reported in patients with SMZL. The presence of trisomy 3 in SMZL and its absence in SLVL has been viewed as evidence that these are different diseases. However, it is possible that the frequency of trisomy 3 in SLVL has been underestimated because previous studies have relied on conventional cytogenetics. We have therefore used interphase fluorescence in situ hybridization (FISH) to re-assess the frequency of trisomy 3 in SLVL. We studied 70 patients, who were stratified into four groups according to the percentage of circulating villous lymphocytes. Trisomy 3 was found overall in 17% of patients. In particular, trisomy 3 was detected in 13% of cases with >50% of villous lymphocytes and which were considered typical of SLVL. In conclusion, we have demonstrated that some patients with SLVL have circulating cells with trisomy 3, which does not support the view that SLVL and SMZL are different diseases on the basis of the incidence of trisomy 3. 相似文献
7.
Costes V Duchayne E Taib J Delfour C Rousset T Baldet P Delsol G Brousset P 《British journal of haematology》2002,119(4):916-922
We report a retrospective immunohistochemical study on bone marrow biopsies of 43 patients with different types of lymphomas showing unusual intrasinusoidal infiltration. Most of these patients presented with splenomegaly (74.4%) and peripheral lymphocytosis (83%). In 20/43 patients, lymphoid infiltrates were not detectable on haematoxylin-eosin sections. After immunohistochemistry on bone marrow biopsies and blood and bone marrow smear examinations, the following diagnoses were made: splenic marginal zone lymphoma with villous lymphocytes (SLVL) in 24 patients, large granular lymphocyte (LGL) leukaemia in 14 patients, hepatosplenic T-cell lymphoma in two patients, anaplastic large cell lymphoma in two patients and intravascular large B-cell lymphoma in one patient. In the presence of intrasinusoidal infiltrates of small lymphocytes, a B-cell phenotype (CD20+, CD76/DBA44+/-) was associated with splenic marginal zone lymphoma whereas intrasinusoidal CD3/CD45RA-positive T-cell infiltrates were strongly suggestive of LGL leukaemia. Intrasinusoidal bone marrow infiltration appears to be a common feature of distinct lymphoma subtypes. Immunohistochemical analysis is essential to detect intrasinusoidal medullary infiltrates (which may be minimal) and should be systematically performed in patients with splenomegaly and peripheral lymphocytosis. 相似文献
8.
Chronic lymphocytic leukemia with two cellular populations: a biphenotypic or biclonal disease 总被引:1,自引:0,他引:1
J. González-Campos E. Ríos-Herranz J. M. De Blas-Orlando A. Martín-Noya R. Parody-Ruiz-Berdejo J. M. Rodríguez-Fernández 《Annals of hematology》1997,74(5):243-246
A case of CLL with two different cellular populations is reported. A 50-year-old man was evaluated for persistent absolute
lymphocytosis. A peripheral blood smear revealed numerous small lymphocytes (83% of white blood cells counted). Frequent Grumpecht
shadows were present, too. On bone marrow aspirate smears lymphocytes comprised 85% of the total cells counted, and the bone
marrow biopsy showed a mixed nodular-interstitial infiltration pattern. The immunophenotypic study showed two different leukemic
populations. The first one (comprising 79% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18–, CD22–, CD23++, lambda dim,
and FMC7–. The second population (comprising 21% leukemic cells) was CD5+, CD19+, CD10–, CD20+, CD18+, CD22+, CD23+, lambda++,
and FMC7+. Gene rearrangement studies detected the germline and one rearranged band in Jk blot with each restriction endonuclease.
In the Jh blot the germline and two rearranged bands were detected with EcoRI and BamHI and three rearranged bands with HindIII. The JBI/JBII blot detected only the germline band. The detection of three rearranged bands was interpreted as evidence
of the presence of at least two monoclonal populations of cells with the same light chain restriction.
Received: 10 September 1996 / Accepted: 17 February 1997 相似文献
9.
Splenic lymphoma with circulating villous lymphocytes/splenic marginal-zone lymphoma. 总被引:11,自引:0,他引:11
Splenic lymphoma with villous lymphocytes (SLVL) represents a low-grade B-cell non-Hodgkin's lymphoma (NHL) that histologically is indistinguishable from splenic marginal-zone lymphoma (SMZL). Characteristic features of SLVL are splenomegaly, moderate lymphocytosis, nodular and intrasinusoidal pattern of bone marrow infiltration, serum monoclonal band, slow benign course, and response to splenectomy. The diagnosis is made by the morphology of the circulating villous cells and their immunophenotype, which is distinct from that of chronic lymphocytic leukemia (CLL) and hairy-cell leukemia (HCL), diseases with which SLVL may be confused. When treatment is indicated, splenectomy is the treatment of choice, but some patients may require additional chemotherapy to control progression. In those circumstances, fludarabine may be the agent of choice. Despite its unique features, which, compounded, suggest that SLVL is a clinicopathologic entity, there are no specific chromosome abnormalities and problems of differential diagnosis with other B-cell NHLs, chiefly mantle-cell lymphoma (MCL), remain in a minority of patients. 相似文献
10.
J. L. Dargent J. P. Delville A. Kornreich O. Pradier P. Cochaux T. Velu P. Capel W. Feremans P. Neve 《Annals of hematology》1997,74(3):149-153
A particular case of marginal zone B-cell lymphoma (MZBCL) presenting with leukemic lymphocytes is reported. In the present
observation, the leukemic cells not only displayed a remarkable morphological fluctuation but also had an unusual phenotype,
changing with time. These phenotypic features, which have been functionally investigated by in vitro assays, might simply
reflect an activation state depending on the microenvironment. Because of its disconcerting similarities with hairy cell leukemia
(HCL) and splenic lymphoma with villous lymphocytes (SLVL), this case relaunches the debate about whether close relationships
might exist between the splenic marginal zone, SLVL and HCL.
Received: 3 September 1996 / Accepted: 22 November 1996 相似文献
11.
Yasukawa M Yamauchi H Azuma T Takada K Ishimura M Fujita S 《European journal of haematology》2002,69(2):112-114
Splenic lymphoma with villous lymphocytes (SLVL) is an indolent lymphoproliferative disorder of mature B lymphocytes. Splenectomy is primarily recommended for treating this disease, and splenic irradiation or alkylating agents may be effective; however, frequent recurrence is observed after these therapies. We report here an unusual case of SLVL in which the degree of splenomegaly and the serum IgM level increased rapidly. Although the effects of splenic irradiation and combination chemotherapy were both unsatisfactory and transient, complete remission lasting for more than 15 months was achieved after two courses of treatment with low-dose fludarabine (15 mg m(-2) daily for 3 d). The present case indicates that treatment with fludarabine is effective for SLVL and recommended as the first-line therapy for elderly patients and those with an aggressive form of the disease. 相似文献
12.
Parry-Jones N Matutes E Gruszka-Westwood AM Swansbury GJ Wotherspoon AC Catovsky D 《British journal of haematology》2003,120(5):759-764
Splenic lymphoma with villous lymphocytes (SLVL) is a low-grade B-cell lymphoma defined in the World Health Organization classification as the leukaemic form of splenic marginal zone lymphoma. Presenting features and response to therapy have been described, but information on prognostic factors is scanty. Clinical, laboratory and follow-up data were collected on 129 patients with SLVL to determine features predicting disease behaviour and survival. Diagnosis was made on clinical, morphological and immunophenotypic features and, where available, bone marrow and spleen histology. Median age was 69 years (range 39-90 years) and male:female ratio, 0.9. The majority had splenomegaly, but lymphadenopathy and hepatomegaly were rare. Median Hb was 11.8 g/dl, white blood cell count was 16 x 10(9)/l and platelet count was 145 x 10(9)/l; 27% of patients had monoclonal protein in serum and/or urine. While 27% of patients remained untreated, 10% transformed to high-grade lymphoma. Median follow-up was 61 months and median survival was 13 years, with 72% of patients alive at 5 years. Cox regression analysis showed that increasing age, anaemia, thrombocytopenia and lymphocytosis > 16 x 10(9)/l were independent adverse predictors of overall survival. However, only anaemia and lymphocytosis > 16 x 10(9)/l remained highly significant independent prognostic factors when only deaths due to lymphoma were analysed. Splenectomized patients fared better than those receiving chemotherapy only (P = 0.001 for SLVL deaths). We conclude that SLVL is mainly a disease of the elderly with a relatively benign course but, when treatment is required, splenectomy is beneficial. 相似文献
13.
Fludarabine is effective in the treatment of splenic lymphoma with villous lymphocytes 总被引:3,自引:0,他引:3
We report on the use of fludarabine in four patients with splenic lymphoma with villous lymphocytes (SLVL). All four had relapsed after, or failed to respond to, recommended first-line therapies. In each case fludarabine resulted in a complete clinico-haematological response with minimal toxicity, which, in the two patients with long-term follow-up, proved durable. Fludarabine is effective in the treatment of SLVL and should be considered as both a first-line therapeutic option as well as salvage therapy in this condition. 相似文献
14.
Fujita T Asagoe K Sakoda H 《[Rinshō ketsueki] The Japanese journal of clinical hematology》2003,44(4):249-253
We report on a case of splenic lymphoma with villous lymphocytes (SLVL) which responded well to rituximab. A 50-year-old man was admitted because of splenomegaly. Abnormal lymphocytes of B cell lineage with moderately basophilic cytoplasm and unevenly distributed villi (villous cells) were found, both in the peripheral blood and bone marrow. CHOP and CHOP-E were performed, without any remarkable change in the size of the spleen. However, after infusion of rituximab (375 mg/m2, once weekly for 2 weeks), there was a marked reduction of the spleen size and the number of circulating villous cells. Splenectomy was performed afterwards, followed by 2 cycles of rituximab infusion. The patient is now followed on an outpatient basis without any sign of relapse. 相似文献
15.
Characterization of the light chain-restricted clonal B cells in peripheral blood of HCV-positive patients 总被引:1,自引:0,他引:1
Korenori Ohtsubo Michio Sata Takumi Kawaguchi Satoshi Morishige Yuka Takata Eijiro Oku Rie Imamura Ritsuko Seki Michitoshi Hashiguchi Koichi Osaki Kazuaki Yakushiji Taisuke Kanaji Kohji Yoshimoto Takato Ueno Takashi Okamura 《International journal of hematology》2009,89(4):452-459
To investigate the association between hepatitis C virus (HCV) and B cell proliferation, we searched for the clonal B cells
by flow cytometric analysis of the surface immunoglobulin kappa (κ):lambda (λ) light chain ratios of the circulating B (CD19+)
cells in 240 HCV-positive patients and 150 negative controls with liver diseases. Clonal B cells with light chain restriction
(κ:λ ratio >3:1 or <1:2) were analyzed for CD5 expression and the presence of monoclonal immunoglobulin heavy-chain (IGH) gene rearrangements and the t(14;18) chromosomal translocation. Clonal B cells were detected in 7 cases with HCV (2.9%), but was never detected in the
controls (p < 0.05). Of the 7 cases, all had monoclonal IGH gene rearrangements and one had the t(14;18) chromosomal translocation. These HCV-related clonal B cells are not uniform in the intensity of CD5 expression and
showed no increase in the frequencies of CD5+ population compared with non-clonal B cells. No “chronic lymphocytic leukemia-phenotype”
cells were found. The loss of clonality was observed in 2 cases treated with interferon and in one case treated with splenectomy.
The longitudinal study is required to determine whether these circulating clonal B cells progress to lymphoproliferative disorders
in future or not. 相似文献
16.
YOSHIO KATAYAMA KENSUKE KOJIMA TADASHI YOSHINO YOSHINOBU MATSUO MASAFUMI ISOKAWA TOMOFUMI YANO HIDEYUKI OKA MIKA YAMAGUCHI SEIGO DEGUCHI JUNJIRO TSUCHIYAMA KYOICHI HAYASHI TAKANORI TESHIMA KATSUJI SHINAGAWA FUMIHIKO ISHIMARU EIJIRO OMOTO & MINE HARADA 《British journal of haematology》1997,97(3):626-634
In two-thirds of patients with splenic lymphoma with villous lymphocytes (SLVL) a small amount of M-protein can be detected in association with the presence of plasma cells in the peripheral blood (PB) and/or bone marrow (BM). However, it is not known whether lymphoma cells and plasma cells originate from the same clone. In this report we describe a case of SLVL which was characterized by the presence of marked monoclonal gammopathy (IgG-κ 90 g/l) and increased plasma cells in the BM. In an attempt to elucidate the origin of lymphoma cells and plasma cells, we performed morphological, cytogenetic and molecular studies on PB mononuclear cells (PBMNC) without plasma cells and BMMNC containing 10% plasma cells from this patient.
Immunofluorescence showed that lymphoma cells and plasma cells were positive for cytoplasmic γ heavy and κ light chains. Well-developed endoplasmic reticulum was observed in the cytoplasmic organelles of PBMNC using an electron microscope. The mean IgG concentration in the 3 d supernatant cultures of PBMNC was 374±24μg/l. More than 50% PBMNC differentiated into plasmacytoid cells in 6 d of liquid culture with IL-3 and IL-6. Analysis by two-colour FISH revealed that karyotypic abnormalities of monosomy X and trisomy 17 existed simultaneously in both lymphoma cells and plasma cells. JH gene rearranged bands from PBMNC and BMMNC by Southern blot hybridization were identical, whereas DNAs from PBMNC failed to hybridize with the Cμ probe.
These observations strongly suggest that lymphoma cells and plasma cells originate from the same clone, and that plasma cells, as well as lymphoma cells, which have undergone class switch recombination, could produce IgG type M-protein in this case. 相似文献
Immunofluorescence showed that lymphoma cells and plasma cells were positive for cytoplasmic γ heavy and κ light chains. Well-developed endoplasmic reticulum was observed in the cytoplasmic organelles of PBMNC using an electron microscope. The mean IgG concentration in the 3 d supernatant cultures of PBMNC was 374±24μg/l. More than 50% PBMNC differentiated into plasmacytoid cells in 6 d of liquid culture with IL-3 and IL-6. Analysis by two-colour FISH revealed that karyotypic abnormalities of monosomy X and trisomy 17 existed simultaneously in both lymphoma cells and plasma cells. JH gene rearranged bands from PBMNC and BMMNC by Southern blot hybridization were identical, whereas DNAs from PBMNC failed to hybridize with the Cμ probe.
These observations strongly suggest that lymphoma cells and plasma cells originate from the same clone, and that plasma cells, as well as lymphoma cells, which have undergone class switch recombination, could produce IgG type M-protein in this case. 相似文献
17.
Margarida Lima Maria dos Anjos Teixeira Maria Luís Queirs Ana Helena Ribeiro dos Santos Benvindo Justia 《American journal of hematology》1997,56(2):122-125
We compared the expression of the BCL-2 oncoprotein (p26) on B cells from 24 patients with splenic lymphoma with circulating villous lymphocytes (SLVL) with that observed on normal, mature B lymphocytes and on neoplastic B cells from 91 patients with other chronic B-cell malignancies. SLVL B cells showed levels of p26 intermediate between those found on normal B lymphocytes and on neoplastic B cells from patients with other chronic B-cell lymphoproliferative disorders. Am. J. Hematol. 56:122–125, 1997. © 1997 Wiley-Liss, Inc. 相似文献
18.
Čolović M Jurisic V Bila J Čolović N Palibrk V 《International journal of hematology》2011,93(2):228-231
The presence of multiple myeloma (MM) in a patient with systemic sclerosis is a rare and unusual occurrence with unclear significance.
We report the case of a 55-year-old woman with a 20-year history of systemic sclerosis, who subsequently presented with clinical
stage IIIA IgG-λ MM. The systemic sclerosis was diagnosed and treated in 1988 with d-penicillamine and methotrexate. Twenty years later, in December 2008, she presented with symptoms of Raynaud’s phenomenon
and intense facial pruritus. Immunoelectrophoresis confirmed the presence of a IgG-λ paraprotein (71.90 g/l) and Bence Jones
proteinuria of the lambda light chains. Bone marrow histology revealed infiltrates of plasmocytes and lymphoplasmocytes which
were on immunohistochemistry CD38+, FGF-R3+ and OPG+. An extensive X-ray skeletal survey did not show any osteolytic lesions
or fractures. The patient was treated according to the CTD protocol (cyclophosphamide, thalidomide, and dexamethasone) which
was effective against the myeloma as well as the systemic sclerosis and patient achieved complete remission. 相似文献
19.
G. Graziadei G. Pruneri N. Carboni S. Luminari M. L. La Targia A. Neri M. Colombi R. Buffa L. Baldini 《Annals of hematology》1998,76(2):81-83
Mucosa-associated lymphoid tissue (MALT) lymphomas are indolent neoplasms which tend to remain localized for a long time
before spreading. We describe here the case of a 36-year-old woman with a low-grade MALT lymphoma involving the lung, stomach,
lingual tonsil, and bone marrow at the time of diagnosis. The clonal origin of the pulmonary and bone marrow neoplastic infiltrates
was assessed by means of gene rearrangement analysis. All of the involved sites were infiltrated by centrocyte- and monocytoid-like
cells expressing the B-cell-associated antigens CD19 and CD20 and showed IgM λ chain restriction; no CD5, CD10, or CD43 expression
was detectable. As the patient had a history of recurrent bronchitis, and computed tomography performed 3 years before the
lymphoma diagnosis had already revealed a lesion of the left lung, we conclude that the present case probably represents a
pulmonary low-grade MALT lymphoma characterized by an early and unusual involvement of different mucosal sites and bone marrow.
Received: 27 June 1997 / Accepted: 20 November 1997 相似文献
20.
Cytogenetic studies in splenic lymphoma with villous lymphocytes 总被引:10,自引:0,他引:10
D. G. Oscier E. Matutes A. Gardiner S. Glide S. Mould V. Brito-Babapulle J. Ellis D. Catovsky 《British journal of haematology》1993,85(3):487-491
Summary. We report the cytogenetic findings on 31 cases of splenic lymphoma with villous lymphocytes (SLVL). TPA stimulated cells from peripheral blood (28 cases), spleen (two cases) and lymph node (one case) with SLVL have been analysed. A clonal chromosome abnormality was found in 27/31 patients (87%): this was identified as a simple abnormality in 12 cases and a complex one in 15. Four recurring abnormalities were seen: t(11:14) (q13:q32)in five patients, deletions or translocations involving 7q in seven patients. iso 17q in four patients and translocations involving 2p11 in four patients. The high frequency of clonal chromosome abnormalities in SLVL contrasts with the usually benign clinical course of this disease.
Abnormalities found frequently in patients with chronic lymphocytic leukaemia (CLL) such as trisosmy 12 and deletions or translocations involving 13q14 were each seen in only one patient. No case had the t(14:18) characteristic of follicular lymphoma.
Our findings demonstrate the high frequency of clonal and often complex chromosome abnormalities in SLVL. Although a unique chromosome rearrangement has not been identified, a pattern of four recurrent abnormalities has emerged. Our results suggest that SLVL is distinct on cytogenetic grounds from B-CLL and follicular lymphoma but shows similarity with mantle cell lymphoma, lymphoplasmacytic lymphoma and B-PLL. 相似文献
Abnormalities found frequently in patients with chronic lymphocytic leukaemia (CLL) such as trisosmy 12 and deletions or translocations involving 13q14 were each seen in only one patient. No case had the t(14:18) characteristic of follicular lymphoma.
Our findings demonstrate the high frequency of clonal and often complex chromosome abnormalities in SLVL. Although a unique chromosome rearrangement has not been identified, a pattern of four recurrent abnormalities has emerged. Our results suggest that SLVL is distinct on cytogenetic grounds from B-CLL and follicular lymphoma but shows similarity with mantle cell lymphoma, lymphoplasmacytic lymphoma and B-PLL. 相似文献